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The map label for this gene is entC

Identifier: 157160089

GI number: 157160089

Start: 660966

End: 662141

Strand: Direct

Name: entC

Synonym: EcHS_A0644

Alternate gene names: 157160089

Gene position: 660966-662141 (Clockwise)

Preceding gene: 157160087

Following gene: 157160090

Centisome position: 14.23

GC content: 56.46

Gene sequence:

>1176_bases
ATGGATACGTCACTGGCTGAGGAAGTACAGCAGACCATGGCAACACTTGCGCCCAATCGCTTTTTCTTTATGTCGCCGTA
CCGCAGTTTTACGACGTCAGGATGTTTCGCCCGCTTCGATGAACCGGCTGTGAACGGGGATTCGCCCGACAGTCCCTTCC
AGCAAAAACTCGCCGCGCTGTTTGCCGATGCCAAAGCGCAGGGCATCAAAAATCCGGTGATGGTCGGGGCGATTCCCTTC
GATCCACGTCAGCCTTCGTCGCTGTATATTCCTGAATCCTGGCAGTCGTTCTCCCGTCAGGAAAAACAAGCTTCCGCACG
CCGTTTCACCCGCAGCCAGTCGCTGAATGTGGTGGAACGCCAGGCAATTCCGGAGCAAACCACGTTTGAACAGATGGTTG
CCCGCGCCGCCGCACTTACCGCCACGCCGCAGGTCGACAAAGTGGTGTTGTCACGGTTGATTGATATCACCACTGACGCC
GCCATTGATAGTGGCGTATTGCTGGAACGGTTGATTGCGCAAAACCCGGTTAGTTACAACTTCCATGTTCCGCTGGCTGA
TGGTGGCGTCCTGCTGGGGGCCAGCCCGGAACTGCTGCTACGTAAAGACGGCGAGCGTTTTAGCTCCATTCCGTTAGCCG
GTTCCGCGCGTCGTCAGCCGGATGAAGTGCTCGATCGCGAAGCAGGTAATCGTCTGCTGGCGTCAGAAAAAGATCGCCAT
GAACATGAACTGGTGACTCAGGCGATGAAAGAGGTACTGCGCGAACGCAGTAGTGAGTTACACGTTCCTTCTTCTCCACA
GCTGATCACCACGCCGACGCTGTGGCATCTCGCAACTCCCTTTGAAGGTAAAGCGAATTCGCAAGAAAACGCACTGACTC
TGGCCTGTCTGCTGCATCCGACCCCCGCGCTGAGCGGTTTCCCGCATCAGGCCGCGACCCAGGTTATTGCTGAACTGGAA
CCGTTCGACCGCGAACTGTTTGGCGGCATTGTGGGTTGGTGTGACAGCGAAGGTAACGGCGAATGGGTGGTGACCATCCG
CTGCGCGAAGCTGCGGGAAAATCAGGTGCGTCTGTTTGCCGGAGCGGGGATTGTGCCTGCGTCGTCACCGTTGGGTGAGT
GGCGCGAAACAGGCGTCAAACTTTCTACCATGTTGAACGTTTTTGGATTGCATTAA

Upstream 100 bases:

>100_bases
ACCTCAAGAGTTGACATAGTGCGCGTTTGCTTTTAGGTTAGCGACCGAAAATATAAATGATAATCATTATTAAAGCCTTT
ATCATTTTGTGGAGGATGAT

Downstream 100 bases:

>100_bases
GGAGCGAGGATGAGCATTCCATTCACCCGCTGGCCGGAAGAGTTTGCCCGTCGCTATCGGGAAAAAGGCTACTGGCAGGA
TTTGCCGCTGACCGACATTC

Product: isochorismate synthase

Products: NA

Alternate protein names: Isochorismate mutase

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MDTSLAEEVQQTMATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPF
DPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDA
AIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRH
EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELE
PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH

Sequences:

>Translated_391_residues
MDTSLAEEVQQTMATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPF
DPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDA
AIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRH
EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELE
PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH
>Mature_391_residues
MDTSLAEEVQQTMATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPF
DPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVERQAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDA
AIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRH
EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELE
PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH

Specific function: Siderophore biosynthesis; enterobactin biosynthesis. [C]

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family

Homologues:

Organism=Escherichia coli, GI1786809, Length=391, Percent_Identity=100, Blast_Score=800, Evalue=0.0,
Organism=Escherichia coli, GI87082077, Length=276, Percent_Identity=31.5217391304348, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788114, Length=200, Percent_Identity=28, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787518, Length=227, Percent_Identity=29.0748898678414, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=212, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ENTC_ECO57 (P0AEJ3)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   D85558
- PIR:   H90707
- RefSeq:   NP_286320.1
- RefSeq:   NP_308659.1
- ProteinModelPortal:   P0AEJ3
- SMR:   P0AEJ3
- EnsemblBacteria:   EBESCT00000027757
- EnsemblBacteria:   EBESCT00000057215
- GeneID:   916991
- GeneID:   957607
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z0735
- KEGG:   ecs:ECs0632
- GeneTree:   EBGT00050000009519
- HOGENOM:   HBG405459
- OMA:   FASGNLK
- ProtClustDB:   PRK15016
- BioCyc:   ECOL83334:ECS0632-MONOMER
- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561
- Gene3D:   G3DSA:3.60.120.10
- PANTHER:   PTHR11236:SF3
- PANTHER:   PTHR11236
- TIGRFAMs:   TIGR00543

Pfam domain/function: PF00425 Chorismate_bind; SSF56322 TRPE_1_chor_bd

EC number: =5.4.4.2

Molecular weight: Translated: 42932; Mature: 42932

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSLAEEVQQTMATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAAL
CCCHHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHH
FADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVER
HHHHHHHCCCCCEEEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
QAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYN
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEE
FHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRH
EEEEECCCCEEECCCCCEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHH
EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHP
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHEECCCCCCCCCCCCCEEEEEEEECC
TPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFA
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCCEEEEEEEECCCCCCEEEEE
GAGIVPASSPLGEWRETGVKLSTMLNVFGLH
CCCCCCCCCCHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDTSLAEEVQQTMATLAPNRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAAL
CCCHHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCHHHCCCCCCCCCCCCCHHHHHHHHH
FADAKAQGIKNPVMVGAIPFDPRQPSSLYIPESWQSFSRQEKQASARRFTRSQSLNVVER
HHHHHHHCCCCCEEEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
QAIPEQTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYN
HCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEE
FHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRH
EEEEECCCCEEECCCCCEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHH
EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHP
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHEECCCCCCCCCCCCCEEEEEEEECC
TPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFA
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCCEEEEEEEECCCCCCEEEEE
GAGIVPASSPLGEWRETGVKLSTMLNVFGLH
CCCCCCCCCCHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796