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The map label for this gene is tdk [H]

Identifier: 157160745

GI number: 157160745

Start: 1341784

End: 1342401

Strand: Direct

Name: tdk [H]

Synonym: EcHS_A1347

Alternate gene names: 157160745

Gene position: 1341784-1342401 (Clockwise)

Preceding gene: 157160742

Following gene: 157160747

Centisome position: 28.9

GC content: 42.23

Gene sequence:

>618_bases
ATGGCACAGCTATATTTCTACTATTCCGCAATGAATGCGGGTAAGTCTACAGCATTGTTGCAATCTTCATACAATTACCA
GGAACGCGGCATGCGCACTGTCGTATATACGGCAGAAATTGATGATCGCTTTGGTGCCGGGAAAGTCAGTTCGCGTATAG
GTTTGTCATCGCCTGCAAAATTATTTAACCAAAATTCATCATTATTTGATGAGATTCGTTCGGAACATGAACAGCAGGCA
ATTCATTGCGTACTGGTTGATGAATGCCAGTTTTTAACCAGACAACAAGTATATGAATTATCGGAGGTTGTCGATCAACT
CGATATACCCGTACTTTGTTATGGTTTACGTACCGATTTTCGAGGTGAATTATTTATTGGCAGCCAATACTTACTGGCAT
GGTCCGACAAACTGGTTGAATTAAAAACCATCTGTTTTTGTGGCCGTAAAGCAAGCATGGTGCTGCGTCTTGATCAAGCA
GGCAGACCTTATAACGAAGGTGAGCAGGTGGTTATTGGTGGTAATGAACGATACGTTTCTGTATGCCGTAAACACTATAA
AGAGGCGTTACAAGTCGGCTCATTAACGGCTATTCAGGAAAGGCATCGCCACGATTAA

Upstream 100 bases:

>100_bases
ACGCATATACCACTTCTGTGCATACTGTTGAGCTGAAAAACTGACGAATTATGATAAACTCCAGCCAACTTTATTTCATA
TCATTGAGGGCCTGTGGCTG

Downstream 100 bases:

>100_bases
TAAGAATTTCTTTACTGACAGGGTGAGCAGGGCGCTTTTATCCTGTCAGTTCGTTTTACTCACTTCTTCCGGGCTATACA
CCCTTCTCGGCAGTTTTTTA

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRSEHEQQA
IHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQA
GRPYNEGEQVVIGGNERYVSVCRKHYKEALQVGSLTAIQERHRHD

Sequences:

>Translated_205_residues
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRSEHEQQA
IHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQA
GRPYNEGEQVVIGGNERYVSVCRKHYKEALQVGSLTAIQERHRHD
>Mature_204_residues
AQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAKLFNQNSSLFDEIRSEHEQQAI
HCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDFRGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAG
RPYNEGEQVVIGGNERYVSVCRKHYKEALQVGSLTAIQERHRHD

Specific function: Phosphorylates both thymidine and deoxyuridine [H]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787490, Length=205, Percent_Identity=99.0243902439024, Blast_Score=422, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634 [H]

Pfam domain/function: PF00265 TK [H]

EC number: =2.7.1.21 [H]

Molecular weight: Translated: 23415; Mature: 23284

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAK
CCEEEEEEEECCCCCHHHHHHCCCCHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
LFNQNSSLFDEIRSEHEQQAIHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDF
HHCCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
RGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAGRPYNEGEQVVIGGNERYVS
CCEEEECCEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECCCHHHHH
VCRKHYKEALQVGSLTAIQERHRHD
HHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure 
AQLYFYYSAMNAGKSTALLQSSYNYQERGMRTVVYTAEIDDRFGAGKVSSRIGLSSPAK
CEEEEEEEECCCCCHHHHHHCCCCHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
LFNQNSSLFDEIRSEHEQQAIHCVLVDECQFLTRQQVYELSEVVDQLDIPVLCYGLRTDF
HHCCCCHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
RGELFIGSQYLLAWSDKLVELKTICFCGRKASMVLRLDQAGRPYNEGEQVVIGGNERYVS
CCEEEECCEEEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEECCCHHHHH
VCRKHYKEALQVGSLTAIQERHRHD
HHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10222209; 11206551; 11258796 [H]