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The map label for this gene is yeiQ [H]

Identifier: 157161654

GI number: 157161654

Start: 2308423

End: 2309889

Strand: Direct

Name: yeiQ [H]

Synonym: EcHS_A2310

Alternate gene names: 157161654

Gene position: 2308423-2309889 (Clockwise)

Preceding gene: 157161653

Following gene: 157161655

Centisome position: 49.71

GC content: 52.15

Gene sequence:

>1467_bases
ATGAAGACAATTGCCTCCGTTACGCTCCCGCATCATGTACACGCTCCACGCTACGATCGCCAGCAGTTGCAATCACGTAT
CGTTCATTTTGGCTTTGGCGCCTTTCACCGCGCTCATCAGGCGTTACTGACCGATCGTGTGCTGAATGCCCAGGGCGGCG
ACTGGGGGATCTGTGAAATCAGCTTGTTCAGCGGTGATCAACTGATGAGCCAGCTCCGCGCACAGAACCATTTATATACC
GTGCTGGAGAAAGGTGCGGACGGCAATCAGGTGATAATTGTCGGTGCCGTTCACGAATGCCTTAATGCAAAACTGGATTC
CTTAGCGGCAATTATTGAGAAATTTTGCGAGCCACAGGTGGCAATTGTTTCCCTGACGATTACCGAAAAAGGCTATTGTA
TTGACCCGGCCACCGGTGCACTCGACACCAGTAATCCGCGGATTATTCACGATCTACAAACCCCTGAAGAACCTCACTCC
GCACCGGGTATTCTCGTCGAAGCACTGAAACGCCGCCGTGAGCGCGGCCTTACACCGTTTACCGTGCTCTCCTGCGACAA
TATTCCCGACAATGGTCATGTGGTGAAAAACGCGGTGCTGGGAATGGCAGAAAAACGTTCGCCAGAACTCGCCGGGTGGA
TAAAAGAGCACGTCAGTTTTCCGGGAACCATGGTCGACCGCATTGTTCCGGCTGCAACCGACGAATCACTGGTGGAAATC
AGCCAGCATCTGGGGGTGAATGATCCCTGCGCGATTAGCTGCGAACCGTTTATCCAGTGGGTGGTGGAAGATAACTTCGT
CGCTGGGCGTCCTGCCTGGGAAGTCGCAGGTGTACAAATGGTGAATGATGTCCTGCCATGGGAAGAGATGAAACTGCGGA
TGCTTAATGGCAGCCACTCTTTTCTCGCTTATCTGGGTTACCTCTCAGGATTCGCCCATATCAGTGATTGCATGCAGGAT
CGCGCATTTCGCCATGCCGCCAGAACATTAATGCTGGATGAGCAAGCGCCGACACTGCAAATTAAAGATGTCGATTTAAC
ACAATATGCGGATAAGTTAATTGCACGTTTTGCTAATCCGGCGCTGAAACATAAGACCTGGCAAATCGCGATGGATGGCA
GCCAGAAATTACCGCAACGCATGCTGGCAGGTATTCGCATACATCAGGGGCGCGAAACGGACTGGTCGTTGCTGGCATTA
GGCGTTGCAGGCTGGATGCGTTACGTCAGCGGCGTTGATGATGCCGGAAATGCCATTGATGTTCGCGATCCGCTTAGCGA
TAAAATTCGCGAACTTGTTGCGGGCAGCAGCAGTGAACAACGCGTAACCGCCCTGCTTTCCCTGCGTGAAGTTTTCGGTG
ATGATCTGCCAGATAACCCGCATTTTGTGCAGGCCATCGAACAAGCCTGGCAACAAATCGTACAATTCGGCGCACATCAG
GCGCTATTAAACACCCTCAAAATTTAA

Upstream 100 bases:

>100_bases
CCTCACACTTCATCGCATTAACAATCCAGACCAATTTCAATTGCTGTCATATAACTTTACACTGTCATTGTTAATTTATC
GTTACTAAGACGTGACTCCT

Downstream 100 bases:

>100_bases
CGATTTCTGCGGTTAAAGCGGATGAAGCTCACCTTCGTCCGCTCTCCCCTTCTCTTTTCTGCCTTTTTTAGCCAGGATTA
ACGCTCAGTTAACTTACCAG

Product: mannitol dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MKTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEISLFSGDQLMSQLRAQNHLYT
VLEKGADGNQVIIVGAVHECLNAKLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGALDTSNPRIIHDLQTPEEPHS
APGILVEALKRRRERGLTPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATDESLVEI
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHSFLAYLGYLSGFAHISDCMQD
RAFRHAARTLMLDEQAPTLQIKDVDLTQYADKLIARFANPALKHKTWQIAMDGSQKLPQRMLAGIRIHQGRETDWSLLAL
GVAGWMRYVSGVDDAGNAIDVRDPLSDKIRELVAGSSSEQRVTALLSLREVFGDDLPDNPHFVQAIEQAWQQIVQFGAHQ
ALLNTLKI

Sequences:

>Translated_488_residues
MKTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEISLFSGDQLMSQLRAQNHLYT
VLEKGADGNQVIIVGAVHECLNAKLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGALDTSNPRIIHDLQTPEEPHS
APGILVEALKRRRERGLTPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATDESLVEI
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHSFLAYLGYLSGFAHISDCMQD
RAFRHAARTLMLDEQAPTLQIKDVDLTQYADKLIARFANPALKHKTWQIAMDGSQKLPQRMLAGIRIHQGRETDWSLLAL
GVAGWMRYVSGVDDAGNAIDVRDPLSDKIRELVAGSSSEQRVTALLSLREVFGDDLPDNPHFVQAIEQAWQQIVQFGAHQ
ALLNTLKI
>Mature_488_residues
MKTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEISLFSGDQLMSQLRAQNHLYT
VLEKGADGNQVIIVGAVHECLNAKLDSLAAIIEKFCEPQVAIVSLTITEKGYCIDPATGALDTSNPRIIHDLQTPEEPHS
APGILVEALKRRRERGLTPFTVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATDESLVEI
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHSFLAYLGYLSGFAHISDCMQD
RAFRHAARTLMLDEQAPTLQIKDVDLTQYADKLIARFANPALKHKTWQIAMDGSQKLPQRMLAGIRIHQGRETDWSLLAL
GVAGWMRYVSGVDDAGNAIDVRDPLSDKIRELVAGSSSEQRVTALLSLREVFGDDLPDNPHFVQAIEQAWQQIVQFGAHQ
ALLNTLKI

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788497, Length=488, Percent_Identity=99.7950819672131, Blast_Score=1008, Evalue=0.0,
Organism=Escherichia coli, GI1790779, Length=485, Percent_Identity=56.0824742268041, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1787823, Length=464, Percent_Identity=54.5258620689655, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI1790028, Length=232, Percent_Identity=28.8793103448276, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI48994885, Length=482, Percent_Identity=22.4066390041494, Blast_Score=95, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324401, Length=493, Percent_Identity=39.7565922920893, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320765, Length=493, Percent_Identity=39.7565922920893, Blast_Score=362, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 54046; Mature: 54046

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEI
CCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
SLFSGDQLMSQLRAQNHLYTVLEKGADGNQVIIVGAVHECLNAKLDSLAAIIEKFCEPQV
EECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCE
AIVSLTITEKGYCIDPATGALDTSNPRIIHDLQTPEEPHSAPGILVEALKRRRERGLTPF
EEEEEEEECCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCE
TVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATDESLVEI
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHH
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHS
HHHCCCCCCCEECHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHH
FLAYLGYLSGFAHISDCMQDRAFRHAARTLMLDEQAPTLQIKDVDLTQYADKLIARFANP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHHHHCCH
ALKHKTWQIAMDGSQKLPQRMLAGIRIHQGRETDWSLLALGVAGWMRYVSGVDDAGNAID
HHHCCEEEEEECCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEE
VRDPLSDKIRELVAGSSSEQRVTALLSLREVFGDDLPDNPHFVQAIEQAWQQIVQFGAHQ
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHH
ALLNTLKI
HHHHHHCC
>Mature Secondary Structure
MKTIASVTLPHHVHAPRYDRQQLQSRIVHFGFGAFHRAHQALLTDRVLNAQGGDWGICEI
CCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
SLFSGDQLMSQLRAQNHLYTVLEKGADGNQVIIVGAVHECLNAKLDSLAAIIEKFCEPQV
EECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCE
AIVSLTITEKGYCIDPATGALDTSNPRIIHDLQTPEEPHSAPGILVEALKRRRERGLTPF
EEEEEEEECCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCE
TVLSCDNIPDNGHVVKNAVLGMAEKRSPELAGWIKEHVSFPGTMVDRIVPAATDESLVEI
EEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHH
SQHLGVNDPCAISCEPFIQWVVEDNFVAGRPAWEVAGVQMVNDVLPWEEMKLRMLNGSHS
HHHCCCCCCCEECHHHHHHHHHCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHH
FLAYLGYLSGFAHISDCMQDRAFRHAARTLMLDEQAPTLQIKDVDLTQYADKLIARFANP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHHHHCCH
ALKHKTWQIAMDGSQKLPQRMLAGIRIHQGRETDWSLLALGVAGWMRYVSGVDDAGNAID
HHHCCEEEEEECCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEE
VRDPLSDKIRELVAGSSSEQRVTALLSLREVFGDDLPDNPHFVQAIEQAWQQIVQFGAHQ
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHH
ALLNTLKI
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]