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The map label for this gene is ggt [H]

Identifier: 157370724

GI number: 157370724

Start: 2725018

End: 2726691

Strand: Direct

Name: ggt [H]

Synonym: Spro_2484

Alternate gene names: 157370724

Gene position: 2725018-2726691 (Clockwise)

Preceding gene: 157370723

Following gene: 157370726

Centisome position: 50.01

GC content: 56.57

Gene sequence:

>1674_bases
ATGCATTCTGGCTTATTGAAAACCTTAGCACTCAGCGTGGCACTCGCCACTCTTAGCCCCTCGGTGTTGGCCGCAAATCT
GAATGCCGGCGCCGTAGCGGCACCGGATCAATACGGTGCCAAAGTGGCCGCACAAATTTTGCAGGCCGGGGGTAACGCGG
TCGATGCGGCAGTCGCCACCGCTTTTACCCTGGCCGTGACCTACCCGGAAGCCGGTAACATTGGCGGCGGCGGCTTTATG
ACGCTGTACGTCGACGGCAAACCCTATTTCCTCGACTACCGTGAAATCGCCCCCAAAGCCGCTACCAAAACCATGTACCT
GAACGAAAAAGGTGAAGTGATTGAAAACCTCAGTTTGGTGGGGACCAAGGCCGCCGGAGTGCCCGGCACGGTGCTGGGGC
TGTGGGAGGCACATAAACGCTTTGGTAAATTACCCTGGGCGGAGCTGTTGACCCCGGCCATCGGCTACGCGCAGCAAGGT
TTTAAGGTCGCCGATCAGCAATATCAGTACCGTGAAGACGCCAACAAGCTGTTCGCCGGAAAAACCAACTTTGGCGATTA
CTTTGGCAGTATGAAACCCGGCGCGGTGTTTAAACAACCGGAGCTGGCCAAAACGCTGGAGCGCATCGCCAATAAAGGCG
CCGAAGACTTCTATCAGGGGGAAACGGCCAAACTGCTGGTGGCCCAGATGCAGCACGATGGCGGCCTGATTACCCAGGCC
GATCTGACTGACTACCGGGTTAAATGGCGTGAACCAATGCAAATCTCCTGGCGCGGCAATACCCTTTACACCGCCCCGCT
GCCCAGTTCTGGCGGCATTGCGCTGGCGCAGTTGCTGGGGATCAAAGAAGATCGTGCCGCCGACTTCAAAGGCGTAGAAC
TTAACTCCGCACGTTATATTCACCTGCTGTCGGAAATAGAGAAACGCGTGTTTGCCGATCGTGCTGATTACCTCGGCGAC
CCGGACTTTGCCAAGGTCCCGGTGGCACAACTGGTCGCGCCGGACTACCTGCAAAAACGCGCAGCGGAGATCAACCCCAC
CGCCATTTCGCCAACCGAAAACGTACGTCCTGGCCTAGAACCGCATCAGACTACCCATTTCTCGATTGTTGACGCCCAGG
GCAATGCGGTCAGCAACACCTATACGTTGAACTGGGACTTTGGCAGCGGTGTGGTGGTGAAAGGGGCCGGCTTCCTGCTG
AATGACGAGATGGATGACTTCAGCGCCAAACCGGGCGTAGCCAACGCTTTTGGCGTGGTCGGCAGCGATGCCAATGCCAT
TGAACCGGGTAAACGCATGCTTTCATCCATGAGCCCGACCATTATCACCCGTGACGGTAACGTCAGCCTGGTGATTGGTA
CCCCCGGCGGCTCGCGCATTTTCACCTCGATTTTCCAGGTGATCAACAACATCTATGATTACCAACTGCCATTGGACAAA
GCCGTGGCCGCCCAACGCGTTCATCACCAACTTCTCCCTAAAGACACCATCTTCTTCGACAGCTTTGCCCCATTGACCGG
CAAAGTAGCGGAACAACTTAAAGCCATGGGCTATAAGCTGGAAGATCAGGGCTGGTATATGGGGGATATTCAGGCGATCC
GCGTCAACGGCGATACGCCAGAGACGGCGTCCGACCCTCGTGGCCGCGGTGTGGGATTGGTGGTGAAAAAGTAA

Upstream 100 bases:

>100_bases
GCTACCTTCAATCAGGCGCCCGAAAACCTGCACAGAATGGCGCTAAGTAATTGTTGAGATTGAAGTCACCTGCCATCGTT
CAATTCGAAAAGGAACCGCT

Downstream 100 bases:

>100_bases
CGATAAAAACCGGGCGGCTTCACAGTAAGCCCGCCCGGTTGGCTTTATTACCTCGCAGCCGTAGCCGCTTTAACGGCCCC
TTGAGTCAATTCACCATAAA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MHSGLLKTLALSVALATLSPSVLAANLNAGAVAAPDQYGAKVAAQILQAGGNAVDAAVATAFTLAVTYPEAGNIGGGGFM
TLYVDGKPYFLDYREIAPKAATKTMYLNEKGEVIENLSLVGTKAAGVPGTVLGLWEAHKRFGKLPWAELLTPAIGYAQQG
FKVADQQYQYREDANKLFAGKTNFGDYFGSMKPGAVFKQPELAKTLERIANKGAEDFYQGETAKLLVAQMQHDGGLITQA
DLTDYRVKWREPMQISWRGNTLYTAPLPSSGGIALAQLLGIKEDRAADFKGVELNSARYIHLLSEIEKRVFADRADYLGD
PDFAKVPVAQLVAPDYLQKRAAEINPTAISPTENVRPGLEPHQTTHFSIVDAQGNAVSNTYTLNWDFGSGVVVKGAGFLL
NDEMDDFSAKPGVANAFGVVGSDANAIEPGKRMLSSMSPTIITRDGNVSLVIGTPGGSRIFTSIFQVINNIYDYQLPLDK
AVAAQRVHHQLLPKDTIFFDSFAPLTGKVAEQLKAMGYKLEDQGWYMGDIQAIRVNGDTPETASDPRGRGVGLVVKK

Sequences:

>Translated_557_residues
MHSGLLKTLALSVALATLSPSVLAANLNAGAVAAPDQYGAKVAAQILQAGGNAVDAAVATAFTLAVTYPEAGNIGGGGFM
TLYVDGKPYFLDYREIAPKAATKTMYLNEKGEVIENLSLVGTKAAGVPGTVLGLWEAHKRFGKLPWAELLTPAIGYAQQG
FKVADQQYQYREDANKLFAGKTNFGDYFGSMKPGAVFKQPELAKTLERIANKGAEDFYQGETAKLLVAQMQHDGGLITQA
DLTDYRVKWREPMQISWRGNTLYTAPLPSSGGIALAQLLGIKEDRAADFKGVELNSARYIHLLSEIEKRVFADRADYLGD
PDFAKVPVAQLVAPDYLQKRAAEINPTAISPTENVRPGLEPHQTTHFSIVDAQGNAVSNTYTLNWDFGSGVVVKGAGFLL
NDEMDDFSAKPGVANAFGVVGSDANAIEPGKRMLSSMSPTIITRDGNVSLVIGTPGGSRIFTSIFQVINNIYDYQLPLDK
AVAAQRVHHQLLPKDTIFFDSFAPLTGKVAEQLKAMGYKLEDQGWYMGDIQAIRVNGDTPETASDPRGRGVGLVVKK
>Mature_557_residues
MHSGLLKTLALSVALATLSPSVLAANLNAGAVAAPDQYGAKVAAQILQAGGNAVDAAVATAFTLAVTYPEAGNIGGGGFM
TLYVDGKPYFLDYREIAPKAATKTMYLNEKGEVIENLSLVGTKAAGVPGTVLGLWEAHKRFGKLPWAELLTPAIGYAQQG
FKVADQQYQYREDANKLFAGKTNFGDYFGSMKPGAVFKQPELAKTLERIANKGAEDFYQGETAKLLVAQMQHDGGLITQA
DLTDYRVKWREPMQISWRGNTLYTAPLPSSGGIALAQLLGIKEDRAADFKGVELNSARYIHLLSEIEKRVFADRADYLGD
PDFAKVPVAQLVAPDYLQKRAAEINPTAISPTENVRPGLEPHQTTHFSIVDAQGNAVSNTYTLNWDFGSGVVVKGAGFLL
NDEMDDFSAKPGVANAFGVVGSDANAIEPGKRMLSSMSPTIITRDGNVSLVIGTPGGSRIFTSIFQVINNIYDYQLPLDK
AVAAQRVHHQLLPKDTIFFDSFAPLTGKVAEQLKAMGYKLEDQGWYMGDIQAIRVNGDTPETASDPRGRGVGLVVKK

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=536, Percent_Identity=33.0223880597015, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI73915090, Length=536, Percent_Identity=33.0223880597015, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI73915096, Length=536, Percent_Identity=33.0223880597015, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI73915094, Length=536, Percent_Identity=33.0223880597015, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI113429324, Length=538, Percent_Identity=30.8550185873606, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI113429326, Length=547, Percent_Identity=30.3473491773309, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI153266885, Length=549, Percent_Identity=26.9581056466302, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI153266901, Length=550, Percent_Identity=26.9090909090909, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI109148539, Length=519, Percent_Identity=29.6724470134875, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI153266907, Length=552, Percent_Identity=25.7246376811594, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI30581157, Length=189, Percent_Identity=38.0952380952381, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI30581155, Length=189, Percent_Identity=38.0952380952381, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI218505805, Length=189, Percent_Identity=37.037037037037, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI310124095, Length=190, Percent_Identity=33.6842105263158, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789856, Length=529, Percent_Identity=43.4782608695652, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI72000294, Length=548, Percent_Identity=33.9416058394161, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI212646519, Length=558, Percent_Identity=33.3333333333333, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17542894, Length=555, Percent_Identity=32.2522522522522, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI193208247, Length=501, Percent_Identity=32.3353293413174, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193208245, Length=501, Percent_Identity=32.3353293413174, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17506189, Length=530, Percent_Identity=31.8867924528302, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17564448, Length=434, Percent_Identity=25.8064516129032, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI72001495, Length=226, Percent_Identity=29.2035398230088, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI72001497, Length=226, Percent_Identity=29.2035398230088, Blast_Score=100, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323330, Length=549, Percent_Identity=30.7832422586521, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI18859893, Length=554, Percent_Identity=36.2815884476534, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI161077496, Length=553, Percent_Identity=33.4538878842676, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI161077880, Length=541, Percent_Identity=32.902033271719, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24642670, Length=541, Percent_Identity=32.902033271719, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24642666, Length=541, Percent_Identity=32.902033271719, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI161077878, Length=541, Percent_Identity=32.902033271719, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI45551474, Length=541, Percent_Identity=32.902033271719, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI18859741, Length=489, Percent_Identity=28.4253578732106, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59886; Mature: 59886

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSGLLKTLALSVALATLSPSVLAANLNAGAVAAPDQYGAKVAAQILQAGGNAVDAAVAT
CCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEECCHHHHHHHHHHHHHCCCCHHHHHHHE
AFTLAVTYPEAGNIGGGGFMTLYVDGKPYFLDYREIAPKAATKTMYLNEKGEVIENLSLV
EEEEEEECCCCCCCCCCEEEEEEECCCEEEEEHHHHCCHHHCEEEEECCCCHHHHHHHHE
GTKAAGVPGTVLGLWEAHKRFGKLPWAELLTPAIGYAQQGFKVADQQYQYREDANKLFAG
ECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECC
KTNFGDYFGSMKPGAVFKQPELAKTLERIANKGAEDFYQGETAKLLVAQMQHDGGLITQA
CCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCHHHHHEEHHHCCCCEEEEC
DLTDYRVKWREPMQISWRGNTLYTAPLPSSGGIALAQLLGIKEDRAADFKGVELNSARYI
CCCCEEEEECCCEEEEECCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCEEECCCHHH
HLLSEIEKRVFADRADYLGDPDFAKVPVAQLVAPDYLQKRAAEINPTAISPTENVRPGLE
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHCCCCCCEECCCCCCCCCCC
PHQTTHFSIVDAQGNAVSNTYTLNWDFGSGVVVKGAGFLLNDEMDDFSAKPGVANAFGVV
CCCCEEEEEEECCCCEECCEEEEEEECCCCEEEECCCEEECCCCCCCCCCCCCCCHHEEE
GSDANAIEPGKRMLSSMSPTIITRDGNVSLVIGTPGGSRIFTSIFQVINNIYDYQLPLDK
CCCCCCCCHHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHH
AVAAQRVHHQLLPKDTIFFDSFAPLTGKVAEQLKAMGYKLEDQGWYMGDIQAIRVNGDTP
HHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCEECCCCEEEECEEEEEECCCCC
ETASDPRGRGVGLVVKK
CCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MHSGLLKTLALSVALATLSPSVLAANLNAGAVAAPDQYGAKVAAQILQAGGNAVDAAVAT
CCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEECCHHHHHHHHHHHHHCCCCHHHHHHHE
AFTLAVTYPEAGNIGGGGFMTLYVDGKPYFLDYREIAPKAATKTMYLNEKGEVIENLSLV
EEEEEEECCCCCCCCCCEEEEEEECCCEEEEEHHHHCCHHHCEEEEECCCCHHHHHHHHE
GTKAAGVPGTVLGLWEAHKRFGKLPWAELLTPAIGYAQQGFKVADQQYQYREDANKLFAG
ECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECC
KTNFGDYFGSMKPGAVFKQPELAKTLERIANKGAEDFYQGETAKLLVAQMQHDGGLITQA
CCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCHHHHHEEHHHCCCCEEEEC
DLTDYRVKWREPMQISWRGNTLYTAPLPSSGGIALAQLLGIKEDRAADFKGVELNSARYI
CCCCEEEEECCCEEEEECCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCEEECCCHHH
HLLSEIEKRVFADRADYLGDPDFAKVPVAQLVAPDYLQKRAAEINPTAISPTENVRPGLE
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHCCCCCCEECCCCCCCCCCC
PHQTTHFSIVDAQGNAVSNTYTLNWDFGSGVVVKGAGFLLNDEMDDFSAKPGVANAFGVV
CCCCEEEEEEECCCCEECCEEEEEEECCCCEEEECCCEEECCCCCCCCCCCCCCCHHEEE
GSDANAIEPGKRMLSSMSPTIITRDGNVSLVIGTPGGSRIFTSIFQVINNIYDYQLPLDK
CCCCCCCCHHHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHH
AVAAQRVHHQLLPKDTIFFDSFAPLTGKVAEQLKAMGYKLEDQGWYMGDIQAIRVNGDTP
HHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCEECCCCEEEECEEEEEECCCCC
ETASDPRGRGVGLVVKK
CCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]