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The map label for this gene is baeS

Identifier: 157161569

GI number: 157161569

Start: 2207117

End: 2208520

Strand: Direct

Name: baeS

Synonym: EcHS_A2220

Alternate gene names: 157161569

Gene position: 2207117-2208520 (Clockwise)

Preceding gene: 157161568

Following gene: 157161570

Centisome position: 47.53

GC content: 53.7

Gene sequence:

>1404_bases
ATGAAGTTCTGGCGACCCGGTATTACCGGCAAACTGTTTCTGGCGATTTTCGCCACCTGCATTGTCTTGCTGATCAGTAT
GCACTGGGCGGTGCGTATCAGTTTTGAGCGTGGCTTTATTGATTACATCAAGCATGGTAATGAACAGCGATTACAACTGT
TAAGTGATGCGCTTGGCGAGCAGTATGCGCAGCATGGCAACTGGCGCTTCCTGCGCAACAATGATCGCTTTGTCTTTCAG
ATCCTGCGTTCATTTGAACACGATAATTCGGAAGATAAACCCGGCCCGGGTATGCCACCGCACGGCTGGCGTACCCAGTT
CTGGGTGGTTGATCAAAACAACAAAGTGCTGGTTGGTCCGCGAGCGCCGATTCCACCTGACGGTACACGGCGACCCATTC
TGGTCAACGGTGCGGAAGTTGGCGCGGTGATCGCCTCCCCCGTTGAGCGGTTAACGCGCAATACTGATATCAATTTCGAT
AAACAACAGCGGCAAACCAGCTGGTTGATTGTCGCCCTGGCAACGTTACTCGCGGCACTTGCCACTTTTCTGCTGGCGCG
CGGTTTACTGGCACCGGTAAAACGACTTGTCGATGGCACGCACAAACTGGCGGCGGGCGATTTCACTACCCGCGTAACGC
CCACCAGTGAAGATGAACTGGGCAAACTGGCGCAAGACTTCAACCAGCTTGCCAGCACACTGGAGAAAAACCAGCAAATG
CGGCGCGATTTTATGGCCGATATTTCTCACGAACTGCGTACGCCATTAGCGGTGCTGCGCGGTGAACTGGAAGCCATTCA
GGATGGCGTGCGTAAATTCACGCCGGAGACGGTGGCGTCTTTACAGGCGGAGGTCGGTACACTGACCAAACTGGTTGACG
ATCTCCATCAGTTGTCGATGTCTGATGAAGGCGCTCTCGCCTATCAAAAAGCACCGGTAGATTTGATCCCACTGCTGGAA
GTGGCGGGCGGCGCATTTCGCGAACGATTCGCCAGTCGTGGCCTGAAACTGCAATTTTCCCTGCCAGACAGTATTACCGT
ATTTGGCGATCGCGACCGTTTAATGCAGTTATTCAATAACTTACTGGAAAACAGCCTGCGCTACACTGACAGCGGCGGCA
GCCTGCAAATCTCTGCCGGGCAGCGCGACAAAACGGTGCGCCTGACCTTTGCCGACAGTGCGCCAGGTGTCAGTGACGAT
CAGCTACAAAAATTGTTTGAACGTTTTTATCGCACCGAAGGTTCCCGCAACCGTGCCAGCGGCGGTTCCGGGCTGGGGCT
GGCGATTTGCCTGAACATTGTTGAAGCACATAATGGTCGCATTATTGCTGCCCATTCGCCTTTTGGCGGGGTAAGCATTA
CAGTAGAGTTACCGCTGGAACGGGATTTACAGAGAGAAGTATGA

Upstream 100 bases:

>100_bases
GCATGGCGTTGATCATCGCCCTTCCGGCGTTCATCTTTGCCAGAGTGCCGAACGATACGCATCAAAATGTAGCTATTTCG
CGGCGAAAAAGGAGCGCGCA

Downstream 100 bases:

>100_bases
CCGAGTTACCAATCGACGAAAACACACCGCGTATTTTGATCGTGGAAGATGAACCGAAGCTGGGGCAGTTGCTCATTGAT
TATCTGCGTGCTGCGAGCTA

Product: signal transduction histidine-protein kinase BaeS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQ
ILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFD
KQQRQTSWLIVALATLLAALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQM
RRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLIPLLE
VAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDD
QLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV

Sequences:

>Translated_467_residues
MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQ
ILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFD
KQQRQTSWLIVALATLLAALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQM
RRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLIPLLE
VAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDD
QLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV
>Mature_467_residues
MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQ
ILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFD
KQQRQTSWLIVALATLLAALATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQM
RRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKAPVDLIPLLE
VAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDD
QLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV

Specific function: Member of the two-component regulatory system BaeS/BaeR. May activate BaeR by phosphorylation

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1788393, Length=467, Percent_Identity=100, Blast_Score=953, Evalue=0.0,
Organism=Escherichia coli, GI1786783, Length=295, Percent_Identity=28.8135593220339, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=27.9411764705882, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786912, Length=276, Percent_Identity=29.7101449275362, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786600, Length=253, Percent_Identity=27.6679841897233, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1787374, Length=297, Percent_Identity=25.5892255892256, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=29.2181069958848, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788279, Length=292, Percent_Identity=26.7123287671233, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI87081816, Length=254, Percent_Identity=28.740157480315, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790861, Length=250, Percent_Identity=29.6, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=23.4527687296417, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790551, Length=299, Percent_Identity=27.7591973244147, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=28, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=23.972602739726, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789808, Length=289, Percent_Identity=26.643598615917, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=264, Percent_Identity=25.7575757575758, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789149, Length=320, Percent_Identity=22.8125, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=299, Percent_Identity=28.7625418060201, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=25, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BAES_ECOLI (P30847)

Other databases:

- EMBL:   D14054
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   E64974
- RefSeq:   AP_002678.1
- RefSeq:   NP_416582.1
- ProteinModelPortal:   P30847
- SMR:   P30847
- DIP:   DIP-9199N
- STRING:   P30847
- EnsemblBacteria:   EBESCT00000002179
- EnsemblBacteria:   EBESCT00000014457
- GeneID:   946611
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2063
- KEGG:   eco:b2078
- EchoBASE:   EB1574
- EcoGene:   EG11617
- eggNOG:   COG0642
- GeneTree:   EBGT00050000008661
- HOGENOM:   HBG334875
- OMA:   LKHINIM
- ProtClustDB:   PRK10549
- BioCyc:   EcoCyc:BAES-MONOMER
- BRENDA:   2.7.13.3
- Genevestigator:   P30847
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 51992; Mature: 51992

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x11dbfc18)-; HASH(0x15661ff4)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHCCCHHHHHHHHHHHHH
QYAQHGNWRFLRNNDRFVFQILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGP
HHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEECC
RAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLLAAL
CCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQM
HHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNN
CCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCEEEECCHHHHHHHHHH
LLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRAS
HHHHCCEEECCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCC
GGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHCCH
>Mature Secondary Structure
MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHCCCHHHHHHHHHHHHH
QYAQHGNWRFLRNNDRFVFQILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGP
HHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEECC
RAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDKQQRQTSWLIVALATLLAAL
CCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ATFLLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQM
HHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
SDEGALAYQKAPVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNN
CCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCEEEECCHHHHHHHHHH
LLENSLRYTDSGGSLQISAGQRDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRAS
HHHHCCEEECCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCC
GGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8282725; 9097040; 9278503