Click here to switch to the map view.

The map label for this gene is lrhA [H]

Identifier: 157161777

GI number: 157161777

Start: 2447274

End: 2448212

Strand: Reverse

Name: lrhA [H]

Synonym: EcHS_A2438

Alternate gene names: 157161777

Gene position: 2448212-2447274 (Counterclockwise)

Preceding gene: 157161780

Following gene: 157161776

Centisome position: 52.72

GC content: 49.63

Gene sequence:

>939_bases
ATGATAAGTGCAAATCGTCCGATAATTAACCTCGACCTCGATCTGCTGAGAACATTTGTTGCTGTTGCCGATCTGAACAC
TTTTGCTGCCGCAGCTGCCGCTGTGTGTCGTACTCAGTCCGCCGTAAGTCAGCAAATGCAGCGTCTGGAACAACTCGTTG
GGAAAGAACTGTTCGCTCGTCACGGTCGCAACAAACTGTTAACTGAACATGGCATTCAACTTCTTGGTTACGCCAGGAAA
ATCCTGCGTTTTAATGATGAGGCCTGCTCATCATTAATGTTCAGTAATCTTCAGGGCGTGTTAACTATCGGTGCTTCAGA
TGAATCTGCCGATACGATCTTACCTTTCCTGTTAAATCGCGTGAGTTCGGTTTATCCGAAATTAGCGCTGGATGTCCGCG
TTAAACGTAATGCCTATATGGCAGAAATGCTGGAATCCCAGGAAGTGGATTTGATGGTAACCACCCATCGTCCTTCTACC
TTTAAGGCATTGAACCTGCGTACCTCGCCAACACACTGGTACTGCGCAGCGGAATACGTATTGCAAAAAGGTGAGCCGAT
CCCTCTTGTATTGCTGGATGATCCAAGTCCGTTTCGCGATATGGTGCTGGCGACGCTTAATAAAGCAGATATTCCATGGC
GACTGGCTTATGTCGCCTCGACGCTTCCGGCCGTTCGTGCGGCAGTGAAAGCCGGTCTTGGCGTGACGGCAAGGCCGGTT
GAAATGATGAGCCCGGACCTGCGTGTGCTGAGTGGAGTAGATGGCTTACCGCCGCTACCTGATACCGAATATTTGCTGTG
CTATGACCCGTCCAGTAATAATGAGCTGGCCCAGGTGATCTATCAGGCGATGGAGAGCTACCATAATCCGTGGCAATACA
GCCCAATGTCTGCTCCGGAAGGGGATGATTCATTGTTGATTGAAAGGGATATCGAGTAA

Upstream 100 bases:

>100_bases
CGGATGAAACTGCCAGGGAGGCACATTACAAATGGAATTGCTTGTTTGTGTGTGCACAGCATTAACCAGCTCAGTATGAG
CCGCCAGTAAGTGATAATAT

Downstream 100 bases:

>100_bases
TCGACGGACGATAGATAATTCCTGAGACAATAGTGTAAAAAACGAGCCGCTGGGGGTGTTTTAAACCCCAGCGGCTTTTT
TTTAGTAAAAATCCTTCCTC

Product: transcriptional regulator LrhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MISANRPIINLDLDLLRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFARHGRNKLLTEHGIQLLGYARK
ILRFNDEACSSLMFSNLQGVLTIGASDESADTILPFLLNRVSSVYPKLALDVRVKRNAYMAEMLESQEVDLMVTTHRPST
FKALNLRTSPTHWYCAAEYVLQKGEPIPLVLLDDPSPFRDMVLATLNKADIPWRLAYVASTLPAVRAAVKAGLGVTARPV
EMMSPDLRVLSGVDGLPPLPDTEYLLCYDPSSNNELAQVIYQAMESYHNPWQYSPMSAPEGDDSLLIERDIE

Sequences:

>Translated_312_residues
MISANRPIINLDLDLLRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFARHGRNKLLTEHGIQLLGYARK
ILRFNDEACSSLMFSNLQGVLTIGASDESADTILPFLLNRVSSVYPKLALDVRVKRNAYMAEMLESQEVDLMVTTHRPST
FKALNLRTSPTHWYCAAEYVLQKGEPIPLVLLDDPSPFRDMVLATLNKADIPWRLAYVASTLPAVRAAVKAGLGVTARPV
EMMSPDLRVLSGVDGLPPLPDTEYLLCYDPSSNNELAQVIYQAMESYHNPWQYSPMSAPEGDDSLLIERDIE
>Mature_312_residues
MISANRPIINLDLDLLRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFARHGRNKLLTEHGIQLLGYARK
ILRFNDEACSSLMFSNLQGVLTIGASDESADTILPFLLNRVSSVYPKLALDVRVKRNAYMAEMLESQEVDLMVTTHRPST
FKALNLRTSPTHWYCAAEYVLQKGEPIPLVLLDDPSPFRDMVLATLNKADIPWRLAYVASTLPAVRAAVKAGLGVTARPV
EMMSPDLRVLSGVDGLPPLPDTEYLLCYDPSSNNELAQVIYQAMESYHNPWQYSPMSAPEGDDSLLIERDIE

Specific function: Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788626, Length=312, Percent_Identity=99.3589743589744, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI48994962, Length=151, Percent_Identity=30.4635761589404, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790399, Length=294, Percent_Identity=24.8299319727891, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787879, Length=133, Percent_Identity=36.0902255639098, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI145693105, Length=240, Percent_Identity=23.75, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787806, Length=130, Percent_Identity=30, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34610; Mature: 34610

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISANRPIINLDLDLLRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFAR
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGRNKLLTEHGIQLLGYARKILRFNDEACSSLMFSNLQGVLTIGASDESADTILPFLLNR
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
VSSVYPKLALDVRVKRNAYMAEMLESQEVDLMVTTHRPSTFKALNLRTSPTHWYCAAEYV
HHHHCCHHEEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHH
LQKGEPIPLVLLDDPSPFRDMVLATLNKADIPWRLAYVASTLPAVRAAVKAGLGVTARPV
HHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
EMMSPDLRVLSGVDGLPPLPDTEYLLCYDPSSNNELAQVIYQAMESYHNPWQYSPMSAPE
HHHCCCHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
GDDSLLIERDIE
CCCCEEEEECCC
>Mature Secondary Structure
MISANRPIINLDLDLLRTFVAVADLNTFAAAAAAVCRTQSAVSQQMQRLEQLVGKELFAR
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGRNKLLTEHGIQLLGYARKILRFNDEACSSLMFSNLQGVLTIGASDESADTILPFLLNR
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
VSSVYPKLALDVRVKRNAYMAEMLESQEVDLMVTTHRPSTFKALNLRTSPTHWYCAAEYV
HHHHCCHHEEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHH
LQKGEPIPLVLLDDPSPFRDMVLATLNKADIPWRLAYVASTLPAVRAAVKAGLGVTARPV
HHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
EMMSPDLRVLSGVDGLPPLPDTEYLLCYDPSSNNELAQVIYQAMESYHNPWQYSPMSAPE
HHHCCCHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
GDDSLLIERDIE
CCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]