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The map label for this gene is dsdX

Identifier: 157161838

GI number: 157161838

Start: 2509252

End: 2510589

Strand: Direct

Name: dsdX

Synonym: EcHS_A2502

Alternate gene names: 157161838

Gene position: 2509252-2510589 (Clockwise)

Preceding gene: 157161836

Following gene: 157161839

Centisome position: 54.04

GC content: 48.73

Gene sequence:

>1338_bases
ATGCACTCTCAAATCTGGGTTGTGAGCACGCTGCTTATCAGCATCGTGTTAATTGTACTGACCATCGTGAAGTTCAAATT
CCACCCGTTTCTGGCGCTGTTGCTGGCCAGCTTCTTCGTGGGAACGATGATGGGCATGGGGCCACTGGATATGGTAAATG
CTATTGAAAGTGGAATTGGCGGAACGCTGGGGTTCCTCGCAGCGGTTATCGGCCTTGGCACGATACTGGGAAAAATGATG
GAAGTATCCGGGGCCGCAGAAAGAATTGGTCTGACACTTCAACGCTGCCGCTGGCTTTCAGTTGATGTCATTATGGTGCT
GGTTGGCCTGATTTGTGGCATCACGCTGTTTGTTGAAGTGGGCGTCGTGCTATTGATTCCTCTGGCTTTTTCAATTGCCA
AAAAAACCAATACCTCATTATTAAAGCTTGCCATTCCGCTATGTACCGCATTGATGGCAGTGCACTGCGTGGTTCCTCCA
CATCCGGCTGCTTTATATGTTGCCAATAAGCTGGGCGCAGATATCGGTTCGGTGATCGTCTACGGTTTGCTGGTTGGGCT
GATGGCATCACTGATCGGTGGCCCACTTTTCCTTAAATTTCTGGGTCAACGACTGCCCTTTAAACCTGTACCCACAGAGT
TTGCAGATCTCAAAGTTCGCGATGAAAAAACACTACCGTCATTAGGCGCAACGTTATTCACCATACTGCTACCCATTGCG
CTGATGTTGGTTAAAACGATTGCCGAATTGAATATGGCGCGTGAGAGTGGTTTGTATATCTTGGTTGAGTTTATTGGCAA
CCCTATCACTGCCATGTTTATCGCCGTGTTTGTCGCCTATTATGTGTTGGGTATACGCCAGCATATGAGCATGGGGACGA
TGCTCACACATACGGAAAATGGCTTCGGTTCTATTGCTAATATTTTGCTGATTATCGGGGCCGGAGGCGCATTCAACGCC
ATTTTAAAAAGCAGCAGTCTCGCTGATACGCTGGCAGTTATTCTCTCCAATATGCATATGCACCCGATTCTTCTGGCCTG
GTTAGTGGCTCTTATTCTGCATGCGGCAGTGGGCTCCGCTACCGTGGCAATGATGGGGGCAACGGCAATTGTTGCACCCA
TGCTGCCGCTTTATCCCGACATCAGCCCGGAAATTATTGCGATTGCTATCGGTTCAGGTGCAATTGGCTGCACGATCGTT
ACGGACTCGCTTTTCTGGCTAGTGAAGCAATATTGCGGCGCTACGCTCAATGAAACATTTAAATACTATACGACAGCGAC
ATTTATCGCTTCAGTCGTCGCTCTGGCGGGCACATTCCTGCTGTCATTTATCATCTAA

Upstream 100 bases:

>100_bases
GATGCAATTTACCTCATGTGAAAGGCAAATTTTATCGTTTGTCAGCCTGCGTTGTTTTTTTGTCCAATATCATCAGGTTA
ATCACAGGGGAAGGTGAGAT

Downstream 100 bases:

>100_bases
GCGCAAAGAGACGTACTATGGAAAACGCTAAAATGAACTCGCTCATCGCCCAGTATCCGTTGGTAAAGGATCTGGTTGCT
CTTAAAGAAACCACCTGGTT

Product: permease DsdX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MHSQIWVVSTLLISIVLIVLTIVKFKFHPFLALLLASFFVGTMMGMGPLDMVNAIESGIGGTLGFLAAVIGLGTILGKMM
EVSGAAERIGLTLQRCRWLSVDVIMVLVGLICGITLFVEVGVVLLIPLAFSIAKKTNTSLLKLAIPLCTALMAVHCVVPP
HPAALYVANKLGADIGSVIVYGLLVGLMASLIGGPLFLKFLGQRLPFKPVPTEFADLKVRDEKTLPSLGATLFTILLPIA
LMLVKTIAELNMARESGLYILVEFIGNPITAMFIAVFVAYYVLGIRQHMSMGTMLTHTENGFGSIANILLIIGAGGAFNA
ILKSSSLADTLAVILSNMHMHPILLAWLVALILHAAVGSATVAMMGATAIVAPMLPLYPDISPEIIAIAIGSGAIGCTIV
TDSLFWLVKQYCGATLNETFKYYTTATFIASVVALAGTFLLSFII

Sequences:

>Translated_445_residues
MHSQIWVVSTLLISIVLIVLTIVKFKFHPFLALLLASFFVGTMMGMGPLDMVNAIESGIGGTLGFLAAVIGLGTILGKMM
EVSGAAERIGLTLQRCRWLSVDVIMVLVGLICGITLFVEVGVVLLIPLAFSIAKKTNTSLLKLAIPLCTALMAVHCVVPP
HPAALYVANKLGADIGSVIVYGLLVGLMASLIGGPLFLKFLGQRLPFKPVPTEFADLKVRDEKTLPSLGATLFTILLPIA
LMLVKTIAELNMARESGLYILVEFIGNPITAMFIAVFVAYYVLGIRQHMSMGTMLTHTENGFGSIANILLIIGAGGAFNA
ILKSSSLADTLAVILSNMHMHPILLAWLVALILHAAVGSATVAMMGATAIVAPMLPLYPDISPEIIAIAIGSGAIGCTIV
TDSLFWLVKQYCGATLNETFKYYTTATFIASVVALAGTFLLSFII
>Mature_445_residues
MHSQIWVVSTLLISIVLIVLTIVKFKFHPFLALLLASFFVGTMMGMGPLDMVNAIESGIGGTLGFLAAVIGLGTILGKMM
EVSGAAERIGLTLQRCRWLSVDVIMVLVGLICGITLFVEVGVVLLIPLAFSIAKKTNTSLLKLAIPLCTALMAVHCVVPP
HPAALYVANKLGADIGSVIVYGLLVGLMASLIGGPLFLKFLGQRLPFKPVPTEFADLKVRDEKTLPSLGATLFTILLPIA
LMLVKTIAELNMARESGLYILVEFIGNPITAMFIAVFVAYYVLGIRQHMSMGTMLTHTENGFGSIANILLIIGAGGAFNA
ILKSSSLADTLAVILSNMHMHPILLAWLVALILHAAVGSATVAMMGATAIVAPMLPLYPDISPEIIAIAIGSGAIGCTIV
TDSLFWLVKQYCGATLNETFKYYTTATFIASVVALAGTFLLSFII

Specific function: Probable permease for an unknown substrate

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family

Homologues:

Organism=Escherichia coli, GI1788707, Length=445, Percent_Identity=100, Blast_Score=875, Evalue=0.0,
Organism=Escherichia coli, GI48994935, Length=440, Percent_Identity=36.8181818181818, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1790716, Length=430, Percent_Identity=32.5581395348837, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1790776, Length=446, Percent_Identity=31.8385650224215, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI2367370, Length=417, Percent_Identity=34.052757793765, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI48994939, Length=429, Percent_Identity=35.4312354312354, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1789097, Length=434, Percent_Identity=29.2626728110599, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DSDX_ECOLI (P08555)

Other databases:

- EMBL:   X91821
- EMBL:   X86379
- EMBL:   J01603
- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   M19035
- EMBL:   X81461
- PIR:   S54140
- RefSeq:   AP_002965.1
- RefSeq:   NP_416866.1
- ProteinModelPortal:   P08555
- DIP:   DIP-9481N
- MINT:   MINT-1235614
- STRING:   P08555
- EnsemblBacteria:   EBESCT00000002510
- EnsemblBacteria:   EBESCT00000017219
- GeneID:   949103
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2362
- KEGG:   eco:b2365
- EchoBASE:   EB0246
- EcoGene:   EG10250
- eggNOG:   COG2610
- GeneTree:   EBGT00050000009137
- HOGENOM:   HBG649941
- OMA:   MEISGAA
- ProtClustDB:   PRK09921
- BioCyc:   EcoCyc:DSDX-MONOMER
- Genevestigator:   P08555
- InterPro:   IPR003474
- TIGRFAMs:   TIGR00791

Pfam domain/function: PF02447 GntP_permease

EC number: NA

Molecular weight: Translated: 47164; Mature: 47164

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14c9022c)-; HASH(0x162ad2e0)-; HASH(0x123a809c)-; HASH(0x15c2b2c8)-; HASH(0x15e99bf4)-; HASH(0x131a9b94)-; HASH(0x1658dfd8)-; HASH(0x157b0d3c)-; HASH(0x1629b2fc)-; HASH(0x15fe29cc)-; HASH(0xd3ed62c)-; HASH(0x15e9faac)-; HASH(0x15fbd0f0)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSQIWVVSTLLISIVLIVLTIVKFKFHPFLALLLASFFVGTMMGMGPLDMVNAIESGIG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
GTLGFLAAVIGLGTILGKMMEVSGAAERIGLTLQRCRWLSVDVIMVLVGLICGITLFVEV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVLLIPLAFSIAKKTNTSLLKLAIPLCTALMAVHCVVPPHPAALYVANKLGADIGSVIV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHH
YGLLVGLMASLIGGPLFLKFLGQRLPFKPVPTEFADLKVRDEKTLPSLGATLFTILLPIA
HHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCHHCCEECCCCCCHHHHHHHHHHHHHHH
LMLVKTIAELNMARESGLYILVEFIGNPITAMFIAVFVAYYVLGIRQHMSMGTMLTHTEN
HHHHHHHHHHHHHHHCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCC
GFGSIANILLIIGAGGAFNAILKSSSLADTLAVILSNMHMHPILLAWLVALILHAAVGSA
CHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
TVAMMGATAIVAPMLPLYPDISPEIIAIAIGSGAIGCTIVTDSLFWLVKQYCGATLNETF
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
KYYTTATFIASVVALAGTFLLSFII
HHHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7592420; 3275618; 9205837; 9278503; 3029015; 1659648; 12218016