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The map label for this gene is nuoL [H]

Identifier: 157371535

GI number: 157371535

Start: 3651505

End: 3653352

Strand: Reverse

Name: nuoL [H]

Synonym: Spro_3298

Alternate gene names: 157371535

Gene position: 3653352-3651505 (Counterclockwise)

Preceding gene: 157371536

Following gene: 157371534

Centisome position: 67.05

GC content: 58.17

Gene sequence:

>1848_bases
ATGAACCTATTATATTTAACTATTCTGCTACCGCTGATCGGGTTCCTGCTGTTGGCCTTCTCCCGAGGCCGCTGGTCTGA
GAACACCTCGGCAATCGTCGGCGTAGGCTCTATCGGCCTGGCTGCTCTGGTCACGGTCCACGTGGGTATGGACTTCTTCG
CCCAGAAAGCCACGGGTGTGCAGCTGTTTGAGCAAAACCTGTGGAACTGGATGAGCGTCGGTAATTTCAATATCGGTGTG
ACCCTGACGCTGGACGGCCTGTCGCTGACCATGCTGTCAGTGGTGACCGGCGTGGGCTTCTTCATCCACATGTTCGCTTC
CTGGTACATGCGCGGTGAAGAGGGCTACTCACGCTTCTTCGCGTACACCAACCTGTTTATCGCCAGCATGGTGGTATTGG
TACTTGCAGACAACCTGTTGCTGCTGTACCTGGGTTGGGAAGGCGTGGGCCTGTGCAGCTACCTGTTGATCGGTTTCTAT
TACAAGGATCCGGCCAACGGTGCGGCGGCAATGAAAGCCTTCATCGTGACCCGCGTCGGTGACGTGTTCCTGGCATTTGC
GCTGTTCATCCTCTACAACGAGCTGGGCACGCTGAACATCCGCGAACTGATGATCCTGGCACCGCAAAAACTGGCGGTCG
GCGATACGGCGATCACCTGGGCTACGTTGATGTTGCTGGGTGGTGCGGTCGGTAAATCGGCGCAGTTGCCGTTGCAGACC
TGGCTGGCAGACGCGATGGCGGGTCCAACCCCGGTTTCTGCACTGATCCACGCAGCAACCATGGTGACCGCGGGCGTTTA
CCTGATTGCCCGTACTCACGGCCTGTTCCTGATGGCGCCGGAAGTGCTGCATCTGGTGGGCATTATCGGGGCGGTGACCC
TGGTGCTGGCCGGCTTTGCCGCGCTGGTGCAAACCGATATCAAGCGCGTGCTTGCCTACTCCACCATGAGCCAGATTGGC
TACATGTTCCTGGCGTTGGGCGTACAGGCGTGGGATGCGGCTATCTTCCACCTGATGACCCATGCGTTCTTCAAGGCGCT
GCTGTTCCTCTCCTCCGGTTCAGTGATCCTGGCCTGTCATCACGAGCAGAACATCTTCAAGATGGGCGGCCTGCGCAAGA
GCATTCCGCTGGTTTACGTCTGCTTCCTGGTGGGTGGCGCTGCGCTGTCGGCACTGCCGCTGATCACCGCAGGCTTCTTC
AGTAAGGATGAGATCCTGGCCGGTGCGATGGCTAACGGTCACATCAACCTGATGATTGCCGGTCTGGTCGGTGCGTTCAT
GACCTCGCTGTACACCTTCCGTATGATTTTCATCGTGTTCCATGGCGAAGAGAAAATCAAAGCGCATGCCGGTAAAGGCA
TCACTCACCACCTGCCGCTGTTGGTTCTGCTGGTGCTGTCCACCTTCGTTGGCGCGATGATCGTTCCGCCATTGCAGGGC
GTACTGCCAGACACCACCGAGCTGGCGCACGGTAGCGTGCTGCAACTGGAGATTACCTCCGGCGTAGTGGCTATTGTCGG
CATCCTGCTGGCGGCGGCGCTGTGGCTGGGCAAACGTAGCCTGGTGACCCGCATTGCCAATAGCGCACCGGGGCGTTTCT
TCTCGACCTGGTGGTTCCATGCCTGGGGCTTCGACTGGCTGTACGACAAAGTGTTCGTCAAGCCGTACCTGGGTATTGCG
AAGTTGCTGCAGCGTGATCCGCTGAACTCGATGATGAACCTGCCGGCCATCTTCTCCCGCTGGGGGAACCGAGGTCTGAC
AGTGAGCGAGAACGGTCAGGTGCGTTGGTATATAGCGTCTATGGGTGTGGGTGCAGTGGTCGTATTGGCTCTGTTGATTC
TGGTTTAA

Upstream 100 bases:

>100_bases
GCCTGGCAGCCGCCGAGGCCAGTATTGGTCTGGCATTGCTGCTGCAGCTTTACCGTCGTCGTCATACCCTGAATATTGAT
ACTGTCAGTGAGATGCGCGG

Downstream 100 bases:

>100_bases
TTGAATAATTTAAACAGACGCATTTTTCGGGCGTAGCGCCCTGCAGGGCAGGCGCTACGTACAAAGTTTGAAATTATTCG
TATAAGGGACACAAAACGCC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L; NUO12 [H]

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MNLLYLTILLPLIGFLLLAFSRGRWSENTSAIVGVGSIGLAALVTVHVGMDFFAQKATGVQLFEQNLWNWMSVGNFNIGV
TLTLDGLSLTMLSVVTGVGFFIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLADNLLLLYLGWEGVGLCSYLLIGFY
YKDPANGAAAMKAFIVTRVGDVFLAFALFILYNELGTLNIRELMILAPQKLAVGDTAITWATLMLLGGAVGKSAQLPLQT
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPEVLHLVGIIGAVTLVLAGFAALVQTDIKRVLAYSTMSQIG
YMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFF
SKDEILAGAMANGHINLMIAGLVGAFMTSLYTFRMIFIVFHGEEKIKAHAGKGITHHLPLLVLLVLSTFVGAMIVPPLQG
VLPDTTELAHGSVLQLEITSGVVAIVGILLAAALWLGKRSLVTRIANSAPGRFFSTWWFHAWGFDWLYDKVFVKPYLGIA
KLLQRDPLNSMMNLPAIFSRWGNRGLTVSENGQVRWYIASMGVGAVVVLALLILV

Sequences:

>Translated_615_residues
MNLLYLTILLPLIGFLLLAFSRGRWSENTSAIVGVGSIGLAALVTVHVGMDFFAQKATGVQLFEQNLWNWMSVGNFNIGV
TLTLDGLSLTMLSVVTGVGFFIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLADNLLLLYLGWEGVGLCSYLLIGFY
YKDPANGAAAMKAFIVTRVGDVFLAFALFILYNELGTLNIRELMILAPQKLAVGDTAITWATLMLLGGAVGKSAQLPLQT
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPEVLHLVGIIGAVTLVLAGFAALVQTDIKRVLAYSTMSQIG
YMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFF
SKDEILAGAMANGHINLMIAGLVGAFMTSLYTFRMIFIVFHGEEKIKAHAGKGITHHLPLLVLLVLSTFVGAMIVPPLQG
VLPDTTELAHGSVLQLEITSGVVAIVGILLAAALWLGKRSLVTRIANSAPGRFFSTWWFHAWGFDWLYDKVFVKPYLGIA
KLLQRDPLNSMMNLPAIFSRWGNRGLTVSENGQVRWYIASMGVGAVVVLALLILV
>Mature_615_residues
MNLLYLTILLPLIGFLLLAFSRGRWSENTSAIVGVGSIGLAALVTVHVGMDFFAQKATGVQLFEQNLWNWMSVGNFNIGV
TLTLDGLSLTMLSVVTGVGFFIHMFASWYMRGEEGYSRFFAYTNLFIASMVVLVLADNLLLLYLGWEGVGLCSYLLIGFY
YKDPANGAAAMKAFIVTRVGDVFLAFALFILYNELGTLNIRELMILAPQKLAVGDTAITWATLMLLGGAVGKSAQLPLQT
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPEVLHLVGIIGAVTLVLAGFAALVQTDIKRVLAYSTMSQIG
YMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFF
SKDEILAGAMANGHINLMIAGLVGAFMTSLYTFRMIFIVFHGEEKIKAHAGKGITHHLPLLVLLVLSTFVGAMIVPPLQG
VLPDTTELAHGSVLQLEITSGVVAIVGILLAAALWLGKRSLVTRIANSAPGRFFSTWWFHAWGFDWLYDKVFVKPYLGIA
KLLQRDPLNSMMNLPAIFSRWGNRGLTVSENGQVRWYIASMGVGAVVVLALLILV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=503, Percent_Identity=35.3876739562624, Blast_Score=258, Evalue=9e-69,
Organism=Escherichia coli, GI1788614, Length=604, Percent_Identity=85.4304635761589, Blast_Score=1042, Evalue=0.0,
Organism=Escherichia coli, GI1788829, Length=427, Percent_Identity=34.192037470726, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI1788827, Length=345, Percent_Identity=31.304347826087, Blast_Score=119, Evalue=8e-28,
Organism=Escherichia coli, GI1788831, Length=363, Percent_Identity=28.9256198347107, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788613, Length=526, Percent_Identity=25.6653992395437, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI2367154, Length=315, Percent_Identity=27.9365079365079, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693160, Length=364, Percent_Identity=25.8241758241758, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66611; Mature: 66611

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLYLTILLPLIGFLLLAFSRGRWSENTSAIVGVGSIGLAALVTVHVGMDFFAQKATGV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
QLFEQNLWNWMSVGNFNIGVTLTLDGLSLTMLSVVTGVGFFIHMFASWYMRGEEGYSRFF
HHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AYTNLFIASMVVLVLADNLLLLYLGWEGVGLCSYLLIGFYYKDPANGAAAMKAFIVTRVG
HHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DVFLAFALFILYNELGTLNIRELMILAPQKLAVGDTAITWATLMLLGGAVGKSAQLPLQT
HHHHHHHHHHHHHHCCCCCHHHHHEECCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHH
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPEVLHLVGIIGAVTLVLAGFA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHH
ALVQTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
HEQNIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFFSKDEILAGAMANGHINLMIA
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEHHH
GLVGAFMTSLYTFRMIFIVFHGEEKIKAHAGKGITHHLPLLVLLVLSTFVGAMIVPPLQG
HHHHHHHHHHHHHHHHHHEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
VLPDTTELAHGSVLQLEITSGVVAIVGILLAAALWLGKRSLVTRIANSAPGRFFSTWWFH
CCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHH
AWGFDWLYDKVFVKPYLGIAKLLQRDPLNSMMNLPAIFSRWGNRGLTVSENGQVRWYIAS
HCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCCCCEECCCCCEEEEEEC
MGVGAVVVLALLILV
CCHHHHHHHHHHHHC
>Mature Secondary Structure
MNLLYLTILLPLIGFLLLAFSRGRWSENTSAIVGVGSIGLAALVTVHVGMDFFAQKATGV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
QLFEQNLWNWMSVGNFNIGVTLTLDGLSLTMLSVVTGVGFFIHMFASWYMRGEEGYSRFF
HHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AYTNLFIASMVVLVLADNLLLLYLGWEGVGLCSYLLIGFYYKDPANGAAAMKAFIVTRVG
HHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DVFLAFALFILYNELGTLNIRELMILAPQKLAVGDTAITWATLMLLGGAVGKSAQLPLQT
HHHHHHHHHHHHHHCCCCCHHHHHEECCCHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHH
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPEVLHLVGIIGAVTLVLAGFA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHH
ALVQTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
HEQNIFKMGGLRKSIPLVYVCFLVGGAALSALPLITAGFFSKDEILAGAMANGHINLMIA
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEEEHHH
GLVGAFMTSLYTFRMIFIVFHGEEKIKAHAGKGITHHLPLLVLLVLSTFVGAMIVPPLQG
HHHHHHHHHHHHHHHHHHEEECCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
VLPDTTELAHGSVLQLEITSGVVAIVGILLAAALWLGKRSLVTRIANSAPGRFFSTWWFH
CCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHH
AWGFDWLYDKVFVKPYLGIAKLLQRDPLNSMMNLPAIFSRWGNRGLTVSENGQVRWYIAS
HCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCCCCEECCCCCEEEEEEC
MGVGAVVVLALLILV
CCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7690854; 9205837; 9278503 [H]