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The map label for this gene is nuoH [H]

Identifier: 157371539

GI number: 157371539

Start: 3654779

End: 3655756

Strand: Reverse

Name: nuoH [H]

Synonym: Spro_3302

Alternate gene names: 157371539

Gene position: 3655756-3654779 (Counterclockwise)

Preceding gene: 157371540

Following gene: 157371538

Centisome position: 67.09

GC content: 55.11

Gene sequence:

>978_bases
ATGAGCTGGTTTACCCCTGAGGTGATCGACATTCTGATCTCCATTGTTAAAGCGGTAGTGATCCTGCTGGTCGTAGTCAC
CTGCGGGGCATTCATGAGCTTCGGCGAACGCCGTTTGCTCGGTCTGTTCCAGAACCGTTATGGACCAAACCGTGTCGGCT
GGGGTGGCTCGCTGCAGCTGGTCGCCGACATGATCAAAATGTTCTTCAAGGAAGACTGGGTACCGAAATTCTCCGACCGG
GTGATCTTTACCCTGGCGCCGATGATCGCCTTTACTTCCCTGTTGCTGGCATTTGCCATCGTCCCGGTCAGCCCGACCTG
GGCGGTGTCCGACCTCAACATCGGTATTTTGTTCTTTCTGATGATGGCCGGCCTGGCGGTATACGCCGTGCTGTTCGCCG
GCTGGTCGAGCAACAACAAATACTCGCTGTTGGGGGCAATGCGTGCTTCTGCGCAAACCCTGAGCTACGAAGTGTTCATC
GGCCTGTCGCTGATGGGCGTGGTGGCACAGGCGGACTCCTTCAACATGCAGGCGATCGTTGAATCTCAGGCGCATATGTG
GAACGTCATCCCGCAATTCTTTGGTTTCATTACCTTTGCGATTGCCGGTGTGGCGGTGTGTCACCGTCACCCGTTTGACC
AACCGGAAGCCGAGCAGGAACTGGCTGACGGTTACCACATTGAATATTCCGGCATGAAGTTCGGGCTGTTCTTTGTGGGT
GAATACATAGGTATCGTCACCGTTTCTGCCCTGATTGTGACGTTGTTCTTCGGTGGCTGGCAGGGTCCATTCCTGCCGCC
ATTCGTCTGGTTCGCGCTGAAAACGGCTTTCTTCATGATGATGTTCATACTGATTCGTGCTGCTCTGCCACGTCCGCGCT
ATGACCAGGTGATGTCCTTCGGCTGGAAAGTGTGTCTGCCGTTGACGCTGCTGAACCTGCTGGCGACTGCCGCCGTCATT
TTGTACAACGCTCAATAA

Upstream 100 bases:

>100_bases
AAACCCTGACCCAGGGCCAACTGGGCTTACCGCTCGGCTTGCCAGGGATCCCGCCGGTACTGGTGGGTGCAACGGTTGAA
AATCTGCGGGAGGCGACACG

Downstream 100 bases:

>100_bases
GGGGTGAATAAACCATGACATTGAAAGAGTTATTGGTTGGTTTCGGCACCCAGGTGCGCAGCATTTGGATGATAGGCCTG
CACGCCTTCGCCAAGCGCGA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSWFTPEVIDILISIVKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWVPKFSDR
VIFTLAPMIAFTSLLLAFAIVPVSPTWAVSDLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFI
GLSLMGVVAQADSFNMQAIVESQAHMWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVG
EYIGIVTVSALIVTLFFGGWQGPFLPPFVWFALKTAFFMMMFILIRAALPRPRYDQVMSFGWKVCLPLTLLNLLATAAVI
LYNAQ

Sequences:

>Translated_325_residues
MSWFTPEVIDILISIVKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWVPKFSDR
VIFTLAPMIAFTSLLLAFAIVPVSPTWAVSDLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFI
GLSLMGVVAQADSFNMQAIVESQAHMWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVG
EYIGIVTVSALIVTLFFGGWQGPFLPPFVWFALKTAFFMMMFILIRAALPRPRYDQVMSFGWKVCLPLTLLNLLATAAVI
LYNAQ
>Mature_324_residues
SWFTPEVIDILISIVKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQLVADMIKMFFKEDWVPKFSDRV
IFTLAPMIAFTSLLLAFAIVPVSPTWAVSDLNIGILFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFIG
LSLMGVVAQADSFNMQAIVESQAHMWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGE
YIGIVTVSALIVTLFFGGWQGPFLPPFVWFALKTAFFMMMFILIRAALPRPRYDQVMSFGWKVCLPLTLLNLLATAAVIL
YNAQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=283, Percent_Identity=40.2826855123675, Blast_Score=198, Evalue=6e-51,
Organism=Escherichia coli, GI1788618, Length=325, Percent_Identity=91.6923076923077, Blast_Score=614, Evalue=1e-177,
Organism=Escherichia coli, GI1789077, Length=234, Percent_Identity=26.9230769230769, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 36210; Mature: 36079

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWFTPEVIDILISIVKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
VADMIKMFFKEDWVPKFSDRVIFTLAPMIAFTSLLLAFAIVPVSPTWAVSDLNIGILFFL
HHHHHHHHHHHCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHH
MMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFIGLSLMGVVAQADSFNMQAIV
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ESQAHMWNVIPQFFGFITFAIAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEECCCEEHHHHHH
EYIGIVTVSALIVTLFFGGWQGPFLPPFVWFALKTAFFMMMFILIRAALPRPRYDQVMSF
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHC
GWKVCLPLTLLNLLATAAVILYNAQ
CHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SWFTPEVIDILISIVKAVVILLVVVTCGAFMSFGERRLLGLFQNRYGPNRVGWGGSLQL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH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CHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA