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The map label for this gene is hemH

Identifier: 157369386

GI number: 157369386

Start: 1258641

End: 1259603

Strand: Direct

Name: hemH

Synonym: Spro_1143

Alternate gene names: 157369386

Gene position: 1258641-1259603 (Clockwise)

Preceding gene: 157369385

Following gene: 157369387

Centisome position: 23.1

GC content: 59.29

Gene sequence:

>963_bases
ATGAAGCAAGAGAAACACGGAGTATTGCTGGTGAACCTGGGCACGCCGGATGCTCCGACCTCGTCGGCGGTAAAACGCTA
TCTAAAGGAATTCCTCAGTGACGACCGCGTGGTGGATACGGCCCCGCTGATTTGGTGGCCGATCCTCAACGGCGCCATCT
TGCCGATCCGTTCACCGCGGGTCGCCAAGTTGTATCAGTCGGTATGGATGGACGAAGGTTCTCCGTTGCTGGTTTACAGC
CGCCGCCAGCAGCGCGCGTTGGCCGCACGTATGCCCAACACGCCGGTTGAACTGGGTATGAGCTACGGCTCCCCAAGCCT
GGCCGAAGCGATTGACAAGCTGCTGGCGCAAGGCGTGACCAATCTGGTGGTGTTGCCGCTGTACCCGCAATACTCCTGCT
CGACCAGCGCCGCGGTATGGGACGGAGTGGCCCGGATACTGAAAGGCTACCGTCGCCTGCCGTCAGTCAGCTTTATCCGC
GACTATGCCGAGCACCCGGCCTACATTGCCGCGCTGCGCCAAAGTGTTGAGCATTCGTTTGCCGAGCATGGTCAGCCGGA
TCGGCTGGTGTTGTCATTCCATGGCATTCCCAAGCGCTATGCGCGTCTGGGCGACGATTATCCGCAGCGTTGCGAGGACA
CGTTACGTGCCCTGACGGCGACGTTACCGCTGGCACCGGAGCGGGTGATGATGACTTATCAGTCGCGCTTTGGTCGTGAG
CCCTGGCTGACGCCTTATACCGACGAGACCCTCAAAGGCCTGCCGGCTCAGGGTGTTAAACATATTCAGCTTATCTGCCC
CGGTTTCTCTGCGGACTGCCTGGAAACGCTGGAGGAGATCAAAGAGCAAAACCGCGAGATCTTCCTTAAGGCCGGCGGTG
AGAAGTTCGAGTACATTTCAGCGCTCAACGACGAGCCGGCGCACATTGATATGATGCAGCAACTGGTGGCACAGCGCTTC
TGA

Upstream 100 bases:

>100_bases
CCGATGAGGCGCTTTTCCGTTACAATAGGCTCCATTAATTGACGTTAACCCCCTGACCCAGAACGGGGGGTTAGCTTGCA
AGGAACCAAGGGGAACTGAG

Downstream 100 bases:

>100_bases
TCCTCAGAACGCAAAATGGTGACGGCCATCATCAATCGGGCAGGAATGTGCTAACATTCTCTGCCTGTTAACTGCCACTG
CCGCCAATTAAATGAAATTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKQEKHGVLLVNLGTPDAPTSSAVKRYLKEFLSDDRVVDTAPLIWWPILNGAILPIRSPRVAKLYQSVWMDEGSPLLVYS
RRQQRALAARMPNTPVELGMSYGSPSLAEAIDKLLAQGVTNLVVLPLYPQYSCSTSAAVWDGVARILKGYRRLPSVSFIR
DYAEHPAYIAALRQSVEHSFAEHGQPDRLVLSFHGIPKRYARLGDDYPQRCEDTLRALTATLPLAPERVMMTYQSRFGRE
PWLTPYTDETLKGLPAQGVKHIQLICPGFSADCLETLEEIKEQNREIFLKAGGEKFEYISALNDEPAHIDMMQQLVAQRF

Sequences:

>Translated_320_residues
MKQEKHGVLLVNLGTPDAPTSSAVKRYLKEFLSDDRVVDTAPLIWWPILNGAILPIRSPRVAKLYQSVWMDEGSPLLVYS
RRQQRALAARMPNTPVELGMSYGSPSLAEAIDKLLAQGVTNLVVLPLYPQYSCSTSAAVWDGVARILKGYRRLPSVSFIR
DYAEHPAYIAALRQSVEHSFAEHGQPDRLVLSFHGIPKRYARLGDDYPQRCEDTLRALTATLPLAPERVMMTYQSRFGRE
PWLTPYTDETLKGLPAQGVKHIQLICPGFSADCLETLEEIKEQNREIFLKAGGEKFEYISALNDEPAHIDMMQQLVAQRF
>Mature_320_residues
MKQEKHGVLLVNLGTPDAPTSSAVKRYLKEFLSDDRVVDTAPLIWWPILNGAILPIRSPRVAKLYQSVWMDEGSPLLVYS
RRQQRALAARMPNTPVELGMSYGSPSLAEAIDKLLAQGVTNLVVLPLYPQYSCSTSAAVWDGVARILKGYRRLPSVSFIR
DYAEHPAYIAALRQSVEHSFAEHGQPDRLVLSFHGIPKRYARLGDDYPQRCEDTLRALTATLPLAPERVMMTYQSRFGRE
PWLTPYTDETLKGLPAQGVKHIQLICPGFSADCLETLEEIKEQNREIFLKAGGEKFEYISALNDEPAHIDMMQQLVAQRF

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=26.3473053892216, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=26.4264264264264, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786681, Length=317, Percent_Identity=69.4006309148265, Blast_Score=447, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6324750, Length=334, Percent_Identity=26.0479041916168, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864156, Length=343, Percent_Identity=26.2390670553936, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24651774, Length=274, Percent_Identity=24.8175182481752, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45552018, Length=183, Percent_Identity=27.8688524590164, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_SERP5 (A8GAV7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477375.1
- ProteinModelPortal:   A8GAV7
- SMR:   A8GAV7
- STRING:   A8GAV7
- GeneID:   5605801
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1143
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- ProtClustDB:   PRK00035
- BioCyc:   SPRO399741:SPRO_1143-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36041; Mature: 36041

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQEKHGVLLVNLGTPDAPTSSAVKRYLKEFLSDDRVVDTAPLIWWPILNGAILPIRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHCCEEECCCCCH
VAKLYQSVWMDEGSPLLVYSRRQQRALAARMPNTPVELGMSYGSPSLAEAIDKLLAQGVT
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHCCHH
NLVVLPLYPQYSCSTSAAVWDGVARILKGYRRLPSVSFIRDYAEHPAYIAALRQSVEHSF
HEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHH
AEHGQPDRLVLSFHGIPKRYARLGDDYPQRCEDTLRALTATLPLAPERVMMTYQSRFGRE
HHCCCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
PWLTPYTDETLKGLPAQGVKHIQLICPGFSADCLETLEEIKEQNREIFLKAGGEKFEYIS
CCCCCCCCHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
ALNDEPAHIDMMQQLVAQRF
HCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQEKHGVLLVNLGTPDAPTSSAVKRYLKEFLSDDRVVDTAPLIWWPILNGAILPIRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCCCHHHHHHHCCEEECCCCCH
VAKLYQSVWMDEGSPLLVYSRRQQRALAARMPNTPVELGMSYGSPSLAEAIDKLLAQGVT
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHCCHH
NLVVLPLYPQYSCSTSAAVWDGVARILKGYRRLPSVSFIRDYAEHPAYIAALRQSVEHSF
HEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHH
AEHGQPDRLVLSFHGIPKRYARLGDDYPQRCEDTLRALTATLPLAPERVMMTYQSRFGRE
HHCCCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
PWLTPYTDETLKGLPAQGVKHIQLICPGFSADCLETLEEIKEQNREIFLKAGGEKFEYIS
CCCCCCCCHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
ALNDEPAHIDMMQQLVAQRF
HCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA