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The map label for this gene is ribH

Identifier: 157369316

GI number: 157369316

Start: 1182166

End: 1182636

Strand: Direct

Name: ribH

Synonym: Spro_1073

Alternate gene names: 157369316

Gene position: 1182166-1182636 (Clockwise)

Preceding gene: 157369315

Following gene: 157369317

Centisome position: 21.7

GC content: 54.14

Gene sequence:

>471_bases
ATGAAAGTTATCGAAGGTGTTGTTGCTACTCCAAATGCCCGTGTGGCGATTGCAATTGCACGTTTTAACAATTTCATCAA
TGACAGCCTGCTGCAAGGTGCTATCGACGCACTTAAGCGCATTGGCCAGGTTGCTGACGACAACATCACCGTTGTCTGGG
TCCCGGGCGCTTACGAGTTGCCGTTGACTGCACGCGTGCTGGCTAACACCGGCAAATACGATGCAGTGATCGCACTGGGC
ACCGTTATCCGTGGGGGCACCGCGCACTTCGAATATGTCGCGGGCGAAGCCAGCTCCGGCCTAGGCAGTGTTTCTCTGAA
CACTGAAATCCCGGTTGCCTTTGGCGTGCTGACGACCGAAAGCATCGAACAGGCTATCGAGCGTGCCGGCACCAAAGCGG
GCAACAAGGGCGCTGAAGCGGCTCTGACCGCACTTGAAATGATTAATGTTATCAAAGCTATTAAAGCCTGA

Upstream 100 bases:

>100_bases
GGTCGGCTGTCGTTTTACAAAACCGCCCGCGCAGGCAGATAAAGAATGTGATAGAATCCGCCCCCCTGCGGGGTATTGAA
CCCATTTTTAAGGAAAGCCC

Downstream 100 bases:

>100_bases
ATTTAGTTAAGGGGAATTCCGTGAAACCTGCTGCTCGTCGCCGCGCTCGTGAGTGCGCTGTTCAAGCGCTTTACTCTTGG
CAGTTGTCTAAAAATGACAT

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKVIEGVVATPNARVAIAIARFNNFINDSLLQGAIDALKRIGQVADDNITVVWVPGAYELPLTARVLANTGKYDAVIALG
TVIRGGTAHFEYVAGEASSGLGSVSLNTEIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVIKAIKA

Sequences:

>Translated_156_residues
MKVIEGVVATPNARVAIAIARFNNFINDSLLQGAIDALKRIGQVADDNITVVWVPGAYELPLTARVLANTGKYDAVIALG
TVIRGGTAHFEYVAGEASSGLGSVSLNTEIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVIKAIKA
>Mature_156_residues
MKVIEGVVATPNARVAIAIARFNNFINDSLLQGAIDALKRIGQVADDNITVVWVPGAYELPLTARVLANTGKYDAVIALG
TVIRGGTAHFEYVAGEASSGLGSVSLNTEIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVIKAIKA

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=156, Percent_Identity=85.8974358974359, Blast_Score=265, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6324429, Length=143, Percent_Identity=38.4615384615385, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_SERP5 (A8GAN7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477305.1
- ProteinModelPortal:   A8GAN7
- SMR:   A8GAN7
- STRING:   A8GAN7
- GeneID:   5606851
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1073
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- ProtClustDB:   PRK00061
- BioCyc:   SPRO399741:SPRO_1073-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16163; Mature: 16163

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIEGVVATPNARVAIAIARFNNFINDSLLQGAIDALKRIGQVADDNITVVWVPGAYEL
CCCCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEC
PLTARVLANTGKYDAVIALGTVIRGGTAHFEYVAGEASSGLGSVSLNTEIPVAFGVLTTE
CHHHHHHHCCCCCHHHEEEHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCEEEEHCCHH
SIEQAIERAGTKAGNKGAEAALTALEMINVIKAIKA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVIEGVVATPNARVAIAIARFNNFINDSLLQGAIDALKRIGQVADDNITVVWVPGAYEL
CCCCCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEC
PLTARVLANTGKYDAVIALGTVIRGGTAHFEYVAGEASSGLGSVSLNTEIPVAFGVLTTE
CHHHHHHHCCCCCHHHEEEHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCEEEEHCCHH
SIEQAIERAGTKAGNKGAEAALTALEMINVIKAIKA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA