Click here to switch to the map view.

The map label for this gene is ybhO [H]

Identifier: 157160264

GI number: 157160264

Start: 849102

End: 850343

Strand: Reverse

Name: ybhO [H]

Synonym: EcHS_A0843

Alternate gene names: 157160264

Gene position: 850343-849102 (Counterclockwise)

Preceding gene: 157160265

Following gene: 157160263

Centisome position: 18.31

GC content: 54.27

Gene sequence:

>1242_bases
ATGAAATGTAGCTGGCGTGAAGGCAATAAGATCGAGTTGCTGGAAAACGGCGAGCAATATTATCCCGCGGTGTTTAAGGC
GATTGGCGAGGCACAAGAACGCATCATTCTTGAAACGTTTATCTGGTTTGAGGATGACGTCGGCAAACAGCTGCATGCGG
CACTACTGGCAGCAGCGCAACGCGGGGTTAAAGCGGAAGTCTTGCTGGATGGCTACGGTTCGCCGGATCTCAGCGATGAG
TTTGTCAATGAACTGACGGCAGCTGGCGTGGTATTTCGCTACTACGATCCCCGCCCTCGCCTTTTTGGTATGCGCACCAA
TGTGTTTCGCCGGATGCATCGCAAAATTGTGGTGATCGACGCGCGTATCGCCTTTATTGGCGGGCTGAATTACTCCGCCG
AGCATATGTCCAGCTACGGTCCAGAGGCTAAACAGGATTACGCGGTACGCCTTGAAGGGCCGATTGTCGAAGATATTCTC
CAGTTTGAGCTGGAAAACCTGCCTGGACAGAGCGCGGCACGACGCTGGTGGCGACGTCATCACAAAGCGGAAGAGAACCG
CCAGCCGGGAGAAGCGCAGGTATTGCTGGTCTGGCGCGATAACGAAGAACATCGCGATGATATTGAACGTCACTATCTGA
AAATGCTCACTCAGGCGCAGCGAGAAGTCATTATCGCCAACGCCTACTTCTTCCCCGGCTATCGATTTTTACACGCCTTG
CGTAAAGCGGCACGGCGCGGGGTGCGGATCAAACTGATCATTCAGGGCGAACCGGATATGCCGATTGTCAGAGTCGGTGC
GCGCTTGCTGTATAACTATCTGGTTAAAGGCGGCGTTCAGGTATTTGAGTACCGCCGCCGCCCGCTCCACGGCAAAGTGG
CATTGATGGACGATCACTGGGCGACAGTAGGGTCCAGTAATCTCGATCCGCTCAGTTTGTCACTGAATCTCGAAGCAAAT
GTCATCATCCACGATCGTCATTTTAACCAGACGCTGCGCGATAATCTGAACGGCATTATTGCCGCAGATTGTCAGCAGGT
CGATGAGACCATGCTGCCGAAACGCACCTGGTGGAACCTGACCAAAAGCGTGCTGGCGTTCCACTTTTTACGCCACTTCC
CGGCGCTGGTTGGCTGGCTTCCGGCACACACACCACGTCTGACGCAGGTTGATCCCCCCGCACAACCGACAATGGAAACG
CAGGATCGGGTAGAAACTGAAAACACGGGGGTAAAACCCTGA

Upstream 100 bases:

>100_bases
TCTACGTCAAAAATGCCAGCGCCAGCGCGCCAACCGCGTTGCCGCTGCAGACATGGCGACACCTTTCTGATCATGCCCCT
TTAAGTGCGGAGATTCATTT

Downstream 100 bases:

>100_bases
TGAGTAAATCACACCCGCGCTGGCGCTTAGCAAAGAAGATCCTCACCTGGCTGTTTTTTATCGCGGTGATTGTGTTGCTG
GTGGTCTACGCCAAAAAGGT

Product: cardiolipin synthase 2

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MKCSWREGNKIELLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDE
FVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDIL
QFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQAQREVIIANAYFFPGYRFLHAL
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
VIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLTQVDPPAQPTMET
QDRVETENTGVKP

Sequences:

>Translated_413_residues
MKCSWREGNKIELLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDE
FVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDIL
QFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQAQREVIIANAYFFPGYRFLHAL
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
VIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLTQVDPPAQPTMET
QDRVETENTGVKP
>Mature_413_residues
MKCSWREGNKIELLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQRGVKAEVLLDGYGSPDLSDE
FVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVIDARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDIL
QFELENLPGQSAARRWWRRHHKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQAQREVIIANAYFFPGYRFLHAL
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHWATVGSSNLDPLSLSLNLEAN
VIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNLTKSVLAFHFLRHFPALVGWLPAHTPRLTQVDPPAQPTMET
QDRVETENTGVKP

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=413, Percent_Identity=99.273607748184, Blast_Score=849, Evalue=0.0,
Organism=Escherichia coli, GI1787502, Length=400, Percent_Identity=24.75, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI87081826, Length=399, Percent_Identity=23.0576441102757, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 47637; Mature: 47637

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCSWREGNKIELLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQ
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVID
CCCEEEEEEECCCCCCCCHHHHHHHHHHCEEEEEECCCCCEECHHHHHHHHHCCEEEEEE
ARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGQSAARRWWRRH
EEEEEEECCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHH
HKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQAQREVIIANAYFFPGYRFLHAL
HHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEECCHHHHHHHH
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHW
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCC
ATVGSSNLDPLSLSLNLEANVIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNL
CCCCCCCCCCEEEEEEEEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHH
TKSVLAFHFLRHFPALVGWLPAHTPRLTQVDPPAQPTMETQDRVETENTGVKP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MKCSWREGNKIELLENGEQYYPAVFKAIGEAQERIILETFIWFEDDVGKQLHAALLAAAQ
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RGVKAEVLLDGYGSPDLSDEFVNELTAAGVVFRYYDPRPRLFGMRTNVFRRMHRKIVVID
CCCEEEEEEECCCCCCCCHHHHHHHHHHCEEEEEECCCCCEECHHHHHHHHHCCEEEEEE
ARIAFIGGLNYSAEHMSSYGPEAKQDYAVRLEGPIVEDILQFELENLPGQSAARRWWRRH
EEEEEEECCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHH
HKAEENRQPGEAQVLLVWRDNEEHRDDIERHYLKMLTQAQREVIIANAYFFPGYRFLHAL
HHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEEEEECCHHHHHHHH
RKAARRGVRIKLIIQGEPDMPIVRVGARLLYNYLVKGGVQVFEYRRRPLHGKVALMDDHW
HHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEECCCC
ATVGSSNLDPLSLSLNLEANVIIHDRHFNQTLRDNLNGIIAADCQQVDETMLPKRTWWNL
CCCCCCCCCCEEEEEEEEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHH
TKSVLAFHFLRHFPALVGWLPAHTPRLTQVDPPAQPTMETQDRVETENTGVKP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]