Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 157370737

GI number: 157370737

Start: 2741548

End: 2742498

Strand: Direct

Name: gyaR [H]

Synonym: Spro_2497

Alternate gene names: 157370737

Gene position: 2741548-2742498 (Clockwise)

Preceding gene: 157370728

Following gene: 157370738

Centisome position: 50.31

GC content: 59.1

Gene sequence:

>951_bases
ATGACGACTCATACGCCCAATGAACTGCTGTTAATCGCTCCCGTGATGGAAAACCTGCTTGCCCGTCTTGAGGCAACCTT
TGTGGTGCACCGGCTGTATGAGCAGGCGGACCCGGTCAATTTTCTGGCGACCCGCGGCGAAGCCATCCGCGCGGTCGTCA
CCCGTGGCGATATCGGTGTCACCACGCCGGTGCTCGAGCAGCTACCGCAACTGGGGCTGATTGCAGTGTTCGGCGTCGGT
ACTGACGCCATTGACCTGAACTACACCCGTCAGCGCGACATCGCGGTAACCATCACCTCCGGCGCGTTGACCGAAGACGT
GGCGGATATGGCGCTGGGGTTGCTGTTGGCCACCGCCCGCCAGCTTTGCTTCAATGACCGCTTTGTCCGTGACGGGCACT
GGCTGCAAAAGGCCCCGGGCTTGTCGGTGCAGGTCAGCGGTAAACGACTGGGGATTTTTGGTATGGGCAACATCGGCCGC
GCCATCGCCCAGCGCGCCGCCGGTTTCAACATGCGTATCCAATATGCCAGCCATCGGCAGGACACCACGCTGCCCTATGC
TTATTACCCGGACTTGCTGGCGCTGGCGCAGGAAAGCGATTTTCTGGTGATCGCCATCTCCGGTGGCAAGGACAGCGCAG
GCCTGGTGGACAAAACCGTATTTGATGCGTTGCCGGCGCATGCGCTGGTGATCAACATTGCCCGTGGCAGCATCGTCAAC
GAAAAGGACCTGATCGCCGCGTTGCAAAACGGTGACATTGCCGGTGCCGGGCTGGATGTTTATGCCCAGGAGCCACAGGT
GCCTGCCGAGCTGATCGCCATGGATAATGTCGTGTTGCAGCCGCATATTGCCAGTGCCACGCAGGAAACCCGGCAAAAAA
TGAGCGACATCGTATTTACCAACGTTGAAGCCTTTTTCAATCAGGCACCGTTACCCCACGCCATTGAATAA

Upstream 100 bases:

>100_bases
TTTTTAACATCCTTCAGCGTGATATCTGTCGCAAAACCACCTGCGGAAAACCGCTTTGATAGCCATAACGTATCAACGCT
ATTTTTAAACAGGTGAAATC

Downstream 100 bases:

>100_bases
TTAAGCCGTTTCTTTCGAATTTATTATCGCCGTACCACAGAACCTCTTTATTAATTGAGAGGTTCTCCCTGCGCCTTATA
AAGAGAGATCGCCATGGATA

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTTHTPNELLLIAPVMENLLARLEATFVVHRLYEQADPVNFLATRGEAIRAVVTRGDIGVTTPVLEQLPQLGLIAVFGVG
TDAIDLNYTRQRDIAVTITSGALTEDVADMALGLLLATARQLCFNDRFVRDGHWLQKAPGLSVQVSGKRLGIFGMGNIGR
AIAQRAAGFNMRIQYASHRQDTTLPYAYYPDLLALAQESDFLVIAISGGKDSAGLVDKTVFDALPAHALVINIARGSIVN
EKDLIAALQNGDIAGAGLDVYAQEPQVPAELIAMDNVVLQPHIASATQETRQKMSDIVFTNVEAFFNQAPLPHAIE

Sequences:

>Translated_316_residues
MTTHTPNELLLIAPVMENLLARLEATFVVHRLYEQADPVNFLATRGEAIRAVVTRGDIGVTTPVLEQLPQLGLIAVFGVG
TDAIDLNYTRQRDIAVTITSGALTEDVADMALGLLLATARQLCFNDRFVRDGHWLQKAPGLSVQVSGKRLGIFGMGNIGR
AIAQRAAGFNMRIQYASHRQDTTLPYAYYPDLLALAQESDFLVIAISGGKDSAGLVDKTVFDALPAHALVINIARGSIVN
EKDLIAALQNGDIAGAGLDVYAQEPQVPAELIAMDNVVLQPHIASATQETRQKMSDIVFTNVEAFFNQAPLPHAIE
>Mature_315_residues
TTHTPNELLLIAPVMENLLARLEATFVVHRLYEQADPVNFLATRGEAIRAVVTRGDIGVTTPVLEQLPQLGLIAVFGVGT
DAIDLNYTRQRDIAVTITSGALTEDVADMALGLLLATARQLCFNDRFVRDGHWLQKAPGLSVQVSGKRLGIFGMGNIGRA
IAQRAAGFNMRIQYASHRQDTTLPYAYYPDLLALAQESDFLVIAISGGKDSAGLVDKTVFDALPAHALVINIARGSIVNE
KDLIAALQNGDIAGAGLDVYAQEPQVPAELIAMDNVVLQPHIASATQETRQKMSDIVFTNVEAFFNQAPLPHAIE

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=255, Percent_Identity=34.9019607843137, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI23308577, Length=252, Percent_Identity=29.3650793650794, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI61743967, Length=253, Percent_Identity=28.4584980237154, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4557497, Length=253, Percent_Identity=28.4584980237154, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=27.6264591439689, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=27.6264591439689, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=27.7992277992278, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI87082289, Length=307, Percent_Identity=36.8078175895765, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789279, Length=249, Percent_Identity=28.1124497991968, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787645, Length=274, Percent_Identity=25.1824817518248, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081824, Length=244, Percent_Identity=26.6393442622951, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=256, Percent_Identity=27.734375, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25147481, Length=238, Percent_Identity=27.3109243697479, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=323, Percent_Identity=26.9349845201238, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=300, Percent_Identity=27, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=236, Percent_Identity=28.3898305084746, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321253, Length=289, Percent_Identity=22.4913494809689, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324964, Length=290, Percent_Identity=24.4827586206897, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=362, Percent_Identity=23.2044198895028, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45552429, Length=242, Percent_Identity=37.1900826446281, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24585514, Length=242, Percent_Identity=37.1900826446281, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574282, Length=242, Percent_Identity=37.1900826446281, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45551003, Length=242, Percent_Identity=37.1900826446281, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574284, Length=242, Percent_Identity=37.1900826446281, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574286, Length=243, Percent_Identity=34.9794238683128, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28571528, Length=286, Percent_Identity=33.5664335664336, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585516, Length=240, Percent_Identity=30, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19921140, Length=272, Percent_Identity=25.7352941176471, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646446, Length=257, Percent_Identity=27.2373540856031, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24646448, Length=257, Percent_Identity=27.2373540856031, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24646452, Length=257, Percent_Identity=27.2373540856031, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24646450, Length=257, Percent_Identity=27.2373540856031, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=27.2, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34109; Mature: 33977

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHTPNELLLIAPVMENLLARLEATFVVHRLYEQADPVNFLATRGEAIRAVVTRGDIGV
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEECCCCCC
TTPVLEQLPQLGLIAVFGVGTDAIDLNYTRQRDIAVTITSGALTEDVADMALGLLLATAR
CCHHHHHCCCCCEEEEEECCCCEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
QLCFNDRFVRDGHWLQKAPGLSVQVSGKRLGIFGMGNIGRAIAQRAAGFNMRIQYASHRQ
HHHHCCCEECCCCHHHCCCCCEEEECCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCC
DTTLPYAYYPDLLALAQESDFLVIAISGGKDSAGLVDKTVFDALPAHALVINIARGSIVN
CCCCCCHHCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCC
EKDLIAALQNGDIAGAGLDVYAQEPQVPAELIAMDNVVLQPHIASATQETRQKMSDIVFT
HHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHH
NVEAFFNQAPLPHAIE
HHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTHTPNELLLIAPVMENLLARLEATFVVHRLYEQADPVNFLATRGEAIRAVVTRGDIGV
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEECCCCCC
TTPVLEQLPQLGLIAVFGVGTDAIDLNYTRQRDIAVTITSGALTEDVADMALGLLLATAR
CCHHHHHCCCCCEEEEEECCCCEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
QLCFNDRFVRDGHWLQKAPGLSVQVSGKRLGIFGMGNIGRAIAQRAAGFNMRIQYASHRQ
HHHHCCCEECCCCHHHCCCCCEEEECCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCC
DTTLPYAYYPDLLALAQESDFLVIAISGGKDSAGLVDKTVFDALPAHALVINIARGSIVN
CCCCCCHHCCHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCC
EKDLIAALQNGDIAGAGLDVYAQEPQVPAELIAMDNVVLQPHIASATQETRQKMSDIVFT
HHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHH
NVEAFFNQAPLPHAIE
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA