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The map label for this gene is paaN [H]

Identifier: 157160869

GI number: 157160869

Start: 1474790

End: 1476835

Strand: Reverse

Name: paaN [H]

Synonym: EcHS_A1474

Alternate gene names: 157160869

Gene position: 1476835-1474790 (Counterclockwise)

Preceding gene: 157160890

Following gene: 157160868

Centisome position: 31.8

GC content: 54.15

Gene sequence:

>2046_bases
ATGCAGCAGTTAGACAGTTTCTTATCCGGTACCTGGCAGTCTGGCCGGGGCCGTAGCCGTTTGATTCACCACGCCATTAG
CGGCGAGGCATTATGGGAAGTGACCAGTGAAGGTCTTGATATGGCGGCTGCCCGCCAGTTTGCCATTGAAAAAGGTGCCC
CCGCCCTCCGCGCGATGACCTTTATCGAACGTGCGGCGATGCTTAAAGCGGTCGCTAAACATCTGCTGAGTGAAAAAGAG
CGCTTCTATGCTCTTTCTGCGCAAACAGGCGCAACGCGGGCAGACAGTTGGGTTGATATTGAAGGCGGTATTGGGACGTT
ATTTACTTACGCCAGCCTCGGTAGCCGGGAGCTGCCTGACGATACGCTGTGGCCGGAAGATGAATTGATCCCCTTATCGA
AAGAAGGTGGATTTGCCGCGCGCCATGTACTGACCTCAAAGTCAGGCGTGGCAGTGCATATTAACGCCTTTAACTTCCCC
TGCTGGGGAATGCTGGAAAAGCTGGCACCAACGTGGCTGGGCGGAATGCCAGCCATCATCAAACCAGCTACCGCGACGGC
CCAACTGACTCAGGCGATGGTGAAATCAATTGTCGATAGTGGTCTTGTTCCCGAAGGCGCAATTAGTCTGATCTGCGGTA
GTGCGGGCGACCTTTTGGATCATCTGGACAGCCAGGATGTGGTGACTTTCACGGGGTCCGCGACGACCGGACAGATGCTG
CGAGTTCAGCCAAATATCGTTGCCAAATCTATCCCCTTCACGATGGAAGCTGATTCCCTGAACTGCTGCGTACTGGGCGA
AGATGTCACCCCGGATCAACCGGAGTTTGCGCTGTTTATTCGTGAAGTTGTGCGTGAGATGACCACAAAAGCCGGGCAAA
AATGTACGGCAATCCGGCGGATTATTGTGCCGCAGGCATTGGTTAATGCTGTCAGTGATGCTCTGGTTGCGCGATTACAG
AAAGTCGTGGTCGGTGATCCTGCACAGGAAGGTGTGAAAATGGGCGCACTGGTAAATGCTGAACAGCGTGCTGATGTGCA
GGAAAAAGTGAACACATTGCTGGCTGCAGGATGCGAGATTCGCCTCGGTGGTCAGGCGGATTTATCTGCTGCGGGTGCAT
TCTTCCCGCCAACCTTATTGTACTGTCCGCAGCCGGATGAAACACCGGCGGTACATGCAACAGAAGCCTTTGGCCCTGTC
GCAACGCTGATGCCAGCACAAAACCAGCAACATGCTCTGCAACTGGCTTGTGCAGGCGGCGGTAGCCTTGCGGGAACGCT
GGTGACGGCTGATCCGCAAATTGCGCGTCAGTTTATTGCCGACGCGGCACGTACGCATGGGCGAATTCAGATCCTCAATG
AAGAGTCGGCAAAAGAATCCACCGGGCATGGCTCCCCACTGCCACAACTGGTACATGGTGGGCCTGGTCGCGCAGGAGGC
GGTGAAGAATTAGGTGGTTTACGAGCGGTGAAACATTACATGCAGCGAACCGCTATACAGGGTAGCCCGTCGATGCTTGC
CGCTATCAGTAAACAGTGGGTGCGTGGTGCGAAAGTCGAAGAAGATCGTATTCATCCGTTCCGCAAATATTTTGAGGAGC
TGCAACCAGGCGACAGCCTGCTGACTCCCCGCCGCACAATGACAGAGGCCGATATTGTTAACTTTGCTTGCCTCAGCGGC
GATCATTTCTATGCACATATGGATAAGATTGCTGCTGCCGAATCTATTTTCGGTGAGCGGGTGGTGCATGGGTATTTTGT
GCTTTCTGCGGCTGCGGGTCTGTTTGTCGATGACGGTGTCGGTCCGGTCATTGCTAACTACGGGCTGGAAAGCTTGCGTT
TTATCGAACCCGTAAAGCCAGGCGATACCATCCAGGTGCGTCTCACCTGTAAGCGCAAGACGCTGAAAAAACAGCGTAGC
GCAGAAGAAAAACCAACAGGTGTGGTGGAATGGGCTGTAGAGGTATTCAATCAGCATCAAACCCCGGTGGCGCTGTATTC
AATTCTGACGCTGGTGGCCAGGCAGCACGGTGATTTTGTCGATTAA

Upstream 100 bases:

>100_bases
ACAGATCGCATAGTTAACATTTCGTTAAAAGATCCCTTGCTTTTTATGATTCGCGATTTAACTATTAGCAACAGAAATGT
GAAACATCTGGAGAGTAGCG

Downstream 100 bases:

>100_bases
TCGGTGAATGAAGGGCAACGGCGAATAGTTGCCCTTTTATTTCACTAAGTTTTGTGACGTTGTCACATTATGCATGATGT
GTACATCTATTTTCAGGGCA

Product: bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase

Products: NA

Alternate protein names: Phenylacetic acid degradation protein paaZ [H]

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MQQLDSFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMTFIERAAMLKAVAKHLLSEKE
RFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPDDTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFP
CWGMLEKLAPTWLGGMPAIIKPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSATTGQML
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRRIIVPQALVNAVSDALVARLQ
KVVVGDPAQEGVKMGALVNAEQRADVQEKVNTLLAAGCEIRLGGQADLSAAGAFFPPTLLYCPQPDETPAVHATEAFGPV
ATLMPAQNQQHALQLACAGGGSLAGTLVTADPQIARQFIADAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
GEELGGLRAVKHYMQRTAIQGSPSMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSLLTPRRTMTEADIVNFACLSG
DHFYAHMDKIAAAESIFGERVVHGYFVLSAAAGLFVDDGVGPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRS
AEEKPTGVVEWAVEVFNQHQTPVALYSILTLVARQHGDFVD

Sequences:

>Translated_681_residues
MQQLDSFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMTFIERAAMLKAVAKHLLSEKE
RFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPDDTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFP
CWGMLEKLAPTWLGGMPAIIKPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSATTGQML
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRRIIVPQALVNAVSDALVARLQ
KVVVGDPAQEGVKMGALVNAEQRADVQEKVNTLLAAGCEIRLGGQADLSAAGAFFPPTLLYCPQPDETPAVHATEAFGPV
ATLMPAQNQQHALQLACAGGGSLAGTLVTADPQIARQFIADAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
GEELGGLRAVKHYMQRTAIQGSPSMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSLLTPRRTMTEADIVNFACLSG
DHFYAHMDKIAAAESIFGERVVHGYFVLSAAAGLFVDDGVGPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRS
AEEKPTGVVEWAVEVFNQHQTPVALYSILTLVARQHGDFVD
>Mature_681_residues
MQQLDSFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMTFIERAAMLKAVAKHLLSEKE
RFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPDDTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFP
CWGMLEKLAPTWLGGMPAIIKPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSATTGQML
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRRIIVPQALVNAVSDALVARLQ
KVVVGDPAQEGVKMGALVNAEQRADVQEKVNTLLAAGCEIRLGGQADLSAAGAFFPPTLLYCPQPDETPAVHATEAFGPV
ATLMPAQNQQHALQLACAGGGSLAGTLVTADPQIARQFIADAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
GEELGGLRAVKHYMQRTAIQGSPSMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSLLTPRRTMTEADIVNFACLSG
DHFYAHMDKIAAAESIFGERVVHGYFVLSAAAGLFVDDGVGPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRS
AEEKPTGVVEWAVEVFNQHQTPVALYSILTLVARQHGDFVD

Specific function: Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361176, Length=505, Percent_Identity=25.1485148514851, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI12007648, Length=416, Percent_Identity=25, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI25777724, Length=497, Percent_Identity=23.7424547283702, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI153266822, Length=490, Percent_Identity=23.0612244897959, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI25777732, Length=502, Percent_Identity=25.0996015936255, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI25777728, Length=402, Percent_Identity=24.1293532338308, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI115387104, Length=444, Percent_Identity=23.4234234234234, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI25777730, Length=503, Percent_Identity=25.2485089463221, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI4507229, Length=307, Percent_Identity=27.6872964169381, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI25777721, Length=321, Percent_Identity=26.791277258567, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI188035924, Length=351, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI310128103, Length=351, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787653, Length=681, Percent_Identity=98.8252569750367, Blast_Score=1382, Evalue=0.0,
Organism=Escherichia coli, GI1789015, Length=457, Percent_Identity=25.382932166302, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI87081926, Length=343, Percent_Identity=26.2390670553936, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1787684, Length=402, Percent_Identity=25.6218905472637, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786504, Length=511, Percent_Identity=25.2446183953033, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788042, Length=501, Percent_Identity=26.1477045908184, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082295, Length=275, Percent_Identity=25.0909090909091, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787715, Length=361, Percent_Identity=25.4847645429363, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1787250, Length=404, Percent_Identity=22.2772277227723, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787558, Length=291, Percent_Identity=24.7422680412371, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25143874, Length=452, Percent_Identity=24.5575221238938, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25143876, Length=452, Percent_Identity=24.5575221238938, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI115534176, Length=363, Percent_Identity=26.7217630853994, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17551164, Length=323, Percent_Identity=22.6006191950464, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562198, Length=418, Percent_Identity=24.4019138755981, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71995606, Length=425, Percent_Identity=24.2352941176471, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534119, Length=293, Percent_Identity=25.5972696245734, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995613, Length=367, Percent_Identity=24.5231607629428, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324950, Length=355, Percent_Identity=22.8169014084507, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320917, Length=356, Percent_Identity=23.5955056179775, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325196, Length=275, Percent_Identity=24.7272727272727, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129399, Length=511, Percent_Identity=25.2446183953033, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281362580, Length=302, Percent_Identity=25.1655629139073, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472918, Length=302, Percent_Identity=25.1655629139073, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472926, Length=302, Percent_Identity=25.1655629139073, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472936, Length=302, Percent_Identity=25.1655629139073, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356737, Length=302, Percent_Identity=25.1655629139073, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650465, Length=450, Percent_Identity=22.6666666666667, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR002539
- InterPro:   IPR011966 [H]

Pfam domain/function: PF00171 Aldedh; PF01575 MaoC_dehydratas [H]

EC number: NA

Molecular weight: Translated: 73067; Mature: 73067

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQLDSFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMT
CCHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
FIERAAMLKAVAKHLLSEKERFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPD
HHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCC
DTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFPCWGMLEKLAPTWLGGMPAII
CCCCCCCCEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHC
KPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSATTGQML
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCHHHHHHHCCCCCEEEEECCCCCCCEE
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRR
EECCCHHHCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
IIVPQALVNAVSDALVARLQKVVVGDPAQEGVKMGALVNAEQRADVQEKVNTLLAAGCEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCHHHCCHHHHHHHHHHCCCEE
RLGGQADLSAAGAFFPPTLLYCPQPDETPAVHATEAFGPVATLMPAQNQQHALQLACAGG
EECCCCCCCCCCCCCCCCEEECCCCCCCCCEECHHHHCCHHHHCCCCCCCCEEEEEECCC
GSLAGTLVTADPQIARQFIADAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
CCEECEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCC
GEELGGLRAVKHYMQRTAIQGSPSMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSL
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCCCC
LTPRRTMTEADIVNFACLSGDHFYAHMDKIAAAESIFGERVVHGYFVLSAAAGLFVDDGV
CCCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
GPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRSAEEKPTGVVEWAVEVFNQHQ
CHHHHHCCHHHHHHHCCCCCCCEEEEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
TPVALYSILTLVARQHGDFVD
CHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQQLDSFLSGTWQSGRGRSRLIHHAISGEALWEVTSEGLDMAAARQFAIEKGAPALRAMT
CCHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHH
FIERAAMLKAVAKHLLSEKERFYALSAQTGATRADSWVDIEGGIGTLFTYASLGSRELPD
HHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCC
DTLWPEDELIPLSKEGGFAARHVLTSKSGVAVHINAFNFPCWGMLEKLAPTWLGGMPAII
CCCCCCCCEEECCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHC
KPATATAQLTQAMVKSIVDSGLVPEGAISLICGSAGDLLDHLDSQDVVTFTGSATTGQML
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCHHHHHHHCCCCCEEEEECCCCCCCEE
RVQPNIVAKSIPFTMEADSLNCCVLGEDVTPDQPEFALFIREVVREMTTKAGQKCTAIRR
EECCCHHHCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
IIVPQALVNAVSDALVARLQKVVVGDPAQEGVKMGALVNAEQRADVQEKVNTLLAAGCEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCHHHCCHHHHHHHHHHCCCEE
RLGGQADLSAAGAFFPPTLLYCPQPDETPAVHATEAFGPVATLMPAQNQQHALQLACAGG
EECCCCCCCCCCCCCCCCEEECCCCCCCCCEECHHHHCCHHHHCCCCCCCCEEEEEECCC
GSLAGTLVTADPQIARQFIADAARTHGRIQILNEESAKESTGHGSPLPQLVHGGPGRAGG
CCEECEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCC
GEELGGLRAVKHYMQRTAIQGSPSMLAAISKQWVRGAKVEEDRIHPFRKYFEELQPGDSL
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCCCC
LTPRRTMTEADIVNFACLSGDHFYAHMDKIAAAESIFGERVVHGYFVLSAAAGLFVDDGV
CCCCHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
GPVIANYGLESLRFIEPVKPGDTIQVRLTCKRKTLKKQRSAEEKPTGVVEWAVEVFNQHQ
CHHHHHCCHHHHHHHCCCCCCCEEEEEEEECHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
TPVALYSILTLVARQHGDFVD
CHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]