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The map label for this gene is thiL [H]

Identifier: 157369318

GI number: 157369318

Start: 1183126

End: 1184109

Strand: Direct

Name: thiL [H]

Synonym: Spro_1075

Alternate gene names: 157369318

Gene position: 1183126-1184109 (Clockwise)

Preceding gene: 157369317

Following gene: 157369319

Centisome position: 21.71

GC content: 57.83

Gene sequence:

>984_bases
ATGGCATGTGGCGAATTTGACCTCATTGCCCGCTATTTTGACCGGTTTAAGAGTCTGCGCCGGGATGTACAGTTGGGCAT
TGGAGATGACTGCGCACTTCTGACAGTGGCAGAAAAACAGCTTTTGGCCGTCAGTACCGACACTCTCGTTTCGGGCGTTC
ACTTCCTGGCGGATATCGATCCCGCCGATCTCGGCTACAAAGCACTGGCAGTTAACCTGAGCGACCTGGCAGCCATGGGC
GCCGATCCCGCCTGGCTTTCGCTGGCGTTAACCCTGCCGGAGGTGAATGAACCCTGGCTGAAGGCGTTCAGCGATAGCCT
GTTCGAACAACTTAATTATTACGGTATGCAATTGATTGGCGGTGATACCACACGCGGCCCGTTAAGCATGACGTTAACCA
TTCACGGCCTGATCCCGGCCGGGCGGGCATTGACCCGCAGCGGTGCGCGTATCGGCGACTGGATCTACACCACAGGTACG
CTGGGTGACAGCGCCGCCGGTCTGGCGGTGCTGCAGGAACGTTTGCAGGTAGCGGACGCCGAGGCACGCAATTACCTGAT
TGGCCGTCATCTGCGGCCTCAGCCACGGGTATTGCAGGGGCAGGCACTGCGCGATCTGGCCAGTTCGGCGATTGATATTT
CCGACGGCCTGATTTCTGACCTGAAACATGTGCTGAAAGCCTCCGAGTGCGGTGCGCGCATCAATCTCGATGAGCTGCCG
TTGTCGCAGGCGTTAAGCAGCCATACGGATGCCGATCAGGCGCTGCGCTGGGCGTTGACCGGCGGTGAAGATTACGAACT
CTGCTTCACCGTACCGGAAATCAACCGTGGTGCACTGGAGGTGGCGTTAAGCCATCTGGGCGCTGACTATACCTGTATTG
GTCAGATTGGCCCGCTTTCCGAAGGCATCAAATTCTACCGCAGCGATGAAGTGGTGGAACTGCCGTGGCACGGTTTCGAT
CATTTCAGCGAAGGGCAGGCGTAA

Upstream 100 bases:

>100_bases
AATGGCGTGCTGGATAAAGTGGCACCAAGCATTCGCAAGAAAAAATAAAAAATTAAGGCCGGTATCCCCGGCCTTAATTT
CTTCTATTGGAATATCGACC

Downstream 100 bases:

>100_bases
CATGGATGAAGCTAAACGCCGCTTGCGGATGAGTAATCCGTGGCACCTGCTGGCCACCGGCTTTGGTAGCGGTTTGTCGC
CGGTGATGCCGGGCACCATG

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MACGEFDLIARYFDRFKSLRRDVQLGIGDDCALLTVAEKQLLAVSTDTLVSGVHFLADIDPADLGYKALAVNLSDLAAMG
ADPAWLSLALTLPEVNEPWLKAFSDSLFEQLNYYGMQLIGGDTTRGPLSMTLTIHGLIPAGRALTRSGARIGDWIYTTGT
LGDSAAGLAVLQERLQVADAEARNYLIGRHLRPQPRVLQGQALRDLASSAIDISDGLISDLKHVLKASECGARINLDELP
LSQALSSHTDADQALRWALTGGEDYELCFTVPEINRGALEVALSHLGADYTCIGQIGPLSEGIKFYRSDEVVELPWHGFD
HFSEGQA

Sequences:

>Translated_327_residues
MACGEFDLIARYFDRFKSLRRDVQLGIGDDCALLTVAEKQLLAVSTDTLVSGVHFLADIDPADLGYKALAVNLSDLAAMG
ADPAWLSLALTLPEVNEPWLKAFSDSLFEQLNYYGMQLIGGDTTRGPLSMTLTIHGLIPAGRALTRSGARIGDWIYTTGT
LGDSAAGLAVLQERLQVADAEARNYLIGRHLRPQPRVLQGQALRDLASSAIDISDGLISDLKHVLKASECGARINLDELP
LSQALSSHTDADQALRWALTGGEDYELCFTVPEINRGALEVALSHLGADYTCIGQIGPLSEGIKFYRSDEVVELPWHGFD
HFSEGQA
>Mature_326_residues
ACGEFDLIARYFDRFKSLRRDVQLGIGDDCALLTVAEKQLLAVSTDTLVSGVHFLADIDPADLGYKALAVNLSDLAAMGA
DPAWLSLALTLPEVNEPWLKAFSDSLFEQLNYYGMQLIGGDTTRGPLSMTLTIHGLIPAGRALTRSGARIGDWIYTTGTL
GDSAAGLAVLQERLQVADAEARNYLIGRHLRPQPRVLQGQALRDLASSAIDISDGLISDLKHVLKASECGARINLDELPL
SQALSSHTDADQALRWALTGGEDYELCFTVPEINRGALEVALSHLGADYTCIGQIGPLSEGIKFYRSDEVVELPWHGFDH
FSEGQA

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=323, Percent_Identity=75.2321981424149, Blast_Score=498, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 35384; Mature: 35253

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACGEFDLIARYFDRFKSLRRDVQLGIGDDCALLTVAEKQLLAVSTDTLVSGVHFLADID
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHEEECHHHHHHHHHHHHCCC
PADLGYKALAVNLSDLAAMGADPAWLSLALTLPEVNEPWLKAFSDSLFEQLNYYGMQLIG
CHHCCCEEEEEEHHHHHHCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEC
GDTTRGPLSMTLTIHGLIPAGRALTRSGARIGDWIYTTGTLGDSAAGLAVLQERLQVADA
CCCCCCCEEEEEEEEECCCCCHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
EARNYLIGRHLRPQPRVLQGQALRDLASSAIDISDGLISDLKHVLKASECGARINLDELP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHCC
LSQALSSHTDADQALRWALTGGEDYELCFTVPEINRGALEVALSHLGADYTCIGQIGPLS
HHHHHHCCCCHHHHHEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCHH
EGIKFYRSDEVVELPWHGFDHFSEGQA
HHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
ACGEFDLIARYFDRFKSLRRDVQLGIGDDCALLTVAEKQLLAVSTDTLVSGVHFLADID
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHEEECHHHHHHHHHHHHCCC
PADLGYKALAVNLSDLAAMGADPAWLSLALTLPEVNEPWLKAFSDSLFEQLNYYGMQLIG
CHHCCCEEEEEEHHHHHHCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEC
GDTTRGPLSMTLTIHGLIPAGRALTRSGARIGDWIYTTGTLGDSAAGLAVLQERLQVADA
CCCCCCCEEEEEEEEECCCCCHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
EARNYLIGRHLRPQPRVLQGQALRDLASSAIDISDGLISDLKHVLKASECGARINLDELP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHCC
LSQALSSHTDADQALRWALTGGEDYELCFTVPEINRGALEVALSHLGADYTCIGQIGPLS
HHHHHHCCCCHHHHHEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCHH
EGIKFYRSDEVVELPWHGFDHFSEGQA
HHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]