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The map label for this gene is yicE

Identifier: 157163135

GI number: 157163135

Start: 3858528

End: 3859919

Strand: Direct

Name: yicE

Synonym: EcHS_A3865

Alternate gene names: 157163135

Gene position: 3858528-3859919 (Clockwise)

Preceding gene: 157163133

Following gene: 157163136

Centisome position: 83.09

GC content: 55.03

Gene sequence:

>1392_bases
ATGTCTGTTTCCACCCTCGAGTCAGAAAATGCGCAACCGGTTGCGCAGACTCAAAACAGCGAACTGATTTACCGTCTTGA
AGATCGTCCGCCGCTTCCTCAAACCCTGTTTGCCGCCTGTCAGCATCTGCTGGCGATGTTCGTTGCGGTGATCACGCCAG
CGCTATTAATCTGCCAGGCGCTGGGTTTACCGGCACAAGACACGCAACACATTATTAGTATGTCGCTGTTTGCCTCCGGT
GTGGCATCGATTATTCAAATTAAGGCCTGGGGTCCGGTTGGCTCCGGGCTGTTGTCTATTCAGGGCACCAGCTTCAACTT
TGTTGCCCCGCTGATTATGGGCGGTACCGCGCTGAAAACCGGTGGTGCTGATGTTCCTACCATGATGGCGGCTTTGTTCG
GCACGTTGATGCTGGCAAGTTGCACCGAGATGGTGATCTCCCGCGTTCTGCATCTGGCGCGCCGCATTATTACGCCGCTG
GTTTCTGGCGTTGTGGTGATGATTATCGGCCTGTCGCTAATTCAGGTTGGGTTAACGTCCATTGGCGGCGGTTACGCAGC
CATGAGCGATAACACCTTCGGCGCACCGAAAAATCTGCTGCTGGCAGGCGTGGTCTTAGCCTTAATTATCCTGCTTAACC
GTCAACGTAACCCTTACTTACGCGTGGCCTCACTGGTGATTGCGATGGCGGCCGGATATGCGCTGGCGTGGTTTATGGGC
ATGTTGCCAGAAAGCAACGAACCGATGACGCAAGAACTGATTATGGTGCCAACGCCGCTCTATTACGGTCTTGGCATTGA
ATGGAGTCTGCTGCTGCCGCTGATGCTGGTCTTTATGATCACTTCGCTGGAAACCATTGGCGATATCACGGCGACCTCTG
ACGTTTCCGAACAGCCAGTGTCCGGTCCGCTGTACATGAAACGCCTGAAAGGTGGCGTGCTGGCAAACGGCCTGAACTCG
TTTGTTTCGGCGGTGTTCAACACCTTCCCGAACTCCTGCTTCGGGCAAAACAACGGAGTGATCCAGTTGACTGGTGTTGC
CAGCCGCTATGTCGGTTTTGTCGTCGCGCTGATGTTGATCGTGCTGGGTCTGTTCCCGGCAGTGAGCGGTTTTGTACAAC
ACATTCCAGAACCGGTTCTGGGCGGCGCAACGCTTGTAATGTTTGGCACCATCGCCGCCTCCGGTGTGCGTATCGTTTCT
CGTGAGCCGCTGAACCGTCGGGCGATTCTGATTATCGCGCTGTCGCTGGCGGTTGGTCTGGGCGTGTCTCAGCAGCCGCT
GATTTTGCAGTTTGCCCCTGAATGGCTGAAAAACCTGCTCTCCTCCGGGATCGCCGCGGGCGGTATTACTGCCATCGTGC
TGAATCTGATTTTCCCACCAGAAAAACAGTAA

Upstream 100 bases:

>100_bases
ATTTATCTCATTTAAATATTTAGATGAGGATGTGGCAAACGTTTGCTTTTCTCTTTCGGTCAGCTAAAATGCCCGCTTTG
CTACCACGGGATTGTTTTCG

Downstream 100 bases:

>100_bases
TTCACTGGCGGCGGTAAGATAATTACCGCCGCAGTCTCACCTCTTTAACCATTCCCGCCTTGAGGATTGCGCGTAAATCG
TGCATAACTCCCTTATGTGC

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASG
VASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPL
VSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNS
FVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVS
REPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ

Sequences:

>Translated_463_residues
MSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASG
VASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPL
VSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNS
FVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVS
REPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ
>Mature_462_residues
SVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASGV
ASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLV
SGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMGM
LPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNSF
VSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSR
EPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily

Homologues:

Organism=Homo sapiens, GI44680148, Length=516, Percent_Identity=23.062015503876, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI40316845, Length=516, Percent_Identity=23.062015503876, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790087, Length=463, Percent_Identity=100, Blast_Score=915, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=443, Percent_Identity=45.1467268623025, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI87082181, Length=460, Percent_Identity=28.695652173913, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1788843, Length=444, Percent_Identity=25.6756756756757, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081818, Length=405, Percent_Identity=24.4444444444444, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17558856, Length=481, Percent_Identity=24.5322245322245, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XANP_ECO57 (P0AGN1)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B91195
- PIR:   C86042
- RefSeq:   NP_290235.1
- RefSeq:   NP_312557.1
- ProteinModelPortal:   P0AGN1
- EnsemblBacteria:   EBESCT00000027618
- EnsemblBacteria:   EBESCT00000060187
- GeneID:   915511
- GeneID:   960890
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5082
- KEGG:   ecs:ECs4530
- GeneTree:   EBGT00050000009612
- HOGENOM:   HBG470187
- OMA:   RRAIMII
- ProtClustDB:   CLSK874889
- BioCyc:   ECOL83334:ECS4530-MONOMER
- InterPro:   IPR006042
- InterPro:   IPR006043
- PANTHER:   PTHR11119:SF3
- PANTHER:   PTHR11119
- TIGRFAMs:   TIGR00801

Pfam domain/function: PF00860 Xan_ur_permease

EC number: NA

Molecular weight: Translated: 48869; Mature: 48738

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x184c7e5c)-; HASH(0x18984d18)-; HASH(0x177f45bc)-; HASH(0x18293758)-; HASH(0x17757920)-; HASH(0x1896d880)-; HASH(0x188b1774)-; HASH(0x1864c5f8)-; HASH(0x183ec1e0)-; HASH(0x1848547c)-; HASH(0x17481778)-; HASH(0x187a633c)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQA
CCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
HCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCC
GGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVMIIGLSLIQVGLTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPV
HCCCCCCCHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
VLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHC
GVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCH
>Mature Secondary Structure 
SVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQA
CCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKT
HCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCCCC
GGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVMIIGLSLIQVGLTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMG
CCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPV
HCCCCCCCHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHH
VLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGL
HHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHC
GVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796