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The map label for this gene is yphC [H]

Identifier: 157162020

GI number: 157162020

Start: 2712257

End: 2713351

Strand: Reverse

Name: yphC [H]

Synonym: EcHS_A2697

Alternate gene names: 157162020

Gene position: 2713351-2712257 (Counterclockwise)

Preceding gene: 157162021

Following gene: 157162019

Centisome position: 58.43

GC content: 54.61

Gene sequence:

>1095_bases
ATGAAAATTAATCGTATTGTTAATGAGGGATTTATGAAAACGATGCTGGCAGCTTATTTACCAGGAAATTCGACCGTCGA
TCTACGGGAAGTTGCGGTGCCGACACCAGGGATTAACCAGGTACTGATCAAAATGAAATCTTCCGGAATTTGCGGAAGCG
ATGTCCACTATATCTACCACCAGCACCGCGCTACGGCAGCGGCACCCGACAAACCGTTATACCAAGGATTTATCAACGGT
CATGAACCGTGCGGGCAGATTGTGGCGATGGGGCAAGGCTGCCGCCATTTTAAAGAGGGCGACCGCGTGCTGGTGTATCA
CATTTCTGGCTGTGGTTTTTGCCCGAACTGCCGCCGCGGCTTTCCTATCTCTTGTACTGGCAAAGGAAAAGCGGCTTACG
GCTGGCAGCGTGACGGCGGTCATGCCGAATATCTGCTGGCGGAAGAAAAAGATCTGATCCTCCTGCCGGATGCGCTGAGC
TACGAAGATGGTGCGTTTATCAGTTGCGGCGTTGGCACGGCCTATGAAGGGATTTTGCGCGGCGAAGTTTCCGGCAGCGA
TAACGTGCTGGTGGTCGGTCTGGGGCCGGTCGGCATGATGGCGATGATGCTGGCGAAAGGTCGCGGTGCAAAACGGATCA
TCGGCGTTGATATGCTGCCGGAACGTCTGGCGATGGCAAAACAGTTAGGGGTGATGGATCACGGCTATTTAGCAACCACC
GAAGGTCTGCCGCAGATTATCGCCGAACTCACCCACGGTGGCGCGGATGTTGCGCTCGATTGTTCCGGTAATGCCGCAGG
TCGCTTGCTGGCACTGCAATCCACCGCTGACTGGGGACGGGTGGTTTACATTGGTGAAACCGGAAAAGTGGAATTCGAGG
TCAGCGCCGATCTGATGCACCATCAACGGCGGATTATCGGCTCCTGGGTGACCAGTCTGTTCCATATGGAAAAATGCGCC
CATGATCTGACGGACTGGAAGCTGTGGCCGCGTAACGCCATTACCCATCGCTTCTCGCTGGAACAGGCAGGTGATGCCTA
TGCGCTGATGGCGAGCGGCAAATGCGGGAAAGTTGTGATTAACTTCCCGGATTAA

Upstream 100 bases:

>100_bases
TCATCATCGTGGTGGCGGTGCTGGCGAATATCTTGCTGACCCAGCGAAGCAGTAAAGCGAAACGCTAAACCTTAACGCCC
CTGGCGCGGGTGCGGCAGGG

Downstream 100 bases:

>100_bases
GGAGTTAGCGGATGACCATCTATACCTTATCCCACGGGTCGCTAAAGCTGGACGTTTCTGACCAGGGCGGCGTAATCGAA
GGCTTCTGGCGCGATACGAC

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKINRIVNEGFMKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFING
HEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGKGKAAYGWQRDGGHAEYLLAEEKDLILLPDALS
YEDGAFISCGVGTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATT
EGLPQIIAELTHGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCA
HDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVINFPD

Sequences:

>Translated_364_residues
MKINRIVNEGFMKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFING
HEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGKGKAAYGWQRDGGHAEYLLAEEKDLILLPDALS
YEDGAFISCGVGTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATT
EGLPQIIAELTHGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCA
HDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVINFPD
>Mature_364_residues
MKINRIVNEGFMKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFING
HEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGKGKAAYGWQRDGGHAEYLLAEEKDLILLPDALS
YEDGAFISCGVGTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATT
EGLPQIIAELTHGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCA
HDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVINFPD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=365, Percent_Identity=26.8493150684932, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=27.2222222222222, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI4501939, Length=354, Percent_Identity=27.4011299435028, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI156627571, Length=371, Percent_Identity=27.2237196765499, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI262073058, Length=384, Percent_Identity=23.6979166666667, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71743840, Length=363, Percent_Identity=23.9669421487603, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501929, Length=365, Percent_Identity=25.2054794520548, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=24.9322493224932, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI34577061, Length=365, Percent_Identity=25.2054794520548, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI71565154, Length=364, Percent_Identity=24.1758241758242, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI194239674, Length=368, Percent_Identity=26.3586956521739, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI13236495, Length=368, Percent_Identity=26.3586956521739, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=99.7167138810198, Blast_Score=729, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=31.6860465116279, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1787863, Length=366, Percent_Identity=28.9617486338798, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788407, Length=337, Percent_Identity=28.486646884273, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788073, Length=268, Percent_Identity=31.3432835820896, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI226510992, Length=324, Percent_Identity=25.6172839506173, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=27.4725274725275, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786825, Length=261, Percent_Identity=27.9693486590038, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786552, Length=386, Percent_Identity=25.9067357512953, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081918, Length=350, Percent_Identity=26.5714285714286, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=256, Percent_Identity=26.953125, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=274, Percent_Identity=32.4817518248175, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17562878, Length=251, Percent_Identity=29.8804780876494, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=23.5772357723577, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=374, Percent_Identity=23.2620320855615, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=24.633431085044, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=349, Percent_Identity=26.647564469914, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=307, Percent_Identity=24.7557003257329, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=24.9275362318841, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=342, Percent_Identity=28.0701754385965, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322619, Length=342, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=348, Percent_Identity=26.4367816091954, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=383, Percent_Identity=23.2375979112272, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=359, Percent_Identity=25.0696378830084, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=29.4339622641509, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=259, Percent_Identity=25.0965250965251, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=297, Percent_Identity=24.2424242424242, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=25.9927797833935, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=201, Percent_Identity=25.3731343283582, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=25.4794520547945, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137530, Length=266, Percent_Identity=30.8270676691729, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17737897, Length=267, Percent_Identity=29.5880149812734, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI221457811, Length=336, Percent_Identity=23.2142857142857, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550770, Length=336, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551930, Length=336, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 39353; Mature: 39353

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINRIVNEGFMKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYH
CCCHHHHHHHHHHHHHHHHCCCCCCEEHHEEECCCCCCCCEEEEEECCCCCCCCHHHHHH
QHRATAAAPDKPLYQGFINGHEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRG
HHCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCCCCCCC
FPISCTGKGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGVGTAYEGILR
CCEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCEEEECCCHHHHHEEE
GEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATT
EECCCCCCEEEEEECHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEC
EGLPQIIAELTHGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMH
CCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECHHHHH
HQRRIIGSWVTSLFHMEKCAHDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVI
HHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHEEEEEHHHCCCEEEEEECCCCCEEEE
NFPD
ECCC
>Mature Secondary Structure
MKINRIVNEGFMKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYH
CCCHHHHHHHHHHHHHHHHCCCCCCEEHHEEECCCCCCCCEEEEEECCCCCCCCHHHHHH
QHRATAAAPDKPLYQGFINGHEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRG
HHCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCCCCCCC
FPISCTGKGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGVGTAYEGILR
CCEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCEEEECCCHHHHHEEE
GEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATT
EECCCCCCEEEEEECHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEC
EGLPQIIAELTHGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMH
CCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECHHHHH
HQRRIIGSWVTSLFHMEKCAHDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVI
HHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHEEEEEHHHCCCEEEEEECCCCCEEEE
NFPD
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]