Click here to switch to the map view.

The map label for this gene is zraR [H]

Identifier: 157163473

GI number: 157163473

Start: 4232881

End: 4234206

Strand: Direct

Name: zraR [H]

Synonym: EcHS_A4238

Alternate gene names: 157163473

Gene position: 4232881-4234206 (Clockwise)

Preceding gene: 157163472

Following gene: 157163476

Centisome position: 91.16

GC content: 56.49

Gene sequence:

>1326_bases
ATGACGCACGATAATATCGATATTCTGGTGGTGGATGATGACATTAGCCACTGCACTATTTTGCAGGCTTTACTGCGCGG
CTGGGGCTATAACGTCGCGCTGGCGAACAGCGGGCGACAGGCGCTGGAGCAGGTGCGGGAACAGGTTTTTGATCTTGTGC
TTTGCGATGTGCGAATGGCGGAGATGGACGGCATCGCCACGCTGAAAGAGATCAAAGCGTTAAACCCGGCAATTCCGGTG
CTGATTATGACTGCGTACTCCAGCGTCGAGACGGCGGTAGAGGCACTGAAAACTGGGGCGCTGGATTATCTCATCAAGCC
GCTGGATTTCGATAACCTACAGGCGACGCTGGAAAAGGCGCTCGCGCATACGCACAGTATTGATGCTGAAACACCTGCGG
TGACTGCCAGCCAGTTCGGTATGGTCGGTAAAAGCTCGGCGATGCAACACCTGCTCAGTGAAATCGCCCTCGTCGCGCCA
TCGGAAGCCACGGTACTGATCCACGGCGATTCCGGCACCGGTAAAGAGCTGGTCGCCAGGGCGATTCACGCCAGTAGCGC
ACGTAGCGAAAAACCGCTGGTAACGCTCAACTGTGCGGCACTCAACGAATCCTTGCTGGAATCTGAATTGTTCGGTCACG
AAAAAGGGGCGTTTACTGGAGCCGATAAACGCCGGGAAGGGCGCTTTGTTGAGGCGGACGGCGGCACGCTGTTTCTCGAT
GAAATTGGCGATATCTCGCCGATGATGCAGGTGCGTCTGCTGCGTGCGATTCAGGAGCGCGAAGTTCAGCGTGTCGGTAG
CAACCAGACTATCTCGGTTGATGTCCGGCTGATTGCGGCGACCCATCGCGATCTTGCCGCAGAGGTGAATGCCGGGCATT
TTCGCCAGGATCTCTACTATCGCCTGAATGTGGTGGCGATTGAAGTACCATCGCTGCGGCAACGGCGGGAAGATATCCCT
CTGCTGGCTGGCCATTTTCTTCAGCGCTTTGCCGAGCGTAATCGCAAGGCGGTAAAAGGCTTTACGCCACAGGCGATGGA
TTTGCTGATCCACTACGACTGGCCGGGAAATATTCGTGAACTGGAAAACGCGGTGGAACGGGCGGTGGTGCTGCTGACCG
GGGAATATATTTCCGAACGCGAGCTGCCGCTGGCGATTGCCGGTACGCCGATCCCGCTGGGGCAAAGTCAGGATATTCAG
CCGCTGGTAGAAGTCGAAAAAGAAGTGATTCTGGCGGCACTGGAGAAAACGGGCGGCAACAAAACCGAGGCCGCCCGTCA
GTTAGGGATCACGCGCAAAACGCTATTGGCAAAACTGTCGCGTTAG

Upstream 100 bases:

>100_bases
AACAACACGGTGGTACAATTCAGGTCGCAAGCCAGGAGGGAAAAGGCTCAACGTTCACCCTCTGGCTTCCGGTCAATATT
ACGCGTAAGGACCCACAAGG

Downstream 100 bases:

>100_bases
TTCTGCTCGCGTTCGATAGCGCGCCAGCCAATATCTTTCCGGCAGAAGCAGTCGTCCCAGTGAATATCGGTCATTAAGGC
ATAAGCGCGTTTCTGCGCTT

Product: transcriptional regulatory protein ZraR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPV
LIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAETPAVTASQFGMVGKSSAMQHLLSEIALVAP
SEATVLIHGDSGTGKELVARAIHASSARSEKPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLD
EIGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGHFRQDLYYRLNVVAIEVPSLRQRREDIP
LLAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLTGEYISERELPLAIAGTPIPLGQSQDIQ
PLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR

Sequences:

>Translated_441_residues
MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPV
LIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAETPAVTASQFGMVGKSSAMQHLLSEIALVAP
SEATVLIHGDSGTGKELVARAIHASSARSEKPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLD
EIGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGHFRQDLYYRLNVVAIEVPSLRQRREDIP
LLAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLTGEYISERELPLAIAGTPIPLGQSQDIQ
PLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR
>Mature_440_residues
THDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVL
IMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSIDAETPAVTASQFGMVGKSSAMQHLLSEIALVAPS
EATVLIHGDSGTGKELVARAIHASSARSEKPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLDE
IGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGHFRQDLYYRLNVVAIEVPSLRQRREDIPL
LAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLTGEYISERELPLAIAGTPIPLGQSQDIQP
LVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=99.0929705215419, Blast_Score=886, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=446, Percent_Identity=48.6547085201794, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1788905, Length=446, Percent_Identity=44.1704035874439, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1790299, Length=463, Percent_Identity=41.6846652267819, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI87082117, Length=315, Percent_Identity=48.5714285714286, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1789087, Length=313, Percent_Identity=46.6453674121406, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI87082152, Length=313, Percent_Identity=46.3258785942492, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=43.125, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=42.6791277258567, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786524, Length=329, Percent_Identity=42.5531914893617, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1787583, Length=304, Percent_Identity=37.171052631579, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789828, Length=256, Percent_Identity=39.0625, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87081858, Length=287, Percent_Identity=32.7526132404181, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789149, Length=112, Percent_Identity=33.9285714285714, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789402, Length=119, Percent_Identity=32.7731092436975, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790860, Length=150, Percent_Identity=25.3333333333333, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=34.4262295081967, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI145693157, Length=115, Percent_Identity=34.7826086956522, Blast_Score=62, Evalue=9e-11,
Organism=Escherichia coli, GI1786784, Length=124, Percent_Identity=27.4193548387097, Blast_Score=62, Evalue=9e-11,
Organism=Escherichia coli, GI1786911, Length=176, Percent_Identity=28.4090909090909, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48324; Mature: 48193

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMA
CCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
EMDGIATLKEIKALNPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHH
LAHTHSIDAETPAVTASQFGMVGKSSAMQHLLSEIALVAPSEATVLIHGDSGTGKELVAR
HHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
AIHASSARSEKPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLD
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEC
EIGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGHFRQDLYY
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEHHHHHHHHCCCHHHHHHHHE
RLNVVAIEVPSLRQRREDIPLLAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRE
EEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCCCHHH
LENAVERAVVLLTGEYISERELPLAIAGTPIPLGQSQDIQPLVEVEKEVILAALEKTGGN
HHHHHHHEEEEEECCHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
KTEAARQLGITRKTLLAKLSR
HHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
THDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMA
CCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
EMDGIATLKEIKALNPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHH
LAHTHSIDAETPAVTASQFGMVGKSSAMQHLLSEIALVAPSEATVLIHGDSGTGKELVAR
HHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
AIHASSARSEKPLVTLNCAALNESLLESELFGHEKGAFTGADKRREGRFVEADGGTLFLD
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEC
EIGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGHFRQDLYY
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEHHHHHHHHCCCHHHHHHHHE
RLNVVAIEVPSLRQRREDIPLLAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRE
EEEEEEEECCHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCCCHHH
LENAVERAVVLLTGEYISERELPLAIAGTPIPLGQSQDIQPLVEVEKEVILAALEKTGGN
HHHHHHHEEEEEECCHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
KTEAARQLGITRKTLLAKLSR
HHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]