Click here to switch to the map view.

The map label for this gene is proY [H]

Identifier: 157369289

GI number: 157369289

Start: 1150795

End: 1152201

Strand: Direct

Name: proY [H]

Synonym: Spro_1046

Alternate gene names: 157369289

Gene position: 1150795-1152201 (Clockwise)

Preceding gene: 157369288

Following gene: 157369292

Centisome position: 21.12

GC content: 56.43

Gene sequence:

>1407_bases
ATGCAACAACAGTCACCCGCCGCTCCTGCGGCCAATAAGCTGAAACGCGGTCTCAGTACGCGTCACATTCGCTTTATGGC
TCTTGGCTCGGCTATCGGCACCGGTCTGTTCTACGGTTCGGCGGACGCCATTAAAATGGCCGGCCCGAGCGTTTTGCTGG
CCTACCTGATTGGCGGTATTGTCGCCTTTATAATCATGCGCGCGCTGGGCGAGATGTCGGTCAACAACCCGCAGGCCAGT
TCGTTTTCACGCTACGCGCAGGACTACCTTGGCCCGATGGCCGGCTATATCACCGGCTGGACCTACTGTTTTGAAATCCT
GATTGTCGCGATTGCCGACGTGACGGCGTTCGGTATCTATATGGGGATTTGGTTCCCAGAGGTGCCGCATTGGATTTGGG
TGCTGAGCGTGGTGCTGGTGATTGGCGCCATCAACCTGATGAGCGTGAAGGTGTTCGGTGAGCTGGAGTTTTGGTTCTCG
TTCTTCAAAGTGGCCACCATCATCATCATGATTGCTGCCGGTATCGGTATCATCATCTGGGGGATTGGCAACGGCGGGCA
GCCGACCGGTATCCATAACCTGTGGTCTAACGGCGGCTTCTTCAGTAACGGGTTTATCGGCATGATCCTGTCGCTGCAGT
TGGTGATGTTTGCCTACGGCGGCATCGAAATTATCGGTATCACCGCCGGTGAAGCCAAAGACCCGAAAAGCTCGATTCCC
AAGGCCATCAACTCGGTGCCGTGGCGTATTCTGGTGTTTTACGTCGGTACACTGTTCGTCATCATGTCTATCTACCCGTG
GAACCAGGTGGGCACCAATGGCAGCCCGTTCGTGCTGACCTTCCAGCACATGGGAATTACCGTGGCGGCAGGTATCCTTA
ACTTTGTGGTGATCACCGCATCATTGTCTGCGATTAACAGCGACGTGTTTGGCGTTGGCCGCATGCTGCACGGCATGGCT
GAACAGGGCCACGCGCCGAAGATATTCAGCAAGGTCTCCAAACGCGGTATTCCGTGGGTCACGGTAGTGGTGATGATGCT
GGCGCTGCTGCTGGCGGTGTATCTCAACTACATCATGCCGGAAAACGTGTTCCTGGTGATTGCCTCCCTGGCGACCTTCG
CCACCGTGTGGGTGTGGATCATGATCCTGTTCTCGCAGATTGCCTTCCGTCGTAGCCTGAGCAAAGAGCAGGTGAAAAAC
CTGGCCTTCCCGCTGCGCGGCGGCGTATTCACCTCGGTAGTGGCGATCATCTTCCTGGTGTTTATCATCGGTCTGATCGG
CTACTTCCCAACCACCCGCGTATCGCTGTACGCCGGTCTGGTCTGGGTGGTGGTACTGCTGGCGGGCTACTACTTCAAGC
TCAACCACCAGAAGAAGCTGGCGGTGCTGGCGCAGCAGCAGGATTGA

Upstream 100 bases:

>100_bases
CGCGCTCCGAAGTGACCGCGCACTCTTAATTCCCCGGCTAAATTTTGGGCCACGGACTTGTCCGTGGCTTTTTTACGTTT
AAAAAACACGGGTTATCTTC

Downstream 100 bases:

>100_bases
AAATGAAAACACCGGCCATGCGCCGTAATGCTTGTAAGTTAAGGTGATCTTGTTCCCTCTCCTTTGGGAGAGGGTTAGGG
TGAGGGGATACAAACCAACG

Product: putative proline-specific permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MQQQSPAAPAANKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYLIGGIVAFIIMRALGEMSVNNPQAS
SFSRYAQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIYMGIWFPEVPHWIWVLSVVLVIGAINLMSVKVFGELEFWFS
FFKVATIIIMIAAGIGIIIWGIGNGGQPTGIHNLWSNGGFFSNGFIGMILSLQLVMFAYGGIEIIGITAGEAKDPKSSIP
KAINSVPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITVAAGILNFVVITASLSAINSDVFGVGRMLHGMA
EQGHAPKIFSKVSKRGIPWVTVVVMMLALLLAVYLNYIMPENVFLVIASLATFATVWVWIMILFSQIAFRRSLSKEQVKN
LAFPLRGGVFTSVVAIIFLVFIIGLIGYFPTTRVSLYAGLVWVVVLLAGYYFKLNHQKKLAVLAQQQD

Sequences:

>Translated_468_residues
MQQQSPAAPAANKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYLIGGIVAFIIMRALGEMSVNNPQAS
SFSRYAQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIYMGIWFPEVPHWIWVLSVVLVIGAINLMSVKVFGELEFWFS
FFKVATIIIMIAAGIGIIIWGIGNGGQPTGIHNLWSNGGFFSNGFIGMILSLQLVMFAYGGIEIIGITAGEAKDPKSSIP
KAINSVPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITVAAGILNFVVITASLSAINSDVFGVGRMLHGMA
EQGHAPKIFSKVSKRGIPWVTVVVMMLALLLAVYLNYIMPENVFLVIASLATFATVWVWIMILFSQIAFRRSLSKEQVKN
LAFPLRGGVFTSVVAIIFLVFIIGLIGYFPTTRVSLYAGLVWVVVLLAGYYFKLNHQKKLAVLAQQQD
>Mature_468_residues
MQQQSPAAPAANKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYLIGGIVAFIIMRALGEMSVNNPQAS
SFSRYAQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIYMGIWFPEVPHWIWVLSVVLVIGAINLMSVKVFGELEFWFS
FFKVATIIIMIAAGIGIIIWGIGNGGQPTGIHNLWSNGGFFSNGFIGMILSLQLVMFAYGGIEIIGITAGEAKDPKSSIP
KAINSVPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITVAAGILNFVVITASLSAINSDVFGVGRMLHGMA
EQGHAPKIFSKVSKRGIPWVTVVVMMLALLLAVYLNYIMPENVFLVIASLATFATVWVWIMILFSQIAFRRSLSKEQVKN
LAFPLRGGVFTSVVAIIFLVFIIGLIGYFPTTRVSLYAGLVWVVVLLAGYYFKLNHQKKLAVLAQQQD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=350, Percent_Identity=24.2857142857143, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI258645169, Length=439, Percent_Identity=22.3234624145786, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI181337167, Length=422, Percent_Identity=23.2227488151659, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258614005, Length=440, Percent_Identity=22.0454545454545, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI258614003, Length=440, Percent_Identity=22.0454545454545, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4507047, Length=362, Percent_Identity=23.2044198895028, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=84.7345132743363, Blast_Score=719, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=452, Percent_Identity=44.2477876106195, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI48994972, Length=465, Percent_Identity=44.5161290322581, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1786302, Length=447, Percent_Identity=44.9664429530201, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1790653, Length=451, Percent_Identity=40.1330376940133, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI87081915, Length=400, Percent_Identity=37.5, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI87081708, Length=465, Percent_Identity=36.5591397849462, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1788480, Length=424, Percent_Identity=37.5, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1789017, Length=386, Percent_Identity=34.7150259067358, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI87081869, Length=239, Percent_Identity=25.1046025104602, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082023, Length=370, Percent_Identity=23.2432432432432, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=422, Percent_Identity=22.7488151658768, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17533459, Length=399, Percent_Identity=23.3082706766917, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=355, Percent_Identity=24.5070422535211, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=495, Percent_Identity=30.3030303030303, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6320772, Length=436, Percent_Identity=32.1100917431193, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=491, Percent_Identity=31.3645621181263, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324924, Length=423, Percent_Identity=31.9148936170213, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6319824, Length=430, Percent_Identity=28.1395348837209, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324059, Length=453, Percent_Identity=30.4635761589404, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=33.1658291457286, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=420, Percent_Identity=30.4761904761905, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319542, Length=432, Percent_Identity=27.0833333333333, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321629, Length=429, Percent_Identity=28.4382284382284, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=441, Percent_Identity=26.0770975056689, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320717, Length=447, Percent_Identity=26.8456375838926, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321053, Length=425, Percent_Identity=26.8235294117647, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319543, Length=429, Percent_Identity=26.5734265734266, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=431, Percent_Identity=25.2900232018561, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=454, Percent_Identity=24.8898678414097, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324981, Length=431, Percent_Identity=25.9860788863109, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=536, Percent_Identity=23.8805970149254, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161077963, Length=353, Percent_Identity=25.2124645892351, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51074; Mature: 51074

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQSPAAPAANKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYLIGGI
CCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHH
VAFIIMRALGEMSVNNPQASSFSRYAQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIY
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGIWFPEVPHWIWVLSVVLVIGAINLMSVKVFGELEFWFSFFKVATIIIMIAAGIGIIIW
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
GIGNGGQPTGIHNLWSNGGFFSNGFIGMILSLQLVMFAYGGIEIIGITAGEAKDPKSSIP
ECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHH
KAINSVPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITVAAGILNFVVITA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHH
SLSAINSDVFGVGRMLHGMAEQGHAPKIFSKVSKRGIPWVTVVVMMLALLLAVYLNYIMP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
ENVFLVIASLATFATVWVWIMILFSQIAFRRSLSKEQVKNLAFPLRGGVFTSVVAIIFLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHH
FIIGLIGYFPTTRVSLYAGLVWVVVLLAGYYFKLNHQKKLAVLAQQQD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHCCCCC
>Mature Secondary Structure
MQQQSPAAPAANKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYLIGGI
CCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHH
VAFIIMRALGEMSVNNPQASSFSRYAQDYLGPMAGYITGWTYCFEILIVAIADVTAFGIY
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGIWFPEVPHWIWVLSVVLVIGAINLMSVKVFGELEFWFSFFKVATIIIMIAAGIGIIIW
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
GIGNGGQPTGIHNLWSNGGFFSNGFIGMILSLQLVMFAYGGIEIIGITAGEAKDPKSSIP
ECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHH
KAINSVPWRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITVAAGILNFVVITA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHH
SLSAINSDVFGVGRMLHGMAEQGHAPKIFSKVSKRGIPWVTVVVMMLALLLAVYLNYIMP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
ENVFLVIASLATFATVWVWIMILFSQIAFRRSLSKEQVKNLAFPLRGGVFTSVVAIIFLV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHH
FIIGLIGYFPTTRVSLYAGLVWVVVLLAGYYFKLNHQKKLAVLAQQQD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]