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The map label for this gene is uxuA

Identifier: 157371475

GI number: 157371475

Start: 3570978

End: 3572168

Strand: Reverse

Name: uxuA

Synonym: Spro_3238

Alternate gene names: 157371475

Gene position: 3572168-3570978 (Counterclockwise)

Preceding gene: 157371477

Following gene: 157371472

Centisome position: 65.56

GC content: 57.09

Gene sequence:

>1191_bases
ATGGAACAAACATGGCGTTGGTATGGGCCGAACGATCCTGTCTCTCTTGACGATGTGCGCCAGGCCGGCGCCACTGGCGT
AGTCACCGCCTTGCACCATATCCCGAATGGCGAGGTGTGGCCGATCGAAGAGATCAAGGCTCGTCAGGCGTTGTTGGCGG
AGAAAGGGTTGGTGTGGTCGGTGGTGGAAAGCATCCCGGTACATGAAGAGATCAAAACCCACAGCGGTAATTACCAACAG
CACATCGCCCATTACCAGCAATCGTTGCGTAACCTGGCGGCCTGCGGTATCGACACCGTGTGCTACAACTTTATGCCGAT
CCTCGACTGGACGCGTACCGATCTGGAGTATTTGCTGCCCGACGGGTCAAAGGCGTTACGTTTTGATCAAATCGCCTTTG
CGGCCTTTGATTTGCATATTTTGCAACGTGCGGGGGCAGAGCAGGATTACACGCAGGAAGAGCAACAGCAGGCCGCCGCG
CGCTTTGCTGCCATGAGCGAGGCGGATATCGCCAAATTGACCGGTAATATCATCGCCGGGCTGCCGGGGGCTGAAGAGGG
GTATACGCTTGATCAGTTCCGCGCCCGTCTGGCTGAGTACGACGCCATCGACAAGGCGCAATTGCGTGAGAATATGGCGG
TGTTTCTGCGCGCCATTGTGCCGGTAGCGGAAGAGGTCGGCGTGCGGCTGGCGGTACATCCGGACGATCCACCACGGCCG
CTCCTGGGTCTGCCACGCATTGTTTCGACCATTGAGGATATGCAGTGGTTCAAGCAGACGGTCGACAGCCTGCATAACGG
TTTCACCATGTGTACCGGCTCCTATGGGGTACGTGAGGATAACGATCTGGTGCGGATGATTGAAACCTTCGGCGATCGCA
TCCATTTCACCCATCTGCGGGCAACCTGCCGTGAAGATAACCCAAAAAGTTTCCATGAGGGTGCGCACCTGCAAGGCGAC
GTCGACATGGTGGCGGTGATTGAGGCGATCCTCAGCGAGGAGCAGCGCCGTCATCAGACGGGTGATACCCGGCCGATACC
AATGCGTCCCGATCATGGGCATCAGATGCTGGATGACTTGAAGAAAAAAACCAATCCGGGTTATTCGGCAATTGGTCGTT
TGAAAGGGCTGGCGGAACTGCGCGGTGTCGAGCTGGCGCTCAAACGCCGTTTCTTCCCTGAATTGCCGTAG

Upstream 100 bases:

>100_bases
AGATAACCGATATCTATTTAAATTTGGTATAACAAGATTGTCGAAACGGTGCAATCTTGATCACCACCACAATACTGGGC
GATTTTTACAAGGATAAATA

Downstream 100 bases:

>100_bases
CGTTAAAATCAACAGGGGCCATAATCGGCCCCTGAATTTGATGACAAAGTTGTCTTTGAATCCGAGATACCCGGGCCTAG
CGCACCGAGGGGCGCTCCGG

Product: mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MEQTWRWYGPNDPVSLDDVRQAGATGVVTALHHIPNGEVWPIEEIKARQALLAEKGLVWSVVESIPVHEEIKTHSGNYQQ
HIAHYQQSLRNLAACGIDTVCYNFMPILDWTRTDLEYLLPDGSKALRFDQIAFAAFDLHILQRAGAEQDYTQEEQQQAAA
RFAAMSEADIAKLTGNIIAGLPGAEEGYTLDQFRARLAEYDAIDKAQLRENMAVFLRAIVPVAEEVGVRLAVHPDDPPRP
LLGLPRIVSTIEDMQWFKQTVDSLHNGFTMCTGSYGVREDNDLVRMIETFGDRIHFTHLRATCREDNPKSFHEGAHLQGD
VDMVAVIEAILSEEQRRHQTGDTRPIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAELRGVELALKRRFFPELP

Sequences:

>Translated_396_residues
MEQTWRWYGPNDPVSLDDVRQAGATGVVTALHHIPNGEVWPIEEIKARQALLAEKGLVWSVVESIPVHEEIKTHSGNYQQ
HIAHYQQSLRNLAACGIDTVCYNFMPILDWTRTDLEYLLPDGSKALRFDQIAFAAFDLHILQRAGAEQDYTQEEQQQAAA
RFAAMSEADIAKLTGNIIAGLPGAEEGYTLDQFRARLAEYDAIDKAQLRENMAVFLRAIVPVAEEVGVRLAVHPDDPPRP
LLGLPRIVSTIEDMQWFKQTVDSLHNGFTMCTGSYGVREDNDLVRMIETFGDRIHFTHLRATCREDNPKSFHEGAHLQGD
VDMVAVIEAILSEEQRRHQTGDTRPIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAELRGVELALKRRFFPELP
>Mature_396_residues
MEQTWRWYGPNDPVSLDDVRQAGATGVVTALHHIPNGEVWPIEEIKARQALLAEKGLVWSVVESIPVHEEIKTHSGNYQQ
HIAHYQQSLRNLAACGIDTVCYNFMPILDWTRTDLEYLLPDGSKALRFDQIAFAAFDLHILQRAGAEQDYTQEEQQQAAA
RFAAMSEADIAKLTGNIIAGLPGAEEGYTLDQFRARLAEYDAIDKAQLRENMAVFLRAIVPVAEEVGVRLAVHPDDPPRP
LLGLPRIVSTIEDMQWFKQTVDSLHNGFTMCTGSYGVREDNDLVRMIETFGDRIHFTHLRATCREDNPKSFHEGAHLQGD
VDMVAVIEAILSEEQRRHQTGDTRPIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAELRGVELALKRRFFPELP

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family

Homologues:

Organism=Escherichia coli, GI1790778, Length=392, Percent_Identity=78.0612244897959, Blast_Score=652, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXUA_SERP5 (A8GGU6)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479464.1
- ProteinModelPortal:   A8GGU6
- SMR:   A8GGU6
- STRING:   A8GGU6
- GeneID:   5606369
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3238
- eggNOG:   COG1312
- HOGENOM:   HBG585927
- OMA:   VHEEIKT
- ProtClustDB:   PRK03906
- BioCyc:   SPRO399741:SPRO_3238-MONOMER
- HAMAP:   MF_00106
- InterPro:   IPR004628
- InterPro:   IPR013022
- Gene3D:   G3DSA:3.20.20.150
- PIRSF:   PIRSF016049
- TIGRFAMs:   TIGR00695

Pfam domain/function: PF03786 UxuA; SSF51658 Xyl_isomerase-like_TIM-brl

EC number: =4.2.1.8

Molecular weight: Translated: 44631; Mature: 44631

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTWRWYGPNDPVSLDDVRQAGATGVVTALHHIPNGEVWPIEEIKARQALLAEKGLVWS
CCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHH
VVESIPVHEEIKTHSGNYQQHIAHYQQSLRNLAACGIDTVCYNFMPILDWTRTDLEYLLP
HHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
DGSKALRFDQIAFAAFDLHILQRAGAEQDYTQEEQQQAAARFAAMSEADIAKLTGNIIAG
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHCC
LPGAEEGYTLDQFRARLAEYDAIDKAQLRENMAVFLRAIVPVAEEVGVRLAVHPDDPPRP
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
LLGLPRIVSTIEDMQWFKQTVDSLHNGFTMCTGSYGVREDNDLVRMIETFGDRIHFTHLR
CCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEHHHH
ATCREDNPKSFHEGAHLQGDVDMVAVIEAILSEEQRRHQTGDTRPIPMRPDHGHQMLDDL
HHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
KKKTNPGYSAIGRLKGLAELRGVELALKRRFFPELP
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEQTWRWYGPNDPVSLDDVRQAGATGVVTALHHIPNGEVWPIEEIKARQALLAEKGLVWS
CCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHH
VVESIPVHEEIKTHSGNYQQHIAHYQQSLRNLAACGIDTVCYNFMPILDWTRTDLEYLLP
HHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
DGSKALRFDQIAFAAFDLHILQRAGAEQDYTQEEQQQAAARFAAMSEADIAKLTGNIIAG
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHCC
LPGAEEGYTLDQFRARLAEYDAIDKAQLRENMAVFLRAIVPVAEEVGVRLAVHPDDPPRP
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
LLGLPRIVSTIEDMQWFKQTVDSLHNGFTMCTGSYGVREDNDLVRMIETFGDRIHFTHLR
CCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEHHHH
ATCREDNPKSFHEGAHLQGDVDMVAVIEAILSEEQRRHQTGDTRPIPMRPDHGHQMLDDL
HHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
KKKTNPGYSAIGRLKGLAELRGVELALKRRFFPELP
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA