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The map label for this gene is putA [H]

Identifier: 157160538

GI number: 157160538

Start: 1137219

End: 1141181

Strand: Reverse

Name: putA [H]

Synonym: EcHS_A1129

Alternate gene names: 157160538

Gene position: 1141181-1137219 (Counterclockwise)

Preceding gene: 157160539

Following gene: 157160536

Centisome position: 24.58

GC content: 56.22

Gene sequence:

>3963_bases
ATGGGAACCACCACCATGGGGGTTAAGCTGGACGACGCGACGCGTGAGCGTATTAAGTCTGCCGCGACACGTATCGATCG
CACGCCACACTGGTTAATTAAGCAGGCGATTTTTTCTTATCTCGAACAACTGGAAAACAGCGATACTCTGCCGGAGCTAC
CTGCGCTGCTTTCTGGCGCTGCCAATGAGAGCGATGAAGCACCGACTCCGGCAGAGGAACCACACCAACCATTCCTCGAC
TTTGCCGAGCAAATTTTGCCCCAGTCGGTTTCCCGCGCCGCGATCACAGCGGCCTATCGCCGCCCGGAAACCGAAGCGGT
TTCTATGCTGCTGGAACAAGCCCGCCTGCCGCAGCCAGTTGCTGAACAGGCGCACAAACTGGCGTATCAACTGGCCGATA
AACTGCGTAATCAAAAAAACGCCAGTGGTCGCGCAGGTATGGTTCAGGGGTTATTGCAGGAGTTTTCGTTGTCATCGCAG
GAAGGCGTGGCGCTGATGTGTCTGGCGGAAGCGTTGTTGCGTATTCCCGACAAAGCCACCCGTGATGCGTTAATTCGCGA
CAAAATCAGCAACGGTAACTGGCAATCACACATTGGTCGTAGCCCGTCTTTGTTTGTTAATGCCGCCACCTGGGGGCTGC
TGTTTACTGGCAAACTGGTTTCCACCCATAACGAAGCCAGCCTCTCCCGCTCGCTGAACCGCATTATCGGTAAAAGCGGT
GAACCGCTGATCCGCAAAGGTGTGGATATGGCGATGCGCCTGATGGGCGAGCAGTTCGTCACTGGCGAAACCATCGCGGA
AGCGTTAGCCAATGCCCGCAAGCTGGAAGAGAAAGGTTTCCGTTACTCTTACGATATGCTTGGCGAAGCTGCACTGACTG
CCGCAGATGCACAAGCGTATATGGTTTCCTATCAGCAGGCGATTCACGCCATTGGTAAAGCGTCCAATGGTCGTGGCATC
TATGAAGGTCCGGGCATTTCAATCAAGCTGTCGGCGCTGCATCCGCGTTACAGCCGCGCCCAGTATGACCGGGTAATGGA
AGAGCTTTACCCACGTCTGAAATCACTCACCCTGCTGGCGCGTCAGTACGATATTGGTATCAACATTGACGCCGAAGAGG
CCGATCGTCTGGAGATCTCCCTCGATCTGCTGGAAAAACTCTGTTTCGAGCCTGAGCTGGCAGGCTGGAACGGTATCGGT
TTTGTTATTCAGGCTTATCAAAAACGCTGCCCACTGGTGATTGATTACCTGATTGATCTCGCCACCCGCAGCCGTCGCCG
TCTGATGATTCGCCTGGTGAAAGGCGCGTACTGGGATAGTGAAATCAAGCGTGCGCAGATGGACGGCCTTGAAGGCTATC
CGGTTTATACCCGCAAGGTGTATACCGACGTTTCATATCTCGCCTGTGCGAAAAAGCTGCTGGCGGTGCCGAATCTAATC
TACCCGCAGTTCGCAACGCACAACGCCCATACGCTGGCAGCGATTTATCAACTGGCTGGTCAAAACTACTATCCGGGTCA
GTACGAGTTCCAGTGCCTGCATGGTATGGGCGAGCCACTGTATGAGCAGGTCACCGGGAAAGTTGCCGACGGCAAACTTA
ACCGTCCGTGTCGTATTTATGCCCCGGTTGGCACACATGAAACGCTGCTGGCGTATCTGGTGCGCCGCCTGCTGGAAAAC
GGTGCTAACACCTCGTTTGTTAACCGTATTGCCGACACCTCTTTGCCACTGGATGAACTGGTCGCCGATCCGGTCACTGC
TGTAGAAAAACTGGCGCAACAGGAAGGGCAAACTGGATTACCGCATCCGAAAATTCCCCTGCCGCGCGATCTTTACGGTC
ACGGGCGCGACAACTCGGCAGGGCTGGATCTCGCTAACGAACACCGTCTGGCCTCGCTCTCTTCTGCCCTGCTCAATAGT
GCACTGCAAAAATGGCAGGCCTTGCCAATGCTGGAACAACCGGTAGCGGCAGGTGAGATGTCGCCCGTTATTAACCCTGC
GGAACCGAAAGATATTGTGGGCTTTGTGCGTGAAGCCACGCCGCGTGAGGTAGAACAGGCGCTGGAAAGTGCGGTTAATA
ACGCGCCAATCTGGTTTGCCACTCCTCCGGTTGAACGCGCGGCGATTTTGCATCGCGCTGCCGTGCTAATGGAAAGCCAG
ATGCAGCAACTGATTGGTATTCTGGTGCGTGAAGCCGGAAAAACCTTCAGTAACGCCATTGCCGAAGTGCGCGAAGCGGT
CGATTTTCTCCACTACTATGCCGGACAGGTGCGGGATGATTTCGCTAACGAAACCCACCGTCCATTAGGGCCTGTGGTGT
GTATCAGTCCGTGGAACTTCCCGCTGGCTATTTTCACCGGGCAGATTGCTGCCGCACTGGCGGCAGGTAACAGCGTGCTG
GCAAAACCGGCAGAACAAACGCCGCTGATTGCCGCGCAAGGGATCGCCATTTTGCTGGAAGCGGGTGTACCGCCAGGCGT
GGTGCAGTTGCTGCCAGGTCAGGGGGAAACCGTGGGCGCGCAACTGACGGGTGATGATCGCGTACGCGGGGTGATGTTTA
CCGGTTCAACCGAAGTCGCTACGTTACTGCAGCGCAATATCGCCAGCCGCCTGGACGCTCAGGGTCGCCCTATTCCGCTC
ATCGCTGAAACCGGCGGCATGAACGCGATGATTGTCGATTCTTCAGCACTGACCGAACAAGTAGTAATAGATGTGCTGGC
CTCGGCGTTCGACAGTGCGGGTCAGCGTTGTTCGGCGCTGCGCGTGCTGTGCCTGCAAGATGAGATTGCCGACCACACGT
TGAAAATGCTGCGCGGCGCAATGGCCGAATGCCGGATGGGTAATCCGGGTCGCCTGACCACCGATATCGGTCCGGTGATT
GATAGCGAAGCGAAAGTCAATATTGAGCGCCATATTCAGACCATGCGTAGCAAAGGCCGTCCGGTGTTCCAGGCGGTGCG
GGAAAACAGTGAAGATGCCCGTGAATGGCAAAGCGGCACCTTTGTCGCCCCGACGCTGATCGAACTGGATGACTTTGCCG
AATTGCAAAAAGAGGTCTTTGGTCCGGTGCTGCATGTGGTGCGTTACAACCGTAACCAGCTACCAGAGCTGATCGAGCAG
ATTAACGCTTCCGGTTATGGTCTGACGCTTGGCGTCCATACGCGTATTGATGAAACTATCGCCCAGGTCACTGGCTCGGC
CCATGTTGGTAACCTGTATGTTAACCGTAATATGGTGGGCGCAGTGGTTGGTGTGCAGCCGTTCGGCGGCGAAGGGTTGT
CCGGTACCGGGCCGAAAGCAGGCGGTCCGCTCTATCTCTACCGTCTGCTGGCGAATCGCCCGGAAAGTGCGCTGGCAGTA
ACGCTCGCGCGTCAGGATGCAGAGTATCCGGTCGATGCGCAGTTGAAAGCCGCATTGACTCAGCCGCTAAATGCACTGCG
GGAATGGGCAGCAAATCGTCCAGAATTGCAGGCGTTATGTACGCAATATGGCGAGCTGGCGCAGGCAGGAACACAACGAT
TGCTGCCGGGGCCGACGGGTGAACGCAACACCTGGACGCTGCTGCCGCGTGAGCGCGTGTTGTGTATTGCCGATGATGAG
CAGGATGCGCTGACTCAGCTCGCCGCCGTGCTGGCGGTGGGCAGCCAGGTACTGTGGCCGGATGACGCGCTGCATCGTCA
GTTAGTGAAGGCATTGCCATCGGCAGTCAGCGAACGTATTCAACTGGCGAAAGCGGAAAATATAACCGCTCAACCGTTTG
ATGCGGTGATCTTCCACGGTGATTCGGATCAGCTTCGCGCATTGTGTGAAGCCGTTGCTGCGCGGGATGGCGCAATTGTT
TCGGTGCAGGGTTTTGCCCGTGGCGAAAGCAATATCCTTCTGGAACGGCTGTATATCGAGCGTTCGCTGAGTGTGAATAC
CGCTGCCGCTGGCGGTAACGCCAGCTTAATGACTATAGGTTAA

Upstream 100 bases:

>100_bases
CTACGCATGTCACATTTAACATGGTTGCACAAAGTTGCAACATCATGGATATTTCACGATAACGTTAAGTTGCACCTTTC
AGAACAACAGGAGTAATGGC

Downstream 100 bases:

>100_bases
ACAGGTAGCCGGAGGATGTTACAACCTCCTCCGGCATCTTTAACGTGGTCGAATCCCCTCAATAATAATCCGCTGCACGT
TTTCAACCGTTTGATTGAAA

Product: trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase

Products: NA

Alternate protein names: Proline dehydrogenase; Proline oxidase; Delta-1-pyrroline-5-carboxylate dehydrogenase; P5C dehydrogenase [H]

Number of amino acids: Translated: 1320; Mature: 1319

Protein sequence:

>1320_residues
MGTTTMGVKLDDATRERIKSAATRIDRTPHWLIKQAIFSYLEQLENSDTLPELPALLSGAANESDEAPTPAEEPHQPFLD
FAEQILPQSVSRAAITAAYRRPETEAVSMLLEQARLPQPVAEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQ
EGVALMCLAEALLRIPDKATRDALIRDKISNGNWQSHIGRSPSLFVNAATWGLLFTGKLVSTHNEASLSRSLNRIIGKSG
EPLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAYMVSYQQAIHAIGKASNGRGI
YEGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLARQYDIGINIDAEEADRLEISLDLLEKLCFEPELAGWNGIG
FVIQAYQKRCPLVIDYLIDLATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLI
YPQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIYAPVGTHETLLAYLVRRLLEN
GANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGLPHPKIPLPRDLYGHGRDNSAGLDLANEHRLASLSSALLNS
ALQKWQALPMLEQPVAAGEMSPVINPAEPKDIVGFVREATPREVEQALESAVNNAPIWFATPPVERAAILHRAAVLMESQ
MQQLIGILVREAGKTFSNAIAEVREAVDFLHYYAGQVRDDFANETHRPLGPVVCISPWNFPLAIFTGQIAAALAAGNSVL
AKPAEQTPLIAAQGIAILLEAGVPPGVVQLLPGQGETVGAQLTGDDRVRGVMFTGSTEVATLLQRNIASRLDAQGRPIPL
IAETGGMNAMIVDSSALTEQVVIDVLASAFDSAGQRCSALRVLCLQDEIADHTLKMLRGAMAECRMGNPGRLTTDIGPVI
DSEAKVNIERHIQTMRSKGRPVFQAVRENSEDAREWQSGTFVAPTLIELDDFAELQKEVFGPVLHVVRYNRNQLPELIEQ
INASGYGLTLGVHTRIDETIAQVTGSAHVGNLYVNRNMVGAVVGVQPFGGEGLSGTGPKAGGPLYLYRLLANRPESALAV
TLARQDAEYPVDAQLKAALTQPLNALREWAANRPELQALCTQYGELAQAGTQRLLPGPTGERNTWTLLPRERVLCIADDE
QDALTQLAAVLAVGSQVLWPDDALHRQLVKALPSAVSERIQLAKAENITAQPFDAVIFHGDSDQLRALCEAVAARDGAIV
SVQGFARGESNILLERLYIERSLSVNTAAAGGNASLMTIG

Sequences:

>Translated_1320_residues
MGTTTMGVKLDDATRERIKSAATRIDRTPHWLIKQAIFSYLEQLENSDTLPELPALLSGAANESDEAPTPAEEPHQPFLD
FAEQILPQSVSRAAITAAYRRPETEAVSMLLEQARLPQPVAEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQ
EGVALMCLAEALLRIPDKATRDALIRDKISNGNWQSHIGRSPSLFVNAATWGLLFTGKLVSTHNEASLSRSLNRIIGKSG
EPLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAYMVSYQQAIHAIGKASNGRGI
YEGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLARQYDIGINIDAEEADRLEISLDLLEKLCFEPELAGWNGIG
FVIQAYQKRCPLVIDYLIDLATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLI
YPQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIYAPVGTHETLLAYLVRRLLEN
GANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGLPHPKIPLPRDLYGHGRDNSAGLDLANEHRLASLSSALLNS
ALQKWQALPMLEQPVAAGEMSPVINPAEPKDIVGFVREATPREVEQALESAVNNAPIWFATPPVERAAILHRAAVLMESQ
MQQLIGILVREAGKTFSNAIAEVREAVDFLHYYAGQVRDDFANETHRPLGPVVCISPWNFPLAIFTGQIAAALAAGNSVL
AKPAEQTPLIAAQGIAILLEAGVPPGVVQLLPGQGETVGAQLTGDDRVRGVMFTGSTEVATLLQRNIASRLDAQGRPIPL
IAETGGMNAMIVDSSALTEQVVIDVLASAFDSAGQRCSALRVLCLQDEIADHTLKMLRGAMAECRMGNPGRLTTDIGPVI
DSEAKVNIERHIQTMRSKGRPVFQAVRENSEDAREWQSGTFVAPTLIELDDFAELQKEVFGPVLHVVRYNRNQLPELIEQ
INASGYGLTLGVHTRIDETIAQVTGSAHVGNLYVNRNMVGAVVGVQPFGGEGLSGTGPKAGGPLYLYRLLANRPESALAV
TLARQDAEYPVDAQLKAALTQPLNALREWAANRPELQALCTQYGELAQAGTQRLLPGPTGERNTWTLLPRERVLCIADDE
QDALTQLAAVLAVGSQVLWPDDALHRQLVKALPSAVSERIQLAKAENITAQPFDAVIFHGDSDQLRALCEAVAARDGAIV
SVQGFARGESNILLERLYIERSLSVNTAAAGGNASLMTIG
>Mature_1319_residues
GTTTMGVKLDDATRERIKSAATRIDRTPHWLIKQAIFSYLEQLENSDTLPELPALLSGAANESDEAPTPAEEPHQPFLDF
AEQILPQSVSRAAITAAYRRPETEAVSMLLEQARLPQPVAEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQE
GVALMCLAEALLRIPDKATRDALIRDKISNGNWQSHIGRSPSLFVNAATWGLLFTGKLVSTHNEASLSRSLNRIIGKSGE
PLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAYMVSYQQAIHAIGKASNGRGIY
EGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLARQYDIGINIDAEEADRLEISLDLLEKLCFEPELAGWNGIGF
VIQAYQKRCPLVIDYLIDLATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLIY
PQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIYAPVGTHETLLAYLVRRLLENG
ANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGLPHPKIPLPRDLYGHGRDNSAGLDLANEHRLASLSSALLNSA
LQKWQALPMLEQPVAAGEMSPVINPAEPKDIVGFVREATPREVEQALESAVNNAPIWFATPPVERAAILHRAAVLMESQM
QQLIGILVREAGKTFSNAIAEVREAVDFLHYYAGQVRDDFANETHRPLGPVVCISPWNFPLAIFTGQIAAALAAGNSVLA
KPAEQTPLIAAQGIAILLEAGVPPGVVQLLPGQGETVGAQLTGDDRVRGVMFTGSTEVATLLQRNIASRLDAQGRPIPLI
AETGGMNAMIVDSSALTEQVVIDVLASAFDSAGQRCSALRVLCLQDEIADHTLKMLRGAMAECRMGNPGRLTTDIGPVID
SEAKVNIERHIQTMRSKGRPVFQAVRENSEDAREWQSGTFVAPTLIELDDFAELQKEVFGPVLHVVRYNRNQLPELIEQI
NASGYGLTLGVHTRIDETIAQVTGSAHVGNLYVNRNMVGAVVGVQPFGGEGLSGTGPKAGGPLYLYRLLANRPESALAVT
LARQDAEYPVDAQLKAALTQPLNALREWAANRPELQALCTQYGELAQAGTQRLLPGPTGERNTWTLLPRERVLCIADDEQ
DALTQLAAVLAVGSQVLWPDDALHRQLVKALPSAVSERIQLAKAENITAQPFDAVIFHGDSDQLRALCEAVAARDGAIVS
VQGFARGESNILLERLYIERSLSVNTAAAGGNASLMTIG

Specific function: Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon [H]

COG id: COG4230

COG function: function code C; Delta 1-pyrroline-5-carboxylate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI25777724, Length=468, Percent_Identity=30.1282051282051, Blast_Score=179, Evalue=2e-44,
Organism=Homo sapiens, GI21361176, Length=466, Percent_Identity=30.9012875536481, Blast_Score=178, Evalue=3e-44,
Organism=Homo sapiens, GI25777736, Length=522, Percent_Identity=29.5019157088123, Blast_Score=177, Evalue=7e-44,
Organism=Homo sapiens, GI25777734, Length=522, Percent_Identity=29.5019157088123, Blast_Score=177, Evalue=7e-44,
Organism=Homo sapiens, GI25777730, Length=489, Percent_Identity=30.0613496932515, Blast_Score=177, Evalue=7e-44,
Organism=Homo sapiens, GI153266822, Length=463, Percent_Identity=29.1576673866091, Blast_Score=177, Evalue=8e-44,
Organism=Homo sapiens, GI238859541, Length=446, Percent_Identity=30.9417040358744, Blast_Score=172, Evalue=2e-42,
Organism=Homo sapiens, GI25777728, Length=413, Percent_Identity=30.9927360774818, Blast_Score=166, Evalue=2e-40,
Organism=Homo sapiens, GI21614513, Length=423, Percent_Identity=29.3144208037825, Blast_Score=160, Evalue=7e-39,
Organism=Homo sapiens, GI25777732, Length=458, Percent_Identity=29.0393013100437, Blast_Score=160, Evalue=7e-39,
Organism=Homo sapiens, GI12007648, Length=432, Percent_Identity=29.1666666666667, Blast_Score=154, Evalue=8e-37,
Organism=Homo sapiens, GI238814322, Length=419, Percent_Identity=26.9689737470167, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI4507229, Length=488, Percent_Identity=29.5081967213115, Blast_Score=148, Evalue=4e-35,
Organism=Homo sapiens, GI25777721, Length=501, Percent_Identity=29.3413173652695, Blast_Score=142, Evalue=2e-33,
Organism=Homo sapiens, GI188035924, Length=523, Percent_Identity=27.5334608030593, Blast_Score=141, Evalue=6e-33,
Organism=Homo sapiens, GI310128103, Length=542, Percent_Identity=27.1217712177122, Blast_Score=140, Evalue=6e-33,
Organism=Homo sapiens, GI115387104, Length=463, Percent_Identity=26.5658747300216, Blast_Score=140, Evalue=7e-33,
Organism=Homo sapiens, GI310128093, Length=542, Percent_Identity=26.7527675276753, Blast_Score=140, Evalue=8e-33,
Organism=Homo sapiens, GI25777726, Length=466, Percent_Identity=25.9656652360515, Blast_Score=124, Evalue=5e-28,
Organism=Homo sapiens, GI11095441, Length=425, Percent_Identity=26.3529411764706, Blast_Score=124, Evalue=7e-28,
Organism=Homo sapiens, GI310128091, Length=390, Percent_Identity=28.974358974359, Blast_Score=123, Evalue=2e-27,
Organism=Homo sapiens, GI25952152, Length=241, Percent_Identity=31.9502074688797, Blast_Score=104, Evalue=5e-22,
Organism=Homo sapiens, GI310128087, Length=362, Percent_Identity=28.4530386740331, Blast_Score=102, Evalue=3e-21,
Organism=Homo sapiens, GI206597441, Length=413, Percent_Identity=25.90799031477, Blast_Score=97, Evalue=1e-19,
Organism=Homo sapiens, GI206597439, Length=413, Percent_Identity=25.90799031477, Blast_Score=97, Evalue=1e-19,
Organism=Homo sapiens, GI22907049, Length=413, Percent_Identity=25.90799031477, Blast_Score=97, Evalue=1e-19,
Organism=Homo sapiens, GI71773324, Length=397, Percent_Identity=27.2040302267003, Blast_Score=95, Evalue=4e-19,
Organism=Homo sapiens, GI4502043, Length=341, Percent_Identity=27.5659824046921, Blast_Score=95, Evalue=4e-19,
Organism=Homo sapiens, GI238814371, Length=341, Percent_Identity=27.5659824046921, Blast_Score=95, Evalue=4e-19,
Organism=Homo sapiens, GI310128089, Length=329, Percent_Identity=27.0516717325228, Blast_Score=92, Evalue=5e-18,
Organism=Homo sapiens, GI310128095, Length=316, Percent_Identity=27.8481012658228, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI73695881, Length=343, Percent_Identity=26.2390670553936, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI73695879, Length=343, Percent_Identity=26.2390670553936, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI310128101, Length=309, Percent_Identity=26.8608414239482, Blast_Score=83, Evalue=2e-15,
Organism=Homo sapiens, GI310128099, Length=297, Percent_Identity=27.6094276094276, Blast_Score=82, Evalue=5e-15,
Organism=Homo sapiens, GI4557303, Length=383, Percent_Identity=26.1096605744125, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI73466520, Length=383, Percent_Identity=26.1096605744125, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI310128097, Length=261, Percent_Identity=28.3524904214559, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI301500698, Length=283, Percent_Identity=25.0883392226148, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI223972651, Length=421, Percent_Identity=26.603325415677, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1787250, Length=1320, Percent_Identity=99.3939393939394, Blast_Score=2685, Evalue=0.0,
Organism=Escherichia coli, GI1789015, Length=466, Percent_Identity=30.4721030042918, Blast_Score=176, Evalue=9e-45,
Organism=Escherichia coli, GI1787715, Length=455, Percent_Identity=31.8681318681319, Blast_Score=168, Evalue=2e-42,
Organism=Escherichia coli, GI1788042, Length=439, Percent_Identity=32.3462414578588, Blast_Score=167, Evalue=5e-42,
Organism=Escherichia coli, GI1787684, Length=461, Percent_Identity=28.8503253796095, Blast_Score=155, Evalue=2e-38,
Organism=Escherichia coli, GI1787558, Length=490, Percent_Identity=28.1632653061224, Blast_Score=154, Evalue=3e-38,
Organism=Escherichia coli, GI1786504, Length=460, Percent_Identity=28.695652173913, Blast_Score=153, Evalue=9e-38,
Organism=Escherichia coli, GI87082295, Length=443, Percent_Identity=28.6681715575621, Blast_Score=143, Evalue=7e-35,
Organism=Escherichia coli, GI87081896, Length=468, Percent_Identity=28.6324786324786, Blast_Score=142, Evalue=2e-34,
Organism=Escherichia coli, GI87081926, Length=448, Percent_Identity=26.5625, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1787653, Length=404, Percent_Identity=21.7821782178218, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144435, Length=465, Percent_Identity=30.5376344086021, Blast_Score=173, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17534447, Length=489, Percent_Identity=28.8343558282209, Blast_Score=168, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI115534176, Length=480, Percent_Identity=29.7916666666667, Blast_Score=163, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI133930964, Length=471, Percent_Identity=28.8747346072187, Blast_Score=163, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17562198, Length=462, Percent_Identity=29.8701298701299, Blast_Score=161, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI32564736, Length=411, Percent_Identity=30.9002433090024, Blast_Score=161, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI115532534, Length=366, Percent_Identity=31.4207650273224, Blast_Score=156, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI25143874, Length=461, Percent_Identity=27.9826464208243, Blast_Score=144, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25143876, Length=461, Percent_Identity=27.9826464208243, Blast_Score=143, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71986308, Length=427, Percent_Identity=28.1030444964871, Blast_Score=142, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17534119, Length=463, Percent_Identity=27.2138228941685, Blast_Score=134, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17551164, Length=451, Percent_Identity=26.1640798226164, Blast_Score=133, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI32564151, Length=415, Percent_Identity=26.9879518072289, Blast_Score=124, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71995606, Length=460, Percent_Identity=25.8695652173913, Blast_Score=124, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71995613, Length=417, Percent_Identity=25.6594724220624, Blast_Score=120, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71990744, Length=302, Percent_Identity=27.4834437086093, Blast_Score=93, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17564084, Length=340, Percent_Identity=25.8823529411765, Blast_Score=90, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25146391, Length=390, Percent_Identity=23.3333333333333, Blast_Score=84, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25146394, Length=390, Percent_Identity=23.3333333333333, Blast_Score=84, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI32566756, Length=386, Percent_Identity=23.3160621761658, Blast_Score=83, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6321826, Length=541, Percent_Identity=29.7597042513863, Blast_Score=181, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6325196, Length=466, Percent_Identity=30.9012875536481, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324950, Length=461, Percent_Identity=27.765726681128, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320917, Length=455, Percent_Identity=29.2307692307692, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323821, Length=476, Percent_Identity=29.4117647058824, Blast_Score=157, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6323822, Length=475, Percent_Identity=28.4210526315789, Blast_Score=155, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6319478, Length=466, Percent_Identity=30.2575107296137, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321828, Length=374, Percent_Identity=26.7379679144385, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20129399, Length=462, Percent_Identity=30.5194805194805, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24650465, Length=461, Percent_Identity=27.9826464208243, Blast_Score=169, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24668425, Length=476, Percent_Identity=28.3613445378151, Blast_Score=168, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24668417, Length=476, Percent_Identity=28.3613445378151, Blast_Score=168, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24668413, Length=476, Percent_Identity=28.3613445378151, Blast_Score=168, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281362580, Length=452, Percent_Identity=27.8761061946903, Blast_Score=164, Evalue=6e-40,
Organism=Drosophila melanogaster, GI62472918, Length=452, Percent_Identity=27.8761061946903, Blast_Score=164, Evalue=6e-40,
Organism=Drosophila melanogaster, GI62472926, Length=452, Percent_Identity=27.8761061946903, Blast_Score=164, Evalue=6e-40,
Organism=Drosophila melanogaster, GI62472936, Length=452, Percent_Identity=27.8761061946903, Blast_Score=164, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21356737, Length=452, Percent_Identity=27.8761061946903, Blast_Score=164, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24585660, Length=462, Percent_Identity=25.974025974026, Blast_Score=152, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24666674, Length=451, Percent_Identity=29.7117516629712, Blast_Score=144, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28571798, Length=451, Percent_Identity=28.6031042128603, Blast_Score=142, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28571796, Length=451, Percent_Identity=28.6031042128603, Blast_Score=142, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28571794, Length=451, Percent_Identity=28.6031042128603, Blast_Score=142, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28571802, Length=451, Percent_Identity=28.6031042128603, Blast_Score=142, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28571800, Length=451, Percent_Identity=28.6031042128603, Blast_Score=142, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28571806, Length=451, Percent_Identity=28.6031042128603, Blast_Score=142, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28574525, Length=498, Percent_Identity=25.7028112449799, Blast_Score=135, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24638876, Length=401, Percent_Identity=27.1820448877805, Blast_Score=104, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24638878, Length=401, Percent_Identity=27.1820448877805, Blast_Score=103, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281360299, Length=341, Percent_Identity=29.3255131964809, Blast_Score=96, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360297, Length=341, Percent_Identity=29.3255131964809, Blast_Score=96, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360295, Length=341, Percent_Identity=29.3255131964809, Blast_Score=96, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24586250, Length=341, Percent_Identity=29.3255131964809, Blast_Score=96, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360301, Length=341, Percent_Identity=29.3255131964809, Blast_Score=95, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552499, Length=341, Percent_Identity=28.4457478005865, Blast_Score=94, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281360303, Length=341, Percent_Identity=28.4457478005865, Blast_Score=94, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR005933
- InterPro:   IPR002872 [H]

Pfam domain/function: PF00171 Aldedh; PF01619 Pro_dh [H]

EC number: =1.5.99.8; =1.5.1.12 [H]

Molecular weight: Translated: 143798; Mature: 143667

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTTTMGVKLDDATRERIKSAATRIDRTPHWLIKQAIFSYLEQLENSDTLPELPALLSGA
CCCCEEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
ANESDEAPTPAEEPHQPFLDFAEQILPQSVSRAAITAAYRRPETEAVSMLLEQARLPQPV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
AEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQEGVALMCLAEALLRIPDKAT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
RDALIRDKISNGNWQSHIGRSPSLFVNAATWGLLFTGKLVSTHNEASLSRSLNRIIGKSG
HHHHHHHHCCCCCHHHHCCCCCCEEEEHHHHHHHEECHHHHCCCHHHHHHHHHHHHCCCC
EPLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAY
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHH
MVSYQQAIHAIGKASNGRGIYEGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLA
HHHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RQYDIGINIDAEEADRLEISLDLLEKLCFEPELAGWNGIGFVIQAYQKRCPLVIDYLIDL
HHHCCCCCCCCCCCCHHEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
ATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLI
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHH
YPQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIY
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEEE
APVGTHETLLAYLVRRLLENGANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGL
ECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCCC
PHPKIPLPRDLYGHGRDNSAGLDLANEHRLASLSSALLNSALQKWQALPMLEQPVAAGEM
CCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC
SPVINPAEPKDIVGFVREATPREVEQALESAVNNAPIWFATPPVERAAILHRAAVLMESQ
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHH
MQQLIGILVREAGKTFSNAIAEVREAVDFLHYYAGQVRDDFANETHRPLGPVVCISPWNF
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
PLAIFTGQIAAALAAGNSVLAKPAEQTPLIAAQGIAILLEAGVPPGVVQLLPGQGETVGA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCEEEEECCCCCCCEEECCCCCCEEEE
QLTGDDRVRGVMFTGSTEVATLLQRNIASRLDAQGRPIPLIAETGGMNAMIVDSSALTEQ
EECCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCHHHHHH
VVIDVLASAFDSAGQRCSALRVLCLQDEIADHTLKMLRGAMAECRMGNPGRLTTDIGPVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCC
DSEAKVNIERHIQTMRSKGRPVFQAVRENSEDAREWQSGTFVAPTLIELDDFAELQKEVF
CCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCCCEECCHHHHHHHHHHHHHHHH
GPVLHVVRYNRNQLPELIEQINASGYGLTLGVHTRIDETIAQVTGSAHVGNLYVNRNMVG
HHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCCEECEEEECCCCEE
AVVGVQPFGGEGLSGTGPKAGGPLYLYRLLANRPESALAVTLARQDAEYPVDAQLKAALT
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHEEEEEECCCCCCCCCHHHHHHHH
QPLNALREWAANRPELQALCTQYGELAQAGTQRLLPGPTGERNTWTLLPRERVLCIADDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEECCC
QDALTQLAAVLAVGSQVLWPDDALHRQLVKALPSAVSERIQLAKAENITAQPFDAVIFHG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
DSDQLRALCEAVAARDGAIVSVQGFARGESNILLERLYIERSLSVNTAAAGGNASLMTIG
CHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEC
>Mature Secondary Structure 
GTTTMGVKLDDATRERIKSAATRIDRTPHWLIKQAIFSYLEQLENSDTLPELPALLSGA
CCCEEEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
ANESDEAPTPAEEPHQPFLDFAEQILPQSVSRAAITAAYRRPETEAVSMLLEQARLPQPV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
AEQAHKLAYQLADKLRNQKNASGRAGMVQGLLQEFSLSSQEGVALMCLAEALLRIPDKAT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHH
RDALIRDKISNGNWQSHIGRSPSLFVNAATWGLLFTGKLVSTHNEASLSRSLNRIIGKSG
HHHHHHHHCCCCCHHHHCCCCCCEEEEHHHHHHHEECHHHHCCCHHHHHHHHHHHHCCCC
EPLIRKGVDMAMRLMGEQFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTAADAQAY
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHH
MVSYQQAIHAIGKASNGRGIYEGPGISIKLSALHPRYSRAQYDRVMEELYPRLKSLTLLA
HHHHHHHHHHHHCCCCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RQYDIGINIDAEEADRLEISLDLLEKLCFEPELAGWNGIGFVIQAYQKRCPLVIDYLIDL
HHHCCCCCCCCCCCCHHEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
ATRSRRRLMIRLVKGAYWDSEIKRAQMDGLEGYPVYTRKVYTDVSYLACAKKLLAVPNLI
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHH
YPQFATHNAHTLAAIYQLAGQNYYPGQYEFQCLHGMGEPLYEQVTGKVADGKLNRPCRIY
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCCCCCCEEEE
APVGTHETLLAYLVRRLLENGANTSFVNRIADTSLPLDELVADPVTAVEKLAQQEGQTGL
ECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCCC
PHPKIPLPRDLYGHGRDNSAGLDLANEHRLASLSSALLNSALQKWQALPMLEQPVAAGEM
CCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCC
SPVINPAEPKDIVGFVREATPREVEQALESAVNNAPIWFATPPVERAAILHRAAVLMESQ
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHH
MQQLIGILVREAGKTFSNAIAEVREAVDFLHYYAGQVRDDFANETHRPLGPVVCISPWNF
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
PLAIFTGQIAAALAAGNSVLAKPAEQTPLIAAQGIAILLEAGVPPGVVQLLPGQGETVGA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCEEEEECCCCCCCEEECCCCCCEEEE
QLTGDDRVRGVMFTGSTEVATLLQRNIASRLDAQGRPIPLIAETGGMNAMIVDSSALTEQ
EECCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCHHHHHH
VVIDVLASAFDSAGQRCSALRVLCLQDEIADHTLKMLRGAMAECRMGNPGRLTTDIGPVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCC
DSEAKVNIERHIQTMRSKGRPVFQAVRENSEDAREWQSGTFVAPTLIELDDFAELQKEVF
CCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCCCEECCHHHHHHHHHHHHHHHH
GPVLHVVRYNRNQLPELIEQINASGYGLTLGVHTRIDETIAQVTGSAHVGNLYVNRNMVG
HHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCCEECEEEECCCCEE
AVVGVQPFGGEGLSGTGPKAGGPLYLYRLLANRPESALAVTLARQDAEYPVDAQLKAALT
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHEEEEEECCCCCCCCCHHHHHHHH
QPLNALREWAANRPELQALCTQYGELAQAGTQRLLPGPTGERNTWTLLPRERVLCIADDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEECCC
QDALTQLAAVLAVGSQVLWPDDALHRQLVKALPSAVSERIQLAKAENITAQPFDAVIFHG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
DSDQLRALCEAVAARDGAIVSVQGFARGESNILLERLYIERSLSVNTAAAGGNASLMTIG
CHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7966312; 8905232; 9278503; 3325781; 12514740 [H]