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The map label for this gene is dsdC [H]

Identifier: 157161837

GI number: 157161837

Start: 2508099

End: 2509034

Strand: Reverse

Name: dsdC [H]

Synonym: EcHS_A2501

Alternate gene names: 157161837

Gene position: 2509034-2508099 (Counterclockwise)

Preceding gene: 157161840

Following gene: 157161835

Centisome position: 54.03

GC content: 48.08

Gene sequence:

>936_bases
ATGGAACCCCTTCGTGAAATAAGAAATCGGCTGCTTAACGGCTGGCAATTATCAAAAATGCATACTTTTGAAGTGGCTGC
CAGGCATCAGTCCTTCGCCCTGGCGGCAGAGGAATTGTCGCTGAGCCCCAGTGCGGTAAGTCACCGTATCAATCAGCTGG
AAGAAGAATTGGGCATTCAGTTGTTTGTTCGTTCCCATCGCAAAGTGGAATTAACGCACGAGGGGAAACGTGTTTATTGG
GCGCTAAAATCGTCGCTGGATACCCTGAACCAGGAAATTCTTGATATCAAAAATCAGGAGTTATCGGGAACGTTAACTCT
GTATTCCCGGCCCTCTATCGCCCAATGCTGGTTGGTGCCCGCATTAGGTGACTTTACACGCCGGTATCCGTCTATTTCGC
TCACCGTGCTCACTGGTAATGACAACGTCAATCTGCAACGTGCCGGAATCGATTTGGCGATCTACTTTGATGATGCGCCG
TCAGCGCAACTCACTCATCACTTTCTGATGGATGAAGAAATCCTGCCAGTATGTAGCTCGGAATACGCTCAAAGACATGC
TTTAACCAACACGGTAATTAACCTGTGTCACTGTACGTTGCTCCATGACAGACAGGCATGGAGCAACGACTCCGGTACGG
ATGAATGGCATAGTTGGGCGCAACATTATGCGGTTAATTTGCCGACATCTTCTGGAATTGGCTTTGATCGTTCTGATTTA
GCTGTTATTGCCGCGATGAATCATATTGGGGTGGCGATGGGAAGAAAACGCCTGGTACAAAAAAGGCTTGCCAGTGGTGA
GCTCGTCGCGCCGTTTGGCGATATGACGGTGAAATGCCATCAGCATTATTACATCACCACATTACCGGGCAGGCAGTGGC
CAAAAATTGAAGCGTTTATTACCTGGCTAAGAGAACAGGTAAAAACCACTTCATAA

Upstream 100 bases:

>100_bases
CTAAAAATGAAGGTGAATTGAGATATGGTTCACTTTAGCTCATCTCATAGCTGAAATTTTGCCGCTATTTTTTTACACTT
AAGCGAAAAATGAGGTGATT

Downstream 100 bases:

>100_bases
TGAATAAAACCACGAGTTCCTGGTGTGCCTTATTCGGCCTGCTAGTTCGAATTTAATTTACGGTTTTTATGTGGTTTTAG
GGATAAACACAAGGATGGTG

Product: DNA-binding transcriptional regulator DsdC

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MEPLREIRNRLLNGWQLSKMHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYW
ALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAP
SAQLTHHFLMDEEILPVCSSEYAQRHALTNTVINLCHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVKTTS

Sequences:

>Translated_311_residues
MEPLREIRNRLLNGWQLSKMHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYW
ALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAP
SAQLTHHFLMDEEILPVCSSEYAQRHALTNTVINLCHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVKTTS
>Mature_311_residues
MEPLREIRNRLLNGWQLSKMHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQLFVRSHRKVELTHEGKRVYW
ALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVPALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAP
SAQLTHHFLMDEEILPVCSSEYAQRHALTNTVINLCHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFITWLREQVKTTS

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=311, Percent_Identity=99.3569131832797, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1786448, Length=298, Percent_Identity=32.8859060402685, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789173, Length=288, Percent_Identity=30.9027777777778, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1786401, Length=298, Percent_Identity=25.8389261744966, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787128, Length=140, Percent_Identity=35.7142857142857, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693105, Length=172, Percent_Identity=27.3255813953488, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081978, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788748, Length=174, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI145693193, Length=143, Percent_Identity=33.5664335664336, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790208, Length=143, Percent_Identity=31.4685314685315, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI157672245, Length=172, Percent_Identity=33.1395348837209, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789440, Length=183, Percent_Identity=27.8688524590164, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787589, Length=248, Percent_Identity=27.0161290322581, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789639, Length=141, Percent_Identity=29.7872340425532, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35311; Mature: 35311

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPLREIRNRLLNGWQLSKMHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQ
CCHHHHHHHHHCCCEEECCEEHHHHHHHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHCCE
LFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVP
EEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEEEH
ALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLTHHFLMDEEILPVCSS
HHHHHHHHCCCEEEEEEECCCCCEEEECCEEEEEEECCCCCHHHHHHHHCCCCHHHHHHH
EYAQRHALTNTVINLCHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
HHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCCCC
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFI
EEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECEEEEEECCCCCCCHHHHHH
TWLREQVKTTS
HHHHHHHHCCC
>Mature Secondary Structure
MEPLREIRNRLLNGWQLSKMHTFEVAARHQSFALAAEELSLSPSAVSHRINQLEEELGIQ
CCHHHHHHHHHCCCEEECCEEHHHHHHHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHCCE
LFVRSHRKVELTHEGKRVYWALKSSLDTLNQEILDIKNQELSGTLTLYSRPSIAQCWLVP
EEEECCCEEEEEECCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHEEEEH
ALGDFTRRYPSISLTVLTGNDNVNLQRAGIDLAIYFDDAPSAQLTHHFLMDEEILPVCSS
HHHHHHHHCCCEEEEEEECCCCCEEEECCEEEEEEECCCCCHHHHHHHHCCCCHHHHHHH
EYAQRHALTNTVINLCHCTLLHDRQAWSNDSGTDEWHSWAQHYAVNLPTSSGIGFDRSDL
HHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCCCCC
AVIAAMNHIGVAMGRKRLVQKRLASGELVAPFGDMTVKCHQHYYITTLPGRQWPKIEAFI
EEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECEEEEEECCCCCCCHHHHHH
TWLREQVKTTS
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]