BacMap

Definition	Escherichia coli HS, complete genome.
Accession	NC_009800
Length	4,643,538

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The map label for this gene is hpaE [H]

Identifier: 157163799

GI number: 157163799

Start: 4591362

End: 4592828

Strand: Reverse

Name: hpaE [H]

Synonym: EcHS_A4583

Alternate gene names: 157163799

Gene position: 4592828-4591362 (Counterclockwise)

Preceding gene: 157163800

Following gene: 157163798

Centisome position: 98.91

GC content: 58.42

Gene sequence:

>1467_bases
ATGAAAAAAGTAAATCATTGGATCAACGGTAAAAATGTTGCAGGTAACGACTACTTCCAGACTACCAATCCGGCAACGGG
TGAAGTGCTGGCGGATGTGGCCTCCGGCGGTGAAGCGGAGATCAATCAGGCGGTAGCGGCAGCGAAAGAGGCGTTCCCGA
AATGGGCCAATCTGCCGATGAAAGAGCGCGCGCGCCTGATGCGCCGTCTGGGCGATCTGATCGACCAGAACGTGCCGGAG
ATCGCCGCGATGGAAACCGCGGACACGGGCCTGCCGATCCATCAGACCAAAAATGTGTTGATCCCACGCGCTTCTCACAA
CTTTGAATTTTTCGCGGAAGTCTGCCAGCAGATGAACGGCAAGACTTATCCGGTCGACGACAAGATGCTCAACTACACGC
TGGTGCAGCCGGTAGGCGTTTGTGCACTGGTGTCACCGTGGAACGTGCCGTTTATGACCGCCACCTGGAAGGTCGCGCCG
TGTCTGGCGCTGGGCAATACCGCGGTACTGAAAATGTCGGAACTCTCCCCGCTGACCGCTGACCGCCTGGGTGAGCTGGC
GCTGGAAGCCGGTATTCCGGCAGGCGTGCTGAACGTGGTACAGGGCTACGGCGCAACCGCAGGGGATGCGCTGGTTCGTC
ATCATGACGTACGTGCCGTGTCGTTCACCGGCGGTACGGCCACCGGGCGCAACATCATGAAAAACGCCGGGCTGAAAAAA
TACTCCATGGAACTGGGCGGTAAATCGCCGGTGCTGATTTTTGAAGATGCCGATATTGAACGCGCGCTGGACGCCGCCCT
GTTCACCATCTTCTCGATCAACGGCGAACGCTGCACCGCCGGTTCGCGCATCTTTATTCAGCAAAGCATCTACCCGGAAT
TCGTTAAACGCTTTGCCGAACGCGCCAACCGTCTGCGCGTGGGCGATCCGAACGATCCGAATACCCAGGTTGGCGCGCTT
ATTAGCCAGCAGCACTGGGAAAAAGTCTCCGGCTATATCCGTCTCGGCATTGAAGAAGGCGCAACCCTGCTGGCGGGCGG
CCCGGATAAACCGTCCGACCTGCCTGCGCACCTGAAAGGCGGCAACTTCCTGCGCCCAACCGTGCTGGCAGACGTTGATA
ACCGTATGCGAGTCGCCCAGGAAGAGATTTTCGGGCCGGTCGCCTGCCTGCTGCCGTTTAAAGACGAAGCCGAAGGCTTA
CGTCTGGCAAACGACGTGGAGTACGGCCTCGCGTCGTACATCTGGACACAGGATGTCAGCAAAGTGTTACGCCTGGCGCG
TGGCATTGAAGCTGGCATGGTGTTCGTCAACACCCAGAACGTGCGTGACCTGCGCCAGCCATTTGGCGGCGTAAAAGCCT
CCGGCACCGGGCGTGAAGGCGGTGAGTACAGCTTCGAAGTGTTCGCGGAAATGAAGAACGTCTGCATTTCCATGGGCGAC
CATCCAATTCCGAAATGGGGAGTCTGA

Upstream 100 bases:

>100_bases
CAAAAGGCTTATCTGACGTGGTGCCTGGCGATGAAGTGGTGGTGGAAGTAGAAGGCGTGGGCCGCCTGGTGAACCGAATT
GTGAGTGAGGAAACAGCGAA

Downstream 100 bases:

>100_bases
TATGGGTAAGTTAGCGTTAGCCGCCAAGATCACGCACGTACCGTCGATGTATCTCTCTGAACTGCCAGGGAAAAACCACG
GTTGCCGCCAGGGCGCGATC

Product: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase

Products: 5-carboxymethyl-2-hydroxymuconate; NADH; H+

Alternate protein names: CHMS dehydrogenase [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADVASGGEAEINQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQNVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPNDPNTQVGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV

Sequences:

>Translated_488_residues
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADVASGGEAEINQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQNVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPNDPNTQVGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV
>Mature_488_residues
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADVASGGEAEINQAVAAAKEAFPKWANLPMKERARLMRRLGDLIDQNVPE
IAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNGKTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAP
CLALGNTAVLKMSELSPLTADRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAERANRLRVGDPNDPNTQVGAL
ISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKGGNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGL
RLANDVEYGLASYIWTQDVSKVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HPIPKWGV

Specific function: Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM) [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI12007648, Length=477, Percent_Identity=42.1383647798742, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI25777730, Length=480, Percent_Identity=41.4583333333333, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI25777732, Length=480, Percent_Identity=41.25, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI153266822, Length=482, Percent_Identity=39.4190871369295, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI25777724, Length=480, Percent_Identity=39.7916666666667, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI238814322, Length=483, Percent_Identity=39.7515527950311, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI115387104, Length=463, Percent_Identity=39.7408207343413, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI21361176, Length=480, Percent_Identity=38.5416666666667, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI21614513, Length=466, Percent_Identity=40.1287553648069, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI25777728, Length=420, Percent_Identity=40.7142857142857, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI25952152, Length=477, Percent_Identity=36.2683438155136, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI25777726, Length=477, Percent_Identity=36.4779874213836, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI301500698, Length=482, Percent_Identity=35.8921161825726, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI4507229, Length=483, Percent_Identity=35.8178053830228, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI25777721, Length=496, Percent_Identity=34.6774193548387, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI11095441, Length=485, Percent_Identity=29.8969072164948, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI188035924, Length=495, Percent_Identity=27.0707070707071, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI310128093, Length=477, Percent_Identity=27.6729559748428, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI310128103, Length=477, Percent_Identity=27.4633123689727, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI310128091, Length=470, Percent_Identity=27.4468085106383, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI223972651, Length=464, Percent_Identity=28.0172413793103, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI310128089, Length=339, Percent_Identity=30.9734513274336, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI238859541, Length=466, Percent_Identity=25.9656652360515, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI25777736, Length=466, Percent_Identity=25.9656652360515, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI25777734, Length=466, Percent_Identity=25.9656652360515, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI310128097, Length=263, Percent_Identity=32.6996197718631, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI310128095, Length=318, Percent_Identity=29.874213836478, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI206597441, Length=450, Percent_Identity=26.2222222222222, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI206597439, Length=450, Percent_Identity=26.2222222222222, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI22907049, Length=450, Percent_Identity=26.2222222222222, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4557303, Length=345, Percent_Identity=28.4057971014493, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI73466520, Length=345, Percent_Identity=28.4057971014493, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI223972653, Length=462, Percent_Identity=25.1082251082251, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI73695881, Length=347, Percent_Identity=26.2247838616715, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI73695879, Length=347, Percent_Identity=26.2247838616715, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI71773324, Length=342, Percent_Identity=27.1929824561404, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4502043, Length=342, Percent_Identity=27.1929824561404, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI238814371, Length=342, Percent_Identity=27.1929824561404, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI310128087, Length=294, Percent_Identity=23.8095238095238, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI310128101, Length=236, Percent_Identity=22.0338983050847, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI310128099, Length=236, Percent_Identity=22.0338983050847, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1787558, Length=480, Percent_Identity=39.375, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1789015, Length=478, Percent_Identity=38.0753138075314, Blast_Score=340, Evalue=2e-94,
Organism=Escherichia coli, GI87082295, Length=492, Percent_Identity=38.4146341463415, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1786504, Length=463, Percent_Identity=39.0928725701944, Blast_Score=331, Evalue=7e-92,
Organism=Escherichia coli, GI87081896, Length=464, Percent_Identity=37.7155172413793, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1787715, Length=476, Percent_Identity=36.9747899159664, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1787684, Length=481, Percent_Identity=31.3929313929314, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI87081926, Length=461, Percent_Identity=30.3687635574837, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1788042, Length=474, Percent_Identity=29.746835443038, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787250, Length=466, Percent_Identity=26.1802575107296, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1787653, Length=301, Percent_Identity=26.2458471760797, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25144435, Length=466, Percent_Identity=40.9871244635193, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17562198, Length=480, Percent_Identity=40, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133930964, Length=485, Percent_Identity=37.9381443298969, Blast_Score=342, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI25143876, Length=486, Percent_Identity=37.037037037037, Blast_Score=332, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI32564736, Length=420, Percent_Identity=40.7142857142857, Blast_Score=331, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI25143874, Length=486, Percent_Identity=37.037037037037, Blast_Score=331, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI17551164, Length=481, Percent_Identity=37.6299376299376, Blast_Score=323, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI71995606, Length=485, Percent_Identity=33.8144329896907, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI71995613, Length=421, Percent_Identity=33.9667458432304, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17534119, Length=473, Percent_Identity=32.3467230443975, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI71986308, Length=442, Percent_Identity=31.9004524886878, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI115534176, Length=488, Percent_Identity=26.0245901639344, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI32566756, Length=443, Percent_Identity=28.2167042889391, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25146391, Length=444, Percent_Identity=28.1531531531532, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25146394, Length=444, Percent_Identity=28.1531531531532, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17534447, Length=485, Percent_Identity=26.1855670103093, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17564084, Length=446, Percent_Identity=27.3542600896861, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32564151, Length=445, Percent_Identity=26.5168539325843, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI115532534, Length=341, Percent_Identity=27.2727272727273, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71990744, Length=323, Percent_Identity=25.3869969040248, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324950, Length=474, Percent_Identity=38.3966244725738, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6320917, Length=484, Percent_Identity=38.2231404958678, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6325196, Length=481, Percent_Identity=37.4220374220374, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6323822, Length=468, Percent_Identity=37.1794871794872, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6323821, Length=468, Percent_Identity=36.1111111111111, Blast_Score=305, Evalue=8e-84,
Organism=Saccharomyces cerevisiae, GI6319478, Length=483, Percent_Identity=35.6107660455487, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6321828, Length=507, Percent_Identity=26.8244575936884, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6321826, Length=505, Percent_Identity=26.1386138613861, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323757, Length=359, Percent_Identity=27.5766016713092, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI20129399, Length=480, Percent_Identity=43.5416666666667, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24585660, Length=482, Percent_Identity=37.9668049792531, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI281362580, Length=476, Percent_Identity=36.5546218487395, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI62472918, Length=476, Percent_Identity=36.5546218487395, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI62472926, Length=476, Percent_Identity=36.5546218487395, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI62472936, Length=476, Percent_Identity=36.5546218487395, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI21356737, Length=476, Percent_Identity=36.5546218487395, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24650465, Length=471, Percent_Identity=39.9150743099788, Blast_Score=325, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24638878, Length=439, Percent_Identity=31.6628701594533, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24638876, Length=439, Percent_Identity=31.6628701594533, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24666674, Length=474, Percent_Identity=26.7932489451477, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24668425, Length=454, Percent_Identity=26.2114537444934, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24668417, Length=454, Percent_Identity=26.2114537444934, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24668413, Length=454, Percent_Identity=26.2114537444934, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI281360299, Length=355, Percent_Identity=26.4788732394366, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360297, Length=355, Percent_Identity=26.4788732394366, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360295, Length=355, Percent_Identity=26.4788732394366, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24586250, Length=355, Percent_Identity=26.4788732394366, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360301, Length=355, Percent_Identity=26.4788732394366, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360303, Length=356, Percent_Identity=25.8426966292135, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45552499, Length=356, Percent_Identity=25.8426966292135, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI28571806, Length=494, Percent_Identity=22.4696356275304, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571802, Length=494, Percent_Identity=22.4696356275304, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571800, Length=494, Percent_Identity=22.4696356275304, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571798, Length=489, Percent_Identity=22.9038854805726, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571796, Length=489, Percent_Identity=22.9038854805726, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571794, Length=489, Percent_Identity=22.9038854805726, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574525, Length=466, Percent_Identity=22.5321888412017, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR011985 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: 1.2.1.60

Molecular weight: Translated: 53028; Mature: 53028

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADVASGGEAEINQAVAAAKEAFPKWANLPM
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHCCCCH
KERARLMRRLGDLIDQNVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNG
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGNTAVLKMSELSPLTA
CCCCCCCHHHCEEEECCCCEEEEECCCCCCEEEEECCHHHHHEECCCEEEEECCCCCCCH
DRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCCE
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAE
EHHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCEEEEEHHHHHHHHHHHHH
RANRLRVGDPNDPNTQVGALISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKG
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCCCCCCCCCC
GNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGLRLANDVEYGLASYIWTQDVS
CCEECCHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHH
KVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
HPIPKWGV
CCCCCCCC
>Mature Secondary Structure
MKKVNHWINGKNVAGNDYFQTTNPATGEVLADVASGGEAEINQAVAAAKEAFPKWANLPM
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCHHHCCCCH
KERARLMRRLGDLIDQNVPEIAAMETADTGLPIHQTKNVLIPRASHNFEFFAEVCQQMNG
HHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
KTYPVDDKMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGNTAVLKMSELSPLTA
CCCCCCCHHHCEEEECCCCEEEEECCCCCCEEEEECCHHHHHEECCCEEEEECCCCCCCH
DRLGELALEAGIPAGVLNVVQGYGATAGDALVRHHDVRAVSFTGGTATGRNIMKNAGLKK
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCCE
YSMELGGKSPVLIFEDADIERALDAALFTIFSINGERCTAGSRIFIQQSIYPEFVKRFAE
EHHHCCCCCCEEEEECCCHHHHHHHHHHHHEECCCCEECCCCEEEEEHHHHHHHHHHHHH
RANRLRVGDPNDPNTQVGALISQQHWEKVSGYIRLGIEEGATLLAGGPDKPSDLPAHLKG
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCCCCCCCCCC
GNFLRPTVLADVDNRMRVAQEEIFGPVACLLPFKDEAEGLRLANDVEYGLASYIWTQDVS
CCEECCHHHHCCHHHHHHHHHHHCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHH
KVLRLARGIEAGMVFVNTQNVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCISMGD
HHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
HPIPKWGV
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-carboxymethyl-2-hydroxymuconate semialdehyde; H2O; NAD+

Specific reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7737515 [H]