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The map label for this gene is rtn

Identifier: 157161658

GI number: 157161658

Start: 2312904

End: 2314460

Strand: Direct

Name: rtn

Synonym: EcHS_A2314

Alternate gene names: 157161658

Gene position: 2312904-2314460 (Clockwise)

Preceding gene: 157161657

Following gene: 157161659

Centisome position: 49.81

GC content: 50.48

Gene sequence:

>1557_bases
ATGTTCATACGCGCTCCCAATTTTGGACGTAAGCTCCTGCTTACCTGCATTGTTGCAGGCGTAATGATTGCGATACTGGT
GAGTTGCCTTCAGTTTTTAGTGGCCTGGCATAAGCACGAAGTCAAATACGACACACTGATTACCGACGTACAAAAGTATC
TCGATACCTATTTTGCCGACCTGAAATCCACTACTGACCGGCTCCAGCCGCTGACCTTAGATACCTGCCAGCAAGCTAAC
CCCGAACTGACCGCCCGCGCAGCGTTTAGCATGAATGTCCGAACGTTTGTGCTGGTGAAAGATAAAAAAACATTCTGTTC
ATCTGCGACCGGTGAGATGGACATTCCACTCAATGAATTGATTCCGGCGCTCGACATTAATAAAAACGTCGATATGGCGA
TCTTACCCGGCACGCCGATGGTGCCGAACAAACCCGCAATCGTCATCTGGTATCGCAACCCTTTGCTGAAAAATAGCGGC
GTCTTTGCCGCTCTGAATCTCAACCTGACGCCTTCACTCTTTTATAGTTCACGGCAGGAAGATTACGATGGCGTCGCCCT
CATTATTGGCAATACTGCGCTATCTACCTTTTCTTCACGTTTGATGAACGTTAACGAATTAACCGACATGCCAGTCCGTG
AAACTAAAATTGCGGGCATTCCTCTGACCGTTCGGCTTTATGCAGATGACTGGACATGGAACGATGTGTGGTACGCATTT
TTACTGGGCGGCATGAGTGGAACTGTCGTTGGCCTGCTCTGCTATTACCTGATGAGCGTACGTATGCGCCCCGGCAGAGA
AATCATGACCGCCATCAAGCGCGAACAATTTTACGTGGCGTATCAACCGGTGGTGGATACACAAGCTTTGCGAGTAACGG
GCCTGGAAGTACTGCTACGCTGGCGGCATCCTGTCGCGGGAGAAATTCCCCCGGATGCCTTCATTAACTTTGCCGAATCG
CAAAAGATGATTGTGCCGCTGACTCAGCACCTGTTTGAGTTAATTGCCCGCGATGCCGCAGAATTAGAAAAAGTGCTGCC
GGTAGGCGTCAAATTTGGTATTAACATTGCGCCGGACCATCTGCACAGCGAAAGCTTTAAAGCAGATATCCAGAAACTGC
TCACTTCCCTGCCCGCACACCATTTCCAGATTGTGCTGGAAATTACCGAGCGCGATATGTTGAAAGAGCAAGAAGCCACA
CAACTCTTCGCCTGGCTGCACTCGGTCGGCGTAGAAATTGCTATTGATGACTTCGGCACCGGGCACAGCGCGCTTATCTA
TCTTGAGCGTTTTACGCTCGATTATCTGAAAATTGACCGTGGATTTATCAACGCCATCGGTACGGAAACGATCACTTCAC
CCGTACTTGACGCGGTGCTGACGCTGGCGAAACGCCTCAATATGCTGACGGTTGCTGAAGGGGTCGAAACGCCGGAACAG
GCGCGATGGCTAAGCGAACGCGGCGTTAATTTCATGCAAGGCTACTGGATTAGTCGCCCGTTACCGCTGGACGATTTTGT
TCGCTGGCTGAAGAAACCGTATACGCCGCAGTGGTAA

Upstream 100 bases:

>100_bases
TTCATCAGAGAAAATGATGTTTCCGCGTCTTGATCCAGGCTATAGTCCGGTCATTGTTATCTTTTAAATGTTGTCGTAAT
TTCAGGAAATTAACGGAATC

Downstream 100 bases:

>100_bases
GGTGTGCTTACGTCCCTTATTATTCATAGTGAAAGCATGCCGGATTGCGGCTAATGATGAGTAAAAGGAAATCCGTTGCA
GATGATTGTGCGCATACTGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MFIRAPNFGRKLLLTCIVAGVMIAILVSCLQFLVAWHKHEVKYDTLITDVQKYLDTYFADLKSTTDRLQPLTLDTCQQAN
PELTARAAFSMNVRTFVLVKDKKTFCSSATGEMDIPLNELIPALDINKNVDMAILPGTPMVPNKPAIVIWYRNPLLKNSG
VFAALNLNLTPSLFYSSRQEDYDGVALIIGNTALSTFSSRLMNVNELTDMPVRETKIAGIPLTVRLYADDWTWNDVWYAF
LLGGMSGTVVGLLCYYLMSVRMRPGREIMTAIKREQFYVAYQPVVDTQALRVTGLEVLLRWRHPVAGEIPPDAFINFAES
QKMIVPLTQHLFELIARDAAELEKVLPVGVKFGINIAPDHLHSESFKADIQKLLTSLPAHHFQIVLEITERDMLKEQEAT
QLFAWLHSVGVEIAIDDFGTGHSALIYLERFTLDYLKIDRGFINAIGTETITSPVLDAVLTLAKRLNMLTVAEGVETPEQ
ARWLSERGVNFMQGYWISRPLPLDDFVRWLKKPYTPQW

Sequences:

>Translated_518_residues
MFIRAPNFGRKLLLTCIVAGVMIAILVSCLQFLVAWHKHEVKYDTLITDVQKYLDTYFADLKSTTDRLQPLTLDTCQQAN
PELTARAAFSMNVRTFVLVKDKKTFCSSATGEMDIPLNELIPALDINKNVDMAILPGTPMVPNKPAIVIWYRNPLLKNSG
VFAALNLNLTPSLFYSSRQEDYDGVALIIGNTALSTFSSRLMNVNELTDMPVRETKIAGIPLTVRLYADDWTWNDVWYAF
LLGGMSGTVVGLLCYYLMSVRMRPGREIMTAIKREQFYVAYQPVVDTQALRVTGLEVLLRWRHPVAGEIPPDAFINFAES
QKMIVPLTQHLFELIARDAAELEKVLPVGVKFGINIAPDHLHSESFKADIQKLLTSLPAHHFQIVLEITERDMLKEQEAT
QLFAWLHSVGVEIAIDDFGTGHSALIYLERFTLDYLKIDRGFINAIGTETITSPVLDAVLTLAKRLNMLTVAEGVETPEQ
ARWLSERGVNFMQGYWISRPLPLDDFVRWLKKPYTPQW
>Mature_518_residues
MFIRAPNFGRKLLLTCIVAGVMIAILVSCLQFLVAWHKHEVKYDTLITDVQKYLDTYFADLKSTTDRLQPLTLDTCQQAN
PELTARAAFSMNVRTFVLVKDKKTFCSSATGEMDIPLNELIPALDINKNVDMAILPGTPMVPNKPAIVIWYRNPLLKNSG
VFAALNLNLTPSLFYSSRQEDYDGVALIIGNTALSTFSSRLMNVNELTDMPVRETKIAGIPLTVRLYADDWTWNDVWYAF
LLGGMSGTVVGLLCYYLMSVRMRPGREIMTAIKREQFYVAYQPVVDTQALRVTGLEVLLRWRHPVAGEIPPDAFINFAES
QKMIVPLTQHLFELIARDAAELEKVLPVGVKFGINIAPDHLHSESFKADIQKLLTSLPAHHFQIVLEITERDMLKEQEAT
QLFAWLHSVGVEIAIDDFGTGHSALIYLERFTLDYLKIDRGFINAIGTETITSPVLDAVLTLAKRLNMLTVAEGVETPEQ
ARWLSERGVNFMQGYWISRPLPLDDFVRWLKKPYTPQW

Specific function: Involved in resistance to phages N4 and lambda

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain

Homologues:

Organism=Escherichia coli, GI1788502, Length=518, Percent_Identity=100, Blast_Score=1071, Evalue=0.0,
Organism=Escherichia coli, GI87081980, Length=520, Percent_Identity=28.8461538461538, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081845, Length=252, Percent_Identity=39.2857142857143, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786507, Length=247, Percent_Identity=36.8421052631579, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1790496, Length=251, Percent_Identity=30.6772908366534, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87081743, Length=270, Percent_Identity=31.4814814814815, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1787541, Length=246, Percent_Identity=30.4878048780488, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081921, Length=255, Percent_Identity=29.8039215686275, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI226510982, Length=253, Percent_Identity=31.2252964426877, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1788849, Length=244, Percent_Identity=28.6885245901639, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082096, Length=243, Percent_Identity=30.0411522633745, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1787055, Length=251, Percent_Identity=29.0836653386454, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787410, Length=226, Percent_Identity=25.2212389380531, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RTN_ECOLI (P76446)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   U12780
- EMBL:   U83404
- PIR:   G64986
- RefSeq:   AP_002774.1
- RefSeq:   NP_416681.1
- ProteinModelPortal:   P76446
- SMR:   P76446
- DIP:   DIP-10813N
- STRING:   P76446
- EnsemblBacteria:   EBESCT00000003442
- EnsemblBacteria:   EBESCT00000017047
- GeneID:   946695
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2164
- KEGG:   eco:b2176
- EchoBASE:   EB3830
- EcoGene:   EG14077
- eggNOG:   COG2200
- GeneTree:   EBGT00050000008780
- HOGENOM:   HBG417232
- OMA:   IQLYADS
- ProtClustDB:   PRK10551
- BioCyc:   EcoCyc:G7148-MONOMER
- Genevestigator:   P76446
- InterPro:   IPR001633
- SMART:   SM00052

Pfam domain/function: PF00563 EAL

EC number: NA

Molecular weight: Translated: 58589; Mature: 58589

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50883 EAL; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x15f13100)-; HASH(0x15fb8158)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIRAPNFGRKLLLTCIVAGVMIAILVSCLQFLVAWHKHEVKYDTLITDVQKYLDTYFAD
CEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LKSTTDRLQPLTLDTCQQANPELTARAAFSMNVRTFVLVKDKKTFCSSATGEMDIPLNEL
HHHHHHHCCCCCHHHHHCCCCCEEEEEEEEECCEEEEEEECCHHHHCCCCCCCCCCHHHC
IPALDINKNVDMAILPGTPMVPNKPAIVIWYRNPLLKNSGVFAALNLNLTPSLFYSSRQE
CCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCC
DYDGVALIIGNTALSTFSSRLMNVNELTDMPVRETKIAGIPLTVRLYADDWTWNDVWYAF
CCCCEEEEECCHHHHHHHHHHCCHHHHCCCCCCCCEECCCCEEEEEEECCCCCHHHHHHH
LLGGMSGTVVGLLCYYLMSVRMRPGREIMTAIKREQFYVAYQPVVDTQALRVTGLEVLLR
HHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHH
WRHPVAGEIPPDAFINFAESQKMIVPLTQHLFELIARDAAELEKVLPVGVKFGINIAPDH
HCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCEECCHH
LHSESFKADIQKLLTSLPAHHFQIVLEITERDMLKEQEATQLFAWLHSVGVEIAIDDFGT
HCHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
GHSALIYLERFTLDYLKIDRGFINAIGTETITSPVLDAVLTLAKRLNMLTVAEGVETPEQ
CCCEEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHEECCCCCCHHH
ARWLSERGVNFMQGYWISRPLPLDDFVRWLKKPYTPQW
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MFIRAPNFGRKLLLTCIVAGVMIAILVSCLQFLVAWHKHEVKYDTLITDVQKYLDTYFAD
CEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LKSTTDRLQPLTLDTCQQANPELTARAAFSMNVRTFVLVKDKKTFCSSATGEMDIPLNEL
HHHHHHHCCCCCHHHHHCCCCCEEEEEEEEECCEEEEEEECCHHHHCCCCCCCCCCHHHC
IPALDINKNVDMAILPGTPMVPNKPAIVIWYRNPLLKNSGVFAALNLNLTPSLFYSSRQE
CCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCC
DYDGVALIIGNTALSTFSSRLMNVNELTDMPVRETKIAGIPLTVRLYADDWTWNDVWYAF
CCCCEEEEECCHHHHHHHHHHCCHHHHCCCCCCCCEECCCCEEEEEEECCCCCHHHHHHH
LLGGMSGTVVGLLCYYLMSVRMRPGREIMTAIKREQFYVAYQPVVDTQALRVTGLEVLLR
HHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHH
WRHPVAGEIPPDAFINFAESQKMIVPLTQHLFELIARDAAELEKVLPVGVKFGINIAPDH
HCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCEECCHH
LHSESFKADIQKLLTSLPAHHFQIVLEITERDMLKEQEATQLFAWLHSVGVEIAIDDFGT
HCHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
GHSALIYLERFTLDYLKIDRGFINAIGTETITSPVLDAVLTLAKRLNMLTVAEGVETPEQ
CCCEEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHEECCCCCCHHH
ARWLSERGVNFMQGYWISRPLPLDDFVRWLKKPYTPQW
HHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 9079933