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The map label for this gene is secY

Identifier: 157162774

GI number: 157162774

Start: 3487109

End: 3488440

Strand: Reverse

Name: secY

Synonym: EcHS_A3494

Alternate gene names: 157162774

Gene position: 3488440-3487109 (Counterclockwise)

Preceding gene: 157162775

Following gene: 157162773

Centisome position: 75.12

GC content: 49.62

Gene sequence:

>1332_bases
ATGGCTAAACAACCGGGATTAGATTTTCAAAGTGCCAAAGGTGGCTTAGGCGAGCTGAAACGCAGACTGCTGTTTGTTAT
CGGTGCGCTGATTGTGTTCCGTATTGGCTCTTTTATTCCGATCCCTGGTATTGATGCCGCTGTACTTGCCAAACTGCTTG
AGCAACAGCGAGGCACCATCATTGAGATGTTTAACATGTTCTCTGGTGGTGCTCTCAGCCGTGCTTCTATCTTTGCTCTG
GGGATCATGCCGTATATTTCGGCGTCGATCATTATCCAGCTGCTGACGGTGGTTCACCCAACGTTGGCAGAAATTAAGAA
AGAAGGGGAGTCTGGTCGTCGTAAGATCAGCCAGTACACCCGCTACGGTACTCTGGTGCTGGCAATATTCCAGTCGATCG
GTATTGCTACCGGTCTGCCGAATATGCCTGGTATGCAAGGCCTGGTGATTAACCCGGGCTTTGCATTCTACTTCACCGCT
GTTGTAAGTCTGGTCACAGGAACCATGTTCCTGATGTGGTTGGGCGAACAGATTACTGAACGAGGTATCGGCAACGGTAT
TTCAATCATTATCTTCGCCGGTATTGTCGCGGGACTCCCGCCAGCCATTGCCCATACTATCGAGCAAGCGCGTCAAGGCG
ACCTGCACTTCCTCGTGTTGCTGTTGGTTGCAGTATTAGTATTTGCAGTGACGTTCTTTGTTGTATTTGTTGAGCGTGGT
CAACGCCGCATTGTGGTAAACTATGCGAAACGTCAGCAAGGTCGTCGTGTCTATGCTGCACAGAGCACACATTTACCGCT
GAAAGTGAATATGGCGGGGGTAATCCCGGCAATCTTCGCTTCCAGTATTATTCTGTTCCCGGCGACCATCGCGTCATGGT
TCGGGGGCGGTACTGGTTGGAACTGGCTGACAACAATTTCGCTGTATTTGCAGCCTGGGCAACCGCTTTATGTGTTACTC
TATGCGTCTGCAATCATCTTCTTCTGTTTCTTCTACACGGCGTTGGTTTTCAACCCGCGTGAAACAGCAGATAACCTGAA
GAAGTCCGGTGCATTTGTACCAGGAATTCGTCCGGGAGAGCAAACGGCGAAGTATATCGATAAAGTAATGACCCGCCTGA
CCCTGGTTGGTGCGCTGTATATTACCTTTATCTGCCTGATCCCGGAGTTCATGCGTGATGCAATGAAAGTACCGTTCTAC
TTCGGTGGGACCTCACTGCTTATCGTTGTTGTCGTGATTATGGACTTTATGGCTCAAGTGCAAACTCTGATGATGTCCAG
TCAGTATGAGTCTGCATTGAAGAAGGCGAACCTGAAAGGCTACGGCCGATAA

Upstream 100 bases:

>100_bases
GAAGTAACGACTCCGGTAACTGTTCGTGGCCTGCGTGTTACTAAAGGCGCTCGTGCTGCTATCGAAGCTGCTGGCGGTAA
AATCGAGGAATAAGTAGCAG

Downstream 100 bases:

>100_bases
TTGGTCGCCCGAGAAGTTACGGAGAGTAAAAATGAAAGTTCGTGCTTCCGTCAAGAAATTATGCCGTAACTGCAAAATCG
TTAAGCGTGATGGTGTCATC

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTIIEMFNMFSGGALSRASIFAL
GIMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYTRYGTLVLAIFQSIGIATGLPNMPGMQGLVINPGFAFYFTA
VVSLVTGTMFLMWLGEQITERGIGNGISIIIFAGIVAGLPPAIAHTIEQARQGDLHFLVLLLVAVLVFAVTFFVVFVERG
QRRIVVNYAKRQQGRRVYAAQSTHLPLKVNMAGVIPAIFASSIILFPATIASWFGGGTGWNWLTTISLYLQPGQPLYVLL
YASAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGEQTAKYIDKVMTRLTLVGALYITFICLIPEFMRDAMKVPFY
FGGTSLLIVVVVIMDFMAQVQTLMMSSQYESALKKANLKGYGR

Sequences:

>Translated_443_residues
MAKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTIIEMFNMFSGGALSRASIFAL
GIMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYTRYGTLVLAIFQSIGIATGLPNMPGMQGLVINPGFAFYFTA
VVSLVTGTMFLMWLGEQITERGIGNGISIIIFAGIVAGLPPAIAHTIEQARQGDLHFLVLLLVAVLVFAVTFFVVFVERG
QRRIVVNYAKRQQGRRVYAAQSTHLPLKVNMAGVIPAIFASSIILFPATIASWFGGGTGWNWLTTISLYLQPGQPLYVLL
YASAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGEQTAKYIDKVMTRLTLVGALYITFICLIPEFMRDAMKVPFY
FGGTSLLIVVVVIMDFMAQVQTLMMSSQYESALKKANLKGYGR
>Mature_442_residues
AKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTIIEMFNMFSGGALSRASIFALG
IMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYTRYGTLVLAIFQSIGIATGLPNMPGMQGLVINPGFAFYFTAV
VSLVTGTMFLMWLGEQITERGIGNGISIIIFAGIVAGLPPAIAHTIEQARQGDLHFLVLLLVAVLVFAVTFFVVFVERGQ
RRIVVNYAKRQQGRRVYAAQSTHLPLKVNMAGVIPAIFASSIILFPATIASWFGGGTGWNWLTTISLYLQPGQPLYVLLY
ASAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGEQTAKYIDKVMTRLTLVGALYITFICLIPEFMRDAMKVPFYF
GGTSLLIVVVVIMDFMAQVQTLMMSSQYESALKKANLKGYGR

Specific function: Involved in protein export. Interacts with secA and secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family

Homologues:

Organism=Escherichia coli, GI1789696, Length=443, Percent_Identity=100, Blast_Score=887, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SECY_ECO57 (P0AGA4)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A85995
- PIR:   E91149
- RefSeq:   NP_289861.1
- RefSeq:   NP_312192.1
- ProteinModelPortal:   P0AGA4
- SMR:   P0AGA4
- EnsemblBacteria:   EBESCT00000025587
- EnsemblBacteria:   EBESCT00000058099
- GeneID:   915941
- GeneID:   958757
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4670
- KEGG:   ecs:ECs4165
- GeneTree:   EBGT00050000011917
- HOGENOM:   HBG565931
- OMA:   IQTYVIS
- ProtClustDB:   PRK09204
- BioCyc:   ECOL83334:ECS4165-MONOMER
- InterPro:   IPR002208
- InterPro:   IPR023201
- PANTHER:   PTHR10906
- PIRSF:   PIRSF004557
- PRINTS:   PR00303
- TIGRFAMs:   TIGR00967

Pfam domain/function: PF00344 SecY; SSF103491 SecY

EC number: NA

Molecular weight: Translated: 48513; Mature: 48381

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS00755 SECY_1; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17858444)-; HASH(0x17d8bf8c)-; HASH(0x17c6f914)-; HASH(0x172de63c)-; HASH(0x17e28714)-; HASH(0x17d4f6c0)-; HASH(0x17da7658)-; HASH(0x17da15c0)-; HASH(0x17e0f1c4)-; HASH(0x17dbe964)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure 
AKQPGLDFQSAKGGLGELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTI
CCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHH
IEMFNMFSGGALSRASIFALGIMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYT
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RYGTLVLAIFQSIGIATGLPNMPGMQGLVINPGFAFYFTAVVSLVTGTMFLMWLGEQITE
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGIGNGISIIIFAGIVAGLPPAIAHTIEQARQGDLHFLVLLLVAVLVFAVTFFVVFVERG
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
QRRIVVNYAKRQQGRRVYAAQSTHLPLKVNMAGVIPAIFASSIILFPATIASWFGGGTGW
CCEEEEEHHHHHCCCEEEEECCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NWLTTISLYLQPGQPLYVLLYASAIIFFCFFYTALVFNPRETADNLKKSGAFVPGIRPGE
HHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCH
QTAKYIDKVMTRLTLVGALYITFICLIPEFMRDAMKVPFYFGGTSLLIVVVVIMDFMAQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHH
QTLMMSSQYESALKKANLKGYGR
HHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796