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The map label for this gene is hemE

Identifier: 157368536

GI number: 157368536

Start: 329323

End: 330387

Strand: Direct

Name: hemE

Synonym: Spro_0287

Alternate gene names: 157368536

Gene position: 329323-330387 (Clockwise)

Preceding gene: 157368535

Following gene: 157368537

Centisome position: 6.04

GC content: 59.72

Gene sequence:

>1065_bases
ATGAATGAGTTGAAGAACGATCGCTACCTGCGCGCACTGCTGCGTCAGCCGGTGGATGTGACCCCTGTATGGATGATGCG
TCAGGCCGGTCGTTATTTGCCGGAGTACAAGGCCACCCGCGCCCAGGCCGGGGATTTCATGTCGCTATGCAAGAACGCGG
AGCTGGCTTGTGAAGTCACGCTGCAGCCGCTGCGCCGTTTCCCACTGGACGCGGCGATCCTGTTCTCCGATATCCTCACC
ATTCCCGATGCCATGGGGCTGGGCCTGTATTTCGAAACCGGTGAAGGTCCGCGTTTCTCCTCGCCTATCACCAGTCGTGC
CGATGTCGACAAGCTACCGGCGTTCGACCCGGAAGTGGAGCTGGGTTATGTGATGAACGCAGTGCGTACCATCCGTCGCG
AGCTGAAGGGCGAAGTGCCGCTGATCGGTTTCTCAGGCAGTCCGTGGACGCTGGCGACCTATATGGTGGAAGGCGGTAGC
AGCAAGGCCTTCACCAAACTGAAAAAAATGATGTACGCCGAGCCGGCGACGTTGCACCTGCTGTTGGATAAGCTGGCAGA
CAGCGTCATTTTGTATCTTAACGCCCAGATTAAAGCCGGCGCGCAGTCGGTGATGGTGTTCGATACCTGGGGCGGCGTGC
TGACCGGTCGTGACTACCGCGAGTTCTCACTGCATTACATGCACAAGATTGTTGACGGCCTGCTGCGTGAAAACGACGGC
CGCCGTGTGCCGGTCACGCTGTTCACCAAAGGTGGCGGCCAGTGGCTGGAGGCGATGGCGGCAACCGGTTGTGACGCACT
GGGTCTTGACTGGACGACCGATATTGCCGATGCACGCCGTCGCGTAGGGGACAAAGTGGCACTGCAGGGCAACATGGACC
CTTCGATGCTGTATGCGTCACCGGAGCGCATCGGCCAGGAAGTGGAAACCATTCTGGCCGGTTTCGGCCACGGCGAAGGG
CATGTGTTCAACCTGGGCCACGGTATTCACCCGGACGTGCCGCCGGAAAACGCCGGTGCCTTTGTTGAGGCAGTCCACGC
GCAGTCGGGGAAATACCATCGTTAA

Upstream 100 bases:

>100_bases
CCCGGCACGGTAGCGCGTCGCCTGATAGAGGACACCGTAGCCTTATGCCGTGAGCAATAAATCGCTACAATACCGGCAGA
TGAATAAGGGAGCCCCATAA

Downstream 100 bases:

>100_bases
GGATTGCATGTGATAGATACTCAAGCCCTGCGTGCAGAACAACGGCTGCGCGCCTCCGAAGTCATTCGCCAGGATGATTT
CCTGGTCGTTCCACCGGCCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MNELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRFPLDAAILFSDILT
IPDAMGLGLYFETGEGPRFSSPITSRADVDKLPAFDPEVELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKLKKMMYAEPATLHLLLDKLADSVILYLNAQIKAGAQSVMVFDTWGGVLTGRDYREFSLHYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSMLYASPERIGQEVETILAGFGHGEG
HVFNLGHGIHPDVPPENAGAFVEAVHAQSGKYHR

Sequences:

>Translated_354_residues
MNELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRFPLDAAILFSDILT
IPDAMGLGLYFETGEGPRFSSPITSRADVDKLPAFDPEVELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKLKKMMYAEPATLHLLLDKLADSVILYLNAQIKAGAQSVMVFDTWGGVLTGRDYREFSLHYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSMLYASPERIGQEVETILAGFGHGEG
HVFNLGHGIHPDVPPENAGAFVEAVHAQSGKYHR
>Mature_354_residues
MNELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVTLQPLRRFPLDAAILFSDILT
IPDAMGLGLYFETGEGPRFSSPITSRADVDKLPAFDPEVELGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKLKKMMYAEPATLHLLLDKLADSVILYLNAQIKAGAQSVMVFDTWGGVLTGRDYREFSLHYMHKIVDGLLRENDG
RRVPVTLFTKGGGQWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSMLYASPERIGQEVETILAGFGHGEG
HVFNLGHGIHPDVPPENAGAFVEAVHAQSGKYHR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=353, Percent_Identity=49.5750708215297, Blast_Score=330, Evalue=1e-90,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=89.2655367231638, Blast_Score=659, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320252, Length=356, Percent_Identity=39.6067415730337, Blast_Score=271, Evalue=9e-74,
Organism=Drosophila melanogaster, GI19921920, Length=346, Percent_Identity=43.6416184971098, Blast_Score=291, Evalue=4e-79,
Organism=Drosophila melanogaster, GI221330099, Length=346, Percent_Identity=43.6416184971098, Blast_Score=291, Evalue=5e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_SERP5 (A8G8F7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476525.1
- ProteinModelPortal:   A8G8F7
- SMR:   A8G8F7
- STRING:   A8G8F7
- GeneID:   5607063
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0287
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   SPRO399741:SPRO_0287-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39107; Mature: 39107

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPRFSSPITSRADVDKLPAFDPEVE
HHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKLKKMMYAEPATLHL
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVILYLNAQIKAGAQSVMVFDTWGGVLTGRDYREFSLHYMHKIVDGLLRENDG
HHHHHHHHEEEEEECEECCCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSMLYAS
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHEEEC
PERIGQEVETILAGFGHGEGHVFNLGHGIHPDVPPENAGAFVEAVHAQSGKYHR
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNELKNDRYLRALLRQPVDVTPVWMMRQAGRYLPEYKATRAQAGDFMSLCKNAELACEVT
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCHHHHHHHCCCCEEEEEE
LQPLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPRFSSPITSRADVDKLPAFDPEVE
HHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCH
LGYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKLKKMMYAEPATLHL
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCHHHHH
LLDKLADSVILYLNAQIKAGAQSVMVFDTWGGVLTGRDYREFSLHYMHKIVDGLLRENDG
HHHHHHHHEEEEEECEECCCCCEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCC
RRVPVTLFTKGGGQWLEAMAATGCDALGLDWTTDIADARRRVGDKVALQGNMDPSMLYAS
CEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHEEEC
PERIGQEVETILAGFGHGEGHVFNLGHGIHPDVPPENAGAFVEAVHAQSGKYHR
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA