Click here to switch to the map view.

The map label for this gene is chpS

Identifier: 157163698

GI number: 157163698

Start: 4483642

End: 4483893

Strand: Direct

Name: chpS

Synonym: EcHS_A4477

Alternate gene names: 157163698

Gene position: 4483642-4483893 (Clockwise)

Preceding gene: 157163697

Following gene: 157163699

Centisome position: 96.56

GC content: 50.79

Gene sequence:

>252_bases
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Upstream 100 bases:

>100_bases
TTAACGCATAAAAAACTCTGCTGGCATTCACAAATGCGCAGGGGTAAAACGTTTCCTGTAGCACCGTGAGTTATACTTTG
TATAACTTAAGGAGGTGCAG

Downstream 100 bases:

>100_bases
AGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGGTGCTGGT
CGACCTGCGCTTGTGCTCTC

Product: antitoxin ChpS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 83; Mature: 83

Protein sequence:

>83_residues
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Sequences:

>Translated_83_residues
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
>Mature_83_residues
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Specific function: Part of a toxin-antitoxin (TA) module. May be involved in the regulation of cell growth. It acts as a suppressor of the inhibitory function of ChpB protein. Both ChpS and ChpB probably bind to the promoter region of the chpSB operon to autoregulate their

COG id: COG2336

COG function: function code T; Growth regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemI family

Homologues:

Organism=Escherichia coli, GI87082393, Length=83, Percent_Identity=100, Blast_Score=170, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CHPS_ECOLI (P08365)

Other databases:

- EMBL:   D16451
- EMBL:   M14018
- EMBL:   U14003
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   S56450
- RefSeq:   AP_004724.1
- RefSeq:   NP_418645.2
- ProteinModelPortal:   P08365
- SMR:   P08365
- DIP:   DIP-9280N
- IntAct:   P08365
- MINT:   MINT-1263242
- STRING:   P08365
- EnsemblBacteria:   EBESCT00000003771
- EnsemblBacteria:   EBESCT00000003772
- EnsemblBacteria:   EBESCT00000016868
- GeneID:   948739
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW5750
- KEGG:   eco:b4224
- EchoBASE:   EB1230
- EcoGene:   EG11250
- eggNOG:   COG2336
- GeneTree:   EBGT00050000010031
- HOGENOM:   HBG504751
- OMA:   QQWGNSA
- ProtClustDB:   PRK11347
- BioCyc:   EcoCyc:EG11250-MONOMER
- BioCyc:   MetaCyc:EG11250-MONOMER
- Genevestigator:   P08365
- InterPro:   IPR007159
- SMART:   SM00966

Pfam domain/function: PF04014 SpoVT_AbrB

EC number: NA

Molecular weight: Translated: 9272; Mature: 9272

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCD
CEEEEEECCCCCCEEHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHHCC
MNAAELSEQDVWGKSTPAGDEIW
CCHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCD
CEEEEEECCCCCCEEHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCCCCCHHHHHHHCC
MNAAELSEQDVWGKSTPAGDEIW
CCHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226627; 3525538; 7610040; 9278503; 8083180