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The map label for this gene is panF

Identifier: 157162738

GI number: 157162738

Start: 3451950

End: 3453401

Strand: Direct

Name: panF

Synonym: EcHS_A3450

Alternate gene names: 157162738

Gene position: 3451950-3453401 (Clockwise)

Preceding gene: 157162737

Following gene: 157162739

Centisome position: 74.34

GC content: 54.34

Gene sequence:

>1452_bases
ATGCAGCTTGAAGTAATTCTACCGCTGGTCGCCTATCTGGTGGTGGTGTTCGGTATCTCGGTTTATGCGATGCGTAAACG
GAGCACCGGCACCTTCCTTAATGAGTATTTCCTCGGCAGCCGCTCTATGGGCGGTATTGTGCTGGCGATGACGCTCACCG
CGACCTATATCAGTGCCAGTTCGTTTATCGGCGGGCCAGGAGCTGCTTATAAATACGGGCTGGGCTGGGTATTGCTGGCG
ATGATTCAGCTTCCTGCAGTCTGGCTTTCACTCGGTATTCTCGGCAAGAAGTTTGCGATTCTTGCGCGCCGCTACAATGC
AGTGACGCTGAACGATATGCTGTTTGCCCGCTACCAGAGTCGTCTTCTGGTGTGGCTGGCGAGTTTGAGTTTGCTGGTTG
CGTTCGTTGGTGCGATGACCGTGCAGTTTATCGGCGGTGCGCGCCTGCTGGAAACCGCGGCGGGTATTCCTTATGAAACC
GGGCTGCTGATTTTTGGTATCAGCATTGCGTTATATACCGCCTTTGGTGGCTTTCGCGCCAGCGTGCTGAACGACACCAT
GCAAGGGCTTGTGATGCTGATTGGCACCGTTGTGCTGCTTATTGGCGTAGTACATGCCGCTGGCGGCTTAAGTAACGCAG
TACAGACCTTGCAAACCATCGATCCGCAACTGGTTACGCCACAAGGCGCTGACGATATTCTGTCGCCTGCCTTTATGACG
TCGTTCTGGGTACTGGTGTGTTTTGGCGTGATTGGCCTGCCGCATACTGCGGTGCGCTGTATCTCTTATAAAGACAGCAA
AGCCGTACATCGGGGGATCATCATCGGTACGATTGTGGTCGCAATTCTGATGTTCGGTATGCACCTGGCCGGAGCGTTAG
GTCGGGCGGTGATCCCCGATCTCACCGTACCGGACCTGGTGATCCCAACGTTAATGGTAAAAGTGCTGCCACCGTTTGCT
GCCGGGATCTTCCTGGCTGCACCGATGGCTGCGATCATGTCGACAATTAACGCCCAACTGCTGCAAAGTTCCGCTACGAT
CATTAAAGATCTCTATCTGAATATCCGTCCGGATCAAATGCAAAACGAGACGCGTCTGAAGCGGATGTCGGCGGTAATTA
CGTTAGTTCTCGGCGCGTTGCTGCTGCTTGCCGCCTGGAAGCCGCCAGAAATGATCATCTGGCTGAATTTGTTGGCCTTC
GGTGGGCTGGAAGCCGTTTTCCTGTGGCCGCTGGTGCTGGGTCTTTACTGGGAACGCGCCAACGCCAAAGGCGCGCTAAG
TGCGATGATCGTTGGCGGCGTGCTGTATGCCGTACTCGCGACGCTGAATATTCAGTACCTGGGCTTCCACCCTATCGTGC
CCTCGTTACTACTAAGTTTGCTGGCTTTCCTGGTCGGAAACCGTTTCGGTACATCCGTCCCGCAAGCTACCGTTTTGACT
ACTGATAAATAA

Upstream 100 bases:

>100_bases
TGGTTTGAGATGGCCTGCATCCTGACGCCGCTGCTGTTTATTGGACTGTGCTGGGCGATGGTGAAATTTATCTATCGCGA
TATCCCACTGGAGGATGACG

Downstream 100 bases:

>100_bases
AGAGTTTTGCCATGCCTTGGATCCAACTGAAACTGAACACCACCGGCGCGAACGCGGAAGATCTTAGCGATGCGCTGATG
GAAGCGGGTGCCGTTTCTAT

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MQLEVILPLVAYLVVVFGISVYAMRKRSTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYET
GLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTVVLLIGVVHAAGGLSNAVQTLQTIDPQLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLVLGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATVLT
TDK

Sequences:

>Translated_483_residues
MQLEVILPLVAYLVVVFGISVYAMRKRSTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYET
GLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTVVLLIGVVHAAGGLSNAVQTLQTIDPQLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLVLGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATVLT
TDK
>Mature_483_residues
MQLEVILPLVAYLVVVFGISVYAMRKRSTGTFLNEYFLGSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYNAVTLNDMLFARYQSRLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYET
GLLIFGISIALYTAFGGFRASVLNDTMQGLVMLIGTVVLLIGVVHAAGGLSNAVQTLQTIDPQLVTPQGADDILSPAFMT
SFWVLVCFGVIGLPHTAVRCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVIPDLTVPDLVIPTLMVKVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQMQNETRLKRMSAVITLVLGALLLLAAWKPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAKGALSAMIVGGVLYAVLATLNIQYLGFHPIVPSLLLSLLAFLVGNRFGTSVPQATVLT
TDK

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family

Homologues:

Organism=Homo sapiens, GI310128183, Length=473, Percent_Identity=27.4841437632135, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI14140236, Length=478, Percent_Identity=23.8493723849372, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI4507033, Length=407, Percent_Identity=26.044226044226, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI4507031, Length=479, Percent_Identity=24.6346555323591, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI110835708, Length=498, Percent_Identity=23.6947791164659, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI4507035, Length=370, Percent_Identity=24.5945945945946, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI157671931, Length=359, Percent_Identity=21.1699164345404, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87082237, Length=483, Percent_Identity=100, Blast_Score=952, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=484, Percent_Identity=27.0661157024793, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1790113, Length=475, Percent_Identity=23.5789473684211, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790503, Length=493, Percent_Identity=22.3123732251521, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24651739, Length=450, Percent_Identity=21.7777777777778, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANF_ECOLI (P16256)

Other databases:

- EMBL:   M30953
- EMBL:   U18997
- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   M83198
- EMBL:   S67010
- RefSeq:   AP_003798.1
- RefSeq:   NP_417724.4
- ProteinModelPortal:   P16256
- DIP:   DIP-10439N
- STRING:   P16256
- EnsemblBacteria:   EBESCT00000000323
- EnsemblBacteria:   EBESCT00000016377
- GeneID:   947752
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW3226
- KEGG:   eco:b3258
- EchoBASE:   EB0679
- EcoGene:   EG10685
- eggNOG:   COG4145
- GeneTree:   EBGT00050000009742
- HOGENOM:   HBG352968
- OMA:   AYLIVVF
- ProtClustDB:   PRK09442
- BioCyc:   EcoCyc:PANF-MONOMER
- Genevestigator:   P16256
- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900
- PANTHER:   PTHR11819
- TIGRFAMs:   TIGR02119
- TIGRFAMs:   TIGR00813

Pfam domain/function: PF00474 SSF

EC number: NA

Molecular weight: Translated: 51718; Mature: 51718

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00456 NA_SOLUT_SYMP_1; PS00457 NA_SOLUT_SYMP_2; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x172dd2c4)-; HASH(0x17cec934)-; HASH(0x175ddecc)-; HASH(0x1707b8d0)-; HASH(0x17782840)-; HASH(0x12ce6d00)-; HASH(0x179eeb20)-; HASH(0x17d6bc24)-; HASH(0x1772207c)-; HASH(0x17662428)-; HASH(0x11be883c)-; HASH(0x167bcc14)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCH
>Mature Secondary Structure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CCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664