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The map label for this gene is betA [C]

Identifier: 157368802

GI number: 157368802

Start: 615720

End: 617327

Strand: Reverse

Name: betA [C]

Synonym: Spro_0557

Alternate gene names: 157368802

Gene position: 617327-615720 (Counterclockwise)

Preceding gene: 157368804

Following gene: 157368799

Centisome position: 11.33

GC content: 60.45

Gene sequence:

>1608_bases
ATGTCGGAAAACGCTTTTGATTACATCATTGTCGGTGCCGGTTCTGCCGGTTGCGTGCTGGCGGCGCAGTTGATCCGCCG
CACCCAGGCGCGGGTACTGCTGCTGGAAGCCGGTGGCGACGACAATAATCTGTTCATCAAGATGCCGGCCGGCGTGGCGA
AAATCATCGCCAAAAAAAGCTGGCCGTATGAAACCGAGCCGGAGCCGCATGCCAATAACCGCCGCATGCAAATCGCCCAG
GGCAAGGTGTTGGGCGGCAGCAGCTCGGTCAACGGCATGATCTATATTCGCGGCCAGCGACAGGATTACGACGAGTGGGC
CGAACGCTATGGCTGTGTTGGTTGGGGCTATCAGGACGTGCTGCCCTACTTCAAACGCGCCGAGGCCAACGAGAGCCTGT
CGGATACCTATCATGGTGGCGAGGGCCTGCTGCCGGTCAGCGAGAACCGCTACCGCCACCCGCTCAGCATGGCGTTTATT
CGCGCCGGCCAGGAGTTGGATCTCCCCTACCGCAACGATTTCAACGGCGACAGCCAACAGGGCGTCGGCTTCTACCAAAC
CACTACCCACAACGGCGAGCGCGCCAGCACTGCACGTACCTATTTGAAAGCCGTGCGTAATGAACAGCGGCTGGTGGTGA
AACTCAATGCGCTGGTACACCGGGTGGTACTCGACAACAACGTCGCCACCGGCGTGGTGTATAGCCAAAACGGCGGTGCC
GAAGTCACGGCCCATGCCGCGCAGGAAGTGATCCTCAGCGCAGGCGCGGTAGGATCGCCAAAGATTCTGATGCTATCCGG
CATCGGGCCACGCGAACATCTGCAGCAGTTGGGGATCGAACCGCTGGCGGATCTGCCGGTCGGCAAGAACTTTCACGATC
ACCTGCATATGTCGATCAACGTCAGCACCCGCGAGCCGATCAGTTTGTACGGTGCCGATCGCGGCCTGCAGGCGCTACGC
CACGGCACCGAATGGCTGGCGTTTCGCAGCGGCGTGCTGAGTTCCAACGTGCTGGAAGGGGCCGCCTTCACCGACAGCCT
GGGCGACGGCCGGCCGGACGTACAAATCCACTTCCTGCCGATGCTCGACAGTTGGGACGACGTACCCGGCGAACCACTGC
CCAATATCCACGGCTTCACGCTCAAGGTTGGCTATCTGCAACCCAGGGCGCGCGGTGAAGTGCTGCTGCGCAGTCGCGAT
CCCAAGGATCCGGTGAAGCTGCACGCCAACTATCTTGGCCACCCGGAAGATTTGGCCGGCAGCGTGCGTGCGGTGAAGTT
CGGCCTGCGTTTTCTGCAAACCGCCGCCCTCAAACCGCTGATCAAAGATTTGCTGATGCCACAGCCGGCATGGCTGAACG
ATGAGGCACAACTGGAAGAGTTCGTGCGCAACTTCTGCAAAACGGTGTATCACCCGGTCGGCAGTTGCCGCATGGGCCAA
TCCCCGCAGGACTCGGTAACCGATTTACAACTGCGGGTGCACGGATTTGAACGGTTGCGGGTGATCGACTGCTCGGTGAT
GCCACAGGTGACCAGTGGCAATACCAATGCGCCGACCATCATGCTGGCGGAAAAAGCGGTGGATTTACTGCTGGGCACGC
CACAATAA

Upstream 100 bases:

>100_bases
GTGATATTCGTTAATAAATTAATGATTGCAAATTGACCTCTGACCCGCTTGGGATACTCTGCCAGAACAGGCTAATGCCG
CAATCGCACAGGGAGCAGTC

Downstream 100 bases:

>100_bases
AATTATCTGGGTGCCCGGCGGTCAGGCGATGGCAGGCACGCCGCTGTGGAAGCGGAATTCGCTGTCCGGGGTTTGGATCA
GCGCCGCTTCTATGCGGCCA

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: SDH [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSENAFDYIIVGAGSAGCVLAAQLIRRTQARVLLLEAGGDDNNLFIKMPAGVAKIIAKKSWPYETEPEPHANNRRMQIAQ
GKVLGGSSSVNGMIYIRGQRQDYDEWAERYGCVGWGYQDVLPYFKRAEANESLSDTYHGGEGLLPVSENRYRHPLSMAFI
RAGQELDLPYRNDFNGDSQQGVGFYQTTTHNGERASTARTYLKAVRNEQRLVVKLNALVHRVVLDNNVATGVVYSQNGGA
EVTAHAAQEVILSAGAVGSPKILMLSGIGPREHLQQLGIEPLADLPVGKNFHDHLHMSINVSTREPISLYGADRGLQALR
HGTEWLAFRSGVLSSNVLEGAAFTDSLGDGRPDVQIHFLPMLDSWDDVPGEPLPNIHGFTLKVGYLQPRARGEVLLRSRD
PKDPVKLHANYLGHPEDLAGSVRAVKFGLRFLQTAALKPLIKDLLMPQPAWLNDEAQLEEFVRNFCKTVYHPVGSCRMGQ
SPQDSVTDLQLRVHGFERLRVIDCSVMPQVTSGNTNAPTIMLAEKAVDLLLGTPQ

Sequences:

>Translated_535_residues
MSENAFDYIIVGAGSAGCVLAAQLIRRTQARVLLLEAGGDDNNLFIKMPAGVAKIIAKKSWPYETEPEPHANNRRMQIAQ
GKVLGGSSSVNGMIYIRGQRQDYDEWAERYGCVGWGYQDVLPYFKRAEANESLSDTYHGGEGLLPVSENRYRHPLSMAFI
RAGQELDLPYRNDFNGDSQQGVGFYQTTTHNGERASTARTYLKAVRNEQRLVVKLNALVHRVVLDNNVATGVVYSQNGGA
EVTAHAAQEVILSAGAVGSPKILMLSGIGPREHLQQLGIEPLADLPVGKNFHDHLHMSINVSTREPISLYGADRGLQALR
HGTEWLAFRSGVLSSNVLEGAAFTDSLGDGRPDVQIHFLPMLDSWDDVPGEPLPNIHGFTLKVGYLQPRARGEVLLRSRD
PKDPVKLHANYLGHPEDLAGSVRAVKFGLRFLQTAALKPLIKDLLMPQPAWLNDEAQLEEFVRNFCKTVYHPVGSCRMGQ
SPQDSVTDLQLRVHGFERLRVIDCSVMPQVTSGNTNAPTIMLAEKAVDLLLGTPQ
>Mature_534_residues
SENAFDYIIVGAGSAGCVLAAQLIRRTQARVLLLEAGGDDNNLFIKMPAGVAKIIAKKSWPYETEPEPHANNRRMQIAQG
KVLGGSSSVNGMIYIRGQRQDYDEWAERYGCVGWGYQDVLPYFKRAEANESLSDTYHGGEGLLPVSENRYRHPLSMAFIR
AGQELDLPYRNDFNGDSQQGVGFYQTTTHNGERASTARTYLKAVRNEQRLVVKLNALVHRVVLDNNVATGVVYSQNGGAE
VTAHAAQEVILSAGAVGSPKILMLSGIGPREHLQQLGIEPLADLPVGKNFHDHLHMSINVSTREPISLYGADRGLQALRH
GTEWLAFRSGVLSSNVLEGAAFTDSLGDGRPDVQIHFLPMLDSWDDVPGEPLPNIHGFTLKVGYLQPRARGEVLLRSRDP
KDPVKLHANYLGHPEDLAGSVRAVKFGLRFLQTAALKPLIKDLLMPQPAWLNDEAQLEEFVRNFCKTVYHPVGSCRMGQS
PQDSVTDLQLRVHGFERLRVIDCSVMPQVTSGNTNAPTIMLAEKAVDLLLGTPQ

Specific function: Can Catalyze The Oxidation Of Choline To Betaine Aldehyde And Betaine Aldehyde To Glycine Betaine At The Same Rate. [C]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=548, Percent_Identity=38.8686131386861, Blast_Score=352, Evalue=4e-97,
Organism=Escherichia coli, GI1786503, Length=536, Percent_Identity=41.044776119403, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17532301, Length=555, Percent_Identity=34.954954954955, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI17137792, Length=549, Percent_Identity=38.9799635701275, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24642042, Length=563, Percent_Identity=37.8330373001776, Blast_Score=321, Evalue=6e-88,
Organism=Drosophila melanogaster, GI24642039, Length=579, Percent_Identity=36.0967184801382, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI18859995, Length=570, Percent_Identity=37.0175438596491, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24642059, Length=563, Percent_Identity=34.8134991119005, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI45551458, Length=563, Percent_Identity=34.9911190053286, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI45549471, Length=563, Percent_Identity=34.9911190053286, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24642048, Length=574, Percent_Identity=35.191637630662, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24642055, Length=575, Percent_Identity=34.9565217391304, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24650267, Length=563, Percent_Identity=34.9911190053286, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24642037, Length=568, Percent_Identity=34.1549295774648, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24642051, Length=560, Percent_Identity=33.3928571428571, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24642035, Length=580, Percent_Identity=33.6206896551724, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI18859993, Length=579, Percent_Identity=34.0241796200345, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24642057, Length=592, Percent_Identity=29.0540540540541, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24645930, Length=585, Percent_Identity=27.008547008547, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.32 [H]

Molecular weight: Translated: 58858; Mature: 58726

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENAFDYIIVGAGSAGCVLAAQLIRRTQARVLLLEAGGDDNNLFIKMPAGVAKIIAKKS
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCHHHHHHHCCC
WPYETEPEPHANNRRMQIAQGKVLGGSSSVNGMIYIRGQRQDYDEWAERYGCVGWGYQDV
CCCCCCCCCCCCCCEEEEECCEEECCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCHHHH
LPYFKRAEANESLSDTYHGGEGLLPVSENRYRHPLSMAFIRAGQELDLPYRNDFNGDSQQ
HHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
GVGFYQTTTHNGERASTARTYLKAVRNEQRLVVKLNALVHRVVLDNNVATGVVYSQNGGA
CCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCEEEEEEECCCCC
EVTAHAAQEVILSAGAVGSPKILMLSGIGPREHLQQLGIEPLADLPVGKNFHDHLHMSIN
EEEHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
VSTREPISLYGADRGLQALRHGTEWLAFRSGVLSSNVLEGAAFTDSLGDGRPDVQIHFLP
ECCCCCEEEECCCHHHHHHHCCHHHHHHHHCCHHCHHHCCCCCCCCCCCCCCCEEEEEEE
MLDSWDDVPGEPLPNIHGFTLKVGYLQPRARGEVLLRSRDPKDPVKLHANYLGHPEDLAG
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCHHHHHH
SVRAVKFGLRFLQTAALKPLIKDLLMPQPAWLNDEAQLEEFVRNFCKTVYHPVGSCRMGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
SPQDSVTDLQLRVHGFERLRVIDCSVMPQVTSGNTNAPTIMLAEKAVDLLLGTPQ
CCCCCCEEEEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEEEHHHHHHHCCCCC
>Mature Secondary Structure 
SENAFDYIIVGAGSAGCVLAAQLIRRTQARVLLLEAGGDDNNLFIKMPAGVAKIIAKKS
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCHHHHHHHCCC
WPYETEPEPHANNRRMQIAQGKVLGGSSSVNGMIYIRGQRQDYDEWAERYGCVGWGYQDV
CCCCCCCCCCCCCCEEEEECCEEECCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCHHHH
LPYFKRAEANESLSDTYHGGEGLLPVSENRYRHPLSMAFIRAGQELDLPYRNDFNGDSQQ
HHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
GVGFYQTTTHNGERASTARTYLKAVRNEQRLVVKLNALVHRVVLDNNVATGVVYSQNGGA
CCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCEEEEEEECCCCC
EVTAHAAQEVILSAGAVGSPKILMLSGIGPREHLQQLGIEPLADLPVGKNFHDHLHMSIN
EEEHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
VSTREPISLYGADRGLQALRHGTEWLAFRSGVLSSNVLEGAAFTDSLGDGRPDVQIHFLP
ECCCCCEEEECCCHHHHHHHCCHHHHHHHHCCHHCHHHCCCCCCCCCCCCCCCEEEEEEE
MLDSWDDVPGEPLPNIHGFTLKVGYLQPRARGEVLLRSRDPKDPVKLHANYLGHPEDLAG
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCHHHHHH
SVRAVKFGLRFLQTAALKPLIKDLLMPQPAWLNDEAQLEEFVRNFCKTVYHPVGSCRMGQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
SPQDSVTDLQLRVHGFERLRVIDCSVMPQVTSGNTNAPTIMLAEKAVDLLLGTPQ
CCCCCCEEEEEEEECCCEEEEEEEEECCCCCCCCCCCCEEEEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9023923 [H]