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The map label for this gene is dmsC1

Identifier: 157160419

GI number: 157160419

Start: 1004377

End: 1005240

Strand: Direct

Name: dmsC1

Synonym: EcHS_A1001

Alternate gene names: 157160419

Gene position: 1004377-1005240 (Clockwise)

Preceding gene: 157160418

Following gene: 157160421

Centisome position: 21.63

GC content: 54.63

Gene sequence:

>864_bases
ATGGGAAGTGGATGGCATGAATGGCCGCTGATGATCTTCACGGTCTTCGGGCAATGTGTAGCAGGTGGTTTTATCGTTCT
GGCTTTGGCGCTGCTCAAAGGCGACCTGCGAGCAGAAGCCCAGCAGCGTGTTATCGCCTGCATGTTTGGTTTATGGGTGC
TGATGGGCATTGGCTTTATCGCCTCTATGCTCCATCTTGGTTCACCAATGCGCGCTTTTAACTCGCTCAACCGGGTAGGG
GCTTCAGCACTCAGTAACGAAATCGCCAGCGGTTCGATCTTTTTTGCCGTAGGCGGCATCGGCTGGTTGCTGGCAATGCT
GAAAAAGCTGTCACCGGCATTGCGTACGCTGTGGCTGATAGTGACGATGGTTCTTGGCGTCATCTTTGTCTGGATGATGG
TGCGTGTGTATAACAGCATTGATACCGTTCCGACCTGGTACAGCATCTGGACGCCGATGGGCTTCTTCCTGACGATGTTT
ATGGGCGGCCCGTTACTGGGTTACCTGTTGTTGAGTCTGGCTGGCGTCGATGGCTGGGCGATGCGTCTGCTGCCAGCAAT
TTCTGTACTGGCACTGGTAGTGAGTGGCGTGGTGTCAGTGATGCAGGGCGCAGAGCTGGCGACTATTCATAGTTCTGTGC
AGCAGGCCGCAGCGCTGGTGCCGGACTATGGTGCGCTGATGTCCTGGCGGATCGTGCTTTTGGCCGTTGCCCTGTGCTTG
TGGATTGCACCACAGCTAAAAGGTTATCAGCCTGCGGTTCCGCTACTTTCTGTATCATTCATTCTGCTTCTGGCAGGGGA
ATTAATCGGTCGCGGCGTATTCTATGGTTTGCATATGACCGTGGGGATGGCCGTCGCAAGCTAA

Upstream 100 bases:

>100_bases
GCTCACTTTACCAAACCGAATATTGTGATCAAACCCAATGCCAATAGCCGCCCGACCGGGGATACCACTGGCTATCTGGC
AAACCCGAAGGAGGTGTGAG

Downstream 100 bases:

>100_bases
TCATAACAACCGGGGTTTCGGCCCCGGTTCTCTTTTATTTCTGCTTCGTTAACGTGTCATAACTGGTCATCAAATTACGA
TAATCAGGAATGTGGTTAGA

Product: anaerobic dimethyl sulfoxide reductase, C subunit

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase anchor subunit

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MGSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVG
ASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLIVTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMF
MGGPLLGYLLLSLAGVDGWAMRLLPAISVLALVVSGVVSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCL
WIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS

Sequences:

>Translated_287_residues
MGSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVG
ASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLIVTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMF
MGGPLLGYLLLSLAGVDGWAMRLLPAISVLALVVSGVVSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCL
WIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS
>Mature_286_residues
GSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVGA
SALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLIVTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMFM
GGPLLGYLLLSLAGVDGWAMRLLPAISVLALVVSGVVSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCLW
IAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the dmsAB dimer to the membrane and stabilizes it

COG id: COG3302

COG function: function code R; DMSO reductase anchor subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli ynfH

Homologues:

Organism=Escherichia coli, GI1787123, Length=287, Percent_Identity=100, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1787873, Length=286, Percent_Identity=56.993006993007, Blast_Score=289, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DMSC_ECOLI (P18777)

Other databases:

- EMBL:   J03412
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   S03787
- RefSeq:   AP_001526.1
- RefSeq:   NP_415416.1
- ProteinModelPortal:   P18777
- STRING:   P18777
- EnsemblBacteria:   EBESCT00000002461
- EnsemblBacteria:   EBESCT00000002462
- EnsemblBacteria:   EBESCT00000016221
- GeneID:   945502
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW0879
- KEGG:   eco:b0896
- EchoBASE:   EB0230
- EcoGene:   EG10234
- eggNOG:   COG3302
- GeneTree:   EBGT00050000010789
- HOGENOM:   HBG625162
- OMA:   IWTPLGF
- ProtClustDB:   CLSK870602
- BioCyc:   EcoCyc:DMSC-MONOMER
- BioCyc:   MetaCyc:DMSC-MONOMER
- Genevestigator:   P18777
- InterPro:   IPR007059

Pfam domain/function: PF04976 DmsC

EC number: NA

Molecular weight: Translated: 30827; Mature: 30696

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x13326e00)-; HASH(0x139a07e8)-; HASH(0x13e203b8)-; HASH(0x13836764)-; HASH(0x139d7148)-; HASH(0x13c74300)-; HASH(0x13d283c8)-; HASH(0x13a4ccfc)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
GSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASMLHLGSPMRAFNSLNRVGASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLI
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMFMGGPLLGYLLLSLAGVDGWA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
MRLLPAISVLALVVSGVVSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
WIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 8429002; 2170332