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The map label for this gene is yqeF [H]

Identifier: 157162297

GI number: 157162297

Start: 3002732

End: 3003913

Strand: Reverse

Name: yqeF [H]

Synonym: EcHS_A2991

Alternate gene names: 157162297

Gene position: 3003913-3002732 (Counterclockwise)

Preceding gene: 157162302

Following gene: 157162296

Centisome position: 64.69

GC content: 53.13

Gene sequence:

>1182_bases
ATGAAAGACGTTGTGATTGTCGGGGCGTTACGGACACCTATCGGCTGCTTTCGCGGTGCGTTAGCGGGTCATTCCGCCGT
GGAACTTGGTAGTCTGGTCGTGAAAGCGTTAATAGAACGTACCGGCGTTCCTGCATATGCGGTGGATGAAGTAATTCTTG
GTCAGGTGTTGACTGCAGGGGCAGGGCAGAATCCGGCAAGGCAATCGGCTATTAAAGGTGGTCTGCCTAATAGCGTTTCT
GCAATCACGATTAATGACGTCTGCGGTTCCGGACTTAAAGCACTGCATCTGGCTACTCAGGCGATACAGTGTGGCGAGGC
TGATATTGTCATCGCCGGTGGCCAGGAAAACATGAGCCGCGCACCACATGTTCTGACTGATAGCCGCACCGGTGCACAGC
TTGGCAATAGCCAGCTGGTTGACAGTCTTGTGCATGATGGGTTATGGGATGCCTTCAATGATTATCATATTGGTGTCACC
GCCGAAAATCTGGCTCGCGAATATGGCATCAGCCGTCAATTGCAGGATGCTTACGCACTTAGCTCGCAACAAAAAGCGCG
AGCGGCGATTGACGCCGGACGATTTAAAGATGAGATCGTCCCGGTAATGACCCAAAGTAACGGTCAGACGTTGGTTGTTG
ATACCGATGAACAGCCACGCACTGACGCCAGTGCAGAAGGTTTAGCCCGTTTAAATCCTTCATTTGATAGTCTCGGTTCT
GTGACAGTGGGTAATGCATCATCCATAAACGATGGCGCAGCTGCGGTAATGATGATGAGCGAAGCCAAAGCACGAGCGTT
GAATTTACCCGTGCTGGCCCGCATTCGCGCATTTGCCAGCGTTGGTGTAGATCCGGCATTGATGGGAATTGCGCCGGTGT
ATGCGACCCGCCGTTGCCTGGAGCGTGTAGGCTGGCAGTTGGCTGATGTCGATCTTATCGAGGCTAATGAAGCGTTTGCT
GCACAGGCGCTTTCGGTTGGCAAGATGCTTGAGTGGGATGAGCGTCGGGTCAATGTCAATGGTGGTGCGATCGCACTTGG
TCACCCGATAGGCGCTTCCGGTTGCCGAATCCTGGTTTCTCTGGTTCATGAAATGGTGAAACGTAATGCCCGCAAAGGAC
TGGCAACGCTTTGTATCGGCGGGGGCCAGGGTGTGGCATTGACCATTGAACGTGACGAATAG

Upstream 100 bases:

>100_bases
GCATATTTCCTTTGTGATAAAAATCACTTTTTTTAAACAATTAAGATAACTGTAATTAACAATCATTTACTATTGCACTG
TTAATTGGTGCGAGGTTGTG

Downstream 100 bases:

>100_bases
CTCTGCATTTCCTCCTTACCGATAAATATCTGCCGTCATTAATCTGTTGAATAATGATGGCTGGCAAGTCGACATACATT
TTCTGGGCTCCCTCATTTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAGAGQNPARQSAIKGGLPNSVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRQLQDAYALSSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
VTVGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRNARKGLATLCIGGGQGVALTIERDE

Sequences:

>Translated_393_residues
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAGAGQNPARQSAIKGGLPNSVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRQLQDAYALSSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
VTVGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRNARKGLATLCIGGGQGVALTIERDE
>Mature_393_residues
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAGAGQNPARQSAIKGGLPNSVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRQLQDAYALSSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
VTVGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRNARKGLATLCIGGGQGVALTIERDE

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=48.849104859335, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=44.1624365482233, Blast_Score=324, Evalue=7e-89,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=42.5692695214106, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=38.1313131313131, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=31.1627906976744, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=28.5353535353535, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=99.4910941475827, Blast_Score=789, Evalue=0.0,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=57.9081632653061, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=44, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=40.8977556109726, Blast_Score=261, Evalue=8e-71,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=32.3529411764706, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=43.9897698209719, Blast_Score=317, Evalue=9e-87,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=41.2820512820513, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=40.3061224489796, Blast_Score=271, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=33.6734693877551, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=29.81220657277, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=40.9547738693467, Blast_Score=283, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.1212121212121, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=50.8951406649616, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=41.7948717948718, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=41.6879795396419, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=31.0747663551402, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41033; Mature: 41033

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPNSVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRQLQDAYAL
CCCEEECCCCCHHCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCHHHHHHHHHH
SSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
HHHHHHHHHHHHHCCHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHCCCCCCCCCC
VTVGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCL
EEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERVGWQLADVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHHCCEEECEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRNARKGLATLCIGGGQGVALTIERDE
HHHHHHHHHHHCCEEEEEEECCCEEEEEEECCC
>Mature Secondary Structure
MKDVVIVGALRTPIGCFRGALAGHSAVELGSLVVKALIERTGVPAYAVDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPNSVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRQLQDAYAL
CCCEEECCCCCHHCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCHHHHHHHHHH
SSQQKARAAIDAGRFKDEIVPVMTQSNGQTLVVDTDEQPRTDASAEGLARLNPSFDSLGS
HHHHHHHHHHHHHCCHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCHHHCCCCCCCCCC
VTVGNASSINDGAAAVMMMSEAKARALNLPVLARIRAFASVGVDPALMGIAPVYATRRCL
EEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERVGWQLADVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHHCCEEECEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRNARKGLATLCIGGGQGVALTIERDE
HHHHHHHHHHHCCEEEEEEECCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]