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The map label for this gene is tldD

Identifier: 157162722

GI number: 157162722

Start: 3434171

End: 3435616

Strand: Reverse

Name: tldD

Synonym: EcHS_A3433

Alternate gene names: 157162722

Gene position: 3435616-3434171 (Counterclockwise)

Preceding gene: 157162723

Following gene: 229220673

Centisome position: 73.99

GC content: 54.56

Gene sequence:

>1446_bases
ATGAGTCTTAACCTGGTAAGTGAACAATTGCTAGCGGCGAACGGCCTGAAACATCAGGACTTGTTCGCGATCCTCGGTCA
ACTGGCCGAACGTCGCCTTGATTATGGCGATCTCTATTTTCAGTCGAGCTATCACGAATCCTGGGTTTTAGAAGACCGCA
TTATTAAAGATGGTTCTTACAACATCGATCAGGGCGTTGGTGTGCGTGCAATCAGCGGTGAAAAAACCGGATTTGCTTAC
GCTGACCAAATCAGCCTGCTGGCGCTGGAACAGAGTGCGCAAGCGGCGCGCACCATCGTCCGTGATAGTGGTGATGGTAA
AGTACAGACGCTGGGCGCGGTAGAGCATAGCCCGTTGTATACCTCGGTAGATCCGCTGCAAAGCATGAGCCGTGAAGAGA
AGCTGGATATCCTGCGTCGCGTCGATAAGGTTGCCCGCGAAGCGGACAAGCGCGTACAGGAAGTGACTGCCAGCCTCAGT
GGTGTCTATGAATTAATTTTGGTTGCGGCCACCGACGGCACGCTAGCGGCGGATGTCCGTCCGCTGGTGCGTCTTTCCGT
GAGCGTTCTCGTCGAAGAAGATGGCAAACGCGAACGCGGTGCCAGTGGCGGCGGCGGTCGTTTTGGTTATGAATTCTTCC
TTGCCGATCTCGACGGCGAAGTCCGTGCGGATGCATGGGCAAAAGAAGCAGTGCGTATGGCGCTGGTCAATCTTTCTGCC
GTTGCTGCACCAGCGGGCACCATGCCGGTAGTACTTGGCGCAGGTTGGCCGGGCGTGCTGTTGCATGAAGCGGTTGGTCA
CGGTCTGGAAGGCGACTTCAACCGCCGTGGCACTTCAGTATTTAGTGGACAGGTCGGGGAGCTGGTGGCTTCAGAACTGT
GTACCGTGGTTGATGATGGCACGATGGTCGATCGCCGAGGTTCGGTGGCGATTGATGACGAAGGTACGCCAGGCCAGTAC
AACGTGCTGATTGAGAACGGCATTCTGAAAGGCTACATGCAGGATAAACTCAACGCGCGTTTGATGGGGATGACGCCGAC
TGGCAACGGTCGCCGTGAATCCTACGCCCATCTGCCCATGCCGCGTATGACCAACACCTATATGCTGCCGGGTAAATCGA
CCCCGCAGGAAATTATTGAATCCGTTGAGTACGGTATCTATGCACCGAACTTTGGTGGCGGTCAGGTGGATATCACCTCC
GGCAAATTCGTTTTCTCCACTTCAGAAGCATATCTGATTGAAAACGGTAAAGTAACGAAGCCGGTGAAAGGCGCAACGTT
GATTGGTTCCGGTATCGAAACCATGCAGCAGATTTCGATGGTTGGCAACGACCTGAAACTGGATAACGGCGTGGGTGTCT
GCGGTAAAGAAGGGCAAAGTTTGCCGGTTGGCGTGGGCCAGCCAACGTTGAAAGTCGATAACCTGACTGTTGGCGGTACT
GCGTAA

Upstream 100 bases:

>100_bases
TACAAACCGGAACATAACCGTAGGCTGGATAGGGCGTTCACGCCGCATCCGGCAGCCGTAAAAAATCCTCTACTGCAGTA
ACTAACGAGTAGCAAAAACG

Downstream 100 bases:

>100_bases
TAATTTCACTATTTTCAGAAGGATAATTAATCTTTCTACGTGCACGAACGGTCCCCTCGCCCCTTTGGGGAGAGGGTTAG
GGTGAGGGGAACCCGTTGGC

Product: protease TldD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MSLNLVSEQLLAANGLKHQDLFAILGQLAERRLDYGDLYFQSSYHESWVLEDRIIKDGSYNIDQGVGVRAISGEKTGFAY
ADQISLLALEQSAQAARTIVRDSGDGKVQTLGAVEHSPLYTSVDPLQSMSREEKLDILRRVDKVAREADKRVQEVTASLS
GVYELILVAATDGTLAADVRPLVRLSVSVLVEEDGKRERGASGGGGRFGYEFFLADLDGEVRADAWAKEAVRMALVNLSA
VAAPAGTMPVVLGAGWPGVLLHEAVGHGLEGDFNRRGTSVFSGQVGELVASELCTVVDDGTMVDRRGSVAIDDEGTPGQY
NVLIENGILKGYMQDKLNARLMGMTPTGNGRRESYAHLPMPRMTNTYMLPGKSTPQEIIESVEYGIYAPNFGGGQVDITS
GKFVFSTSEAYLIENGKVTKPVKGATLIGSGIETMQQISMVGNDLKLDNGVGVCGKEGQSLPVGVGQPTLKVDNLTVGGT
A

Sequences:

>Translated_481_residues
MSLNLVSEQLLAANGLKHQDLFAILGQLAERRLDYGDLYFQSSYHESWVLEDRIIKDGSYNIDQGVGVRAISGEKTGFAY
ADQISLLALEQSAQAARTIVRDSGDGKVQTLGAVEHSPLYTSVDPLQSMSREEKLDILRRVDKVAREADKRVQEVTASLS
GVYELILVAATDGTLAADVRPLVRLSVSVLVEEDGKRERGASGGGGRFGYEFFLADLDGEVRADAWAKEAVRMALVNLSA
VAAPAGTMPVVLGAGWPGVLLHEAVGHGLEGDFNRRGTSVFSGQVGELVASELCTVVDDGTMVDRRGSVAIDDEGTPGQY
NVLIENGILKGYMQDKLNARLMGMTPTGNGRRESYAHLPMPRMTNTYMLPGKSTPQEIIESVEYGIYAPNFGGGQVDITS
GKFVFSTSEAYLIENGKVTKPVKGATLIGSGIETMQQISMVGNDLKLDNGVGVCGKEGQSLPVGVGQPTLKVDNLTVGGT
A
>Mature_480_residues
SLNLVSEQLLAANGLKHQDLFAILGQLAERRLDYGDLYFQSSYHESWVLEDRIIKDGSYNIDQGVGVRAISGEKTGFAYA
DQISLLALEQSAQAARTIVRDSGDGKVQTLGAVEHSPLYTSVDPLQSMSREEKLDILRRVDKVAREADKRVQEVTASLSG
VYELILVAATDGTLAADVRPLVRLSVSVLVEEDGKRERGASGGGGRFGYEFFLADLDGEVRADAWAKEAVRMALVNLSAV
AAPAGTMPVVLGAGWPGVLLHEAVGHGLEGDFNRRGTSVFSGQVGELVASELCTVVDDGTMVDRRGSVAIDDEGTPGQYN
VLIENGILKGYMQDKLNARLMGMTPTGNGRRESYAHLPMPRMTNTYMLPGKSTPQEIIESVEYGIYAPNFGGGQVDITSG
KFVFSTSEAYLIENGKVTKPVKGATLIGSGIETMQQISMVGNDLKLDNGVGVCGKEGQSLPVGVGQPTLKVDNLTVGGTA

Specific function: Suppresses the inhibitory activity of the carbon storage regulator (CsrA)

COG id: COG0312

COG function: function code R; Predicted Zn-dependent proteases and their inactivated homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase U62 family

Homologues:

Organism=Escherichia coli, GI1789640, Length=481, Percent_Identity=100, Blast_Score=974, Evalue=0.0,
Organism=Escherichia coli, GI1790682, Length=408, Percent_Identity=20.343137254902, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TLDD_ECOL6 (P0AGG9)

Other databases:

- EMBL:   AE014075
- RefSeq:   NP_755865.1
- ProteinModelPortal:   P0AGG9
- EnsemblBacteria:   EBESCT00000041718
- GeneID:   1040379
- GenomeReviews:   AE014075_GR
- KEGG:   ecc:c3999
- GeneTree:   EBGT00050000011043
- HOGENOM:   HBG726714
- OMA:   DLYFQYT
- ProtClustDB:   PRK10735
- InterPro:   IPR002510

Pfam domain/function: PF01523 PmbA_TldD

EC number: NA

Molecular weight: Translated: 51365; Mature: 51234

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNLVSEQLLAANGLKHQDLFAILGQLAERRLDYGDLYFQSSYHESWVLEDRIIKDGSY
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEHHHEECCCCC
NIDQGVGVRAISGEKTGFAYADQISLLALEQSAQAARTIVRDSGDGKVQTLGAVEHSPLY
CCCCCCCEEEECCCCCCCEECCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
TSVDPLQSMSREEKLDILRRVDKVAREADKRVQEVTASLSGVYELILVAATDGTLAADVR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHH
PLVRLSVSVLVEEDGKRERGASGGGGRFGYEFFLADLDGEVRADAWAKEAVRMALVNLSA
HHHHHEEEEEEECCCCHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
VAAPAGTMPVVLGAGWPGVLLHEAVGHGLEGDFNRRGTSVFSGQVGELVASELCTVVDDG
HCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCC
TMVDRRGSVAIDDEGTPGQYNVLIENGILKGYMQDKLNARLMGMTPTGNGRRESYAHLPM
EEEECCCCEEECCCCCCCEEEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCC
PRMTNTYMLPGKSTPQEIIESVEYGIYAPNFGGGQVDITSGKFVFSTSEAYLIENGKVTK
CCCCCEEECCCCCCHHHHHHHHHCCEECCCCCCCEEEEECCEEEEECCCEEEEECCCCCC
PVKGATLIGSGIETMQQISMVGNDLKLDNGVGVCGKEGQSLPVGVGQPTLKVDNLTVGGT
CCCCCEEECCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCEEECCEECCCC
A
C
>Mature Secondary Structure 
SLNLVSEQLLAANGLKHQDLFAILGQLAERRLDYGDLYFQSSYHESWVLEDRIIKDGSY
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEHHHEECCCCC
NIDQGVGVRAISGEKTGFAYADQISLLALEQSAQAARTIVRDSGDGKVQTLGAVEHSPLY
CCCCCCCEEEECCCCCCCEECCCEEEEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
TSVDPLQSMSREEKLDILRRVDKVAREADKRVQEVTASLSGVYELILVAATDGTLAADVR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHH
PLVRLSVSVLVEEDGKRERGASGGGGRFGYEFFLADLDGEVRADAWAKEAVRMALVNLSA
HHHHHEEEEEEECCCCHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
VAAPAGTMPVVLGAGWPGVLLHEAVGHGLEGDFNRRGTSVFSGQVGELVASELCTVVDDG
HCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCC
TMVDRRGSVAIDDEGTPGQYNVLIENGILKGYMQDKLNARLMGMTPTGNGRRESYAHLPM
EEEECCCCEEECCCCCCCEEEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCC
PRMTNTYMLPGKSTPQEIIESVEYGIYAPNFGGGQVDITSGKFVFSTSEAYLIENGKVTK
CCCCCEEECCCCCCHHHHHHHHHCCEECCCCCCCEEEEECCEEEEECCCEEEEECCCCCC
PVKGATLIGSGIETMQQISMVGNDLKLDNGVGVCGKEGQSLPVGVGQPTLKVDNLTVGGT
CCCCCEEECCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCEEECCEECCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157