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The map label for this gene is ddtA [H]

Identifier: 157162537

GI number: 157162537

Start: 3249926

End: 3250819

Strand: Direct

Name: ddtA [H]

Synonym: EcHS_A3241

Alternate gene names: 157162537

Gene position: 3249926-3250819 (Clockwise)

Preceding gene: 157162536

Following gene: 157162538

Centisome position: 69.99

GC content: 54.03

Gene sequence:

>894_bases
TTGGAGTCATTACCGAATAAGTTGACAGAGATTGTCGCTAACTTTACCGCCATGATTTCTACCCGAATGCCTGATGACGT
GGTGGATAAACTAAAACAGCTAAAGGATGCCGAAACGTCGTCGATGGGGAAAATTATCTACCATACGATGTTCGACAACA
TGCAAAAAGCGATTGACCTGAATCGTCCTGCCTGTCAGGACACCGGGGAGATTATGTTCTTCGTTAAAGTCGGTTCCCGC
TTCCCACTGCTTGGCGAGCTGCAAAGCATACTCAAACAAGCCGTGGAAGAGGCAACCGTCAAAGCGCCACTACGTCACAA
TGCGGTAGAAATTTTTGACGAAGTAAACACCGGCAAAAATACCGGTAGCGGCGTACCGTGGGTCACCTGGGACATCATCC
CCGACAATGACGATGCGGAAATCGAAGTTTACATGGCAGGCGGCGGCTGCACGCTACCTGGCCGCTCGAAAGTGTTAATG
CCGTCAGAAGGCTACGAAGGCGTGGTGAAATTCGTCTTCGAAAATATCTCCACCCTCGCCGTAAACGCCTGTCCACCGGT
ACTGGTGGGCGTGGGCATCGCCACCTCGGTGGAAACCGCCGCCGTACTCTCGCGTAAAGCCATTTTGCGCCCGATTGGCA
GCCGCCATCCCAATCCAAAAGCGGCAGAACTGGAGCTACGCCTGGAAGAAGGACTCAACCGTCTGGGGATTGGTCCACAA
GGGCTGACCGGCAACAGTTCAGTGATGGGCGTACATATCGAATCTGCCGCCCGCCATCCGTCAACCATCGGCGTTGCTGT
TTCTACCGGCTGCTGGGCGCATCGTCGCGGCACGCTGCTGGTTCATGCCGATCTCTCCTTTGAAAATCTGTCTCACACCC
GGAGCGCGTTATGA

Upstream 100 bases:

>100_bases
CTGGCACGGCTGGGACGGAAGTCGCTGTCGTTCTCAAAATCGGTGGAGCTGCATGACAAAGTCATCGGGCATTATCTGAA
CATAAAACACTATCAATAAG

Downstream 100 bases:

>100_bases
AAAAGATCCTGACAACCCCGATCAAAGCTGAAGATCTGCAAGATATTCGCGTCGGCGATGTGATCTACCTGACCGGTACG
CTGGTGACCTGCCGCGACGT

Product: tartrate dehydratase subunit alpha

Products: NA

Alternate protein names: L-TTD alpha [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MESLPNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNMQKAIDLNRPACQDTGEIMFFVKVGSR
FPLLGELQSILKQAVEEATVKAPLRHNAVEIFDEVNTGKNTGSGVPWVTWDIIPDNDDAEIEVYMAGGGCTLPGRSKVLM
PSEGYEGVVKFVFENISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNRLGIGPQ
GLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLSFENLSHTRSAL

Sequences:

>Translated_297_residues
MESLPNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNMQKAIDLNRPACQDTGEIMFFVKVGSR
FPLLGELQSILKQAVEEATVKAPLRHNAVEIFDEVNTGKNTGSGVPWVTWDIIPDNDDAEIEVYMAGGGCTLPGRSKVLM
PSEGYEGVVKFVFENISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNRLGIGPQ
GLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLSFENLSHTRSAL
>Mature_297_residues
MESLPNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNMQKAIDLNRPACQDTGEIMFFVKVGSR
FPLLGELQSILKQAVEEATVKAPLRHNAVEIFDEVNTGKNTGSGVPWVTWDIIPDNDDAEIEVYMAGGGCTLPGRSKVLM
PSEGYEGVVKFVFENISTLAVNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNRLGIGPQ
GLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLSFENLSHTRSAL

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789442, Length=292, Percent_Identity=99.6575342465753, Blast_Score=603, Evalue=1e-174,
Organism=Escherichia coli, GI1790564, Length=258, Percent_Identity=26.7441860465116, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646 [H]

Pfam domain/function: PF05681 Fumerase [H]

EC number: =4.2.1.32 [H]

Molecular weight: Translated: 32043; Mature: 32043

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLPNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNMQKAIDL
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
NRPACQDTGEIMFFVKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAVEIFDEVNTGKN
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCCCC
TGSGVPWVTWDIIPDNDDAEIEVYMAGGGCTLPGRSKVLMPSEGYEGVVKFVFENISTLA
CCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHEE
VNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNRLGIGPQ
ECCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEHHHCHHHHCCCCC
GLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLSFENLSHTRSAL
CCCCCCCEEEEEECCCCCCCCEEEEEEECCCEEECCCCEEEEECCCHHHHHHHHHCC
>Mature Secondary Structure
MESLPNKLTEIVANFTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTMFDNMQKAIDL
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
NRPACQDTGEIMFFVKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAVEIFDEVNTGKN
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCCCC
TGSGVPWVTWDIIPDNDDAEIEVYMAGGGCTLPGRSKVLMPSEGYEGVVKFVFENISTLA
CCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHEE
VNACPPVLVGVGIATSVETAAVLSRKAILRPIGSRHPNPKAAELELRLEEGLNRLGIGPQ
ECCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEHHHCHHHHCCCCC
GLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGTLLVHADLSFENLSHTRSAL
CCCCCCCEEEEEECCCCCCCCEEEEEEECCCEEECCCCEEEEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]