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The map label for this gene is dacC

Identifier: 157160319

GI number: 157160319

Start: 909563

End: 910765

Strand: Direct

Name: dacC

Synonym: EcHS_A0900

Alternate gene names: 157160319

Gene position: 909563-910765 (Clockwise)

Preceding gene: 157160317

Following gene: 157160322

Centisome position: 19.59

GC content: 51.79

Gene sequence:

>1203_bases
ATGACGCAATACTCCTCTCTCCTTCGTGGTCTTGCAGCGGGTTCTGCATTTTTATTCCTTTTTGCCCCAACGGCATTCGC
GGCGGAACAAACCGTTGAAGCGCCGAGCGTGGATGCGCGTGCATGGATTTTAATGGATTACGCCAGCGGTAAAGTGCTAG
CAGAAGGCAACGCGGATGAGAAACTGGATCCCGCGAGCCTGACTAAAATCATGACCAGCTATGTGGTTGGGCAGGCGCTT
AAGGCCGATAAGATTAAACTCACCGATATGGTGACGGTCGGTAAAGATGCCTGGGCGACGGGAAATCCGGCACTGCGTGG
TTCATCGGTAATGTTCCTCAAACCGGGCGATCAGGTTTCGGTGGCAGACTTGAACAAAGGTGTGATTATCCAGTCCGGTA
ATGACGCCTGTATTGCGCTGGCCGATTACGTTGCCGGGAGCCAGGAGTCATTTATTGGTTTGATGAATGGTTATGCCAAA
AAACTGGGTCTGACCAACACTACCTTCCAGACGGTGCACGGTCTGGATGCGCCGGGGCAGTTCAGTACCGCGCGCGATAT
GGCATTGCTGGGCAAAGCATTGATCCACGATGTGCCGGAAGAGTACGCCATTCATAAAGAGAAAGAGTTCACCTTCAACA
AAATTCGTCAGCCTAACCGTAACCGTCTGCTGTGGAGCAGCAATCTGAATGTTGATGGCATGAAGACAGGAACCACGGCA
GGCGCGGGATATAATCTGGTTGCTTCGGCTACCCAGGGCGATATGCGTTTAATCTCCGTAGTGCTGGGGGCGAAAACCGA
CCGTATCCGTTTTAATGAGTCTGAGAAATTATTGACCTGGGGTTTCCGCTTCTTTGAAACTGTGACGCCAATTAAACCTG
ATGCCACCTTTGTGACTCAGCGCGTCTGGTTTGGTGATAAGAGCGAAGTGAATCTCGGGGCAGGCGAAGCGGGCTCCGTG
ACCATACCGCGTGGGCAGCTGAAAAACCTGAAAGCGAGTTATACGTTAACGGAACCGCAGCTTACCGCACCGCTGAAAAA
AGGTCAGGTTGTCGGGACCATTGATTTCCAGCTTAACGGTAAATCCATTGAGCAGCGTCCGCTGATCGTGATGGAAAATG
TGGAAGAGGGCGGATTCTTTGGTCGGGTGTGGGATTTCGTGATGATGAAATTCCATCAGTGGTTCGGCAGCTGGTTCTCT
TAA

Upstream 100 bases:

>100_bases
ACTTACGGTTTCTTTAAGTTTGTGTGTGCGTTATTAATCACCGAACTTATCATACGGCGATATAACGTATTTTTTTTGAA
TGGATACTCGGGTGGCATTT

Downstream 100 bases:

>100_bases
TCTTCTGATAACCGGATGGCGCGAAACGTCATCCGGTTATACGTCATTAATACATCAACTTAATGCGCTGCGTCTGCGCG
TACTTCACATACTCATCTTC

Product: D-alanyl-D-alanine carboxypeptidase fraction C

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQAL
KADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAK
KLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTA
GAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSV
TIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFGRVWDFVMMKFHQWFGSWFS

Sequences:

>Translated_400_residues
MTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQAL
KADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAK
KLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTA
GAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSV
TIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFGRVWDFVMMKFHQWFGSWFS
>Mature_399_residues
TQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALK
ADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKK
LGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTAG
AGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSVT
IPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFGRVWDFVMMKFHQWFGSWFS

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family

Homologues:

Organism=Escherichia coli, GI1787062, Length=400, Percent_Identity=100, Blast_Score=821, Evalue=0.0,
Organism=Escherichia coli, GI1786851, Length=397, Percent_Identity=60.2015113350126, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI87082022, Length=385, Percent_Identity=47.7922077922078, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI87082054, Length=251, Percent_Identity=27.0916334661355, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DACC_ECOLI (P08506)

Other databases:

- EMBL:   X06480
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   G64821
- RefSeq:   AP_001470.1
- RefSeq:   NP_415360.1
- PDB:   3IT9
- PDB:   3ITA
- PDB:   3ITB
- PDBsum:   3IT9
- PDBsum:   3ITA
- PDBsum:   3ITB
- ProteinModelPortal:   P08506
- SMR:   P08506
- STRING:   P08506
- MEROPS:   S11.003
- PhosSite:   P08506
- EnsemblBacteria:   EBESCT00000001352
- EnsemblBacteria:   EBESCT00000015199
- GeneID:   945455
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW0823
- KEGG:   eco:b0839
- EchoBASE:   EB0199
- EcoGene:   EG10203
- eggNOG:   COG1686
- GeneTree:   EBGT00050000011015
- HOGENOM:   HBG728991
- OMA:   YCRRKIL
- ProtClustDB:   PRK10001
- BioCyc:   EcoCyc:EG10203-MONOMER
- BioCyc:   MetaCyc:EG10203-MONOMER
- Genevestigator:   P08506
- GO:   GO:0006508
- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967
- Gene3D:   G3DSA:2.60.410.10
- PRINTS:   PR00725
- SMART:   SM00936

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11; SSF56601 PBP_transp_fold; SSF69189 Peniciliin-bd_prot-assoc

EC number: =3.4.16.4

Molecular weight: Translated: 43609; Mature: 43478

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: ACT_SITE 66-66 ACT_SITE 69-69 ACT_SITE 132-132 BINDING 235-235

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADE
CCCHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCEEEEEEEECCCEEEECCCCCC
KLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVS
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEE
VADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLDAPGQ
EEECCCCEEEECCCCCEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCC
FSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTA
CCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCC
GAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQ
CCCCEEEEECCCCCHHHHHHHHCCCCCCEEECCCCCEEEHHHHHHHHCCCCCCCCCEEEE
RVWFGDKSEVNLGAGEAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNG
EEECCCCCCEEECCCCCCCEEECCHHHHCCEEEEEECCCCCCCCCCCCCEEEEEEEEECC
KSIEQRPLIVMENVEEGGFFGRVWDFVMMKFHQWFGSWFS
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADE
CCHHHHHHHHHCCCEEEEEEECCHHHHHHHCCCCCCCCEEEEEEEECCCEEEECCCCCC
KLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVS
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEE
VADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLDAPGQ
EEECCCCEEEECCCCCEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCC
FSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTA
CCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCC
GAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQ
CCCCEEEEECCCCCHHHHHHHHCCCCCCEEECCCCCEEEHHHHHHHHCCCCCCCCCEEEE
RVWFGDKSEVNLGAGEAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNG
EEECCCCCCEEECCCCCCCEEECCHHHHCCEEEEEECCCCCCCCCCCCCEEEEEEEEECC
KSIEQRPLIVMENVEEGGFFGRVWDFVMMKFHQWFGSWFS
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389