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The map label for this gene is htpG [H]

Identifier: 157369381

GI number: 157369381

Start: 1251942

End: 1253813

Strand: Direct

Name: htpG [H]

Synonym: Spro_1138

Alternate gene names: 157369381

Gene position: 1251942-1253813 (Clockwise)

Preceding gene: 157369380

Following gene: 157369382

Centisome position: 22.98

GC content: 55.24

Gene sequence:

>1872_bases
ATGAGTATGAAAGGTCAAGAAACCCGTGGTTTCCAGTCTGAAGTAAAACAACTGCTTCATTTGATGATTCATTCGCTGTA
CTCCAATAAAGAAATTTTCCTGCGCGAGCTGATCTCCAACGCCTCAGACGCCGCCGACAAGCTGCGTTTCCGCGCGCTGT
CCGCGCCAGAGCTGTATGAAGGCGACGGCGAGCTGCGTGTGCGTCTTTCCTTCGATAAAGACCAGCGTACGCTGACCATT
GCCGACAACGGCATTGGCATGAACCGCGAAGAAGTGATTGAAAACCTGGGCACCATTGCAAAATCAGGGACTAAAGCCTT
CCTGGAATCTATCGGCTCCGATCAGGCCAAAGACAGCCAATTGATCGGCCAGTTTGGCGTGGGCTTCTACTCCGCGTTCA
TCGTGGCGGATAAAGTCACCGTGCGTACCCGCGCAGCCGGTGCCGCCGCCGATCAGGGCGTGTTCTGGGAGTCTATCGGT
GAGGGCGATTACACCATTGCCGACGTCAGCAAAGAAGATCGCGGTACCGAAATCACTCTGCATCTGCGCGAAGGCGAAGA
TGAATACCTCGACGCCTGGCGTCTGCGTTCGGTGATCGGTAAATACTCCGACCACATCGCACTGCCGGTTGAGATTGAAA
CCAAAAACGAAGAAGACGGCACCGTCACCTGGGAAAAAATCAACAAGGCGCAGGCCCTGTGGACCCGTAGCAAGGCCGAC
GTCACCGACGAAGAATACAAAGAGTTCTACAAACACATTGCTCACGACTTTACCGATCCGCTGAGCTGGAGCCACAACCG
GGTGGAAGGCAAGCAGGAATACACCAGCCTGCTGTATATCCCGGCCCAGGCCCCGTGGGACATGTGGAACCGCGATCACA
AGCACGGTCTGAAACTGTATGTACAGCGCGTGTTTATCATGGACGAAGCTGAACAGTTCATGCCGAACTACCTGCGTTTC
GTGCGTGGCCTGATAGATTCCAACGATCTGCCGCTGAACGTCTCGCGTGAAATTCTGCAAGACAGCCGTGTGACGCAAAA
CCTGCGTGGCGCGCTGACCAAGCGTGTGCTGCAGATGCTGGAAAAACTGGCCAAAGACGACGCGGAAGGCTACCAGAAGT
TCTGGCAGCAGTTCGGTCTGGTGTTGAAAGAAGGCCCGGCGGAAGACGCGAACAATAAAGAAACCATCGCCAAATTGCTG
CGTTTCGCCTCTACCCAGAGTGAAAGCTCGGCGCAGACGGTTTCGCTGGAAGAGTACGTTGGCCGCATGGCCGAAGGGCA
GGAGAAGATTTATTACATCACTGCCGACAGCTATGCCGCCGCCAAGAGCAGCCCGCACCTGGAACTGTTCCGCAAGAAAG
GTATCGAGGTATTGCTGCTTTCTGACCGTATCGATGAATGGATGATGAGCTACCTGACCGAATTTGACGGCAAGCCGTTC
CAGTCGGTCAGCAAGGCGGACGATGCGCTGGACAAACTGGCGGATGAAACCGAAGAGCAGAAGGCCGCTGAGAAGCAGCT
GGAGCCTTTTGTTGACCGCGTGAAGACTCTGCTGGGCGATCGTGTGAAGGATGTGCGTCTGACGCACCGCCTGACCGATA
CGCCGGCTATCGTCATCACCGACGCCGATGAAATGAGCACCCAGATGGCAAAACTGTTTGCCGCTGCGGGCCAGGAAGCG
CCGGCCGTGAAATACATTTTCGAATTGAATCCGGAGCATGCGCTGGTCAAACGCGCATCCGATGTGGGCGATAACGAACA
ATTCGCCGAGTGGATTGACCTGTTATTGGATCAGGCGCTGCTGGCCGAACGCGGCACGCTGGAAGACCCAAATCAGTTTA
TCCGCCGCATGAATAAGCTGTTGTCCGCATAA

Upstream 100 bases:

>100_bases
CTTTGCCAAAAAAATTCCCCCAGTCGCTTGAAAAACAATGCTCTGACCCCCACTTGATCCTCATTGTCCGATTTTGGTAG
CTATATCTTTGAGGTAATCA

Downstream 100 bases:

>100_bases
TTTCGACCTTATACGCCTCTGACCTAAAGGTTGGAGGCGTTTTTTTTTTGCTTTTCTCACTGATTTTCAGCGTTTTACCC
TCTTTTTTGTCCTTTCTGCT

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 623; Mature: 622

Protein sequence:

>623_residues
MSMKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSAPELYEGDGELRVRLSFDKDQRTLTI
ADNGIGMNREEVIENLGTIAKSGTKAFLESIGSDQAKDSQLIGQFGVGFYSAFIVADKVTVRTRAAGAAADQGVFWESIG
EGDYTIADVSKEDRGTEITLHLREGEDEYLDAWRLRSVIGKYSDHIALPVEIETKNEEDGTVTWEKINKAQALWTRSKAD
VTDEEYKEFYKHIAHDFTDPLSWSHNRVEGKQEYTSLLYIPAQAPWDMWNRDHKHGLKLYVQRVFIMDEAEQFMPNYLRF
VRGLIDSNDLPLNVSREILQDSRVTQNLRGALTKRVLQMLEKLAKDDAEGYQKFWQQFGLVLKEGPAEDANNKETIAKLL
RFASTQSESSAQTVSLEEYVGRMAEGQEKIYYITADSYAAAKSSPHLELFRKKGIEVLLLSDRIDEWMMSYLTEFDGKPF
QSVSKADDALDKLADETEEQKAAEKQLEPFVDRVKTLLGDRVKDVRLTHRLTDTPAIVITDADEMSTQMAKLFAAAGQEA
PAVKYIFELNPEHALVKRASDVGDNEQFAEWIDLLLDQALLAERGTLEDPNQFIRRMNKLLSA

Sequences:

>Translated_623_residues
MSMKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSAPELYEGDGELRVRLSFDKDQRTLTI
ADNGIGMNREEVIENLGTIAKSGTKAFLESIGSDQAKDSQLIGQFGVGFYSAFIVADKVTVRTRAAGAAADQGVFWESIG
EGDYTIADVSKEDRGTEITLHLREGEDEYLDAWRLRSVIGKYSDHIALPVEIETKNEEDGTVTWEKINKAQALWTRSKAD
VTDEEYKEFYKHIAHDFTDPLSWSHNRVEGKQEYTSLLYIPAQAPWDMWNRDHKHGLKLYVQRVFIMDEAEQFMPNYLRF
VRGLIDSNDLPLNVSREILQDSRVTQNLRGALTKRVLQMLEKLAKDDAEGYQKFWQQFGLVLKEGPAEDANNKETIAKLL
RFASTQSESSAQTVSLEEYVGRMAEGQEKIYYITADSYAAAKSSPHLELFRKKGIEVLLLSDRIDEWMMSYLTEFDGKPF
QSVSKADDALDKLADETEEQKAAEKQLEPFVDRVKTLLGDRVKDVRLTHRLTDTPAIVITDADEMSTQMAKLFAAAGQEA
PAVKYIFELNPEHALVKRASDVGDNEQFAEWIDLLLDQALLAERGTLEDPNQFIRRMNKLLSA
>Mature_622_residues
SMKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSAPELYEGDGELRVRLSFDKDQRTLTIA
DNGIGMNREEVIENLGTIAKSGTKAFLESIGSDQAKDSQLIGQFGVGFYSAFIVADKVTVRTRAAGAAADQGVFWESIGE
GDYTIADVSKEDRGTEITLHLREGEDEYLDAWRLRSVIGKYSDHIALPVEIETKNEEDGTVTWEKINKAQALWTRSKADV
TDEEYKEFYKHIAHDFTDPLSWSHNRVEGKQEYTSLLYIPAQAPWDMWNRDHKHGLKLYVQRVFIMDEAEQFMPNYLRFV
RGLIDSNDLPLNVSREILQDSRVTQNLRGALTKRVLQMLEKLAKDDAEGYQKFWQQFGLVLKEGPAEDANNKETIAKLLR
FASTQSESSAQTVSLEEYVGRMAEGQEKIYYITADSYAAAKSSPHLELFRKKGIEVLLLSDRIDEWMMSYLTEFDGKPFQ
SVSKADDALDKLADETEEQKAAEKQLEPFVDRVKTLLGDRVKDVRLTHRLTDTPAIVITDADEMSTQMAKLFAAAGQEAP
AVKYIFELNPEHALVKRASDVGDNEQFAEWIDLLLDQALLAERGTLEDPNQFIRRMNKLLSA

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI20149594, Length=679, Percent_Identity=36.5243004418262, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI4507677, Length=677, Percent_Identity=36.0413589364845, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI155722983, Length=643, Percent_Identity=36.8584758942457, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI154146191, Length=411, Percent_Identity=35.7664233576642, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI153792590, Length=408, Percent_Identity=36.0294117647059, Blast_Score=271, Evalue=2e-72,
Organism=Escherichia coli, GI1786679, Length=622, Percent_Identity=85.048231511254, Blast_Score=1106, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559162, Length=666, Percent_Identity=36.6366366366366, Blast_Score=446, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17542208, Length=670, Percent_Identity=37.1641791044776, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI115535205, Length=636, Percent_Identity=35.2201257861635, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI115535167, Length=422, Percent_Identity=38.8625592417062, Blast_Score=281, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6323840, Length=675, Percent_Identity=37.9259259259259, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6325016, Length=681, Percent_Identity=37.4449339207048, Blast_Score=449, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17647529, Length=682, Percent_Identity=36.217008797654, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI21357739, Length=627, Percent_Identity=38.1180223285486, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24586016, Length=638, Percent_Identity=36.5203761755486, Blast_Score=377, Evalue=1e-104,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 70744; Mature: 70613

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSAPELYE
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
GDGELRVRLSFDKDQRTLTIADNGIGMNREEVIENLGTIAKSGTKAFLESIGSDQAKDSQ
CCCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHH
LIGQFGVGFYSAFIVADKVTVRTRAAGAAADQGVFWESIGEGDYTIADVSKEDRGTEITL
HHHHHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCCEEEE
HLREGEDEYLDAWRLRSVIGKYSDHIALPVEIETKNEEDGTVTWEKINKAQALWTRSKAD
EEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEHHHHHHHHHHHHCCCCC
VTDEEYKEFYKHIAHDFTDPLSWSHNRVEGKQEYTSLLYIPAQAPWDMWNRDHKHGLKLY
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCEEEEECCCCCHHHCCCCHHHHHHHH
VQRVFIMDEAEQFMPNYLRFVRGLIDSNDLPLNVSREILQDSRVTQNLRGALTKRVLQML
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLAKDDAEGYQKFWQQFGLVLKEGPAEDANNKETIAKLLRFASTQSESSAQTVSLEEYV
HHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHEEEHHHHH
GRMAEGQEKIYYITADSYAAAKSSPHLELFRKKGIEVLLLSDRIDEWMMSYLTEFDGKPF
HHHHCCCCEEEEEEECCHHHCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCH
QSVSKADDALDKLADETEEQKAAEKQLEPFVDRVKTLLGDRVKDVRLTHRLTDTPAIVIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCEEEEE
DADEMSTQMAKLFAAAGQEAPAVKYIFELNPEHALVKRASDVGDNEQFAEWIDLLLDQAL
CCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LAERGTLEDPNQFIRRMNKLLSA
HHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SMKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSAPELYE
CCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
GDGELRVRLSFDKDQRTLTIADNGIGMNREEVIENLGTIAKSGTKAFLESIGSDQAKDSQ
CCCCEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHH
LIGQFGVGFYSAFIVADKVTVRTRAAGAAADQGVFWESIGEGDYTIADVSKEDRGTEITL
HHHHHHHHHHHHHHHHCCCEEEHHCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCCEEEE
HLREGEDEYLDAWRLRSVIGKYSDHIALPVEIETKNEEDGTVTWEKINKAQALWTRSKAD
EEECCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEHHHHHHHHHHHHCCCCC
VTDEEYKEFYKHIAHDFTDPLSWSHNRVEGKQEYTSLLYIPAQAPWDMWNRDHKHGLKLY
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCEEEEECCCCCHHHCCCCHHHHHHHH
VQRVFIMDEAEQFMPNYLRFVRGLIDSNDLPLNVSREILQDSRVTQNLRGALTKRVLQML
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLAKDDAEGYQKFWQQFGLVLKEGPAEDANNKETIAKLLRFASTQSESSAQTVSLEEYV
HHHHHCCHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHEEEHHHHH
GRMAEGQEKIYYITADSYAAAKSSPHLELFRKKGIEVLLLSDRIDEWMMSYLTEFDGKPF
HHHHCCCCEEEEEEECCHHHCCCCCHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCH
QSVSKADDALDKLADETEEQKAAEKQLEPFVDRVKTLLGDRVKDVRLTHRLTDTPAIVIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCEEEEE
DADEMSTQMAKLFAAAGQEAPAVKYIFELNPEHALVKRASDVGDNEQFAEWIDLLLDQAL
CCHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LAERGTLEDPNQFIRRMNKLLSA
HHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA