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The map label for this gene is efeU

Identifier: 157160541

GI number: 157160541

Start: 1143654

End: 1144484

Strand: Direct

Name: efeU

Synonym: EcHS_A1132

Alternate gene names: 157160541

Gene position: 1143654-1144484 (Clockwise)

Preceding gene: 157160540

Following gene: 157160542

Centisome position: 24.63

GC content: 54.27

Gene sequence:

>831_bases
ATGTTTGTTCCGTTTCTCATTATGTTGCGCGAAGGACTTGAAGCCGCGCTGATTGTCAGTTTGATTGCCAGCTATCTTAA
GCGTACCCAGCGAGGCCGATGGATTGGTGTGATGTGGATTGGCGTGTTGCTTGCCGCTGCGTTGTGCCTGGGCTTGGGTA
TCTTCATTAACGAAACCACCGGCGAATTTCCGCAAAAAGAACAGGAACTGTTTGAAGGTATCGTGGCGGTGATCGCCGTG
GTGATCCTTACCTGGATGGTTTTCTGGATGCGCAAAGTGTCGCGCAACGTCAAAGTGCAACTGGAACAGGCAGTCGATAG
CGCATTGCAGCGTGGAAATCATCATGGCTGGGCGCTGGTGATGATGGTCTTTTTTGCCGTTGCAAGGGAAGGGCTGGAGT
CGGTCTTTTTCCTGCTGGCGGCATTTCAACAAGATGTCGGGATCTGGCCGCCGCTGGGTGCAATGCTCGGTCTTGCTACT
GCCGTGGTGCTAGGCTTCCTGCTCTACTGGGGCGGTATTCGCCTCAATCTTGGTGCATTTTTTAAATGGACCAGCCTGTT
TATTCTCTTCGTCGCCGCAGGGCTGGCAGCTGGTGCCATTCGCGCATTTCATGAAGCCGGATTGTGGAACCACTTTCAGG
AAATCGCCTTCGATATGAGTGCGGTGCTCTCAACTCACTCGCTGTTTGGCACGCTGATGGAAGGGATTTTTGGCTATCAG
GAAGCGCCGAGCGTCAGCGAAGTCGCCGTCTGGTTTATTTATCTCATCCCGGCGCTGGTGGCATTTGCTCTGCCACCACG
CGCAGGGGCGACAGCGTCTCGCTCCGCGTAA

Upstream 100 bases:

>100_bases
TTCCGCTTGTATTTTTCTTTACCGTAATGATAATCGCTATCACTGCGATTTACTTTTCTTTGCATAGATTGACTCAGAAA
AACGTTTAAGGGTGGGTGGC

Downstream 100 bases:

>100_bases
CAAATACGACGCAAACTCTTGCTTAGTTACAACATACTTTAAAGGGATAGTCTCGTCATGACCATTAACTTCCGCCGTAA
CGCATTGCAGTTGAGCGTGG

Product: iron permease FTR1 family protein

Products: NA

Alternate protein names: Fe(2+) ion permease efeU; Ferrous iron uptake protein

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKEQELFEGIVAVIAV
VILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNHHGWALVMMVFFAVAREGLESVFFLLAAFQQDVGIWPPLGAMLGLAT
AVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFGYQ
EAPSVSEVAVWFIYLIPALVAFALPPRAGATASRSA

Sequences:

>Translated_276_residues
MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKEQELFEGIVAVIAV
VILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNHHGWALVMMVFFAVAREGLESVFFLLAAFQQDVGIWPPLGAMLGLAT
AVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFGYQ
EAPSVSEVAVWFIYLIPALVAFALPPRAGATASRSA
>Mature_276_residues
MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKEQELFEGIVAVIAV
VILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNHHGWALVMMVFFAVAREGLESVFFLLAAFQQDVGIWPPLGAMLGLAT
AVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFGYQ
EAPSVSEVAVWFIYLIPALVAFALPPRAGATASRSA

Specific function: Functions only as an uptake system for Fe(2+) ion acquisition

COG id: COG0672

COG function: function code P; High-affinity Fe2+/Pb2+ permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family

Homologues:

Organism=Saccharomyces cerevisiae, GI6320993, Length=213, Percent_Identity=27.6995305164319, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EFEU_ECO57 (Q8XAS8)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   G85646
- PIR:   G90786
- RefSeq:   NP_287024.1
- RefSeq:   NP_309290.1
- EnsemblBacteria:   EBESCT00000027455
- EnsemblBacteria:   EBESCT00000056023
- GeneID:   912835
- GeneID:   959155
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z1519
- KEGG:   ecs:ECs1263
- GeneTree:   EBGT00050000010013
- HOGENOM:   HBG724625
- OMA:   SMVFWMR
- ProtClustDB:   CLSK879929
- BioCyc:   ECOL83334:ECS1263-MONOMER
- InterPro:   IPR005217
- InterPro:   IPR004923
- TIGRFAMs:   TIGR00145

Pfam domain/function: PF03239 FTR1

EC number: NA

Molecular weight: Translated: 30344; Mature: 30344

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1397f920)-; HASH(0x1379acc8)-; HASH(0x12976e34)-; HASH(0x133456b8)-; HASH(0x140814f4)-; HASH(0x14067c68)-; HASH(0x13eeadc0)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
>Mature Secondary Structure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CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796