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The map label for this gene is kdgK

Identifier: 157163005

GI number: 157163005

Start: 3720731

End: 3721660

Strand: Direct

Name: kdgK

Synonym: EcHS_A3729

Alternate gene names: 157163005

Gene position: 3720731-3721660 (Clockwise)

Preceding gene: 157163002

Following gene: 157163010

Centisome position: 80.13

GC content: 57.1

Gene sequence:

>930_bases
ATGTCCAAAAAGATTGCCGTGATTGGCGAATGCATGATTGAGCTTTCCGAGAAAGGCGCGGACGTTAAGCGCGGTTTCGG
CGGCGATACCCTGAACACTTCCGTCTATATCGCCCGTCAGGTCGATCCTGCGGCATTAACCGTTCATTACGTAACGGCGC
TGGGAACGGACAGTTTTAGCCAGCAGATGCTGGACGCCTGGCACGGCGAGAACGTTGATACTTCCCTGACCCAACGGATG
GAAAACCGTCTGCCGGGCCTTTACTACATTGAAACCGACAGCACCGGCGAGCGTACGTTCTACTACTGGCGGAACGAAGC
CGCCGCCAAATTCTGGCTGGAGAGTGAGCAGTCTGCGGCGATTTGCGAAGAGCTGGCGAATTTCGATTATCTCTACCTGA
GCGGGATTAGCCTGGCGATCTTAAGCCCGACCAGCCGCGAAAAGCTGCTTTCCCTGCTGCGCGAATGCCGCGCCAACGGC
GGAAAAGTGATTTTCGACAATAACTATCGTCCGCGCCTGTGGGCCAGCAAAGAAGAGACACAGCAGGTGTACCAACAAAT
GCTGGAATGCACGGATATCGCCTTCCTGACGCTGGACGACGAAGACGCGCTGTGGGGTCAACAGCCGGTGGAAGACGTCA
TTGCGCGCACCCATAACGCGGGCGTGAAAGAAGTGGTGGTGAAACGCGGGGCGGATTCTTGCCTGGTGTCCATTGCTGGC
GAAGGGTTAGTGGATGTTCCGGCGGTGAAACTGCCGAAAGAAAAAGTGATCGATACCACCGCAGCTGGCGACTCTTTCAG
TGCCGGTTATCTGGCGGTACGTCTGACAGGCGGCAGCGCGGAAGACGCGGCGAAACGTGGGCACCTGACCGCAAGTACCG
TTATTCAGTATCGCGGCGCGATTATCCCGCGTGAGGCGATGCCAGCGTAA

Upstream 100 bases:

>100_bases
CTGGCTCAAAAAAATAATGGAACACTGTTTTAATATGGTTGACCAGCAAACCACCACAGCGCAAACTAACGCTAATTTTT
TACAGATCAGGTTCACGACT

Downstream 100 bases:

>100_bases
ACGCAGCATATGCAAAAGGCTGGATAAAGTGTTACCCCTCTATCCAGCTCATCCATAAATACCTGATGGTTGTGCTAACT
CATCACCATCAGGCATTACT

Product: 2-dehydro-3-deoxygluconokinase

Products: NA

Alternate protein names: 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSKKIAVIGECMIELSEKGADVKRGFGGDTLNTSVYIARQVDPAALTVHYVTALGTDSFSQQMLDAWHGENVDTSLTQRM
ENRLPGLYYIETDSTGERTFYYWRNEAAAKFWLESEQSAAICEELANFDYLYLSGISLAILSPTSREKLLSLLRECRANG
GKVIFDNNYRPRLWASKEETQQVYQQMLECTDIAFLTLDDEDALWGQQPVEDVIARTHNAGVKEVVVKRGADSCLVSIAG
EGLVDVPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSAEDAAKRGHLTASTVIQYRGAIIPREAMPA

Sequences:

>Translated_309_residues
MSKKIAVIGECMIELSEKGADVKRGFGGDTLNTSVYIARQVDPAALTVHYVTALGTDSFSQQMLDAWHGENVDTSLTQRM
ENRLPGLYYIETDSTGERTFYYWRNEAAAKFWLESEQSAAICEELANFDYLYLSGISLAILSPTSREKLLSLLRECRANG
GKVIFDNNYRPRLWASKEETQQVYQQMLECTDIAFLTLDDEDALWGQQPVEDVIARTHNAGVKEVVVKRGADSCLVSIAG
EGLVDVPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSAEDAAKRGHLTASTVIQYRGAIIPREAMPA
>Mature_308_residues
SKKIAVIGECMIELSEKGADVKRGFGGDTLNTSVYIARQVDPAALTVHYVTALGTDSFSQQMLDAWHGENVDTSLTQRME
NRLPGLYYIETDSTGERTFYYWRNEAAAKFWLESEQSAAICEELANFDYLYLSGISLAILSPTSREKLLSLLRECRANGG
KVIFDNNYRPRLWASKEETQQVYQQMLECTDIAFLTLDDEDALWGQQPVEDVIARTHNAGVKEVVVKRGADSCLVSIAGE
GLVDVPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSAEDAAKRGHLTASTVIQYRGAIIPREAMPA

Specific function: Unknown

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family

Homologues:

Organism=Escherichia coli, GI87082281, Length=309, Percent_Identity=100, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI87081971, Length=276, Percent_Identity=27.8985507246377, Blast_Score=74, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDGK_ECOLI (P37647)

Other databases:

- EMBL:   U00039
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   S47747
- RefSeq:   AP_004267.1
- RefSeq:   NP_417983.2
- ProteinModelPortal:   P37647
- SMR:   P37647
- DIP:   DIP-10056N
- MINT:   MINT-1219186
- STRING:   P37647
- EnsemblBacteria:   EBESCT00000000927
- EnsemblBacteria:   EBESCT00000015388
- GeneID:   948041
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW5668
- KEGG:   eco:b3526
- EchoBASE:   EB2163
- EcoGene:   EG12253
- eggNOG:   COG0524
- GeneTree:   EBGT00050000008219
- HOGENOM:   HBG697973
- OMA:   ANFLQIR
- ProtClustDB:   CLSK880706
- BioCyc:   EcoCyc:DEOXYGLUCONOKIN-MONOMER
- BioCyc:   MetaCyc:DEOXYGLUCONOKIN-MONOMER
- Genevestigator:   P37647
- InterPro:   IPR011611
- InterPro:   IPR002173

Pfam domain/function: PF00294 PfkB

EC number: =2.7.1.45

Molecular weight: Translated: 33963; Mature: 33831

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKIAVIGECMIELSEKGADVKRGFGGDTLNTSVYIARQVDPAALTVHYVTALGTDSFS
CCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEECCCHHEEEEEHHHHCCCHHH
QQMLDAWHGENVDTSLTQRMENRLPGLYYIETDSTGERTFYYWRNEAAAKFWLESEQSAA
HHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCHHEEEECCCCHHH
ICEELANFDYLYLSGISLAILSPTSREKLLSLLRECRANGGKVIFDNNYRPRLWASKEET
HHHHHCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEECCHHHH
QQVYQQMLECTDIAFLTLDDEDALWGQQPVEDVIARTHNAGVKEVVVKRGADSCLVSIAG
HHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCEEEEECC
EGLVDVPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSAEDAAKRGHLTASTVIQYRGA
CCCEECCCCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHCCC
IIPREAMPA
CCCHHCCCC
>Mature Secondary Structure 
SKKIAVIGECMIELSEKGADVKRGFGGDTLNTSVYIARQVDPAALTVHYVTALGTDSFS
CCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEECCCHHEEEEEHHHHCCCHHH
QQMLDAWHGENVDTSLTQRMENRLPGLYYIETDSTGERTFYYWRNEAAAKFWLESEQSAA
HHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCHHEEEECCCCHHH
ICEELANFDYLYLSGISLAILSPTSREKLLSLLRECRANGGKVIFDNNYRPRLWASKEET
HHHHHCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCEECCHHHH
QQVYQQMLECTDIAFLTLDDEDALWGQQPVEDVIARTHNAGVKEVVVKRGADSCLVSIAG
HHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCCEEEEECC
EGLVDVPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSAEDAAKRGHLTASTVIQYRGA
CCCEECCCCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHCCC
IIPREAMPA
CCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503