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The map label for this gene is gyrA [H]

Identifier: 157371506

GI number: 157371506

Start: 3608745

End: 3611393

Strand: Reverse

Name: gyrA [H]

Synonym: Spro_3269

Alternate gene names: 157371506

Gene position: 3611393-3608745 (Counterclockwise)

Preceding gene: 157371511

Following gene: 157371505

Centisome position: 66.28

GC content: 56.93

Gene sequence:

>2649_bases
ATGAGCGACCTTGCCAGAGAAATCACACCGGTAAACATCGAAGACGAGTTGAAAAACTCGTATCTGGACTACGCGATGTC
CGTAATTGTCGGACGTGCGCTGCCAGATGTTCGTGATGGACTGAAGCCGGTGCACCGTCGCGTTTTGTTCGCGATGAGTG
TATTGGGTAACGACTGGAATAAACCATACAAGAAATCGGCCCGTGTCGTTGGGGACGTAATCGGTAAATATCACCCACAC
GGTGACAGCGCGGTTTACGACACCATCGTGCGTATGGCCCAACCGTTTTCACTGCGCTATATGCTGGTGGACGGTCAGGG
TAACTTCGGTTCTGTCGATGGCGACTCCGCCGCGGCGATGCGTTATACCGAAGTGCGCATGTCCAAAATTGCTCACGAAC
TGCTGGCGGATCTGGAAAAAGAAACCGTCGACTTCGTGCCTAACTACGATGGCACCGAGCAGATCCCGGCCGTCATGCCA
ACCAAGATCCCGAACCTGCTGGTAAACGGCGCGTCGGGCATCGCCGTGGGTATGGCCACCAACATTCCGCCGCATAACCT
GTCAGAGGTTATCAACGGCTGCCTGGCCTATATCGATGATGAAAACATCAGCATCGAAGGCCTGATGGAATACATCCCGG
GGCCGGACTTCCCGACTGCGGCGATCATCAACGGCCGTCGCGGCATTGAAGAGGCTTACCGCACCGGGCGCGGCAAAATC
TACCTGCGCGCACGCGCCGAAGTAGAAGCCGATGCCAAAACCGGTCGCGAAACCATCATTGTTCACGAGATCCCGTATCA
GGTGAACAAGGCGCGTCTGATCGAGAAGATCGCCGAGCTGGTCAAAGAAAAACGCGTGGAAGGCATCAGCGCGCTGCGTG
ACGAATCCGACAAAGACGGCATGCGCATCGTAATTGAAATCAAACGCGACGCGGTCGGCGAAGTGGTGCTGAACAACCTG
TATTCGCTGACGCAACTGCAGGTCACCTTCGGCATCAACATGGTGGCATTGCATCAGGGCCAGCCGAAACTGCTGAACCT
GAAAGACATTCTGCAGGCGTTTGTTCGCCACCGCCGTGAAGTGGTGACCCGCCGTACCATCTTCGAACTGCGTAAAGCCC
GCGATCGCGCCCATATCCTGGAAGCGCTGGCCATCGCACTGGCGAACATCGATCCGATTATCGAGATGATCCGCCGTGCG
CCAACCCCTGCGGAAGCGAAAGCCGCGTTGGTTGCTCAAGCCTGGGATCTGGGTAATGTGGCAGCCATGCTGGAGCGCGC
CGGTGACGACGCCGCTCGCCCTGAGTGGCTGGAGCCGGAGTTCGGCATCCGTGACGGTAAATACCATCTGACCGAGCAGC
AGGCTCAGGCGATCCTGGATCTGCGCCTGCAGAAACTGACCGGCCTGGAGCATGAAAAGCTGCTGGACGAGTATAAAGAG
CTGCTGACGGCGATTGCCGCGCTGATCTTTATTCTGGAAAACCCAGACCGTCTGATGGAAGTGATCCGCGAAGAGCTGGT
GGCAATCAAAGAGCAGTACAACGATGGCCGCCGCACCGAGATCACCGCCAATACTTCAGATATCAATATCGAAGACCTGA
TCAACCAGGAAGACGTGGTCGTTACGCTGTCGCACCAGGGCTATGTGAAGTATCAGCCTCTGACCGACTATGAAGCGCAA
CGTCGTGGTGGTAAAGGCAAGTCAGCGGCACGTATTAAAGAAGAAGACTTTATCGATCGTCTGTTGGTGGCCAACACCCA
CGACACGATCCTGTGCTTCTCCAGCCGTGGCCGTCTGTACTGGATGAAGGTGTATCAACTGCCTGAAGCCAGCCGTGGCG
CGCGCGGTCGTCCAATCGTCAACCTGCTGCCGCTGGAAGCCAATGAGCGTATTACCGCCATTCTGCCGGTACGCGAGTAT
GAAGAAGGGCGTCACGTGTTTATGGCTACCGCCAGCGGCACCGTGAAGAAAACCGCATTGACCGATTTCAGCCGCCCGCG
CAGCGCCGGCATCATCGCCGTTAACCTCAACGAGGGTGACGAGCTGATTGGTGTTGACCTGACCGACGGCAGCAATGAAG
TCATGCTGTTCTCCGCCAATGGTAAAGTAGTGCGCTTCCCGGAAACGCAGGTGCGTTCTATGGGTCGTACTGCCACCGGC
GTACGCGGTATCAACCTGGGCGAAGGCGACAGCGTTATTTCCCTGATTGTGCCACGCGGTGAAGGCGACATTCTGACCGT
TACCCAGAATGGCTACGGTAAACGTACCGCAGTCACCGAATATCCGACCAAGTCACGCGCTACCCAAGGGGTTATCTCCA
TTAAGGTGAGCGAGCGTAATGGTCAGGTCGTGGGTGCGGTTCAGGTGGATACCACCGACCAGATCATGATGATTACCGAT
GCCGGCACGCTGGTGCGTACCCGCGTATCGGAAGTTAGCGTGGTGGGTCGTAATACCCAGGGTGTTACGCTGATCCGTAC
TGCGGAAGACGAGAACGTCGTCGGTCTGCAGCGTGTAGCCGAGCCGGTGGAAGACGAAGAGCTGGACAGCCTCGAACCGG
GTGCGGAAGTTGCAGAAGAAGACGCTGCACCGCTGGACGAAGGCGATGATTCTGAAGCGCCAGACGACGCGGAAGAAGAC
AACGCCTAA

Upstream 100 bases:

>100_bases
GGCGGTTATTTTCCCGTAAAGCGTGCTTTGTGATATAGTTTTACACCTTTGCCACTATGGCAGCGGGCAGATGAATCATT
AGTAGAGGGATAGCAGCTCC

Downstream 100 bases:

>100_bases
GCCATAGGGGCCGGCACATGCCCCTATCGCACTGAGGTAACAAGGGCCTGGCAGCGATGCTAGGCCCTTTTTCAGTTCTA
TGGTTTAATTGCCGGACCCA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 882; Mature: 881

Protein sequence:

>882_residues
MSDLAREITPVNIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEVRMSKIAHELLADLEKETVDFVPNYDGTEQIPAVMP
TKIPNLLVNGASGIAVGMATNIPPHNLSEVINGCLAYIDDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKI
YLRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEIKRDAVGEVVLNNL
YSLTQLQVTFGINMVALHQGQPKLLNLKDILQAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIEMIRRA
PTPAEAKAALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGIRDGKYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLTAIAALIFILENPDRLMEVIREELVAIKEQYNDGRRTEITANTSDINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREY
EEGRHVFMATASGTVKKTALTDFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSANGKVVRFPETQVRSMGRTATG
VRGINLGEGDSVISLIVPRGEGDILTVTQNGYGKRTAVTEYPTKSRATQGVISIKVSERNGQVVGAVQVDTTDQIMMITD
AGTLVRTRVSEVSVVGRNTQGVTLIRTAEDENVVGLQRVAEPVEDEELDSLEPGAEVAEEDAAPLDEGDDSEAPDDAEED
NA

Sequences:

>Translated_882_residues
MSDLAREITPVNIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEVRMSKIAHELLADLEKETVDFVPNYDGTEQIPAVMP
TKIPNLLVNGASGIAVGMATNIPPHNLSEVINGCLAYIDDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKI
YLRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEIKRDAVGEVVLNNL
YSLTQLQVTFGINMVALHQGQPKLLNLKDILQAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIEMIRRA
PTPAEAKAALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGIRDGKYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLTAIAALIFILENPDRLMEVIREELVAIKEQYNDGRRTEITANTSDINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQ
RRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREY
EEGRHVFMATASGTVKKTALTDFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSANGKVVRFPETQVRSMGRTATG
VRGINLGEGDSVISLIVPRGEGDILTVTQNGYGKRTAVTEYPTKSRATQGVISIKVSERNGQVVGAVQVDTTDQIMMITD
AGTLVRTRVSEVSVVGRNTQGVTLIRTAEDENVVGLQRVAEPVEDEELDSLEPGAEVAEEDAAPLDEGDDSEAPDDAEED
NA
>Mature_881_residues
SDLAREITPVNIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWNKPYKKSARVVGDVIGKYHPHG
DSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEVRMSKIAHELLADLEKETVDFVPNYDGTEQIPAVMPT
KIPNLLVNGASGIAVGMATNIPPHNLSEVINGCLAYIDDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKIY
LRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEIKRDAVGEVVLNNLY
SLTQLQVTFGINMVALHQGQPKLLNLKDILQAFVRHRREVVTRRTIFELRKARDRAHILEALAIALANIDPIIEMIRRAP
TPAEAKAALVAQAWDLGNVAAMLERAGDDAARPEWLEPEFGIRDGKYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKEL
LTAIAALIFILENPDRLMEVIREELVAIKEQYNDGRRTEITANTSDINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQR
RGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYE
EGRHVFMATASGTVKKTALTDFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSANGKVVRFPETQVRSMGRTATGV
RGINLGEGDSVISLIVPRGEGDILTVTQNGYGKRTAVTEYPTKSRATQGVISIKVSERNGQVVGAVQVDTTDQIMMITDA
GTLVRTRVSEVSVVGRNTQGVTLIRTAEDENVVGLQRVAEPVEDEELDSLEPGAEVAEEDAAPLDEGDDSEAPDDAEEDN
A

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=27.0348837209302, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI19913406, Length=343, Percent_Identity=26.530612244898, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=870, Percent_Identity=85.5172413793103, Blast_Score=1523, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=744, Percent_Identity=35.2150537634409, Blast_Score=402, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=34.1317365269461, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212645657, Length=166, Percent_Identity=33.7349397590361, Blast_Score=73, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=182, Percent_Identity=30.2197802197802, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136538, Length=362, Percent_Identity=27.9005524861878, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 97524; Mature: 97393

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAREITPVNIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWN
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMSKIAHELLADLEKETVDFVPNYDGTEQIPAVMPTKIPNLLVNGASGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEECCCCEEEEEEC
NIPPHNLSEVINGCLAYIDDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKI
CCCCCCHHHHHHHHHEEECCCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCCEE
YLRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
EEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEIKRDAVGEVVLNNLYSLTQLQVTFGINMVALHQGQPKLLNLKDILQAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHHEEEEEECCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKARDRAHILEALAIALANIDPIIEMIRRAPTPAEAKAALVAQAWDLGNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHH
AAMLERAGDDAARPEWLEPEFGIRDGKYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLTAIAALIFILENPDRLMEVIREELVAIKEQYNDGRRTEITANTSDINIEDLINQEDVV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGRHVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEECHHCCCCCEEEEEECCCCEEHHHH
TDFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSANGKVVRFPETQVRSMGRTATG
HCCCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCHHHHHHCCCCCCC
VRGINLGEGDSVISLIVPRGEGDILTVTQNGYGKRTAVTEYPTKSRATQGVISIKVSERN
CCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCEEEEEEECCC
GQVVGAVQVDTTDQIMMITDAGTLVRTRVSEVSVVGRNTQGVTLIRTAEDENVVGLQRVA
CCEEEEEEECCCCCEEEEECCCHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCHHHHHH
EPVEDEELDSLEPGAEVAEEDAAPLDEGDDSEAPDDAEEDNA
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLAREITPVNIEDELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWN
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMSKIAHELLADLEKETVDFVPNYDGTEQIPAVMPTKIPNLLVNGASGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEECCCCEEEEEEC
NIPPHNLSEVINGCLAYIDDENISIEGLMEYIPGPDFPTAAIINGRRGIEEAYRTGRGKI
CCCCCCHHHHHHHHHEEECCCCCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHCCCCEE
YLRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
EEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
MRIVIEIKRDAVGEVVLNNLYSLTQLQVTFGINMVALHQGQPKLLNLKDILQAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHHEEEEEECCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKARDRAHILEALAIALANIDPIIEMIRRAPTPAEAKAALVAQAWDLGNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHH
AAMLERAGDDAARPEWLEPEFGIRDGKYHLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLTAIAALIFILENPDRLMEVIREELVAIKEQYNDGRRTEITANTSDINIEDLINQEDVV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY
EEEECCCEEEECCCCCHHHHHCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCCCCEE
WMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGRHVFMATASGTVKKTAL
EEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEECHHCCCCCEEEEEECCCCEEHHHH
TDFSRPRSAGIIAVNLNEGDELIGVDLTDGSNEVMLFSANGKVVRFPETQVRSMGRTATG
HCCCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCHHHHHHCCCCCCC
VRGINLGEGDSVISLIVPRGEGDILTVTQNGYGKRTAVTEYPTKSRATQGVISIKVSERN
CCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCEEEEEEECCC
GQVVGAVQVDTTDQIMMITDAGTLVRTRVSEVSVVGRNTQGVTLIRTAEDENVVGLQRVA
CCEEEEEEECCCCCEEEEECCCHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCHHHHHH
EPVEDEELDSLEPGAEVAEEDAAPLDEGDDSEAPDDAEEDNA
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7642123 [H]