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The map label for this gene is lysP [H]

Identifier: 157371461

GI number: 157371461

Start: 3553506

End: 3554987

Strand: Reverse

Name: lysP [H]

Synonym: Spro_3224

Alternate gene names: 157371461

Gene position: 3554987-3553506 (Counterclockwise)

Preceding gene: 157371462

Following gene: 157371459

Centisome position: 65.24

GC content: 56.95

Gene sequence:

>1482_bases
ATGGCTCAGCAGGATATAAAAACAACATCGGAGCAAGCAGTGCCCGGATTACGCCGCGAGCTGAAAGCTCGGCACTTAAC
CATGATTGCTATTGGTGGCTCTATCGGCACCGGTCTGTTTGTCGCCTCTGGCGCTACGGTTTCTCAGGCCGGTCCGGGCG
GGGCACTGCTGTCTTACGCGCTGATCGGACTGATGGTTTACTTCCTGATGACCAGCCTGGGCGAATTGGCAGCCTTTATG
CCGGTGTCCGGCTCTTTCTCCACCTACGGTGCCAAATACGTAGAAGAAGGCTTTGGTTTCGCGCTGGGCTGGAACTACTG
GTACAACTGGGCGGTGACCATCGCCGTTGACCTGGTGGCCTCGCAGCTGGTGATGACCTATTGGTTCCCGGATACGCCGG
GCTGGATCTGGAGCGCACTGTTCCTTGGCCTGATGTTCCTGTTGAACTACATCTCGGTCAAAGGCTTCGGTGAAGCGGAA
TACTGGTTCTCGCTGATCAAAGTGACCACCGTCATTATCTTTATCGGTATCGGCGTGCTGATGATCTTCGGCATCCTCAA
GGGGGGCGAGCACGCGGGCTGGCAGAACTGGACTATTGGCGATGCGCCGTTTGCCGGGGGCTTCTCGGCGATGATAGGCG
TGGCGATGATAGTCGGCTTCTCGTTCCAGGGGACCGAGCTTATCGGCATCGCGGCCGGCGAGTCGGAAAACCCGGGCAAA
AACATCCCGCGCGCTGTGCGTCAGGTGTTCTGGCGTATCCTGCTGTTCTATATCTTCGCCATTTTGATTATCAGCCTGAT
CATTCCTTATACCGATCCGAGCCTGCTGCGTAATGATGTGAAAGACATCAGCGTCAGCCCGTTCACGCTGGTATTCCAGC
ACGCCGGCCTGCTGTCGGCGGCGGCGGTGATGAATGCGGTGATCCTGACGGCGGTGCTGTCCGCCGGTAACTCCGGGATG
TACGCTTCCACCCGCATGCTGTTTACCCTGGCATCGGAAGGCAAAGCGCCGCGTATTTTCGCCAAACTGTCGAAGGGCGG
GGTGCCACGCAACGCGCTCTATGCCACTACCGTGGTGGCGGGCCTGTGTTTCCTCAGCTCAATGTTCGGCAACCAGTCGG
TTTATCTGTGGTTGCTGAACACCTCGGGGATGACCGGCTTTATCGCCTGGTTGGGGATTGCCATCAGTCATTACCGTTTC
CGTCGCGGCTATATGATCCAGGGGCGTGATCTGAACGATTTACCTTACCGTTCCGGTTTCTTCCCGCTGGGCCCAATCTT
TGCGTTTGTCCTGTGCCTGATTATCACGCTGGGGCAGAACTATCAGGCGTTCCTGCAAGACCGCATCGATTGGTACGGCG
TGACCGCAACTTATATCGGTCTGCCGCTGTTCCTGATTATCTGGTTCGGCTACAAGCTGACGCGCGGCACCCGTGTCGTG
AAGTACAGCGAAATGGAATTCCCGAAAATGGACGTGAAGTAA

Upstream 100 bases:

>100_bases
AATTATGAAGCTATCTTATATCAGTGGAATGTTATTAGTTCGCCGGCGGGTATTTGTTACAATCCGCCCTCATTTTTTTT
GACCAGCAGATAGGGTAAGA

Downstream 100 bases:

>100_bases
TCCCTGTCTATACCCGTTAAATTTCAGGCTGCAGCTTGCCCTTTGGCTGCAGCCTGAAACTAATCCTTTCCTTTTATCCC
CAGCGTTTGCTGCGCCGCCG

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MAQQDIKTTSEQAVPGLRRELKARHLTMIAIGGSIGTGLFVASGATVSQAGPGGALLSYALIGLMVYFLMTSLGELAAFM
PVSGSFSTYGAKYVEEGFGFALGWNYWYNWAVTIAVDLVASQLVMTYWFPDTPGWIWSALFLGLMFLLNYISVKGFGEAE
YWFSLIKVTTVIIFIGIGVLMIFGILKGGEHAGWQNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPGK
NIPRAVRQVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGM
YASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVAGLCFLSSMFGNQSVYLWLLNTSGMTGFIAWLGIAISHYRF
RRGYMIQGRDLNDLPYRSGFFPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGLPLFLIIWFGYKLTRGTRVV
KYSEMEFPKMDVK

Sequences:

>Translated_493_residues
MAQQDIKTTSEQAVPGLRRELKARHLTMIAIGGSIGTGLFVASGATVSQAGPGGALLSYALIGLMVYFLMTSLGELAAFM
PVSGSFSTYGAKYVEEGFGFALGWNYWYNWAVTIAVDLVASQLVMTYWFPDTPGWIWSALFLGLMFLLNYISVKGFGEAE
YWFSLIKVTTVIIFIGIGVLMIFGILKGGEHAGWQNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPGK
NIPRAVRQVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGM
YASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVAGLCFLSSMFGNQSVYLWLLNTSGMTGFIAWLGIAISHYRF
RRGYMIQGRDLNDLPYRSGFFPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGLPLFLIIWFGYKLTRGTRVV
KYSEMEFPKMDVK
>Mature_492_residues
AQQDIKTTSEQAVPGLRRELKARHLTMIAIGGSIGTGLFVASGATVSQAGPGGALLSYALIGLMVYFLMTSLGELAAFMP
VSGSFSTYGAKYVEEGFGFALGWNYWYNWAVTIAVDLVASQLVMTYWFPDTPGWIWSALFLGLMFLLNYISVKGFGEAEY
WFSLIKVTTVIIFIGIGVLMIFGILKGGEHAGWQNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPGKN
IPRAVRQVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMY
ASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVAGLCFLSSMFGNQSVYLWLLNTSGMTGFIAWLGIAISHYRFR
RGYMIQGRDLNDLPYRSGFFPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGLPLFLIIWFGYKLTRGTRVVK
YSEMEFPKMDVK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=354, Percent_Identity=24.5762711864407, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788480, Length=488, Percent_Identity=87.5, Blast_Score=877, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=479, Percent_Identity=39.2484342379958, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1786789, Length=419, Percent_Identity=38.4248210023866, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI48994972, Length=426, Percent_Identity=38.7323943661972, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1786302, Length=398, Percent_Identity=37.4371859296482, Blast_Score=265, Evalue=7e-72,
Organism=Escherichia coli, GI1790653, Length=457, Percent_Identity=34.5733041575492, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1789017, Length=392, Percent_Identity=33.4183673469388, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87081915, Length=488, Percent_Identity=31.7622950819672, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1786602, Length=395, Percent_Identity=36.2025316455696, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87081869, Length=410, Percent_Identity=23.4146341463415, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082250, Length=235, Percent_Identity=27.6595744680851, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082023, Length=327, Percent_Identity=22.9357798165138, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=472, Percent_Identity=36.4406779661017, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6324990, Length=484, Percent_Identity=35.3305785123967, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6324061, Length=497, Percent_Identity=35.4124748490946, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6322892, Length=469, Percent_Identity=37.1002132196162, Blast_Score=295, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6324059, Length=483, Percent_Identity=35.6107660455487, Blast_Score=280, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6324924, Length=480, Percent_Identity=33.5416666666667, Blast_Score=277, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=498, Percent_Identity=31.5261044176707, Blast_Score=272, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6324553, Length=492, Percent_Identity=31.7073170731707, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6319824, Length=481, Percent_Identity=28.6902286902287, Blast_Score=246, Evalue=6e-66,
Organism=Saccharomyces cerevisiae, GI6320717, Length=474, Percent_Identity=27.8481012658228, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6322967, Length=431, Percent_Identity=32.7146171693735, Blast_Score=229, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6321053, Length=468, Percent_Identity=28.8461538461538, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6320251, Length=473, Percent_Identity=26.6384778012685, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6319543, Length=470, Percent_Identity=28.7234042553192, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319542, Length=465, Percent_Identity=27.0967741935484, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6324981, Length=483, Percent_Identity=32.5051759834368, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6319608, Length=493, Percent_Identity=29.4117647058824, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6320364, Length=551, Percent_Identity=27.4047186932849, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24666159, Length=356, Percent_Identity=24.7191011235955, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221512776, Length=356, Percent_Identity=24.7191011235955, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366235, Length=389, Percent_Identity=21.5938303341902, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007820, Length=389, Percent_Identity=21.5938303341902, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54052; Mature: 53921

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQDIKTTSEQAVPGLRRELKARHLTMIAIGGSIGTGLFVASGATVSQAGPGGALLSYA
CCCCCCCCCHHHHCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHH
LIGLMVYFLMTSLGELAAFMPVSGSFSTYGAKYVEEGFGFALGWNYWYNWAVTIAVDLVA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHH
SQLVMTYWFPDTPGWIWSALFLGLMFLLNYISVKGFGEAEYWFSLIKVTTVIIFIGIGVL
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MIFGILKGGEHAGWQNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPGK
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
NIPRAVRQVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AAVMNAVILTAVLSAGNSGMYASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVA
HHHHHHHHHHHHHHCCCCCCEEHHHHEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHH
GLCFLSSMFGNQSVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYMIQGRDLNDLPYRSGF
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCC
FPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGLPLFLIIWFGYKLTRGTRVV
CCHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
KYSEMEFPKMDVK
EECCCCCCCCCCC
>Mature Secondary Structure 
AQQDIKTTSEQAVPGLRRELKARHLTMIAIGGSIGTGLFVASGATVSQAGPGGALLSYA
CCCCCCCCHHHHCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHH
LIGLMVYFLMTSLGELAAFMPVSGSFSTYGAKYVEEGFGFALGWNYWYNWAVTIAVDLVA
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHH
SQLVMTYWFPDTPGWIWSALFLGLMFLLNYISVKGFGEAEYWFSLIKVTTVIIFIGIGVL
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MIFGILKGGEHAGWQNWTIGDAPFAGGFSAMIGVAMIVGFSFQGTELIGIAAGESENPGK
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
NIPRAVRQVFWRILLFYIFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AAVMNAVILTAVLSAGNSGMYASTRMLFTLASEGKAPRIFAKLSKGGVPRNALYATTVVA
HHHHHHHHHHHHHHCCCCCCEEHHHHEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHH
GLCFLSSMFGNQSVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYMIQGRDLNDLPYRSGF
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCC
FPLGPIFAFVLCLIITLGQNYQAFLQDRIDWYGVTATYIGLPLFLIIWFGYKLTRGTRVV
CCHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
KYSEMEFPKMDVK
EECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]