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The map label for this gene is bacC [H]

Identifier: 157368591

GI number: 157368591

Start: 392916

End: 394655

Strand: Direct

Name: bacC [H]

Synonym: Spro_0342

Alternate gene names: 157368591

Gene position: 392916-394655 (Clockwise)

Preceding gene: 157368590

Following gene: 157368592

Centisome position: 7.21

GC content: 58.22

Gene sequence:

>1740_bases
ATGCCCATCGTTGAGGTTTTCAATCCGCCGTCCCTGAACTCGCGTCTTGATATGACGGCCCGGCGTTACGCCACTCGTTT
GGCTGTGCAGGATGAGACGAGAGCGCTGACGTTCGCCGAGTTTTCTGATGAGGTTGGCACCCTGGCTGCAAGGTTGCAGC
TGGTGCTTGAGCCCGGCGATCACGTGGCGGTGCAACTGCCGCGCGGGTTGGATTATATCGTTGCCGCCTATGCGATCTGG
CAGGCAGGCGGGGTTTATTTGCCGCTGGACGATCAATGGCCATCGTCGCGCATTGAGGGGATCTTGCATCGTTCGCACGT
GCGGGTACTGATCCATGCGCCGCAGGCGGGACATGGCATAGCGCTGACCGAGTTGGCCGCAGAACCGCGGGCCGAACTGC
CGGCGGCCGGCACGCCCGCTTATATCATTCATACCTCCGGCACCACCGGCGAGCCAAAAGGCGTGGTGGTCAGCCAAGAA
TCGCTGCTGCATTTGGTGGACAGCCATCAGCGTGATATTTATCAGATACATGGCGTCACCGAAGGGCCTGTGGTTATCAA
TGCTTCCTTCTGTTTCGACAGCGCGCTGGAGCGTATGGCGTTGGTTGCCTTGGGCTACAGCGTACAGGTTGTCAGCGATC
GGGTGAGAAAATCGCCGCATGAGCTGGTGGGATACCTATGCGACCACCATATTGTCAATGTGGACTTGGTGCCTTCTCAT
CTGAAAGTGCTGCTCAGCGCCGGCCTCAATGAGAAGTGTGACGCGCTGCGGCTGGTGATTGTCGGCGGTGAGGCGATTGA
CGTCGAACTCTGGCGCCAGCTTGCCGCCAACGAGGCCGTTTACATCAACGTATACGGCCCTACCGAGAACACCATCAACA
CCAGCTTTTGTGAAATCCGTGGCGAAATGCCGCACATCGGCCGCCCGTTTGAAAATGTGTCATGTCTGATCCTGGATGAG
GGTGGACAGCGTTGCCCACCGGGCGAGGACGGTGAACTGCTGGTGGCCGGCCGCCATCTTGCGCTGGGGTATTACAATGC
GCCAGCGCTTACCGCCCGAGCCTTTGTCAACGTCGATGGCCTCCGCTACTACCGCACAGGCGATCGGGTGAGGCAGAACG
AACAGGGAAATCTGCTGTTTCTCGGCCGTATTGACGATCAGGTAAAAATCAACGGATTCCGCATTGAACTTGCCGATGTG
CAGCACAATCTGGCGCAATTGCCCGGCGTGCAATATGCCGCCGTGACGCCGATCAAACTACCGTCAGGGCAGGGATTGCT
GGCCTCCGTCGTCTGGCATGCCGATACCGCCGGACAAACGCTCGCCAGCCTTGAAACCTTGCTTGGCGAGAAATTGCCGG
CCTATATGGTGCCGGATCGCTGGCAGCAGCTTGACGCCTTGCCACTGACCGACAATTTGAAGCTTGACCACAAATCGCTG
CTGAGCTATTGGCAACGCCGTCAGGAGCAGGCCGATGAGCCTGTTGTCGGCGAGTCGCTTTCTGCGACCGAACGTCAGAT
TCAAACCCTTTGGCAGCGTATCCTGATGCGGACATCCTTGTCCCCGGATGCTCACTTCTTCGCTTCAGGCGGGGATTCCA
TGGCAGCCATGACGCTGCTGGTCGAATTGAAGAAGGTGACACCACACGAGGTGGGGTTGGGGGACATTTTCAAATATCCG
ACGATTCGCAAAATGGCCGCTTGGTTGGATGAGTCCTCCGTGCATGCGGAGGGCGAATAA

Upstream 100 bases:

>100_bases
AACATTTTGGTCAGCCACGGCCGCAAGCCTTTTGAAGGGGAGCGGGCGGTGCGCGTTGCCCTGATCGACCCGATTTATCC
TTCAGCAGAGGAGAATTCTT

Downstream 100 bases:

>100_bases
TGTGCCTGATCTTTTGTCTGCCGCATGCCGGCGGCGGAGCTCATCACTATTTTGGCTGGGCGGCGCACCTTGCCCCTGAC
ATTCAATGGGAGCCGCTTGA

Product: amino acid adenylation domain-containing protein

Products: NA

Alternate protein names: BA3; ATP-dependent isoleucine adenylase; IleA; Isoleucine activase; ATP-dependent D-phenylalanine adenylase; D-PheA; D-phenylalanine activase; ATP-dependent histidine adenylase; HisA; Histidine activase; ATP-dependent D-aspartate adenylase; D-AspA; D-aspartate activase; ATP-dependent asparagine adenylase; AsnA; Asparagine activase; Aspartate racemase; Phenylalanine racemase [ATP hydrolyzing] [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MPIVEVFNPPSLNSRLDMTARRYATRLAVQDETRALTFAEFSDEVGTLAARLQLVLEPGDHVAVQLPRGLDYIVAAYAIW
QAGGVYLPLDDQWPSSRIEGILHRSHVRVLIHAPQAGHGIALTELAAEPRAELPAAGTPAYIIHTSGTTGEPKGVVVSQE
SLLHLVDSHQRDIYQIHGVTEGPVVINASFCFDSALERMALVALGYSVQVVSDRVRKSPHELVGYLCDHHIVNVDLVPSH
LKVLLSAGLNEKCDALRLVIVGGEAIDVELWRQLAANEAVYINVYGPTENTINTSFCEIRGEMPHIGRPFENVSCLILDE
GGQRCPPGEDGELLVAGRHLALGYYNAPALTARAFVNVDGLRYYRTGDRVRQNEQGNLLFLGRIDDQVKINGFRIELADV
QHNLAQLPGVQYAAVTPIKLPSGQGLLASVVWHADTAGQTLASLETLLGEKLPAYMVPDRWQQLDALPLTDNLKLDHKSL
LSYWQRRQEQADEPVVGESLSATERQIQTLWQRILMRTSLSPDAHFFASGGDSMAAMTLLVELKKVTPHEVGLGDIFKYP
TIRKMAAWLDESSVHAEGE

Sequences:

>Translated_579_residues
MPIVEVFNPPSLNSRLDMTARRYATRLAVQDETRALTFAEFSDEVGTLAARLQLVLEPGDHVAVQLPRGLDYIVAAYAIW
QAGGVYLPLDDQWPSSRIEGILHRSHVRVLIHAPQAGHGIALTELAAEPRAELPAAGTPAYIIHTSGTTGEPKGVVVSQE
SLLHLVDSHQRDIYQIHGVTEGPVVINASFCFDSALERMALVALGYSVQVVSDRVRKSPHELVGYLCDHHIVNVDLVPSH
LKVLLSAGLNEKCDALRLVIVGGEAIDVELWRQLAANEAVYINVYGPTENTINTSFCEIRGEMPHIGRPFENVSCLILDE
GGQRCPPGEDGELLVAGRHLALGYYNAPALTARAFVNVDGLRYYRTGDRVRQNEQGNLLFLGRIDDQVKINGFRIELADV
QHNLAQLPGVQYAAVTPIKLPSGQGLLASVVWHADTAGQTLASLETLLGEKLPAYMVPDRWQQLDALPLTDNLKLDHKSL
LSYWQRRQEQADEPVVGESLSATERQIQTLWQRILMRTSLSPDAHFFASGGDSMAAMTLLVELKKVTPHEVGLGDIFKYP
TIRKMAAWLDESSVHAEGE
>Mature_578_residues
PIVEVFNPPSLNSRLDMTARRYATRLAVQDETRALTFAEFSDEVGTLAARLQLVLEPGDHVAVQLPRGLDYIVAAYAIWQ
AGGVYLPLDDQWPSSRIEGILHRSHVRVLIHAPQAGHGIALTELAAEPRAELPAAGTPAYIIHTSGTTGEPKGVVVSQES
LLHLVDSHQRDIYQIHGVTEGPVVINASFCFDSALERMALVALGYSVQVVSDRVRKSPHELVGYLCDHHIVNVDLVPSHL
KVLLSAGLNEKCDALRLVIVGGEAIDVELWRQLAANEAVYINVYGPTENTINTSFCEIRGEMPHIGRPFENVSCLILDEG
GQRCPPGEDGELLVAGRHLALGYYNAPALTARAFVNVDGLRYYRTGDRVRQNEQGNLLFLGRIDDQVKINGFRIELADVQ
HNLAQLPGVQYAAVTPIKLPSGQGLLASVVWHADTAGQTLASLETLLGEKLPAYMVPDRWQQLDALPLTDNLKLDHKSLL
SYWQRRQEQADEPVVGESLSATERQIQTLWQRILMRTSLSPDAHFFASGGDSMAAMTLLVELKKVTPHEVGLGDIFKYPT
IRKMAAWLDESSVHAEGE

Specific function: Induces peptide synthesis, activates and incorporates five amino acids, forms a thiazoline ring between the first two amino acids and incoporates a D-glutamine in the fourth position [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 5 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=485, Percent_Identity=28.0412371134021, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI38505220, Length=401, Percent_Identity=24.9376558603491, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786801, Length=582, Percent_Identity=31.2714776632302, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1788107, Length=549, Percent_Identity=23.1329690346084, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI145693145, Length=542, Percent_Identity=23.4317343173432, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786810, Length=518, Percent_Identity=25.0965250965251, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17556356, Length=533, Percent_Identity=25.328330206379, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=589, Percent_Identity=22.4108658743633, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32564420, Length=491, Percent_Identity=24.0325865580448, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32564422, Length=491, Percent_Identity=24.0325865580448, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319591, Length=658, Percent_Identity=24.6200607902736, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319699, Length=392, Percent_Identity=22.1938775510204, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648676, Length=578, Percent_Identity=29.0657439446367, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19922652, Length=375, Percent_Identity=25.6, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: =5.1.1.13; =5.1.1.11 [H]

Molecular weight: Translated: 63677; Mature: 63546

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVEVFNPPSLNSRLDMTARRYATRLAVQDETRALTFAEFSDEVGTLAARLQLVLEPGD
CCEEEECCCCCCCCCHHHHHHHHHHHHEECCCCCEEEEHHHHHHHHHHHHEEEEEECCCC
HVAVQLPRGLDYIVAAYAIWQAGGVYLPLDDQWPSSRIEGILHRSHVRVLIHAPQAGHGI
EEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCCE
ALTELAAEPRAELPAAGTPAYIIHTSGTTGEPKGVVVSQESLLHLVDSHQRDIYQIHGVT
EEEHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECHHHHHHHHHCCCCCEEEEECCC
EGPVVINASFCFDSALERMALVALGYSVQVVSDRVRKSPHELVGYLCDHHIVNVDLVPSH
CCCEEEEEHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCHHHHHHHHHCCEEEEEEECHHH
LKVLLSAGLNEKCDALRLVIVGGEAIDVELWRQLAANEAVYINVYGPTENTINTSFCEIR
HHHHHHCCCCCCCCEEEEEEECCCEECHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEC
GEMPHIGRPFENVSCLILDEGGQRCPPGEDGELLVAGRHLALGYYNAPALTARAFVNVDG
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCEEEEEEECCCCCEEEEEEEECC
LRYYRTGDRVRQNEQGNLLFLGRIDDQVKINGFRIELADVQHNLAQLPGVQYAAVTPIKL
EEEEECCCHHCCCCCCCEEEEEECCCEEEEEEEEEEEHHHHHHHHHCCCCEEEEEEEEEC
PSGQGLLASVVWHADTAGQTLASLETLLGEKLPAYMVPDRWQQLDALPLTDNLKLDHKSL
CCCCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHH
LSYWQRRQEQADEPVVGESLSATERQIQTLWQRILMRTSLSPDAHFFASGGDSMAAMTLL
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
VELKKVTPHEVGLGDIFKYPTIRKMAAWLDESSVHAEGE
HHHHHCCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PIVEVFNPPSLNSRLDMTARRYATRLAVQDETRALTFAEFSDEVGTLAARLQLVLEPGD
CEEEECCCCCCCCCHHHHHHHHHHHHEECCCCCEEEEHHHHHHHHHHHHEEEEEECCCC
HVAVQLPRGLDYIVAAYAIWQAGGVYLPLDDQWPSSRIEGILHRSHVRVLIHAPQAGHGI
EEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCCE
ALTELAAEPRAELPAAGTPAYIIHTSGTTGEPKGVVVSQESLLHLVDSHQRDIYQIHGVT
EEEHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECHHHHHHHHHCCCCCEEEEECCC
EGPVVINASFCFDSALERMALVALGYSVQVVSDRVRKSPHELVGYLCDHHIVNVDLVPSH
CCCEEEEEHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCHHHHHHHHHCCEEEEEEECHHH
LKVLLSAGLNEKCDALRLVIVGGEAIDVELWRQLAANEAVYINVYGPTENTINTSFCEIR
HHHHHHCCCCCCCCEEEEEEECCCEECHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEC
GEMPHIGRPFENVSCLILDEGGQRCPPGEDGELLVAGRHLALGYYNAPALTARAFVNVDG
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCEEEEEEECCCCCEEEEEEEECC
LRYYRTGDRVRQNEQGNLLFLGRIDDQVKINGFRIELADVQHNLAQLPGVQYAAVTPIKL
EEEEECCCHHCCCCCCCEEEEEECCCEEEEEEEEEEEHHHHHHHHHCCCCEEEEEEEEEC
PSGQGLLASVVWHADTAGQTLASLETLLGEKLPAYMVPDRWQQLDALPLTDNLKLDHKSL
CCCCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHH
LSYWQRRQEQADEPVVGESLSATERQIQTLWQRILMRTSLSPDAHFFASGGDSMAAMTLL
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
VELKKVTPHEVGLGDIFKYPTIRKMAAWLDESSVHAEGE
HHHHHCCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9427658 [H]