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The map label for this gene is fnr [H]

Identifier: 157370822

GI number: 157370822

Start: 2838608

End: 2839372

Strand: Direct

Name: fnr [H]

Synonym: Spro_2582

Alternate gene names: 157370822

Gene position: 2838608-2839372 (Clockwise)

Preceding gene: 157370821

Following gene: 157370823

Centisome position: 52.1

GC content: 53.99

Gene sequence:

>765_bases
ATGATCCCGGAAAAACGCGTGATTCGTCGTATCCAGTCTGGTGGTTGTGCGATCCATTGTCAGGATTGCAGTATCAGCCA
ACTGTGTATTCCTTTTACTCTTAATGCCCATGAGCTGGACCAGCTCGACAACATTATCGAAAGGAAGAAGCCTATCCAGA
AGGGCCAGACCTTGTTCAAGGCCGGCGATGAACTGAAATCGCTGTACGCTATCCGCTCCGGGACCATCAAAAGTTATACC
ATTACCGAGCAAGGCGATGAGCAGATCACCGGTTTCCACCTGGCGGGCGATCTGGTTGGTTTTGACGCCATTGGCGGCCT
GAAGCACCCAAGCTTCGCTCAGGCGCTGGAAACGTCCATGGTGTGTGAGATCCCGTTCGAAACCCTGGATGACCTGTCCG
GTAAAATGCCTAACCTGCGCCAGCAAATCATGCGTCTGATGAGCGGCGAGATTAAAGGCGACCAGGACATGATCCTGCTG
TTGTCGAAGAAAAATGCCGAAGAGCGCCTGGCCGCATTCGTCTATAACCTGTCGCGCCGCTTTGCGGAACGCGGTTTCTC
ACCGCGTGAGTTCCGTCTGACCATGACCCGTGGCGACATCGGCAACTACCTTGGTCTGACGGTAGAAACCATCAGCCGTC
TGCTGGGCCGCTTCCAGAAAAGCGAAATCCTCAGCGTTAAAGGTAAATATATCACCATCGAAAACGTCGACGCCCTGTCG
GTGCTGGCCGGTACGCCACGCATTAACGTGACCGTAAACGCCTGA

Upstream 100 bases:

>100_bases
ATTCGCACAGAATGCCCCCGTTGTTATTAATGCTACCCTTATCACCTGCCGGAAAAGATGTTAAAATTGACGCATATCAA
TTATTGAATGAGCGTAATCT

Downstream 100 bases:

>100_bases
TCCCAAGCTGGGTTAGTAATTCAACAGAATTATTGACCCAGCCTATCTCTGCTGCTGTTCTGTTTTTCAATGTTGGGTTA
CTCTGTAAATTGACAGACTG

Product: fumarate/nitrate reduction transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNAHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGGLKHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILL
LSKKNAEERLAAFVYNLSRRFAERGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSEILSVKGKYITIENVDALS
VLAGTPRINVTVNA

Sequences:

>Translated_254_residues
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNAHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGGLKHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILL
LSKKNAEERLAAFVYNLSRRFAERGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSEILSVKGKYITIENVDALS
VLAGTPRINVTVNA
>Mature_254_residues
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNAHELDQLDNIIERKKPIQKGQTLFKAGDELKSLYAIRSGTIKSYT
ITEQGDEQITGFHLAGDLVGFDAIGGLKHPSFAQALETSMVCEIPFETLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILL
LSKKNAEERLAAFVYNLSRRFAERGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSEILSVKGKYITIENVDALS
VLAGTPRINVTVNA

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=247, Percent_Identity=93.5222672064777, Blast_Score=477, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 28311; Mature: 28311

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNAHELDQLDNIIERKKPIQKGQTLFK
CCCHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGGLKHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHCCCCCCHHHHHHHHHH
VCEIPFETLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILLLSKKNAEERLAAFVYNLSRR
EEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAERGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSEILSVKGKYITIENVDALS
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCHHH
VLAGTPRINVTVNA
HEECCCEEEEEEEC
>Mature Secondary Structure
MIPEKRVIRRIQSGGCAIHCQDCSISQLCIPFTLNAHELDQLDNIIERKKPIQKGQTLFK
CCCHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHH
AGDELKSLYAIRSGTIKSYTITEQGDEQITGFHLAGDLVGFDAIGGLKHPSFAQALETSM
HHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCHHHHHHHCCCCCCHHHHHHHHHH
VCEIPFETLDDLSGKMPNLRQQIMRLMSGEIKGDQDMILLLSKKNAEERLAAFVYNLSRR
EEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
FAERGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKSEILSVKGKYITIENVDALS
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCHHH
VLAGTPRINVTVNA
HEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]