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The map label for this gene is trpA

Identifier: 157370912

GI number: 157370912

Start: 2942487

End: 2943293

Strand: Direct

Name: trpA

Synonym: Spro_2672

Alternate gene names: 157370912

Gene position: 2942487-2943293 (Clockwise)

Preceding gene: 157370911

Following gene: 157370913

Centisome position: 54.0

GC content: 59.11

Gene sequence:

>807_bases
ATGGAACGTTACCAGCAACTGTTCGACCGCCTGGCAAGCAACAAGGAAGGCGCCTTCGTCCCGTTCGTGACCCTCGGCGA
TCCTAACCCGGCATTGTCATTGCAAATCATCGATACCCTGGTTGAAGCCGGCGCCGACGCGCTGGAGTTGGGTATCCCGT
TCTCCGATCCGCTGGCTGACGGTCCAACCATTCAAAGTGCGGCGCTGCGCGCATTCGCCTCTGGCGTCACTCCGACTCAG
TGCTTCGAAATGCTGGCCGCTATCCGCCAGAAACACCCCAGCATGCCGATCGGCCTGTTGATGTACGCCAATCTGGTGTT
CCATAAAGGCATCGATGCGTTTTACCAACGCTGTGCCGAAGTGGGCGTAGACTCGGTGCTGATCGCCGACGTGCCGTATG
AAGAGTCTGCGCCTTTCCGTGCCGCCGCTATCCGCCATGGTATCGCGCCAATCTTTATCTGCCCGCCCAATGCAGACGAC
GATTTGCTGCGTGAAATCTCCTCACATGGCCGGGGCTACACCTACCTGCTGTCACGTGCAGGCGTAACCGGAACCGAAAG
CCGCGCCCAGTTGCCACTGCATCATCTGGTGAACAAACTGCGTGAATACCATGCTGCGCCACCGCTGCAAGGCTTTGGTA
TCTCTGAGCCGGCCCAGGTGCGTGATGCACTGCAGGCCGGGGCTGCCGGGGCGATATCCGGCTCGGCGATCGTCAAGATT
ATCGAGCAAAACCATACGCAACCGGCCGAAATGCTGACGCGACTGGCGACCTTCGTTAGTGAAATGAAAGCCGCAACCCG
GGCATAA

Upstream 100 bases:

>100_bases
CACCGCAAAAGGAACAGATCCTGGTGGTTAACCTGTCCGGCCGCGGCGACAAAGACATATTTACCGTTCACGACATTCTG
AAAGCACGGGGAGAAATCTG

Downstream 100 bases:

>100_bases
TTGGCCAGCAACGGGCGCAGAGGATCTGTGCCCGTTGTTAACATATTGTTTCTCTTAAAAGTTGTGCTATTTTTTACAGC
CTGGATTTGAACAAACCCAA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MERYQQLFDRLASNKEGAFVPFVTLGDPNPALSLQIIDTLVEAGADALELGIPFSDPLADGPTIQSAALRAFASGVTPTQ
CFEMLAAIRQKHPSMPIGLLMYANLVFHKGIDAFYQRCAEVGVDSVLIADVPYEESAPFRAAAIRHGIAPIFICPPNADD
DLLREISSHGRGYTYLLSRAGVTGTESRAQLPLHHLVNKLREYHAAPPLQGFGISEPAQVRDALQAGAAGAISGSAIVKI
IEQNHTQPAEMLTRLATFVSEMKAATRA

Sequences:

>Translated_268_residues
MERYQQLFDRLASNKEGAFVPFVTLGDPNPALSLQIIDTLVEAGADALELGIPFSDPLADGPTIQSAALRAFASGVTPTQ
CFEMLAAIRQKHPSMPIGLLMYANLVFHKGIDAFYQRCAEVGVDSVLIADVPYEESAPFRAAAIRHGIAPIFICPPNADD
DLLREISSHGRGYTYLLSRAGVTGTESRAQLPLHHLVNKLREYHAAPPLQGFGISEPAQVRDALQAGAAGAISGSAIVKI
IEQNHTQPAEMLTRLATFVSEMKAATRA
>Mature_268_residues
MERYQQLFDRLASNKEGAFVPFVTLGDPNPALSLQIIDTLVEAGADALELGIPFSDPLADGPTIQSAALRAFASGVTPTQ
CFEMLAAIRQKHPSMPIGLLMYANLVFHKGIDAFYQRCAEVGVDSVLIADVPYEESAPFRAAAIRHGIAPIFICPPNADD
DLLREISSHGRGYTYLLSRAGVTGTESRAQLPLHHLVNKLREYHAAPPLQGFGISEPAQVRDALQAGAAGAISGSAIVKI
IEQNHTQPAEMLTRLATFVSEMKAATRA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=268, Percent_Identity=77.2388059701492, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321412, Length=240, Percent_Identity=33.3333333333333, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_SERP5 (A8GF83)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478901.1
- ProteinModelPortal:   A8GF83
- SMR:   A8GF83
- STRING:   A8GF83
- GeneID:   5606002
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2672
- eggNOG:   COG0159
- HOGENOM:   HBG391690
- OMA:   NPIYIYG
- BioCyc:   SPRO399741:SPRO_2672-MONOMER
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 28803; Mature: 28803

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 49-49 ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERYQQLFDRLASNKEGAFVPFVTLGDPNPALSLQIIDTLVEAGADALELGIPFSDPLAD
CCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
GPTIQSAALRAFASGVTPTQCFEMLAAIRQKHPSMPIGLLMYANLVFHKGIDAFYQRCAE
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHH
VGVDSVLIADVPYEESAPFRAAAIRHGIAPIFICPPNADDDLLREISSHGRGYTYLLSRA
CCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHC
GVTGTESRAQLPLHHLVNKLREYHAAPPLQGFGISEPAQVRDALQAGAAGAISGSAIVKI
CCCCCCCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
IEQNHTQPAEMLTRLATFVSEMKAATRA
HHHCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERYQQLFDRLASNKEGAFVPFVTLGDPNPALSLQIIDTLVEAGADALELGIPFSDPLAD
CCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
GPTIQSAALRAFASGVTPTQCFEMLAAIRQKHPSMPIGLLMYANLVFHKGIDAFYQRCAE
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHH
VGVDSVLIADVPYEESAPFRAAAIRHGIAPIFICPPNADDDLLREISSHGRGYTYLLSRA
CCCCCEEEECCCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHC
GVTGTESRAQLPLHHLVNKLREYHAAPPLQGFGISEPAQVRDALQAGAAGAISGSAIVKI
CCCCCCCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHH
IEQNHTQPAEMLTRLATFVSEMKAATRA
HHHCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA