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The map label for this gene is aidB [H]

Identifier: 157163652

GI number: 157163652

Start: 4439011

End: 4440636

Strand: Direct

Name: aidB [H]

Synonym: EcHS_A4431

Alternate gene names: 157163652

Gene position: 4439011-4440636 (Clockwise)

Preceding gene: 157163651

Following gene: 157163655

Centisome position: 95.6

GC content: 55.04

Gene sequence:

>1626_bases
GTGCACTGGCAAACTCACACCGTTTTTAATCAACCTATACCATTAAATAACAGCAACTTATACCTGTCTGATGGCGCGCT
CTGCGAAGCGGTAACGCGTGAAGGTGCTGGCTGGGATAGCGATTTTCTAGCCAGTATTGGTCAGCAGTTAGGAACGGCTG
AATCCCTTGAACTGGGGCGGCTGGCGAATGTGAATCCGCCTGAATTATTGCGCTACGATGCGCAAGGACGCCGTCTGGAC
GATGTGCGTTTTCACCCCGCCTGGCACCTGCTGATGCAGGCGCTATGTACCAATCGGGTGCACAATCTTGCCTGGGAAGA
AGACGCTCGCTCCGGCGCATTTGTGGCGCGCGCGGCGCGTTTTATGTTGCACGCACAGGTTGAGGCAGGGTCGTTATGTC
CGATAACCATGACCTTTGCCGCCACGCCATTGCTGTTACAGATGTTACCCGCGCCGTTTCAGGACTGGACCACGCCGCTG
CTGAGCGATCGCTACGATTCTCACTTATTGCCAGGTGGGCAAAAACGCGGTTTGTTGATTGGCATGGGAATGACGGAAAA
GCAGGGCGGTTCCGATGTCATGAGCAACACCACCCGCGCAGAGCGCCTGGAAGATGGCTCTTATCGGCTGGTGGGGCATA
AATGGTTTTTCTCGGTGCCGCAAAGCGATGCGCATCTGGTGCTGGCGCAGACTACGGGCGGTTTGTCCTGCTTTTTTGTG
CCGCGCTTTTTGCCTGACGGGCAACGCAACGCGATTCGCCTCGAGCGGCTGAAAGATAAGCTGGGTAATCGCTCTAACGC
CAGCTGCGAAGTGGAGTTTCAGGATGCCATTGGCTGGTTGTTGGGGCAGGAAGGGGAAGGAATTCGTCTGATCCTGAAAA
TGGGTGGGATGACGCGTTTTGATTGCGCCCTGGGTAGCCATGCCATGATGCGCCGTGCATTTTCGCTGGCGATTTATCAT
GCACATCAACGCCATGTTTTTGGTAATCCATTGATCCAACAGCCCCTTATGCGTCATGTCTTAAGTCGCATGGCACTTCA
GCTTGAAGGGCAAACGGCGTTGCTGTTTCGTCTTGCGCGAGCGTGGGACCGGCGTGCCGATGCCAAAGAAGCCCTGTGGG
CGCGTTTATTTACGCCTGCGGCAAAATTTGTGATCTGCAAAAGAGGTATGACGTTTGTGGCCGAAGCGATGGAGGTGCTG
GGCGGCATTGGTTATTGCGAGGAGAGCGAGCTGCCGCGGCTTTACCGGGAGATGCCGGTAAACAGTATTTGGGAAGGTTC
CGGCAATATTATGTGCCTGGATGTGCTGCGCGTTCTCAATAAGCAAGCGGGCGTATACGACTTATTGTCGGAAGCGTTTG
TGGAAGTGAAAGGGCAGGATCGCTATTTTGATCGCGCGGTTCGTCGTTTACAGCAGCAGCTGCGCAAGCCAGCTGAAGAA
CTGGGGCGAGAGATTACTCATCAGCTATTCCTGCTGGGCTGCGGTGCGCAAATGTTGAAATATGCCTCTCCGCCAATGGC
GCAGGCGTGGTGTCAGGTGATGTTAGATACGCGCGGCGGCGTACGGTTGTCAGAGCAGATCCAGAATGATTTATTGCTGC
GGGCGACGGGGGGAGTGTGTGTGTAA

Upstream 100 bases:

>100_bases
ATTACATTGCTGGATAAGAATGTTTTAGCAATCTCTTTCTGTCATGAATCCATGGCAGTGACCATACTAATGGTGACTGC
CATTGATGGAGGGAGACACA

Downstream 100 bases:

>100_bases
GCGTATACGACTGATGCGACGCTGGTTTCGATTAACTCAATGAAATATGTGAAAATTGTAGGCCGGACAAGGCGCTCGCG
CCGCATCCGGCATTGTTCAT

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQGRRLD
DVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPL
LSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGLSCFFV
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRFDCALGSHAMMRRAFSLAIYH
AHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGMTFVAEAMEVL
GGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
LGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRATGGVCV

Sequences:

>Translated_541_residues
MHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQGRRLD
DVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPL
LSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGLSCFFV
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRFDCALGSHAMMRRAFSLAIYH
AHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGMTFVAEAMEVL
GGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
LGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRATGGVCV
>Mature_541_residues
MHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQGRRLD
DVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPL
LSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGLSCFFV
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRFDCALGSHAMMRRAFSLAIYH
AHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGMTFVAEAMEVL
GGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
LGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRATGGVCV

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=287, Percent_Identity=29.616724738676, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI226958412, Length=271, Percent_Identity=24.7232472324723, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI226958414, Length=271, Percent_Identity=24.7232472324723, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501859, Length=252, Percent_Identity=25.3968253968254, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI7656849, Length=266, Percent_Identity=27.8195488721804, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI4557231, Length=274, Percent_Identity=25.1824817518248, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI187960098, Length=274, Percent_Identity=25.1824817518248, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI21361497, Length=260, Percent_Identity=24.2307692307692, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082384, Length=541, Percent_Identity=99.4454713493531, Blast_Score=1107, Evalue=0.0,
Organism=Escherichia coli, GI1786223, Length=329, Percent_Identity=25.531914893617, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87081958, Length=258, Percent_Identity=26.3565891472868, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI86563383, Length=538, Percent_Identity=29.9256505576208, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI86563381, Length=538, Percent_Identity=29.9256505576208, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17538396, Length=271, Percent_Identity=28.7822878228782, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=267, Percent_Identity=23.9700374531835, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17506239, Length=270, Percent_Identity=24.0740740740741, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=266, Percent_Identity=24.4360902255639, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=269, Percent_Identity=24.5353159851301, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17569725, Length=268, Percent_Identity=24.2537313432836, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17505929, Length=298, Percent_Identity=26.510067114094, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=312, Percent_Identity=25.6410256410256, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355753, Length=297, Percent_Identity=28.2828282828283, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=23.7536656891496, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646207, Length=274, Percent_Identity=25.5474452554745, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24660351, Length=279, Percent_Identity=25.4480286738351, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24666513, Length=269, Percent_Identity=22.3048327137546, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 60640; Mature: 60640

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAESLELGR
CCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCC
LANVNPPELLRYDAQGRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAAR
CCCCCCHHHHEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
FMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPLLSDRYDSHLLPGGQKRGLLI
HHHHEECCCCCCCCEEHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCCCCCCCCCCCCEEE
GMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGLSCFFV
ECCCCCCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEE
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRF
HHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCEE
DCALGSHAMMRRAFSLAIYHAHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLAR
HHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AWDRRADAKEALWARLFTPAAKFVICKRGMTFVAEAMEVLGGIGYCEESELPRLYREMPV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
NSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
CCEECCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRATGGVC
HHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEHHHHHCCEEEEECCCCC
V
C
>Mature Secondary Structure
MHWQTHTVFNQPIPLNNSNLYLSDGALCEAVTREGAGWDSDFLASIGQQLGTAESLELGR
CCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCC
LANVNPPELLRYDAQGRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAAR
CCCCCCHHHHEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
FMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPLLSDRYDSHLLPGGQKRGLLI
HHHHEECCCCCCCCEEHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCCCCCCCCCCCCEEE
GMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFSVPQSDAHLVLAQTTGGLSCFFV
ECCCCCCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEE
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRF
HHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCEE
DCALGSHAMMRRAFSLAIYHAHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLAR
HHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AWDRRADAKEALWARLFTPAAKFVICKRGMTFVAEAMEVLGGIGYCEESELPRLYREMPV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
NSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
CCEECCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LGREITHQLFLLGCGAQMLKYASPPMAQAWCQVMLDTRGGVRLSEQIQNDLLLRATGGVC
HHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEHHHHHCCEEEEECCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]