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The map label for this gene is acrR [H]

Identifier: 157369371

GI number: 157369371

Start: 1242195

End: 1242878

Strand: Direct

Name: acrR [H]

Synonym: Spro_1128

Alternate gene names: 157369371

Gene position: 1242195-1242878 (Clockwise)

Preceding gene: 157369366

Following gene: 157369372

Centisome position: 22.8

GC content: 49.85

Gene sequence:

>684_bases
ATGGCACGAAAAACCAAACAGCAGGCGCTAGAAACTCGACAGCACATACTTGATGCTGCGGTGCAAGAATTTTCTGAACG
TGGCGTTTCTGCAACGTCACTGACAGATATTGCCACTGCTGCCGGAGTTACGCGTGGTGCAATTTATTGGCACTTCAAGA
ACAAGGTAGACCTGTTTAATGAAGTTTGGGAATTATCAGAGTCAAAAATTGGTGATCTGGAACTAGAGTATCAGGCAAAG
TTCCCCGAGAATCCACTGCGTATTTTACGGGAAATTCTGATTTACATTCTGACGGCTACGGTCGATGACAGCCGCCGACG
AGCGCTGATGGAAATCGTTTTCCACAAGTGCGAATTCGTCGGTGAGATGATGCCGCTGCATGAGGCGCGTAAAGTCTTAT
ACCTGACAGGTTATGAACGCATTGAGTCGGTGCTGCGTGACTGTATGGCCCATGGCCAACTGCCCGTTGATTTGCACACC
CGCCGCGCGGCAATTATCCTGCATGCTTATATTACCGGCCTGATGGAGAATTGGCTGTTTATGCCGGAGAGCTTTGATCT
GAAAGCCGAAGCGACGGCGCTGATCGACTCCTTCCTCGAAATGGTTCAATTCAGTCCCGCCTTACGAATCAAGCCGGAAG
AACTGGCGACGCAGCCACACAGCGTCGAAATCCATCCTTTATAG

Upstream 100 bases:

>100_bases
ACAAGCTTTAAAACCCATTGCTGCGTTAATTATATGTGCGTGCTATGGTACATACATACGCGAATGTATGTAAATCACAC
TCCCCCGAAAAAACAACGTC

Downstream 100 bases:

>100_bases
GAGAAACACCATGTCATCCGTAGTGTTGATTGCCAATGGCGCCGCCTATGGCCACGAATCCCTGTTTAACGCCCTGCGTC
TGGCTATTACCCTGAAAGAG

Product: DNA-binding transcriptional repressor AcrR

Products: NA

Alternate protein names: Potential acrAB operon repressor [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MARKTKQQALETRQHILDAAVQEFSERGVSATSLTDIATAAGVTRGAIYWHFKNKVDLFNEVWELSESKIGDLELEYQAK
FPENPLRILREILIYILTATVDDSRRRALMEIVFHKCEFVGEMMPLHEARKVLYLTGYERIESVLRDCMAHGQLPVDLHT
RRAAIILHAYITGLMENWLFMPESFDLKAEATALIDSFLEMVQFSPALRIKPEELATQPHSVEIHPL

Sequences:

>Translated_227_residues
MARKTKQQALETRQHILDAAVQEFSERGVSATSLTDIATAAGVTRGAIYWHFKNKVDLFNEVWELSESKIGDLELEYQAK
FPENPLRILREILIYILTATVDDSRRRALMEIVFHKCEFVGEMMPLHEARKVLYLTGYERIESVLRDCMAHGQLPVDLHT
RRAAIILHAYITGLMENWLFMPESFDLKAEATALIDSFLEMVQFSPALRIKPEELATQPHSVEIHPL
>Mature_226_residues
ARKTKQQALETRQHILDAAVQEFSERGVSATSLTDIATAAGVTRGAIYWHFKNKVDLFNEVWELSESKIGDLELEYQAKF
PENPLRILREILIYILTATVDDSRRRALMEIVFHKCEFVGEMMPLHEARKVLYLTGYERIESVLRDCMAHGQLPVDLHTR
RAAIILHAYITGLMENWLFMPESFDLKAEATALIDSFLEMVQFSPALRIKPEELATQPHSVEIHPL

Specific function: Potential regulator protein for the acrAB genes [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=209, Percent_Identity=65.0717703349282, Blast_Score=286, Evalue=7e-79,
Organism=Escherichia coli, GI1789664, Length=207, Percent_Identity=39.6135265700483, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26065; Mature: 25934

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTKQQALETRQHILDAAVQEFSERGVSATSLTDIATAAGVTRGAIYWHFKNKVDLFN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHCEEEEEECCHHHHHH
EVWELSESKIGDLELEYQAKFPENPLRILREILIYILTATVDDSRRRALMEIVFHKCEFV
HHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GEMMPLHEARKVLYLTGYERIESVLRDCMAHGQLPVDLHTRRAAIILHAYITGLMENWLF
HHHHCHHHHHHEEEEECHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCC
MPESFDLKAEATALIDSFLEMVQFSPALRIKPEELATQPHSVEIHPL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEECCC
>Mature Secondary Structure 
ARKTKQQALETRQHILDAAVQEFSERGVSATSLTDIATAAGVTRGAIYWHFKNKVDLFN
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHCEEEEEECCHHHHHH
EVWELSESKIGDLELEYQAKFPENPLRILREILIYILTATVDDSRRRALMEIVFHKCEFV
HHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
GEMMPLHEARKVLYLTGYERIESVLRDCMAHGQLPVDLHTRRAAIILHAYITGLMENWLF
HHHHCHHHHHHEEEEECHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCC
MPESFDLKAEATALIDSFLEMVQFSPALRIKPEELATQPHSVEIHPL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]