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The map label for this gene is glpK [H]

Identifier: 157370932

GI number: 157370932

Start: 2963269

End: 2964711

Strand: Direct

Name: glpK [H]

Synonym: Spro_2692

Alternate gene names: 157370932

Gene position: 2963269-2964711 (Clockwise)

Preceding gene: 157370930

Following gene: 157370933

Centisome position: 54.38

GC content: 53.98

Gene sequence:

>1443_bases
ATGCTGAACCAACGCTATGCAGCCATTGACCAAGGAACAACCGGAACACGCGTCGTGGTGTTCGGCGAGGATGGGAAACA
CTTTTCCCCCGCCGCCATCGCGCATAAACAGTTAACGCCCAATCCGGGTTGGGTTGAACATGACCCGATGGAGATCCTGC
GCAACATACGAACCTGTCTCAGCCAGTGTGGCGTCGTCGATGCTATGGGTTTGGCTCATCAGGGAGAGAGCGTTGTTGCC
TGGGATGCGCAGAGCGGTTTACCGTTATATAACGCCATTATTTGGCAAGACCAGCGAACTGAATCCGTTCTCCGCCGTCT
GCGAGCAGAAGGTGTAGAGGAAACCGTTCGAGCAAAAACCGGCTTGCCATTGGATACCTATTTCTCAGGCAGTAAGCTGG
GCTGGATTATGCGCAATGTGCCCGGTGCCGACGAGCTTTCCCGCCGCGGTCAGTTACGGCTTGGCACCATGGACAGTTTT
TTCATGTTCCATCTGTGCGGCACTCATGTCACGGACTACAACTCAGCCTCCAGGACTTCGCTGTTCAATATTCACACCCT
GCAATGGGATGAGGAACTGTGCCGGATTTTTGGTGTTCCAATCGCCGCATTGCCAGAAATTCGGGATAATATCGGCCACT
TTGGCGATGTGACTTGCTCTGGCAATACCACGCCATTGACCGCCTGCATCGTCGATCAATTTGCCGGTACCTATGGCCAT
GGCTGCCTGCAACCCGGCCAGATGAAAATCACTTTCGGTACTGGCGCATTTTTGCAGTCTATTACCGGTACCGTGGTGCC
CGATGCGCAGGGTTCGGGTCTATTGCCGACGCTATGTTGGAAATTACCGGGTGAACCCCCGCTCTATGGCCTGGATGGCG
GCGTCTATAACGCGGCATCAGCCATCAACTGGGCCAAAAAGATCGGCCTGTACAGTGATATCGAGGAGTTCTCAGACTTC
CCGGATCAACCTGCTATTGCTCGTGGATTGGCATTTATCCCTGCGCTCTCCGGGTTGGGCTGCCCATATTGGGATCGCTC
CGCTGCGGGTCTCTGGGCCGGGTTGTCGCTCGAAACCGAACGCAAAGATATGCTGCAATCCATTCTTGAAGGGATCGCCA
TGCGCTCAGCCGAGGTGATCTACGCCATGGACAAAGTTCGCCCCATTGGCGACACCATTTCTGTGGACGGTGGCCTATCG
GCAAATCTCTACTTTAAACAGTTTCTGGCCAGCCTGATCCAAAAACGCATCGTCACTCCGTCAAACCGGGAAATTACCGC
CCAGGGCGTCGCTTTATTGGCGCGCAAGGGGTTAGGTAATGCCCACCCCATGAACGTCAGCACACAACACGTTACTACTG
AACCTGCAGAACGCGATCTGTCCCCTTATTTTGCAAAATATAAGGACATTATTTCCCGTTCCCGCAATCTGCGTAGCGAA
TAA

Upstream 100 bases:

>100_bases
TGTTGTGATTTTAATGTTGATTTAATGTGCTTTAATGATAATAAGTAATATAAACGGGCACAATGACAACATATAAACCA
CAAATAGACCTGAGGGCTTT

Downstream 100 bases:

>100_bases
ATAATAAGAAAAATGGAGGCAGTTATGTCTGAGATTGGCAACATCATTATCTATATCATTATGGCCGGAACCCTGCTCGG
TGCCATGGCATCGGTGATAA

Product: carbohydrate kinase FGGY

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MLNQRYAAIDQGTTGTRVVVFGEDGKHFSPAAIAHKQLTPNPGWVEHDPMEILRNIRTCLSQCGVVDAMGLAHQGESVVA
WDAQSGLPLYNAIIWQDQRTESVLRRLRAEGVEETVRAKTGLPLDTYFSGSKLGWIMRNVPGADELSRRGQLRLGTMDSF
FMFHLCGTHVTDYNSASRTSLFNIHTLQWDEELCRIFGVPIAALPEIRDNIGHFGDVTCSGNTTPLTACIVDQFAGTYGH
GCLQPGQMKITFGTGAFLQSITGTVVPDAQGSGLLPTLCWKLPGEPPLYGLDGGVYNAASAINWAKKIGLYSDIEEFSDF
PDQPAIARGLAFIPALSGLGCPYWDRSAAGLWAGLSLETERKDMLQSILEGIAMRSAEVIYAMDKVRPIGDTISVDGGLS
ANLYFKQFLASLIQKRIVTPSNREITAQGVALLARKGLGNAHPMNVSTQHVTTEPAERDLSPYFAKYKDIISRSRNLRSE

Sequences:

>Translated_480_residues
MLNQRYAAIDQGTTGTRVVVFGEDGKHFSPAAIAHKQLTPNPGWVEHDPMEILRNIRTCLSQCGVVDAMGLAHQGESVVA
WDAQSGLPLYNAIIWQDQRTESVLRRLRAEGVEETVRAKTGLPLDTYFSGSKLGWIMRNVPGADELSRRGQLRLGTMDSF
FMFHLCGTHVTDYNSASRTSLFNIHTLQWDEELCRIFGVPIAALPEIRDNIGHFGDVTCSGNTTPLTACIVDQFAGTYGH
GCLQPGQMKITFGTGAFLQSITGTVVPDAQGSGLLPTLCWKLPGEPPLYGLDGGVYNAASAINWAKKIGLYSDIEEFSDF
PDQPAIARGLAFIPALSGLGCPYWDRSAAGLWAGLSLETERKDMLQSILEGIAMRSAEVIYAMDKVRPIGDTISVDGGLS
ANLYFKQFLASLIQKRIVTPSNREITAQGVALLARKGLGNAHPMNVSTQHVTTEPAERDLSPYFAKYKDIISRSRNLRSE
>Mature_480_residues
MLNQRYAAIDQGTTGTRVVVFGEDGKHFSPAAIAHKQLTPNPGWVEHDPMEILRNIRTCLSQCGVVDAMGLAHQGESVVA
WDAQSGLPLYNAIIWQDQRTESVLRRLRAEGVEETVRAKTGLPLDTYFSGSKLGWIMRNVPGADELSRRGQLRLGTMDSF
FMFHLCGTHVTDYNSASRTSLFNIHTLQWDEELCRIFGVPIAALPEIRDNIGHFGDVTCSGNTTPLTACIVDQFAGTYGH
GCLQPGQMKITFGTGAFLQSITGTVVPDAQGSGLLPTLCWKLPGEPPLYGLDGGVYNAASAINWAKKIGLYSDIEEFSDF
PDQPAIARGLAFIPALSGLGCPYWDRSAAGLWAGLSLETERKDMLQSILEGIAMRSAEVIYAMDKVRPIGDTISVDGGLS
ANLYFKQFLASLIQKRIVTPSNREITAQGVALLARKGLGNAHPMNVSTQHVTTEPAERDLSPYFAKYKDIISRSRNLRSE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=452, Percent_Identity=36.9469026548673, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI4504007, Length=446, Percent_Identity=37.219730941704, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI189409120, Length=446, Percent_Identity=37.219730941704, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI41393575, Length=442, Percent_Identity=35.2941176470588, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI88196792, Length=460, Percent_Identity=25.8695652173913, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1790361, Length=455, Percent_Identity=36.043956043956, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1789987, Length=490, Percent_Identity=23.6734693877551, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790005, Length=492, Percent_Identity=23.1707317073171, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535599, Length=444, Percent_Identity=36.9369369369369, Blast_Score=277, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI71986140, Length=463, Percent_Identity=24.8380129589633, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71986147, Length=248, Percent_Identity=31.0483870967742, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321755, Length=503, Percent_Identity=28.4294234592445, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17864214, Length=503, Percent_Identity=33.2007952286282, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24654573, Length=429, Percent_Identity=34.4988344988345, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24655555, Length=454, Percent_Identity=30.1762114537445, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655560, Length=454, Percent_Identity=30.1762114537445, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655570, Length=454, Percent_Identity=30.1762114537445, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655574, Length=454, Percent_Identity=30.1762114537445, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655565, Length=454, Percent_Identity=30.1762114537445, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI19922058, Length=477, Percent_Identity=27.8825995807128, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24652871, Length=444, Percent_Identity=28.8288288288288, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24656367, Length=469, Percent_Identity=27.9317697228145, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI21357867, Length=485, Percent_Identity=27.8350515463918, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24656372, Length=291, Percent_Identity=30.9278350515464, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45552909, Length=230, Percent_Identity=30.4347826086957, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 52425; Mature: 52425

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQRYAAIDQGTTGTRVVVFGEDGKHFSPAAIAHKQLTPNPGWVEHDPMEILRNIRTCL
CCCCCCEECCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
SQCGVVDAMGLAHQGESVVAWDAQSGLPLYNAIIWQDQRTESVLRRLRAEGVEETVRAKT
HHCCCHHHHHHHCCCCEEEEECCCCCCCHHHHEEECCCHHHHHHHHHHHCCHHHHHHHHC
GLPLDTYFSGSKLGWIMRNVPGADELSRRGQLRLGTMDSFFMFHLCGTHVTDYNSASRTS
CCCCHHCCCCCCHHHHHHCCCCHHHHHHCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCE
LFNIHTLQWDEELCRIFGVPIAALPEIRDNIGHFGDVTCSGNTTPLTACIVDQFAGTYGH
EEEEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCC
GCLQPGQMKITFGTGAFLQSITGTVVPDAQGSGLLPTLCWKLPGEPPLYGLDGGVYNAAS
CCCCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHH
AINWAKKIGLYSDIEEFSDFPDQPAIARGLAFIPALSGLGCPYWDRSAAGLWAGLSLETE
HHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHH
RKDMLQSILEGIAMRSAEVIYAMDKVRPIGDTISVDGGLSANLYFKQFLASLIQKRIVTP
HHHHHHHHHHHHHHHHHHHEEHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCC
SNREITAQGVALLARKGLGNAHPMNVSTQHVTTEPAERDLSPYFAKYKDIISRSRNLRSE
CCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLNQRYAAIDQGTTGTRVVVFGEDGKHFSPAAIAHKQLTPNPGWVEHDPMEILRNIRTCL
CCCCCCEECCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
SQCGVVDAMGLAHQGESVVAWDAQSGLPLYNAIIWQDQRTESVLRRLRAEGVEETVRAKT
HHCCCHHHHHHHCCCCEEEEECCCCCCCHHHHEEECCCHHHHHHHHHHHCCHHHHHHHHC
GLPLDTYFSGSKLGWIMRNVPGADELSRRGQLRLGTMDSFFMFHLCGTHVTDYNSASRTS
CCCCHHCCCCCCHHHHHHCCCCHHHHHHCCCEEECCHHHHHHHHHHHCCCCCCCCCCCCE
LFNIHTLQWDEELCRIFGVPIAALPEIRDNIGHFGDVTCSGNTTPLTACIVDQFAGTYGH
EEEEEEECHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCC
GCLQPGQMKITFGTGAFLQSITGTVVPDAQGSGLLPTLCWKLPGEPPLYGLDGGVYNAAS
CCCCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHH
AINWAKKIGLYSDIEEFSDFPDQPAIARGLAFIPALSGLGCPYWDRSAAGLWAGLSLETE
HHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHH
RKDMLQSILEGIAMRSAEVIYAMDKVRPIGDTISVDGGLSANLYFKQFLASLIQKRIVTP
HHHHHHHHHHHHHHHHHHHEEHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCC
SNREITAQGVALLARKGLGNAHPMNVSTQHVTTEPAERDLSPYFAKYKDIISRSRNLRSE
CCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA