| Definition | Escherichia coli HS, complete genome. |
|---|---|
| Accession | NC_009800 |
| Length | 4,643,538 |
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The map label for this gene is kduD
Identifier: 157162295
GI number: 157162295
Start: 3000818
End: 3001579
Strand: Reverse
Name: kduD
Synonym: EcHS_A2989
Alternate gene names: 157162295
Gene position: 3001579-3000818 (Counterclockwise)
Preceding gene: 157162296
Following gene: 157162294
Centisome position: 64.64
GC content: 51.97
Gene sequence:
>762_bases ATGATTTTAAGTGCATTTTCTCTCGAAGGTAAAGTTGCGGTCGTCACTGGTTGTGATACTGGACTGGGTCAGGGGATGGC GTTGGGGCTGGCGCAAGCGGGCTGTGACATTGTTGGCATTAACATCGTTGAACCGACTGAAACCATCGAGCAGGTCACAG CGCTGGGGCGTCGTTTTTTAAGCCTGACCGCCGATCTGCGAAAGATTGATGGTATTCCAGCACTGCTGGATCGCGCGGTA GCGGAGTTTGGTCATATTGATATCCTGGTGAATAACGCCGGATTGATTCGCCGCGAAGATGCTCTCGAGTTCAGCGAAAA GGACTGGGACGATGTCATGAACCTGAATATCAAGAGCGTATTCTTCATGTCTCAGGCAGCGGCGAAACACTTTATCGCGC AAGGCAATGGCGGCAAGATTATCAATATCGCGTCAATGCTCTCCTTCCAGGGCGGGATCCGTGTGCCTTCTTATACCGCA TCAAAAAGCGGCGTGATGGGTGTGACGCGATTGATGGCGAACGAATGGGCTAAACACAACATTAATGTTAATGCGATAGC CCCGGGTTACATGGCGACCAACAATACTCAACAACTACGGGCAGATGAACAACGTAGCGCGGAAATTCTCGACCGCATTC CAGCTGGTCGTTGGGGACTGCCGAGTGACCTGATGGGGCCGATAGTGTTCCTTGCCTCCAGCGCTTCAGATTATGTGAAT GGTTATACCATTGCCGTGGATGGCGGTTGGCTGGCGCGTTAA
Upstream 100 bases:
>100_bases TCTGGGGCATGGTTGGTGAAAACCAGGTCTTTGATGATATGGACCATGTGGCCGTTAAAGATTTGCGCTAGTTGTGGGCA TAAACGAATAAGGTATTGTT
Downstream 100 bases:
>100_bases TTCATTCTTCTTACTTTTATGACCCTGCCGCATGGCAGGGTTTTTTATACCTGTAGATCATCATAATCCATATCATGGTT ATGAAATAATCCATATTAAT
Product: 2-deoxy-D-gluconate 3-dehydrogenase
Products: NA
Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase
Number of amino acids: Translated: 253; Mature: 253
Protein sequence:
>253_residues MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPALLDRAV AEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVN GYTIAVDGGWLAR
Sequences:
>Translated_253_residues MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPALLDRAV AEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVN GYTIAVDGGWLAR >Mature_253_residues MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFLSLTADLRKIDGIPALLDRAV AEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGVTRLMANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVN GYTIAVDGGWLAR
Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family
Homologues:
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=31.8897637795276, Blast_Score=134, Evalue=1e-31, Organism=Homo sapiens, GI66933014, Length=249, Percent_Identity=31.3253012048193, Blast_Score=115, Evalue=5e-26, Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=29.5275590551181, Blast_Score=111, Evalue=6e-25, Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=30.4, Blast_Score=110, Evalue=1e-24, Organism=Homo sapiens, GI10190704, Length=251, Percent_Identity=31.4741035856574, Blast_Score=105, Evalue=4e-23, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=27.2373540856031, Blast_Score=104, Evalue=6e-23, Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=30.4878048780488, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI4504505, Length=261, Percent_Identity=26.8199233716475, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=28.8537549407115, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=27.7551020408163, Blast_Score=89, Evalue=5e-18, Organism=Homo sapiens, GI4503301, Length=253, Percent_Identity=29.2490118577075, Blast_Score=85, Evalue=6e-17, Organism=Homo sapiens, GI31542939, Length=205, Percent_Identity=28.780487804878, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI40254986, Length=199, Percent_Identity=29.6482412060301, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI59889578, Length=191, Percent_Identity=27.7486910994764, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI4758504, Length=261, Percent_Identity=27.9693486590038, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=26.0204081632653, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI209862901, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI19923983, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI109715829, Length=242, Percent_Identity=25.2066115702479, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI224922801, Length=172, Percent_Identity=29.6511627906977, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI20149619, Length=211, Percent_Identity=29.3838862559242, Blast_Score=65, Evalue=6e-11, Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=100, Blast_Score=516, Evalue=1e-148, Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=43.7007874015748, Blast_Score=199, Evalue=1e-52, Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=41.9354838709677, Blast_Score=180, Evalue=8e-47, Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=34.9593495934959, Blast_Score=145, Evalue=2e-36, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=34.2857142857143, Blast_Score=134, Evalue=6e-33, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=32.8063241106719, Blast_Score=120, Evalue=6e-29, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=32.3770491803279, Blast_Score=107, Evalue=7e-25, Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=28, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=26.6129032258064, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=27.7551020408163, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=26.4591439688716, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI2367365, Length=176, Percent_Identity=28.9772727272727, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1787526, Length=192, Percent_Identity=26.5625, Blast_Score=65, Evalue=6e-12, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=32.6530612244898, Blast_Score=125, Evalue=3e-29, Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=31.3008130081301, Blast_Score=122, Evalue=2e-28, Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=33.9920948616601, Blast_Score=120, Evalue=5e-28, Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=29.4820717131474, Blast_Score=114, Evalue=4e-26, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=31.7647058823529, Blast_Score=114, Evalue=4e-26, Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=31.9066147859922, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=31.1740890688259, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI17562910, Length=257, Percent_Identity=30.3501945525292, Blast_Score=105, Evalue=3e-23, Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=26.7206477732794, Blast_Score=102, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=30.5660377358491, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=29.3893129770992, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=30, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=30.0751879699248, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=31.1538461538462, Blast_Score=98, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=30.0751879699248, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=29.8449612403101, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=29.0076335877863, Blast_Score=96, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=28.735632183908, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=30.0380228136882, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=28.4090909090909, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=28.6458333333333, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=30.6201550387597, Blast_Score=90, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=28.735632183908, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17565030, Length=258, Percent_Identity=31.3953488372093, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=27.906976744186, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17536025, Length=255, Percent_Identity=27.0588235294118, Blast_Score=86, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17538486, Length=260, Percent_Identity=29.6153846153846, Blast_Score=85, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17564282, Length=200, Percent_Identity=28.5, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17561272, Length=253, Percent_Identity=29.2490118577075, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=25.5813953488372, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=29.2307692307692, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=29.5336787564767, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=29.1338582677165, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17555612, Length=222, Percent_Identity=28.8288288288288, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI71982365, Length=190, Percent_Identity=27.3684210526316, Blast_Score=70, Evalue=8e-13, Organism=Caenorhabditis elegans, GI32563809, Length=217, Percent_Identity=24.4239631336406, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17507613, Length=217, Percent_Identity=24.4239631336406, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17508651, Length=254, Percent_Identity=25.5905511811024, Blast_Score=65, Evalue=3e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=198, Percent_Identity=30.3030303030303, Blast_Score=88, Evalue=2e-18, Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=25.6, Blast_Score=72, Evalue=8e-14, Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=5e-32, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=30.8300395256917, Blast_Score=111, Evalue=5e-25, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=28.9156626506024, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=31.2252964426877, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=28.8, Blast_Score=108, Evalue=4e-24, Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=29.0983606557377, Blast_Score=98, Evalue=5e-21, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=26.7716535433071, Blast_Score=94, Evalue=9e-20, Organism=Drosophila melanogaster, GI18859837, Length=258, Percent_Identity=31.3953488372093, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI24644337, Length=206, Percent_Identity=27.6699029126214, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI21358495, Length=201, Percent_Identity=28.8557213930348, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI24649181, Length=198, Percent_Identity=29.7979797979798, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=28.4046692607004, Blast_Score=77, Evalue=9e-15, Organism=Drosophila melanogaster, GI21357673, Length=192, Percent_Identity=28.6458333333333, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI24665243, Length=223, Percent_Identity=27.8026905829596, Blast_Score=74, Evalue=7e-14, Organism=Drosophila melanogaster, GI221331218, Length=220, Percent_Identity=28.1818181818182, Blast_Score=74, Evalue=8e-14, Organism=Drosophila melanogaster, GI24665247, Length=226, Percent_Identity=27.8761061946903, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI221331216, Length=223, Percent_Identity=28.2511210762332, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24640492, Length=214, Percent_Identity=26.6355140186916, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24580925, Length=201, Percent_Identity=26.865671641791, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24648944, Length=201, Percent_Identity=29.3532338308458, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24584748, Length=196, Percent_Identity=29.0816326530612, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI161076933, Length=196, Percent_Identity=29.0816326530612, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI281364892, Length=171, Percent_Identity=28.6549707602339, Blast_Score=68, Evalue=5e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): KDUD_ECOLI (P37769)
Other databases:
- EMBL: U29581 - EMBL: U00096 - EMBL: AP009048 - EMBL: J03732 - PIR: C65067 - RefSeq: AP_003405.1 - RefSeq: NP_417319.1 - ProteinModelPortal: P37769 - SMR: P37769 - STRING: P37769 - EnsemblBacteria: EBESCT00000002903 - EnsemblBacteria: EBESCT00000014280 - GeneID: 947323 - GenomeReviews: AP009048_GR - GenomeReviews: U00096_GR - KEGG: ecj:JW2810 - KEGG: eco:b2842 - EchoBASE: EB2264 - EcoGene: EG12361 - eggNOG: COG1028 - GeneTree: EBGT00050000009181 - HOGENOM: HBG750976 - OMA: TIERVTA - ProtClustDB: PRK08993 - BioCyc: EcoCyc:KDUD-MONOMER - Genevestigator: P37769 - InterPro: IPR011286 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 - Gene3D: G3DSA:3.40.50.720 - PANTHER: PTHR19410 - PRINTS: PR00081 - PRINTS: PR00080 - TIGRFAMs: TIGR01832
Pfam domain/function: PF00106 adh_short
EC number: =1.1.1.127
Molecular weight: Translated: 27070; Mature: 27070
Theoretical pI: Translated: 5.06; Mature: 5.06
Prosite motif: PS00061 ADH_SHORT
Important sites: ACT_SITE 158-158 BINDING 145-145
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.6 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFL CEEEEEECCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRKIDGIPALLDRAVAEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSV HHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCEEECCHHCCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHN HHHHHHHHHHHEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVN CCEEEECCCEEECCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHC GYTIAVDGGWLAR CEEEEECCCEECC >Mature Secondary Structure MILSAFSLEGKVAVVTGCDTGLGQGMALGLAQAGCDIVGINIVEPTETIEQVTALGRRFL CEEEEEECCCCEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRKIDGIPALLDRAVAEFGHIDILVNNAGLIRREDALEFSEKDWDDVMNLNIKSV HHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCEEECCHHCCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGVTRLMANEWAKHN HHHHHHHHHHHEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMATNNTQQLRADEQRSAEILDRIPAGRWGLPSDLMGPIVFLASSASDYVN CCEEEECCCEEECCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHC GYTIAVDGGWLAR CEEEEECCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9278503; 2836407; 1766386