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The map label for this gene is etp

Identifier: 157160502

GI number: 157160502

Start: 1105844

End: 1106290

Strand: Reverse

Name: etp

Synonym: EcHS_A1091

Alternate gene names: 157160502

Gene position: 1106290-1105844 (Counterclockwise)

Preceding gene: 157160503

Following gene: 157160501

Centisome position: 23.82

GC content: 51.9

Gene sequence:

>447_bases
ATGGCCCAACTAAAATTTAACTCAATCCTGGTGGTTTGTACCGGCAACATTTGCCGTTCGCCCATTGGCGAGCGCTTGCT
GCGTAAACGTCTGCCAGGCGTAAAAGTCAAATCGGCAGGTGTTCATGGTCTGGTAAAACACCCTGCAGATGCGACAGCAG
CAGATGTTGCCGCTAATCATGGCGTATCTCTTGAAGGACATGCCGGACGTAAGCTCACTGCTGAGATGGCACGAAATTAC
GATCTGATTCTGGCAATGGAGTCGGAACATATTGCTCAGGTTACCGCAATCGCTCCCGAGGTCCGCGGGAAGACAATGCT
GTTTGGGCAATGGCTGGAACAGAAAGAGATCCCTGATCCCTATCGTAAAAGTCAGGACGCATTTGAACATGTCTACGGTA
TGTTGGAGCGCGCCAGTCAGGAATGGGCGAAGCGCCTCAGCCGGTAA

Upstream 100 bases:

>100_bases
CTACTGCGCCGCTGGCTCGTTGGAACCGTGTGATTTCTCTGCTGGTACCGACGATTTCCGGGGTGCATGACCTGACAGAG
ACTTCACGGTGGATTCAAAC

Downstream 100 bases:

>100_bases
TTTGAGTTTATAAGATACGATGACAACTAAAAATATGAATACGCCACCAGGCAGCACTCAGGAAAATGAGATCGATCTGC
TTCGTCTGGTCGGCGAGTTA

Product: phosphotyrosine-protein phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MAQLKFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNY
DLILAMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR

Sequences:

>Translated_148_residues
MAQLKFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNY
DLILAMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR
>Mature_147_residues
AQLKFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYD
LILAMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR

Specific function: Dephosphorylates etk

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family

Homologues:

Organism=Homo sapiens, GI4757714, Length=157, Percent_Identity=30.5732484076433, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI6005988, Length=157, Percent_Identity=30.5732484076433, Blast_Score=70, Evalue=8e-13,
Organism=Escherichia coli, GI87081812, Length=148, Percent_Identity=100, Blast_Score=308, Evalue=1e-85,
Organism=Escherichia coli, GI1788375, Length=142, Percent_Identity=56.3380281690141, Blast_Score=174, Evalue=2e-45,
Organism=Drosophila melanogaster, GI78706770, Length=151, Percent_Identity=32.4503311258278, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI78706772, Length=151, Percent_Identity=32.4503311258278, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ETP_ECO57 (P0ACZ3)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- RefSeq:   NP_286919.2
- RefSeq:   NP_309165.2
- ProteinModelPortal:   P0ACZ3
- SMR:   P0ACZ3
- EnsemblBacteria:   EBESCT00000027131
- EnsemblBacteria:   EBESCT00000055776
- GeneID:   914076
- GeneID:   959046
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z1399
- KEGG:   ecs:ECs1138
- GeneTree:   EBGT00050000010250
- HOGENOM:   HBG730979
- OMA:   PYRQSKE
- ProtClustDB:   PRK11391
- BioCyc:   ECOL83334:ECS1138-MONOMER
- InterPro:   IPR000106
- InterPro:   IPR017867
- PANTHER:   PTHR11717
- PRINTS:   PR00719
- SMART:   SM00226

Pfam domain/function: PF01451 LMWPc; SSF52788 Tyr_Pase_low_mol_wt

EC number: =3.1.3.48

Molecular weight: Translated: 16386; Mature: 16255

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: ACT_SITE 13-13 ACT_SITE 18-18 ACT_SITE 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLKFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANH
CCCCCCCCEEEEEECHHHCCHHHHHHHHHHCCCCEEECCCCCHHHCCCCCCHHHHHHHCC
GVSLEGHAGRKLTAEMARNYDLILAMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDP
CCCCCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCH
YRKSQDAFEHVYGMLERASQEWAKRLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQLKFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANH
CCCCCCCEEEEEECHHHCCHHHHHHHHHHCCCCEEECCCCCHHHCCCCCCHHHHHHHCC
GVSLEGHAGRKLTAEMARNYDLILAMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDP
CCCCCCCCCCHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCH
YRKSQDAFEHVYGMLERASQEWAKRLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796