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The map label for this gene is ybdR [H]

Identifier: 157160105

GI number: 157160105

Start: 678169

End: 679407

Strand: Direct

Name: ybdR [H]

Synonym: EcHS_A0660

Alternate gene names: 157160105

Gene position: 678169-679407 (Clockwise)

Preceding gene: 157160103

Following gene: 157160115

Centisome position: 14.6

GC content: 50.04

Gene sequence:

>1239_bases
ATGAAAGCATTGACTTATCACGGCCCACATCACGTTCAGGTAGAAAATGTTCCCGATCCGGGCGTTGAACAGGCAGATGA
TATTATTCTGCGTATTACGGCAACGGCGATCTGTGGCTCTGACCTCCATCTTTATCGAGGCAAAATACCTCAGGTTAAAC
ATGGCGATATTTTTGGTCATGAATTTATGGGGGAAGTAGTTGAAACCGGAAAGGACGTAAAAAATTTGCAAAAAGGCGAC
CGAGTGGTAATTCCGTTCGTCATTGCTTGTGGCGACTGTTTTTTCTGTCGATTGCAACAATATGCCGCCTGCGAAAATAC
CAATGCGGGTAAAGGCGCTGCGCTCAATAAAAAACAGATACCAGCTCCAGCGGCATTGTTTGGTTATAGTCACCTGTATG
GCGGCGTTCCTGGTGGGCAGGCGGAATATGTCCGCGTCCCTAAAGGGAATGTGGGGCCGTTTAAAGTACCGCCTTTGCTT
TCAGATGATAAAGCGCTTTTCCTTTCTGATATTCTGCCAACGGCATGGCAGGCAGCAAAAAATGCGCAGATCCAACAAGG
TTCAAGCGTTGCAGTCTATGGTGCTGGTCCTGTGGGATTGTTGACAATCGCCTGTGCACGGTTGCTCGGTGCGGAACAGA
TTTTTGTTGTTGATCATCATCCCTACCGCTTGCATTTCGCCGCCGACCGCTACGGCGCGATCCCGATTAATTTTGATGAA
GACAGCGATCCGGCACAGTCAATTATTGAACAAACGGCAGGTCACCGGGGCGTGGATGCAGTAATAGACGCCGTCGGTTT
TGAAGCGAAAGGCAGCACCACGGAAACGGTGCTGACTAACCTGAAACTGGAGGGCAGCAGCGGTAAAGCGTTGCGTCAGT
GTATTGCGGCGGTCAGGCGTGGCGGCATTGTTAGCGTACCGGGCGTCTACGCTGGATTTATTCACGGTTTCCTGTTTGGC
GACGCCTTTGATAAAGGGTTGTCGTTTAAAATGGGACAGACCCACGTTCACGCATGGCTGGGAGAATTATTACCGTTAAT
TGAGAAAGGATTACTGAAACCAGAAGAAATTGTTACCCACTATATGCCGTTTGAAGAGGCCGGCCGGGGATATGAGATTT
TCGAAAAACGTGAAGAGGAGTGCCGTAAGGTGATTCTGGTACCCGGTGCACAAAACGCAGAGGCGGCGCAGAAGGCGGTT
TCAGGTCTGGTGAATGCGATGCCGGGGGGAACAATATGA

Upstream 100 bases:

>100_bases
ACACCAGGAATTCTCCCAAAACCTGCGGTACCGCCCGTTTTCCCGCTGTGATAGCTACCCTTAAAGACTGACTCTTTTTT
GAACTGTCTCTGGAGGTTGC

Downstream 100 bases:

>100_bases
TCGTCAGGAGTGGTTTTCGAGGTAAAGGACAGCCATGACGATAATCGCCGCCATAATCAGAAATCCTATCAGGATGTAAA
ATGCTTCTGCCATGGTTATT

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKALTYHGPHHVQVENVPDPGVEQADDIILRITATAICGSDLHLYRGKIPQVKHGDIFGHEFMGEVVETGKDVKNLQKGD
RVVIPFVIACGDCFFCRLQQYAACENTNAGKGAALNKKQIPAPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLL
SDDKALFLSDILPTAWQAAKNAQIQQGSSVAVYGAGPVGLLTIACARLLGAEQIFVVDHHPYRLHFAADRYGAIPINFDE
DSDPAQSIIEQTAGHRGVDAVIDAVGFEAKGSTTETVLTNLKLEGSSGKALRQCIAAVRRGGIVSVPGVYAGFIHGFLFG
DAFDKGLSFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTHYMPFEEAGRGYEIFEKREEECRKVILVPGAQNAEAAQKAV
SGLVNAMPGGTI

Sequences:

>Translated_412_residues
MKALTYHGPHHVQVENVPDPGVEQADDIILRITATAICGSDLHLYRGKIPQVKHGDIFGHEFMGEVVETGKDVKNLQKGD
RVVIPFVIACGDCFFCRLQQYAACENTNAGKGAALNKKQIPAPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLL
SDDKALFLSDILPTAWQAAKNAQIQQGSSVAVYGAGPVGLLTIACARLLGAEQIFVVDHHPYRLHFAADRYGAIPINFDE
DSDPAQSIIEQTAGHRGVDAVIDAVGFEAKGSTTETVLTNLKLEGSSGKALRQCIAAVRRGGIVSVPGVYAGFIHGFLFG
DAFDKGLSFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTHYMPFEEAGRGYEIFEKREEECRKVILVPGAQNAEAAQKAV
SGLVNAMPGGTI
>Mature_412_residues
MKALTYHGPHHVQVENVPDPGVEQADDIILRITATAICGSDLHLYRGKIPQVKHGDIFGHEFMGEVVETGKDVKNLQKGD
RVVIPFVIACGDCFFCRLQQYAACENTNAGKGAALNKKQIPAPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLL
SDDKALFLSDILPTAWQAAKNAQIQQGSSVAVYGAGPVGLLTIACARLLGAEQIFVVDHHPYRLHFAADRYGAIPINFDE
DSDPAQSIIEQTAGHRGVDAVIDAVGFEAKGSTTETVLTNLKLEGSSGKALRQCIAAVRRGGIVSVPGVYAGFIHGFLFG
DAFDKGLSFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTHYMPFEEAGRGYEIFEKREEECRKVILVPGAQNAEAAQKAV
SGLVNAMPGGTI

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=248, Percent_Identity=30.6451612903226, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI156523966, Length=388, Percent_Identity=23.1958762886598, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4501939, Length=376, Percent_Identity=23.1382978723404, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI71565152, Length=361, Percent_Identity=24.3767313019391, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786825, Length=412, Percent_Identity=99.5145631067961, Blast_Score=839, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=400, Percent_Identity=28, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787863, Length=394, Percent_Identity=23.6040609137056, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI226510992, Length=385, Percent_Identity=25.7142857142857, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082125, Length=261, Percent_Identity=27.9693486590038, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790718, Length=216, Percent_Identity=28.2407407407407, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788407, Length=317, Percent_Identity=25.8675078864353, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788075, Length=381, Percent_Identity=25.4593175853018, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786552, Length=246, Percent_Identity=28.0487804878049, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081918, Length=255, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=276, Percent_Identity=25.3623188405797, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71997431, Length=276, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565904, Length=247, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320033, Length=405, Percent_Identity=26.6666666666667, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=301, Percent_Identity=29.2358803986711, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=296, Percent_Identity=29.0540540540541, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17737895, Length=209, Percent_Identity=27.7511961722488, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 44189; Mature: 44189

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTYHGPHHVQVENVPDPGVEQADDIILRITATAICGSDLHLYRGKIPQVKHGDIFGH
CCCEECCCCCEEEECCCCCCCCCCCCCEEEEEEEHHHCCCCCHHHCCCCCCCCCCCCCCH
EFMGEVVETGKDVKNLQKGDRVVIPFVIACGDCFFCRLQQYAACENTNAGKGAALNKKQI
HHHHHHHHCCHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PAPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLLSDDKALFLSDILPTAWQAAK
CCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHC
NAQIQQGSSVAVYGAGPVGLLTIACARLLGAEQIFVVDHHPYRLHFAADRYGAIPINFDE
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCEEECCCC
DSDPAQSIIEQTAGHRGVDAVIDAVGFEAKGSTTETVLTNLKLEGSSGKALRQCIAAVRR
CCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHEEEEEEEECCCCHHHHHHHHHHHC
GGIVSVPGVYAGFIHGFLFGDAFDKGLSFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTH
CCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YMPFEEAGRGYEIFEKREEECRKVILVPGAQNAEAAQKAVSGLVNAMPGGTI
HCCHHHCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKALTYHGPHHVQVENVPDPGVEQADDIILRITATAICGSDLHLYRGKIPQVKHGDIFGH
CCCEECCCCCEEEECCCCCCCCCCCCCEEEEEEEHHHCCCCCHHHCCCCCCCCCCCCCCH
EFMGEVVETGKDVKNLQKGDRVVIPFVIACGDCFFCRLQQYAACENTNAGKGAALNKKQI
HHHHHHHHCCHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PAPAALFGYSHLYGGVPGGQAEYVRVPKGNVGPFKVPPLLSDDKALFLSDILPTAWQAAK
CCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHC
NAQIQQGSSVAVYGAGPVGLLTIACARLLGAEQIFVVDHHPYRLHFAADRYGAIPINFDE
CCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCEEECCCC
DSDPAQSIIEQTAGHRGVDAVIDAVGFEAKGSTTETVLTNLKLEGSSGKALRQCIAAVRR
CCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHEEEEEEEECCCCHHHHHHHHHHHC
GGIVSVPGVYAGFIHGFLFGDAFDKGLSFKMGQTHVHAWLGELLPLIEKGLLKPEEIVTH
CCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YMPFEEAGRGYEIFEKREEECRKVILVPGAQNAEAAQKAVSGLVNAMPGGTI
HCCHHHCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]