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The map label for this gene is trpE [H]

Identifier: 157370907

GI number: 157370907

Start: 2936743

End: 2938305

Strand: Direct

Name: trpE [H]

Synonym: Spro_2667

Alternate gene names: 157370907

Gene position: 2936743-2938305 (Clockwise)

Preceding gene: 157370901

Following gene: 157370908

Centisome position: 53.9

GC content: 59.95

Gene sequence:

>1563_bases
ATGATGAACATCAAACCACAACTCAAATTACTGAAGGCGGAGGCCAGTTACCGGGGCGATCCGACCACCATTTTCCACCA
GCTGTGCGGCGCTCGTCCGGCCACCCTGCTGTTGGAATCGGCTGAAATCAACAGCAAGCAAAACCTGCAAAGCCTGTTGG
TCATTGACAGCGCTCTGCGCATTACCGCACTGGGCCGCACCGTGACGCTGCATGCGCTGACCGCCAACGGCGCGGCGATG
CTGCCGCTGCTGGATGAGGCCCTGCCGGCAGAAGTCCAGAACCAGGTGCGTCCTAATGGACGTGAACTGACTTTCCCGGT
GATTGATGCGATTCAGGATGAAGATGCCCGCCTGCGTTCGCTGTCGGTGTTTGATGCACTGCGCACCCTGCTGACACTGG
TTGACTCCCCGGCTGACGAACGTGAAGCAGTGATGCTCGGCGGACTCTTTGCCTACGACTTGGTCGCCGGGTTCGAAGAC
CTGCCGCCACTGCGTCAGGAAAACCGCTGCCCGGACTTCTGCTTCTATCTGGCGGAAACCTTGTTGGTGCTGGATCATCA
ACGCAGCGTTGCCCGTCTTCAGGCCAGCGTTTTCACGGCCGATACGGCGGAAGAACAGCGCTTGCAACAGCGCCTGGAGC
AGTTGCAGCTGCAATTGAAACAGACCCCACAGCCGATCCCGCACCAGAAGCTGGAAAACATGCAACTGAGCTGTAACCAG
ACCGATGAAGAATACGGTGCGGTTGTCAGCGAATTGCAACAGGCCATCCGTCAGGGCGAAATCTTCCAGGTGGTGCCGTC
GCGCCGTTTCTCGCTGCCGTGCCCGGCCCCGTTGGCCGCTTACCAGACGCTGAAGGACAACAACCCAAGCCCATACATGT
TCTATATGCAGGATGACGAGTTCACCCTGTTCGGTGCTTCGCCGGAAAGCGCGCTGAAATACGACGCCGGCAACCGCCAG
ATCGAGATCTACCCGATTGCCGGTACCCGTCCTCGCGGCCGTCGCGCCGACGGTTCGCTGGATCTGGATCTCGACAGCCG
TATCGAGCTGGAAATGCGGACCGATCATAAAGAACTGGCCGAGCACCTGATGCTGGTCGATCTGGCGCGTAACGATCTGG
CGCGCATCTGTCAGGCCGGTAGCCGCTATGTGGCCGACCTGACCAAAGTGGACCGCTACTCATTCGTGATGCACCTGGTG
TCTCGGGTAATCGGCACCCTGCGCGCCGACCTCGACGTGCTGCACGCTTATCAGGCCTGTATGAACATGGGCACCCTGAG
CGGCGCCCCCAAAGTGCGCGCCATGCAGTTAATCGCCGCCTCTGAAGGTACCCGCCGCGGCAGCTACGGCGGTGCGGTCG
GTTATTTCACCGCCACCGGCGATTTGGATACCTGTATTGTCATCCGCTCCGCGTATGTTGAAGACGGCATTGCTACCGTG
CAAGCCGGTGCCGGTGTGGTGTTGGATTCTGTTCCTCAGGCGGAAGCCGATGAGACCCGTAATAAGGCACGTGCCGTGCT
GCGTGCCATTGCCAGCGCGCACCAGGCCAAGGAGGTGTTCTGA

Upstream 100 bases:

>100_bases
GGCGGAGTAATCACGCATACCTGTCATCTGACACTGCAGATTCCCTAAGCCCGCTGGTAACGCGGGCTTTTTTATGGACA
AATTTTAACTGGAACCACCA

Downstream 100 bases:

>100_bases
TGGCCGATATCTTACTGCTCGATAACGTCGATTCCTTTACCTACAACCTGGTCGATCAGCTGCGCGCCAGCGGTCATCAG
GTAGTGATTTACCGTAACCA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MMNIKPQLKLLKAEASYRGDPTTIFHQLCGARPATLLLESAEINSKQNLQSLLVIDSALRITALGRTVTLHALTANGAAM
LPLLDEALPAEVQNQVRPNGRELTFPVIDAIQDEDARLRSLSVFDALRTLLTLVDSPADEREAVMLGGLFAYDLVAGFED
LPPLRQENRCPDFCFYLAETLLVLDHQRSVARLQASVFTADTAEEQRLQQRLEQLQLQLKQTPQPIPHQKLENMQLSCNQ
TDEEYGAVVSELQQAIRQGEIFQVVPSRRFSLPCPAPLAAYQTLKDNNPSPYMFYMQDDEFTLFGASPESALKYDAGNRQ
IEIYPIAGTRPRGRRADGSLDLDLDSRIELEMRTDHKELAEHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLV
SRVIGTLRADLDVLHAYQACMNMGTLSGAPKVRAMQLIAASEGTRRGSYGGAVGYFTATGDLDTCIVIRSAYVEDGIATV
QAGAGVVLDSVPQAEADETRNKARAVLRAIASAHQAKEVF

Sequences:

>Translated_520_residues
MMNIKPQLKLLKAEASYRGDPTTIFHQLCGARPATLLLESAEINSKQNLQSLLVIDSALRITALGRTVTLHALTANGAAM
LPLLDEALPAEVQNQVRPNGRELTFPVIDAIQDEDARLRSLSVFDALRTLLTLVDSPADEREAVMLGGLFAYDLVAGFED
LPPLRQENRCPDFCFYLAETLLVLDHQRSVARLQASVFTADTAEEQRLQQRLEQLQLQLKQTPQPIPHQKLENMQLSCNQ
TDEEYGAVVSELQQAIRQGEIFQVVPSRRFSLPCPAPLAAYQTLKDNNPSPYMFYMQDDEFTLFGASPESALKYDAGNRQ
IEIYPIAGTRPRGRRADGSLDLDLDSRIELEMRTDHKELAEHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLV
SRVIGTLRADLDVLHAYQACMNMGTLSGAPKVRAMQLIAASEGTRRGSYGGAVGYFTATGDLDTCIVIRSAYVEDGIATV
QAGAGVVLDSVPQAEADETRNKARAVLRAIASAHQAKEVF
>Mature_520_residues
MMNIKPQLKLLKAEASYRGDPTTIFHQLCGARPATLLLESAEINSKQNLQSLLVIDSALRITALGRTVTLHALTANGAAM
LPLLDEALPAEVQNQVRPNGRELTFPVIDAIQDEDARLRSLSVFDALRTLLTLVDSPADEREAVMLGGLFAYDLVAGFED
LPPLRQENRCPDFCFYLAETLLVLDHQRSVARLQASVFTADTAEEQRLQQRLEQLQLQLKQTPQPIPHQKLENMQLSCNQ
TDEEYGAVVSELQQAIRQGEIFQVVPSRRFSLPCPAPLAAYQTLKDNNPSPYMFYMQDDEFTLFGASPESALKYDAGNRQ
IEIYPIAGTRPRGRRADGSLDLDLDSRIELEMRTDHKELAEHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLV
SRVIGTLRADLDVLHAYQACMNMGTLSGAPKVRAMQLIAASEGTRRGSYGGAVGYFTATGDLDTCIVIRSAYVEDGIATV
QAGAGVVLDSVPQAEADETRNKARAVLRAIASAHQAKEVF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=520, Percent_Identity=73.6538461538462, Blast_Score=769, Evalue=0.0,
Organism=Escherichia coli, GI1788114, Length=369, Percent_Identity=31.4363143631436, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI87082077, Length=265, Percent_Identity=27.5471698113208, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=384, Percent_Identity=38.28125, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6324361, Length=421, Percent_Identity=26.3657957244656, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57431; Mature: 57431

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNIKPQLKLLKAEASYRGDPTTIFHQLCGARPATLLLESAEINSKQNLQSLLVIDSALR
CCCCCCHHHHEEHHHCCCCCHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHHHHH
ITALGRTVTLHALTANGAAMLPLLDEALPAEVQNQVRPNGRELTFPVIDAIQDEDARLRS
EEECCCEEEEEEEECCCCEEHHHHHHHCCHHHHHHCCCCCCEEEHHHHHHHCCCCHHHHH
LSVFDALRTLLTLVDSPADEREAVMLGGLFAYDLVAGFEDLPPLRQENRCPDFCFYLAET
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHCCCCCCCCCCCHHHHHHHHHH
LLVLDHQRSVARLQASVFTADTAEEQRLQQRLEQLQLQLKQTPQPIPHQKLENMQLSCNQ
HHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEECCCC
TDEEYGAVVSELQQAIRQGEIFQVVPSRRFSLPCPAPLAAYQTLKDNNPSPYMFYMQDDE
CHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCC
FTLFGASPESALKYDAGNRQIEIYPIAGTRPRGRRADGSLDLDLDSRIELEMRTDHKELA
EEEECCCCCHHHEECCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCEEEEECCCHHHHH
EHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLVSRVIGTLRADLDVLHAYQAC
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAASEGTRRGSYGGAVGYFTATGDLDTCIVIRSAYVEDGIATV
HHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHCCHHHH
QAGAGVVLDSVPQAEADETRNKARAVLRAIASAHQAKEVF
HCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMNIKPQLKLLKAEASYRGDPTTIFHQLCGARPATLLLESAEINSKQNLQSLLVIDSALR
CCCCCCHHHHEEHHHCCCCCHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHHHHHHHHH
ITALGRTVTLHALTANGAAMLPLLDEALPAEVQNQVRPNGRELTFPVIDAIQDEDARLRS
EEECCCEEEEEEEECCCCEEHHHHHHHCCHHHHHHCCCCCCEEEHHHHHHHCCCCHHHHH
LSVFDALRTLLTLVDSPADEREAVMLGGLFAYDLVAGFEDLPPLRQENRCPDFCFYLAET
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHCCCCCCCCCCCHHHHHHHHHH
LLVLDHQRSVARLQASVFTADTAEEQRLQQRLEQLQLQLKQTPQPIPHQKLENMQLSCNQ
HHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEECCCC
TDEEYGAVVSELQQAIRQGEIFQVVPSRRFSLPCPAPLAAYQTLKDNNPSPYMFYMQDDE
CHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCC
FTLFGASPESALKYDAGNRQIEIYPIAGTRPRGRRADGSLDLDLDSRIELEMRTDHKELA
EEEECCCCCHHHEECCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCEEEEECCCHHHHH
EHLMLVDLARNDLARICQAGSRYVADLTKVDRYSFVMHLVSRVIGTLRADLDVLHAYQAC
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAASEGTRRGSYGGAVGYFTATGDLDTCIVIRSAYVEDGIATV
HHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHCCHHHH
QAGAGVVLDSVPQAEADETRNKARAVLRAIASAHQAKEVF
HCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11371633; 4598537; 366432; 7007652 [H]