Click here to switch to the map view.

The map label for this gene is pgi [H]

Identifier: 157163493

GI number: 157163493

Start: 4265707

End: 4267356

Strand: Direct

Name: pgi [H]

Synonym: EcHS_A4264

Alternate gene names: 157163493

Gene position: 4265707-4267356 (Clockwise)

Preceding gene: 157163490

Following gene: 157163494

Centisome position: 91.86

GC content: 51.7

Gene sequence:

>1650_bases
ATGAAAAACATCAATCCAACGCAGACCGCTGCCTGGCAGGCACTACAGAAACACTTCGATGAAATGAAAGACGTTACGAT
CGCCGATCTTTTTGCTAAAGACGGCGATCGTTTTTCTAAGTTCTCCGCAACCTTCGGCGATCAGATGCTGGTGGATTACT
CCAAAAACCGCATCACTGAAGAGACGCTGGCGAAATTACAAGATCTGGCGAAAGAGTGCGATCTGGCGGGCGCGATTAAG
TCGATGTTCTCTGGCGAGAAGATCAACCGCACTGAAAACCGCGCTGTGCTGCACGTAGCGCTGCGTAACCGTAGCAATAC
CCCGATTTTGGTTGATGGCAAAGACGTAATGCCGGAAGTCAACGCGGTGCTGGAGAAGATGAAAACCTTCTCGGAAGCGA
TTATCTCCGGTGAGTGGAAGGGTTATACCGGCAAAGCAATCACTGACGTAGTGAACATCGGGATCGGCGGTTCTGACCTC
GGCCCGTACATGGTGACCGAAGCACTGCGTCCGTACAAAAATCACCTGAACATGCACTTTGTTTCTAACGTCGATGGGAC
TCACATCGCGGAAGTGCTGAAAAAAGTAAACCCGGAAACCACGCTGTTCCTGGTAGCATCTAAAACCTTCACCACTCAGG
AAACCATGACCAACGCCCATAGCGCGCGTGACTGGTTCCTGAAAGCGGCAGGTGATGAAAAACACGTTGCGAAACACTTT
GCGGCGCTCTCAACCAATGCCAAAGCCGTTGGCGAGTTTGGTATTGATACTGCCAACATGTTCGAGTTCTGGGACTGGGT
CGGCGGCCGTTACTCTTTGTGGTCAGCGATTGGCCTGTCGATTGTTCTCTCCATCGGCTTTGATAACTTCGTTGAACTGC
TTTCTGGCGCACACGCGATGGACAAGCATTTCTCCACCACGCCTGCCGAGAAAAACCTGCCTGTACTGCTGGCGCTGATT
GGCATCTGGTACAACAATTTCTTTGGTGCGGAAACTGAGGCGATTCTGCCGTATGACCAGTATATGCACCGTTTCGCGGC
GTACTTCCAGCAGGGCAATATGGAGTCCAACGGTAAGTATGTTGACCGTAACGGTAACGTTGTGGATTACCAGACTGGCC
CGATTATCTGGGGTGAACCAGGCACTAACGGTCAGCACGCGTTCTACCAGCTGATCCACCAGGGAACCAAAATGGTACCG
TGCGATTTCATCGCTCCGGCTATCACCCATAACCCGCTCTCTGATCATCACCAGAAACTGCTGTCTAACTTCTTCGCCCA
GACCGAAGCGCTGGCGTTTGGTAAATCCCGCGAAGTGGTTGAGCAGGAATATCGTGATCAGGGTAAAGATCCGGCAACGC
TTGACTACGTGGTGCCGTTCAAAGTGTTCGAAGGTAACCGCCCGACCAACTCCATCCTGCTGCGTGAAATCACTCCGTTC
AGCCTGGGTGCGTTGATTGCGCTGTATGAGCACAAAATCTTTACTCAGGGCGTGATCCTGAACATCTTCACCTTCGACCA
GTGGGGCGTGGAGCTGGGTAAACAACTGGCAAACCGTATTCTGCCAGAGCTGAAAGATGATAAAGAAATCAGCAGCCACG
ATAGCTCGACCAATGGTCTGATTAACCGCTATAAAGCGTGGCGCGGTTAA

Upstream 100 bases:

>100_bases
CTCAACATTACGCTAACGGCACTAAAACCATCACATTTTTCTGTGACTGGCGCTACAATCTTCCAAAGTCACAATTCTCA
AAATCAGAAGAGTATTGCTA

Downstream 100 bases:

>100_bases
TTTAAAAACCTTAATAACAATGCCGACGTTATGTCGGCATTGTTTTATCAGATAAATCCCCTTGTCTGTGATTTAACGGA
AATCATACCGTGAGGTTAAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFGDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIK
SMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG

Sequences:

>Translated_549_residues
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFGDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIK
SMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG
>Mature_549_residues
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFGDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIK
SMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDL
GPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALI
GIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVP
CDFIAPAITHNPLSDHHQKLLSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGLINRYKAWRG

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=549, Percent_Identity=64.8451730418944, Blast_Score=739, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=549, Percent_Identity=60.8378870673953, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=99.8178506375228, Blast_Score=1142, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=547, Percent_Identity=64.3510054844607, Blast_Score=720, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=542, Percent_Identity=64.760147601476, Blast_Score=719, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=549, Percent_Identity=59.5628415300546, Blast_Score=657, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=549, Percent_Identity=65.7559198542805, Blast_Score=731, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=549, Percent_Identity=65.7559198542805, Blast_Score=731, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=549, Percent_Identity=65.7559198542805, Blast_Score=731, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 61472; Mature: 61472

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFGDQMLVDYSKNRITE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCHHEEECHHHCCCH
ETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHHHH
NAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHH
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAM
HHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHH
DKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKL
EECCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
LSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHH
INRYKAWRG
HHHHHHCCC
>Mature Secondary Structure
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFGDQMLVDYSKNRITE
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCHHEEECHHHCCCH
ETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCEEECCHHHHHHH
NAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHF
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHF
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHH
AALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAM
HHHCCCCHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHH
DKHFSTTPAEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKY
HHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCEE
VDRNGNVVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPAITHNPLSDHHQKL
EECCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHH
LSNFFAQTEALAFGKSREVVEQEYRDQGKDPATLDYVVPFKVFEGNRPTNSILLREITPF
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCCCEEEECCCCH
SLGALIALYEHKIFTQGVILNIFTFDQWGVELGKQLANRILPELKDDKEISSHDSSTNGL
HHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHH
INRYKAWRG
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA